The Vanguard Group |
Pennsylvania |
0 |
426250 |
17481283 |
637211 |
18118494 |
7.77 % |
12/11/2024 |
Invesco Ltd. |
Bermuda |
12033698 |
0 |
12619769 |
0 |
12793559 |
5.5 % |
08/11/2024 |
The Vanguard Group |
Pennsylvania |
0 |
426250 |
17481283 |
637211 |
18118494 |
7.77 % |
04/11/2024 |
STATE STREET CORPORATION |
MA |
0 |
12203756 |
0 |
13004993 |
13004993 |
5.6 % |
17/10/2024 |
Millennium Group Management LLC |
Delaware |
0 |
1374038 |
0 |
1374038 |
1374038 |
0.6 % |
23/09/2024 |
Millennium Management LLC |
Delaware |
0 |
1374038 |
0 |
1374038 |
1374038 |
0.6 % |
23/09/2024 |
Israel A. Englander |
United States |
0 |
1374038 |
0 |
1374038 |
1374038 |
0.6 % |
23/09/2024 |
Nuveen Asset Management, LLC |
Delaware |
5062545 |
0 |
5062545 |
0 |
5062545 |
2.24 % |
14/02/2024 |
Teachers Advisors, LLC |
Delaware |
2215363 |
0 |
2215363 |
0 |
2215363 |
0.98 % |
14/02/2024 |
Investment Management, LLC |
Delaware |
4077569 |
0 |
4077569 |
0 |
4077569 |
1.8 % |
14/02/2024 |
Investment Management, LLC |
Delaware |
4077569 |
0 |
4077569 |
0 |
4077569 |
1.8 % |
14/02/2024 |
Nuveen Asset Management, LLC |
Delaware |
5062545 |
0 |
5062545 |
0 |
5062545 |
2.24 % |
14/02/2024 |
Teachers Advisors, LLC |
Delaware |
2215363 |
0 |
2215363 |
0 |
2215363 |
0.98 % |
14/02/2024 |
Teachers Advisors, LLC |
Delaware |
2215363 |
0 |
2215363 |
0 |
2215363 |
0.98 % |
14/02/2024 |
Nuveen Asset Management, LLC |
Delaware |
5062545 |
0 |
5062545 |
0 |
5062545 |
2.24 % |
14/02/2024 |
Investment Management, LLC |
Delaware |
4077569 |
0 |
4077569 |
0 |
4077569 |
1.8 % |
14/02/2024 |
The Vanguard Group |
Pennsylvania |
0 |
290217 |
12402529 |
489346 |
12891875 |
5.71 % |
13/02/2024 |
BlackRock, Inc. |
Delaware |
17486048 |
0 |
17917745 |
0 |
17917745 |
7.9 % |
26/01/2024 |
Teachers Advisors, LLC |
Delaware |
2090576 |
0 |
2090576 |
0 |
2090576 |
0.95 % |
14/02/2023 |
Nuveen Asset Management, LLC |
Delaware |
4291906 |
0 |
5483369 |
0 |
5483369 |
2.48 % |
14/02/2023 |
Teachers Advisors, LLC |
Delaware |
2090576 |
0 |
2090576 |
0 |
2090576 |
0.95 % |
14/02/2023 |
Investment Management, LLC |
Delaware |
1358417 |
0 |
1358417 |
0 |
1358417 |
0.61 % |
14/02/2023 |
Nuveen Asset Management, LLC |
Delaware |
4291906 |
0 |
5483369 |
0 |
5483369 |
2.48 % |
14/02/2023 |
Investment Management, LLC |
Delaware |
1358417 |
0 |
1358417 |
0 |
1358417 |
0.61 % |
14/02/2023 |
Investment Management, LLC |
Delaware |
1358417 |
0 |
1358417 |
0 |
1358417 |
0.61 % |
14/02/2023 |
Teachers Advisors, LLC |
Delaware |
2090576 |
0 |
2090576 |
0 |
2090576 |
0.95 % |
14/02/2023 |
Nuveen Asset Management, LLC |
Delaware |
4291906 |
0 |
5483369 |
0 |
5483369 |
2.48 % |
14/02/2023 |
Investment Management, LLC |
Delaware |
1358417 |
0 |
1358417 |
0 |
1358417 |
0.61 % |
14/02/2023 |
Teachers Advisors, LLC |
Delaware |
2090576 |
0 |
2090576 |
0 |
2090576 |
0.95 % |
14/02/2023 |
Nuveen Asset Management, LLC |
Delaware |
4291906 |
0 |
5483369 |
0 |
5483369 |
2.48 % |
14/02/2023 |
Investment Management, LLC |
Delaware |
1358417 |
0 |
1358417 |
0 |
1358417 |
0.61 % |
14/02/2023 |
Teachers Advisors, LLC |
Delaware |
2090576 |
0 |
2090576 |
0 |
2090576 |
0.95 % |
14/02/2023 |
Nuveen Asset Management, LLC |
Delaware |
4291906 |
0 |
5483369 |
0 |
5483369 |
2.48 % |
14/02/2023 |
Timothy P. Lynch |
U.S.A. |
6940000 |
0 |
6940000 |
0 |
6940000 |
3.1 % |
13/02/2023 |
Stonepine Capital Management, LLC |
California |
6940000 |
0 |
6940000 |
0 |
6940000 |
3.1 % |
13/02/2023 |
Jon M. Plexico |
U.S.A. |
6940000 |
0 |
6940000 |
0 |
6940000 |
3.1 % |
13/02/2023 |
Timothy P. Lynch |
U.S.A. |
6940000 |
0 |
6940000 |
0 |
6940000 |
3.1 % |
13/02/2023 |
Stonepine Capital, L.P. |
Delaware |
6940000 |
0 |
6940000 |
0 |
6940000 |
3.1 % |
13/02/2023 |
Stonepine Capital Management, LLC |
California |
6940000 |
0 |
6940000 |
0 |
6940000 |
3.1 % |
13/02/2023 |
Stonepine Capital, L.P. |
Delaware |
6940000 |
0 |
6940000 |
0 |
6940000 |
3.1 % |
13/02/2023 |
Jon M. Plexico |
U.S.A. |
6940000 |
0 |
6940000 |
0 |
6940000 |
3.1 % |
13/02/2023 |
Millennium Management LLC |
|
|
|
|
|
6254409 |
3.2 % |
28/06/2022 |
Israel A. Englander |
|
|
|
|
|
6254409 |
3.2 % |
28/06/2022 |
Millennium Group Management LLC |
|
|
|
|
|
6254409 |
3.2 % |
28/06/2022 |
Millennium Management LLC |
|
|
|
|
|
6254409 |
3.2 % |
28/06/2022 |
Israel A. Englander |
|
|
|
|
|
6254409 |
3.2 % |
28/06/2022 |
Millennium Group Management LLC |
|
|
|
|
|
6254409 |
3.2 % |
28/06/2022 |
Consonance Capman GP LLC |
Delaware USA |
0 |
1558290 |
0 |
1558290 |
1558290 |
1.65 % |
14/02/2022 |
Mitchell Blutt |
USA |
0 |
1558290 |
0 |
1558290 |
1558290 |
1.65 % |
14/02/2022 |
Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
268809 |
0 |
268809 |
268809 |
0.28 % |
14/02/2022 |
Consonance Capital Management LP |
Delaware USA |
0 |
1289481 |
0 |
1289481 |
1289481 |
1.36 % |
14/02/2022 |
Stonepine Capital Management, LLC |
California |
9911577 |
0 |
9911577 |
0 |
9911577 |
5.1 % |
14/02/2022 |
Stonepine Capital, L.P. |
Delaware |
9911577 |
0 |
9911577 |
0 |
9911577 |
5.1 % |
14/02/2022 |
Stonepine Capital Management, LLC |
California |
9911577 |
0 |
9911577 |
0 |
9911577 |
5.1 % |
14/02/2022 |
Jon M. Plexico |
U.S.A. |
9911577 |
0 |
9911577 |
0 |
9911577 |
5.1 % |
14/02/2022 |
Timothy P. Lynch |
U.S.A. |
9911577 |
0 |
9911577 |
0 |
9911577 |
5.1 % |
14/02/2022 |
Stonepine Capital, L.P. |
Delaware |
9911577 |
0 |
9911577 |
0 |
9911577 |
5.1 % |
14/02/2022 |
Timothy P. Lynch |
U.S.A. |
9911577 |
0 |
9911577 |
0 |
9911577 |
5.1 % |
14/02/2022 |
Jon M. Plexico |
U.S.A. |
9911577 |
0 |
9911577 |
0 |
9911577 |
5.1 % |
14/02/2022 |
Timothy P. Lynch |
U.S.A. |
9972877 |
0 |
9972877 |
0 |
9972877 |
5.1 % |
30/12/2021 |
Stonepine Capital Management, LLC |
California |
9972877 |
0 |
9972877 |
0 |
9972877 |
5.1 % |
30/12/2021 |
Stonepine Capital, L.P. |
Delaware |
9972877 |
0 |
9972877 |
0 |
9972877 |
5.1 % |
30/12/2021 |
Jon M. Plexico |
U.S.A. |
9972877 |
0 |
9972877 |
0 |
9972877 |
5.1 % |
30/12/2021 |
Timothy P. Lynch |
U.S.A. |
9972877 |
0 |
9972877 |
0 |
9972877 |
5.1 % |
30/12/2021 |
Stonepine Capital, L.P. |
Delaware |
9972877 |
0 |
9972877 |
0 |
9972877 |
5.1 % |
30/12/2021 |
Jon M. Plexico |
U.S.A. |
9972877 |
0 |
9972877 |
0 |
9972877 |
5.1 % |
30/12/2021 |
Stonepine Capital Management, LLC |
California |
9972877 |
0 |
9972877 |
0 |
9972877 |
5.1 % |
30/12/2021 |
BlackRock, Inc. |
Delaware |
5685417 |
0 |
5753820 |
0 |
5753820 |
4.7 % |
09/04/2021 |
Consonance Capital Opportunity Fund Management LP |
Delaware, USA |
0 |
268809 |
0 |
268809 |
268809 |
0.28 % |
16/02/2021 |
Mitchell Blutt |
USA |
0 |
1558290 |
0 |
1558290 |
1558290 |
1.65 % |
16/02/2021 |
Consonance Capital Management LP |
Delaware, USA |
0 |
1289481 |
0 |
1289481 |
1289481 |
1.36 % |
16/02/2021 |
Consonance Capman GP LLC |
Delaware, USA |
0 |
1558290 |
0 |
1558290 |
1558290 |
1.65 % |
16/02/2021 |
BlackRock, Inc. |
Delaware |
5391013 |
0 |
5423699 |
0 |
5423699 |
5.7 % |
02/02/2021 |
BlackRock, Inc. |
Delaware |
4130009 |
0 |
4172761 |
0 |
4172761 |
4.8 % |
09/03/2020 |
Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
993607 |
0 |
993607 |
993607 |
1.68 % |
14/02/2020 |
Consonance Capman GP LLC |
Delaware USA |
0 |
5166961 |
0 |
5166961 |
5166961 |
8.71 % |
14/02/2020 |
Mitchell Blutt |
USA |
0 |
5166961 |
0 |
5166961 |
5166961 |
8.71 % |
14/02/2020 |
Consonance Capital Management LP |
Delaware USA |
0 |
4173354 |
0 |
4173354 |
4173354 |
7.04 % |
14/02/2020 |
Broadfin Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Kevin Kotler |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Broadfin Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Kevin Kotler |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Perceptive Advisors LLC |
Delaware |
0 |
11521102 |
0 |
11521102 |
11521102 |
19.4 % |
23/05/2019 |
Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
11521102 |
0 |
11521102 |
11521102 |
19.4 % |
23/05/2019 |
Joseph Edelman |
United States of America |
0 |
11521102 |
0 |
11521102 |
11521102 |
19.4 % |
23/05/2019 |
Consonance Capman GP LLC |
Delaware USA |
0 |
4588352 |
0 |
4588352 |
4588352 |
9.9 % |
14/02/2019 |
Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
713928 |
0 |
713928 |
713928 |
1.54 % |
14/02/2019 |
Consonance Capital Management LP |
Delaware USA |
3874424 |
0 |
3874424 |
0 |
3874424 |
8.36 % |
14/02/2019 |
Mitchell Blutt |
USA |
0 |
4588352 |
0 |
4588352 |
4588352 |
9.9 % |
14/02/2019 |
Kevin Kotler |
United States of America |
0 |
4226077 |
0 |
4226077 |
4226077 |
9.12 % |
13/02/2019 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
4226077 |
0 |
4226077 |
4226077 |
9.12 % |
13/02/2019 |
Broadfin Capital, LLC |
Delaware |
0 |
4226077 |
0 |
4226077 |
4226077 |
9.12 % |
13/02/2019 |
Broadfin Capital, LLC |
Delaware |
0 |
3249829 |
0 |
3249829 |
3249829 |
7.21 % |
11/06/2018 |
Broadfin Capital, LLC |
Delaware |
0 |
3249829 |
0 |
3249829 |
3249829 |
7.21 % |
11/06/2018 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
3249829 |
0 |
3249829 |
3249829 |
7.21 % |
11/06/2018 |
Kevin Kotler |
United States of America |
0 |
3249829 |
0 |
3249829 |
3249829 |
7.21 % |
11/06/2018 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
3249829 |
0 |
3249829 |
3249829 |
7.21 % |
11/06/2018 |
Kevin Kotler |
United States of America |
0 |
3249829 |
0 |
3249829 |
3249829 |
7.21 % |
11/06/2018 |
Mitchell Blutt |
USA |
0 |
3367635 |
0 |
3367635 |
3367635 |
7.43 % |
14/02/2018 |
Consonance Capital Management LP |
Delaware USA |
0 |
3070624 |
0 |
3070624 |
3070624 |
6.78 % |
14/02/2018 |
Consonance Capman GP LLC |
Delaware USA |
0 |
3367635 |
0 |
3367635 |
3367635 |
7.43 % |
14/02/2018 |
Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
297011 |
0 |
297011 |
297011 |
0.66 % |
14/02/2018 |
Kevin Kotler |
United States America |
0 |
1102200 |
0 |
1102200 |
1102200 |
2.43 % |
13/02/2018 |
Broadfin Capital, LLC |
Delaware |
0 |
1102200 |
0 |
1102200 |
1102200 |
2.43 % |
13/02/2018 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
1102200 |
0 |
1102200 |
1102200 |
2.43 % |
13/02/2018 |
Perceptive Advisors LLC |
Delaware |
0 |
3821102 |
0 |
3821102 |
3821102 |
10.4 % |
15/11/2017 |
Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
3821102 |
0 |
3821102 |
3821102 |
10.4 % |
15/11/2017 |
Joseph Edelman |
United States of America |
0 |
3821102 |
0 |
3821102 |
3821102 |
10.4 % |
15/11/2017 |
s Joseph Edelman |
United States America |
0 |
721102 |
0 |
721102 |
721102 |
5.59 % |
14/02/2017 |
s Perceptive Advisors LLC |
Delaware United States America |
0 |
721102 |
0 |
721102 |
721102 |
5.59 % |
14/02/2017 |
s Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
683244 |
0 |
683244 |
683244 |
5.3 % |
14/02/2017 |
Consonance Capital Management LP |
Delaware USA |
0 |
1151135 |
0 |
1151135 |
1151135 |
8.93 % |
13/02/2017 |
Consonance Capman GP LLC |
Delaware |
0 |
1273933 |
0 |
1273933 |
1273933 |
9.89 % |
13/02/2017 |
Mitchell Blutt |
USA |
0 |
1273933 |
0 |
1273933 |
1273933 |
9.89 % |
13/02/2017 |
Consonance Capital Opportunity Fund Management LP |
Delaware |
0 |
122798 |
0 |
122798 |
122798 |
0.95 % |
13/02/2017 |
Kevin Kotler |
United States America |
0 |
1113293 |
0 |
1113293 |
1113293 |
8.64 % |
13/02/2017 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
1113293 |
0 |
1113293 |
1113293 |
8.64 % |
13/02/2017 |
Broadfin Capital, LLC |
Delaware |
0 |
1113293 |
0 |
1113293 |
1113293 |
8.64 % |
13/02/2017 |
Consonance Capman GP LLC |
Delaware |
0 |
1060017 |
0 |
1060017 |
1060017 |
9.9 % |
11/02/2016 |
Mitchell Blutt |
USA |
0 |
1060017 |
0 |
1060017 |
1060017 |
9.9 % |
11/02/2016 |
Consonance Capital Management LP |
Delaware USA |
0 |
957865 |
0 |
957865 |
957865 |
8.9 % |
11/02/2016 |
Consonance Capital Opportunity Fund Management LP |
Delaware |
0 |
102152 |
0 |
102152 |
102152 |
1 % |
11/02/2016 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
964193 |
0 |
964193 |
964193 |
9.2 % |
19/03/2015 |
Broadfin Capital, LLC |
Delaware |
0 |
964193 |
0 |
964193 |
964193 |
9.2 % |
19/03/2015 |
Broadfin Capital, LLC |
Delaware |
0 |
964193 |
0 |
964193 |
964193 |
9.2 % |
19/03/2015 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
964193 |
0 |
964193 |
964193 |
9.2 % |
19/03/2015 |
Kevin Kotler |
United States of America |
0 |
964193 |
0 |
964193 |
964193 |
9.2 % |
19/03/2015 |
Kevin Kotler |
United States of America |
0 |
964193 |
0 |
964193 |
964193 |
9.2 % |
19/03/2015 |
Consonance Capman GP LLC |
Delaware |
0 |
877407 |
0 |
877407 |
877407 |
9.4 % |
17/02/2015 |
Consonance Capital Opportunity Fund Management LP |
Delaware |
0 |
55000 |
0 |
55000 |
55000 |
0.6 % |
17/02/2015 |
Consonance Capital Management LP |
Delaware |
0 |
822407 |
0 |
822407 |
822407 |
8.9 % |
17/02/2015 |
Mitchell Blutt |
USA |
0 |
877407 |
0 |
877407 |
877407 |
9.4 % |
17/02/2015 |
ACM Capital Partners, LLC |
Delaware USA |
0 |
364585 |
0 |
364585 |
364585 |
8.06 % |
22/02/2012 |
Ayer Capital Management, LP |
Delaware USA |
0 |
364585 |
0 |
364585 |
364585 |
8.06 % |
22/02/2012 |
Ayer Capital Management, LP |
Delaware USA |
0 |
364585 |
0 |
364585 |
364585 |
8.06 % |
22/02/2012 |
Jay Venkatesan |
USA |
0 |
364585 |
0 |
364585 |
364585 |
8.06 % |
22/02/2012 |
ACM Capital Partners, LLC |
Delaware USA |
0 |
364585 |
0 |
364585 |
364585 |
8.06 % |
22/02/2012 |
Jay Venkatesan |
USA |
0 |
364585 |
0 |
364585 |
364585 |
8.06 % |
22/02/2012 |