| 98-0557567 |
Bermuda |
12033698 |
0 |
12619769 |
0 |
12793559 |
5.5 % |
08/11/2024 |
| STATE STREET CORPORATION |
MA |
0 |
12203756 |
0 |
0 |
13004993 |
5.6 % |
17/10/2024 |
| Israel A. Englander |
Delaware |
0 |
1374038 |
0 |
1374038 |
1374038 |
0.6 % |
23/09/2024 |
| Millennium Group Management LLC |
Delaware |
0 |
1374038 |
0 |
1374038 |
1374038 |
0.6 % |
23/09/2024 |
| Millennium Management LLC |
Delaware |
0 |
1374038 |
0 |
1374038 |
1374038 |
0.6 % |
23/09/2024 |
| Nuveen Asset Management, LLC |
Delaware |
5062545 |
0 |
5062545 |
0 |
5062545 |
2.24 % |
14/02/2024 |
| Teachers Advisors, LLC |
Delaware |
2215363 |
0 |
2215363 |
0 |
2215363 |
0.98 % |
14/02/2024 |
| TIAA-CREF Investment Management, LLC |
Delaware |
4077569 |
0 |
4077569 |
0 |
4077569 |
1.8 % |
14/02/2024 |
| Teachers Advisors, LLC |
Delaware |
2215363 |
0 |
2215363 |
0 |
2215363 |
0.98 % |
14/02/2024 |
| TIAA-CREF Investment Management, LLC |
Delaware |
4077569 |
0 |
4077569 |
0 |
4077569 |
1.8 % |
14/02/2024 |
| Nuveen Asset Management, LLC |
Delaware |
5062545 |
0 |
5062545 |
0 |
5062545 |
2.24 % |
14/02/2024 |
| Nuveen Asset Management, LLC |
Delaware |
5062545 |
0 |
5062545 |
0 |
5062545 |
2.24 % |
14/02/2024 |
| TIAA-CREF Investment Management, LLC |
Delaware |
4077569 |
0 |
4077569 |
0 |
4077569 |
1.8 % |
14/02/2024 |
| Teachers Advisors, LLC |
Delaware |
2215363 |
0 |
2215363 |
0 |
2215363 |
0.98 % |
14/02/2024 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
0 |
12402529 |
489346 |
12891875 |
5.71 % |
13/02/2024 |
| (1) BlackRock, Inc. |
Delaware |
14673914 |
0 |
15101281 |
0 |
15101281 |
6.9 % |
03/02/2023 |
| Millennium Group Management LLC |
|
0 |
6254409 |
0 |
6254409 |
6254409 |
3.2 % |
28/06/2022 |
| Millennium Management LLC |
|
0 |
6254409 |
0 |
6254409 |
6254409 |
3.2 % |
28/06/2022 |
| Israel A. Englander |
|
0 |
6254409 |
0 |
6254409 |
6254409 |
3.2 % |
28/06/2022 |
| Perceptive Advisors LLC |
Delaware |
0 |
11933387 |
0 |
11933387 |
11933387 |
6.1 % |
14/02/2022 |
| Consonance Capital Management LP |
Delaware USA |
0 |
1289481 |
0 |
1289481 |
1289481 |
1.36 % |
14/02/2022 |
| Timothy P. Lynch |
California |
9911577 |
0 |
9911577 |
0 |
9911577 |
11 % |
14/02/2022 |
| Stonepine Capital Management, LLC |
California |
9911577 |
0 |
9911577 |
0 |
9911577 |
11 % |
14/02/2022 |
| Stonepine Capital, L.P. |
California |
9911577 |
0 |
9911577 |
0 |
9911577 |
11 % |
14/02/2022 |
| Jon M. Plexico |
California |
9911577 |
0 |
9911577 |
0 |
9911577 |
11 % |
14/02/2022 |
| NWQ Investment Management Company, LLC |
U.S.A. |
10612600 |
0 |
10612600 |
0 |
10612600 |
5.42 % |
11/02/2022 |
| David Johnson |
United States |
0 |
10893237 |
0 |
10 |
10893237 |
5.6 % |
04/02/2022 |
| Caligan Partners LP |
Delaware |
0 |
10893237 |
0 |
10 |
10893237 |
5.6 % |
04/02/2022 |
| Perceptive Advisors LLC |
|
0 |
11933387 |
0 |
11933387 |
11933387 |
6.6 % |
27/10/2021 |
| Perceptive Life Sciences Master Fund, Ltd. |
|
0 |
11933387 |
0 |
11933387 |
11933387 |
6.6 % |
27/10/2021 |
| Joseph Edelman |
|
0 |
11933387 |
0 |
11933387 |
11933387 |
6.6 % |
27/10/2021 |
| (1) BlackRock, Inc. |
Delaware |
5685417 |
0 |
5753820 |
0 |
5753820 |
4.7 % |
09/04/2021 |
| Perceptive Life Sciences Master Fund, Ltd. |
Delaware |
0 |
16584802 |
0 |
16584802 |
16584802 |
17.5 % |
16/02/2021 |
| Perceptive Advisors LLC |
Delaware |
0 |
16584802 |
0 |
16584802 |
16584802 |
17.5 % |
16/02/2021 |
| Joseph Edelman |
Delaware |
0 |
16584802 |
0 |
16584802 |
16584802 |
17.5 % |
16/02/2021 |
| Consonance Capman GP LLC |
Delaware, USA |
0 |
1558290 |
0 |
0 |
1558290 |
1.65 % |
16/02/2021 |
| Consonance Capital Management LP |
Delaware, USA |
0 |
1289481 |
0 |
0 |
1289481 |
1.36 % |
16/02/2021 |
| Consonance Capital Opportunity Fund Management LP |
Delaware, USA |
0 |
268809 |
0 |
0 |
268809 |
0.28 % |
16/02/2021 |
| Mitchell Blutt |
Delaware, USA |
0 |
1558290 |
0 |
0 |
1558290 |
1.65 % |
16/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
5391013 |
0 |
5423699 |
0 |
5423699 |
5.7 % |
02/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
4130009 |
0 |
4172761 |
0 |
4172761 |
4.8 % |
09/03/2020 |
| 16,084,802 |
Delaware |
0 |
16084802 |
0 |
16084802 |
16084802 |
19.4 % |
14/02/2020 |
| 19.4% |
Delaware |
0 |
16084802 |
0 |
16084802 |
16084802 |
19.4 % |
14/02/2020 |
| 16,084,802 |
Delaware |
0 |
16084802 |
0 |
16084802 |
16084802 |
19.4 % |
14/02/2020 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
993607 |
0 |
0 |
993607 |
1.68 % |
14/02/2020 |
| Mitchell Blutt |
Delaware USA |
0 |
5166961 |
0 |
0 |
5166961 |
8.71 % |
14/02/2020 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
5166961 |
0 |
0 |
5166961 |
8.71 % |
14/02/2020 |
| Consonance Capital Management LP |
Delaware USA |
0 |
4173354 |
0 |
0 |
4173354 |
7.04 % |
14/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
3920740 |
0 |
3971107 |
0 |
3971107 |
6.7 % |
07/02/2020 |
| Perceptive Life Sciences Master Fund, Ltd. |
Delaware |
0 |
11521102 |
0 |
11521102 |
11521102 |
19.4 % |
23/05/2019 |
| Joseph Edelman |
Delaware |
0 |
11521102 |
0 |
11521102 |
11521102 |
19.4 % |
23/05/2019 |
| Perceptive Advisors LLC |
Delaware |
0 |
11521102 |
0 |
11521102 |
11521102 |
19.4 % |
23/05/2019 |
| 10 |
Delaware |
0 |
6521102 |
0 |
6521102 |
6521102 |
14.1 % |
14/02/2019 |
| 14.1% |
Delaware |
0 |
6521102 |
0 |
6521102 |
6521102 |
14.1 % |
14/02/2019 |
| 10 |
Delaware |
0 |
6521102 |
0 |
6521102 |
6521102 |
14.1 % |
14/02/2019 |
| Mitchell Blutt |
Delaware USA |
0 |
4588352 |
0 |
0 |
4588352 |
9.9 % |
14/02/2019 |
| Consonance Capital Management LP |
Delaware USA |
3874424 |
0 |
3874424 |
0 |
3874424 |
8.36 % |
14/02/2019 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
4588352 |
0 |
0 |
4588352 |
9.9 % |
14/02/2019 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
713928 |
0 |
0 |
713928 |
1.54 % |
14/02/2019 |
| Broadfin Capital, LLC |
Delaware |
0 |
4226077 |
0 |
4226077 |
4226077 |
9.12 % |
13/02/2019 |
| Kevin Kotler |
Delaware |
0 |
4226077 |
0 |
4226077 |
4226077 |
9.12 % |
13/02/2019 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
4226077 |
0 |
4226077 |
4226077 |
9.12 % |
13/02/2019 |
| The Biotest Divestiture Trust |
Maryland |
0 |
0 |
0 |
10109534 |
10109534 |
21.8 % |
09/08/2018 |
| Eric Rosenbach |
United States |
0 |
0 |
0 |
10 |
10109534 |
21.8 % |
09/08/2018 |
| Kevin Kotler |
Delaware |
0 |
3249829 |
0 |
3249829 |
3249829 |
7.21 % |
11/06/2018 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
3249829 |
0 |
3249829 |
3249829 |
7.21 % |
11/06/2018 |
| Broadfin Capital, LLC |
Delaware |
0 |
3249829 |
0 |
3249829 |
3249829 |
7.21 % |
11/06/2018 |
| Mitchell Blutt |
USA |
0 |
3367635 |
0 |
0 |
3367635 |
7.43 % |
14/02/2018 |
| Consonance Capital Management LP |
Delaware, USA |
0 |
3070624 |
0 |
0 |
3070624 |
6.78 % |
14/02/2018 |
| Consonance Capital Opportunity Fund Management LP |
Delaware, USA |
0 |
297011 |
0 |
0 |
297011 |
0.66 % |
14/02/2018 |
| Consonance Capman GP LLC |
Delaware, USA |
0 |
3367635 |
0 |
0 |
3367635 |
7.43 % |
14/02/2018 |
| Kevin Kotler |
Delaware |
0 |
1102200 |
0 |
1102200 |
1102200 |
2.43 % |
13/02/2018 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
1102200 |
0 |
1102200 |
1102200 |
2.43 % |
13/02/2018 |
| Broadfin Capital, LLC |
Delaware |
0 |
1102200 |
0 |
1102200 |
1102200 |
2.43 % |
13/02/2018 |
| Aisling Capital II, LP |
Delaware |
3608171 |
0 |
3608171 |
0 |
3608171 |
8 % |
16/11/2017 |
| Aisling Capital Partners LLC |
Delaware |
3608171 |
0 |
3608171 |
0 |
3608171 |
8 % |
16/11/2017 |
| Dennis Purcell |
United States |
0 |
3608171 |
0 |
3608171 |
3608171 |
8 % |
16/11/2017 |
| Aisling Capital Partners, LP |
Delaware |
3608171 |
0 |
3608171 |
0 |
3608171 |
8 % |
16/11/2017 |
| Andrew Schiff |
United States |
0 |
3608171 |
0 |
3608171 |
3608171 |
8 % |
16/11/2017 |
| Steve Elms |
United States |
0 |
3608171 |
0 |
3608171 |
3608171 |
8 % |
16/11/2017 |
| 10 |
Delaware |
0 |
3821102 |
0 |
3821102 |
3821102 |
10.4 % |
15/11/2017 |
| 10 |
Delaware |
0 |
3821102 |
0 |
3821102 |
3821102 |
10.4 % |
15/11/2017 |
| 10 |
Delaware |
0 |
3821102 |
0 |
3821102 |
3821102 |
10.4 % |
15/11/2017 |
| Biotest AG |
Germany |
0 |
0 |
0 |
4295580 |
4295580 |
25 % |
16/06/2017 |
| Biotest Pharmaceuticals Corporation |
Delaware |
0 |
0 |
0 |
4295580 |
4295580 |
25 % |
16/06/2017 |
| Sciences Master Fund, Ltd. |
Delaware United States America |
0 |
683244 |
0 |
0 |
683244 |
5.3 % |
14/02/2017 |
| Advisors LLC |
Delaware United States America |
0 |
721102 |
0 |
0 |
721102 |
5.59 % |
14/02/2017 |
| Joseph Edelman |
Delaware United States America |
0 |
721102 |
0 |
0 |
721102 |
5.59 % |
14/02/2017 |
| Consonance Capital Management LP |
Delaware USA |
0 |
1151135 |
0 |
1151135 |
1151135 |
8.93 % |
13/02/2017 |
| Kevin Kotler |
Delaware |
0 |
1113293 |
0 |
1113293 |
1113293 |
8.64 % |
13/02/2017 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
1113293 |
0 |
1113293 |
1113293 |
8.64 % |
13/02/2017 |
| Broadfin Capital, LLC |
Delaware |
0 |
1113293 |
0 |
1113293 |
1113293 |
8.64 % |
13/02/2017 |
| Steve Elms |
United States |
0 |
3608171 |
0 |
3608171 |
3608171 |
28 % |
24/01/2017 |
| Aisling Capital Partners LLC |
Delaware |
3608171 |
0 |
3608171 |
0 |
3608171 |
28 % |
24/01/2017 |
| Aisling Capital II, LP |
Delaware |
3608171 |
0 |
3608171 |
0 |
3608171 |
28 % |
24/01/2017 |
| Aisling Capital Partners, LP |
Delaware |
3608171 |
0 |
3608171 |
0 |
3608171 |
28 % |
24/01/2017 |
| Dennis Purcell |
United States |
0 |
3608171 |
0 |
3608171 |
3608171 |
28 % |
24/01/2017 |
| Andrew Schiff |
United States |
0 |
3608171 |
0 |
3608171 |
3608171 |
28 % |
24/01/2017 |
| Grossman, Jerrold B. |
United States |
215188 |
0 |
215188 |
0 |
215188 |
1.66 % |
24/01/2017 |
| Maggro, LLC |
New Jersey |
528016 |
0 |
528016 |
0 |
528016 |
4.1 % |
24/01/2017 |
| Consonance Capital Management LP |
USA |
0 |
957865 |
0 |
0 |
957865 |
8.9 % |
11/02/2016 |
| Consonance Capman GP LLC |
USA |
0 |
1060017 |
0 |
0 |
1060017 |
9.9 % |
11/02/2016 |
| Mitchell Blutt |
USA |
0 |
1060017 |
0 |
0 |
1060017 |
9.9 % |
11/02/2016 |
| Consonance Capital Opportunity Fund Management LP |
USA |
0 |
102152 |
0 |
0 |
102152 |
1 % |
11/02/2016 |
| Broadfin Capital, LLC |
Delaware |
0 |
964193 |
0 |
964193 |
964193 |
9.2 % |
19/03/2015 |
| Consonance Capman GP LLC |
Delaware |
0 |
877407 |
0 |
0 |
877407 |
9.4 % |
17/02/2015 |
| Consonance Capital Management LP |
Delaware |
0 |
822407 |
0 |
0 |
822407 |
8.9 % |
17/02/2015 |
| Consonance Capital Opportunity Fund Management LP |
Delaware |
0 |
55000 |
0 |
0 |
55000 |
0.6 % |
17/02/2015 |
| Mitchell Blutt |
USA |
0 |
877407 |
0 |
0 |
877407 |
9.4 % |
17/02/2015 |
| Steve Elms |
United States |
0 |
3620143 |
0 |
3620143 |
3620143 |
1 % |
23/10/2013 |
| Aisling Capital Partners, LP |
Delaware |
3620143 |
0 |
3620143 |
0 |
3620143 |
1 % |
23/10/2013 |
| Aisling Capital Partners LLC |
Delaware |
3620143 |
0 |
3620143 |
0 |
3620143 |
1 % |
23/10/2013 |
| Andrew Schiff |
United States |
0 |
3620143 |
0 |
3620143 |
3620143 |
39.25 % |
23/10/2013 |
| Dennis Purcell |
United States |
0 |
3620143 |
0 |
3620143 |
3620143 |
1 % |
23/10/2013 |
| Aisling Capital II, LP |
Delaware |
3620143 |
0 |
3620143 |
0 |
3620143 |
1 % |
23/10/2013 |
| Ayer Capital Management, LP |
Delaware USA |
0 |
364585 |
0 |
364585 |
364585 |
8.06 % |
22/02/2012 |
| ACM Capital Partners, LLC |
Delaware USA |
0 |
364585 |
0 |
364585 |
364585 |
8.06 % |
22/02/2012 |
| Jay Venkatesan |
Delaware USA |
0 |
364585 |
0 |
364585 |
364585 |
8.06 % |
22/02/2012 |
| Dennis Purcell |
United States |
0 |
2516855 |
0 |
2516855 |
2516855 |
1 % |
22/02/2012 |
| Aisling Capital Partners, LP |
Delaware |
2516855 |
0 |
2516855 |
0 |
2516855 |
1 % |
22/02/2012 |
| Aisling Capital II, LP |
Delaware |
2516855 |
0 |
2516855 |
0 |
2516855 |
1 % |
22/02/2012 |
| Aisling Capital Partners LLC |
Delaware |
2516855 |
0 |
2516855 |
0 |
2516855 |
1 % |
22/02/2012 |
| Steve Elms |
United States |
0 |
2516855 |
0 |
2516855 |
2516855 |
1 % |
22/02/2012 |
| Andrew Schiff |
United States |
0 |
2516855 |
0 |
2516855 |
2516855 |
54.08 % |
22/02/2012 |