| GAP Coinvestments CDA, L.P. |
Delaware |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| GAP Coinvestments IV, LLC |
Delaware |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| General Atlantic GenPar, L.P. |
Delaware |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| General Atlantic Partners (Lux) SCSp |
Luxembourg |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| General Atlantic GenPar (Lux) SCSp |
Luxembourg |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| General Atlantic, L.P. |
Delaware |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| General Atlantic Partners 100, L.P. |
Delaware |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| GAP Coinvestments V, LLC |
Delaware |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| General Atlantic (Lux) S.à.r.l. |
Luxembourg |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| GAP (Bermuda) L.P. |
Bermuda |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| General Atlantic (AK), L.P. |
Delaware |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| General Atlantic GenPar (Bermuda), L.P. |
Bermuda |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| General Atlantic (SPV) GP, LLC |
Delaware |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| GAP Coinvestments III, LLC |
Delaware |
0 |
5233989 |
0 |
5233989 |
5233989 |
7.7 % |
15/03/2024 |
| 52-0556948 |
Maryland |
762037 |
0 |
3675924 |
0 |
3681209 |
6.6 % |
14/02/2024 |
| RTW Investments, LP |
Delaware |
0 |
3592759 |
0 |
0 |
3592759 |
6.4 % |
14/02/2024 |
| Roderick Wong, M.D. |
United States |
0 |
3592759 |
0 |
0 |
3592759 |
6.4 % |
14/02/2024 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
0 |
0 |
0 |
3085048 |
5.54 % |
13/02/2024 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2397162 |
0 |
0 |
2881989 |
5.17 % |
08/02/2024 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
2397162 |
0 |
0 |
2881989 |
5.17 % |
08/02/2024 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
2397162 |
0 |
0 |
2881989 |
5.17 % |
08/02/2024 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
2802627 |
0 |
0 |
2802627 |
5.97 % |
10/04/2023 |
| Phillip Gross |
United States |
0 |
2802627 |
0 |
0 |
2802627 |
5.97 % |
10/04/2023 |
| Robert Atchinson |
United States |
0 |
2802627 |
0 |
0 |
2802627 |
5.97 % |
10/04/2023 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
2802627 |
0 |
0 |
2802627 |
5.97 % |
10/04/2023 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
2802627 |
0 |
0 |
2802627 |
5.97 % |
10/04/2023 |
| Jeremy C. Green |
United Kingdom |
0 |
2632912 |
0 |
2632912 |
2632912 |
5.6 % |
14/02/2023 |
| Redmile Group, LLC |
Delaware |
0 |
2632912 |
0 |
2632912 |
2632912 |
5.6 % |
14/02/2023 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
2368378 |
0 |
2368378 |
0 |
2368378 |
5.1 % |
14/02/2023 |
| Julian C. Baker |
United States |
2368378 |
0 |
2368378 |
0 |
2368378 |
5.1 % |
14/02/2023 |
| Felix J. Baker |
United States |
2368378 |
0 |
2368378 |
0 |
2368378 |
5.1 % |
14/02/2023 |
| Baker Bros. Advisors LP |
Delaware |
2368378 |
0 |
2368378 |
0 |
2368378 |
5.1 % |
14/02/2023 |
| 52-0556948 |
Maryland |
418881 |
0 |
2401037 |
0 |
2401037 |
5.1 % |
14/02/2023 |
| STATE STREET CORPORATION |
|
0 |
2434739 |
0 |
2500969 |
2500969 |
5.35 % |
03/02/2023 |
| (1) BlackRock, Inc. |
Delaware |
2682754 |
0 |
2758529 |
0 |
2758529 |
5.9 % |
03/02/2023 |
| (1) BlackRock, Inc. |
Delaware |
2199586 |
0 |
2264243 |
0 |
2264243 |
4.9 % |
09/11/2022 |
| Avidity Partners Management (GP) LLC |
Delaware |
0 |
3105000 |
0 |
3105000 |
3105000 |
6.9 % |
16/09/2022 |
| Avidity Master Fund LP |
Delaware |
0 |
2560625 |
0 |
2560625 |
2560625 |
5.7 % |
16/09/2022 |
| Avidity Capital Partners (GP) LLC |
Delaware |
0 |
3105000 |
0 |
3105000 |
3105000 |
6.9 % |
16/09/2022 |
| David Witzke |
Delaware |
0 |
3105000 |
0 |
3105000 |
3105000 |
6.9 % |
16/09/2022 |
| Michael Gregory |
Delaware |
0 |
3105000 |
0 |
3105000 |
3105000 |
6.9 % |
16/09/2022 |
| Avidity Capital Partners Fund (GP) LP |
Delaware |
0 |
3105000 |
0 |
3105000 |
3105000 |
6.9 % |
16/09/2022 |
| Avidity Partners Management LP |
Delaware |
0 |
3105000 |
0 |
3105000 |
3105000 |
6.9 % |
16/09/2022 |
| venBio Global Strategic Fund II, L.P. |
|
0 |
714000 |
0 |
714000 |
714000 |
1.9 % |
15/09/2022 |
| Robert Adelman |
|
0 |
714000 |
0 |
714000 |
714000 |
1.9 % |
15/09/2022 |
| venBio Global Strategic GP II, Ltd. |
|
0 |
714000 |
0 |
714000 |
714000 |
1.9 % |
15/09/2022 |
| Corey Goodman |
|
0 |
714000 |
0 |
714000 |
714000 |
1.9 % |
15/09/2022 |
| venBio Global Strategic GP II, L.P. |
|
0 |
714000 |
0 |
714000 |
714000 |
1.9 % |
15/09/2022 |
| PFIZER INC. 13-5315170 |
Delaware |
2525252 |
0 |
2525252 |
0 |
2525252 |
6.7 % |
28/06/2022 |
| Jeremy C. Green |
Delaware |
0 |
1602285 |
0 |
0 |
1602285 |
4.6 % |
14/02/2022 |
| Redmile Group, LLC |
Delaware |
0 |
1602285 |
0 |
0 |
1602285 |
4.6 % |
14/02/2022 |
| Alkeon Capital Management, LLC |
Delaware |
0 |
2479671 |
0 |
2479671 |
2479671 |
11 % |
11/02/2022 |
| Panayotis D. Sparaggis |
U.S.A. |
0 |
2479671 |
0 |
2479671 |
2479671 |
11 % |
11/02/2022 |
| Atlas Venture Associates Opportunity I, LLC |
Delaware |
0 |
268722 |
0 |
268722 |
268722 |
0.8 % |
11/02/2022 |
| Atlas Venture Associates XI, LLC |
Delaware |
0 |
1963529 |
0 |
1963529 |
1963529 |
5.6 % |
11/02/2022 |
| Atlas Venture Associates Opportunity I, L.P. |
Delaware |
0 |
268722 |
0 |
268722 |
268722 |
0.8 % |
11/02/2022 |
| Atlas Venture Opportunity Fund I, L.P. |
Delaware |
0 |
268722 |
0 |
268722 |
268722 |
0.8 % |
11/02/2022 |
| Atlas Venture Fund XI, L.P. |
Delaware |
0 |
1963529 |
0 |
1963529 |
1963529 |
5.6 % |
11/02/2022 |
| Atlas Venture Associates XI, L.P. |
Delaware |
0 |
1963529 |
0 |
1963529 |
1963529 |
5.6 % |
11/02/2022 |
| EIN #00-0000000 |
Jersey, Channel Islands |
0 |
3163622 |
0 |
3163622 |
3163622 |
9.1 % |
10/02/2022 |
| THE GOLDMAN SACHS GROUP, INC. |
Delaware |
0 |
0 |
0 |
13 |
1776192 |
5.1 % |
08/02/2022 |
| GOLDMAN SACHS & CO. LLC |
Delaware |
0 |
0 |
0 |
13 |
1776192 |
5.1 % |
08/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
1924534 |
0 |
1944122 |
0 |
1944122 |
5.6 % |
04/02/2022 |
| Wellington Management Company LLP |
Delaware |
0 |
1514280 |
0 |
0 |
1797052 |
5.15 % |
04/02/2022 |
| Wellington Group Holdings LLP |
Delaware |
0 |
1514280 |
0 |
0 |
1876811 |
5.38 % |
04/02/2022 |
| Wellington Management Group LLP |
Massachusetts |
0 |
1514280 |
0 |
0 |
1876811 |
5.38 % |
04/02/2022 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
1514280 |
0 |
0 |
1876811 |
5.38 % |
04/02/2022 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
3714 |
0 |
3714 |
3714 |
4 % |
13/12/2021 |
| Steven A. Cohen |
Delaware |
0 |
1751563 |
0 |
1751563 |
1751563 |
4 % |
13/12/2021 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
1747849 |
0 |
1747849 |
1747849 |
4 % |
13/12/2021 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
1747849 |
0 |
1747849 |
1747849 |
4 % |
13/12/2021 |
| Ezbon International Limited |
British Virgin Islands |
0 |
2561531 |
0 |
2561531 |
2561531 |
7.4 % |
30/06/2021 |
| Blue Horizon Enterprise Ltd. |
British Virgin Islands |
0 |
2346298 |
0 |
2346298 |
2346298 |
6.7 % |
30/06/2021 |
| Skorpios Trust |
British Virgin Islands |
0 |
4907829 |
0 |
4907829 |
4907829 |
14.1 % |
30/06/2021 |
| Montrago Trustees Limited |
British Virgin Islands |
0 |
4907829 |
0 |
4907829 |
4907829 |
14.1 % |
30/06/2021 |
| venBio Global Strategic GP II, Ltd. |
|
0 |
2315893 |
0 |
2315893 |
2315893 |
6.65 % |
07/05/2021 |
| venBio Global Strategic GP II, L.P. |
|
0 |
2315893 |
0 |
2315893 |
2315893 |
6.65 % |
07/05/2021 |
| Robert Adelman |
|
0 |
2315893 |
0 |
2315893 |
2315893 |
6.65 % |
07/05/2021 |
| Corey Goodman |
|
0 |
2315893 |
0 |
2315893 |
2315893 |
6.65 % |
07/05/2021 |
| venBio Global Strategic Fund II, L.P. |
|
0 |
2315893 |
0 |
2315893 |
2315893 |
6.65 % |
07/05/2021 |
| Venture Fund XI, L.P. |
Delaware |
0 |
2206412 |
0 |
2206412 |
2206412 |
6.4 % |
16/02/2021 |
| Venture Associates XI, LLC |
Delaware |
0 |
2206412 |
0 |
2206412 |
2206412 |
6.4 % |
16/02/2021 |
| Venture Associates XI, L.P. |
Delaware |
0 |
2206412 |
0 |
2206412 |
2206412 |
6.4 % |
16/02/2021 |
| Venture Associates Opportunity I, LLC |
Delaware |
0 |
304079 |
0 |
304079 |
304079 |
0.9 % |
16/02/2021 |
| Venture Opportunity Fund I, L.P. |
Delaware |
0 |
304079 |
0 |
304079 |
304079 |
0.9 % |
16/02/2021 |
| Venture Associates Opportunity I, L.P. |
Delaware |
0 |
304079 |
0 |
304079 |
304079 |
0.9 % |
16/02/2021 |
| Redmile Group, LLC |
Delaware |
0 |
2322557 |
0 |
2322557 |
2322557 |
6.69 % |
16/02/2021 |
| Jeremy C. Green |
Delaware |
0 |
2322557 |
0 |
2322557 |
2322557 |
6.69 % |
16/02/2021 |
| GP-GP, |
|
0 |
777727 |
0 |
777727 |
777727 |
2.2 % |
12/02/2021 |
| Versant Venture Capital VI, L.P. |
|
777727 |
0 |
777727 |
0 |
777727 |
2.2 % |
12/02/2021 |
| Versant Ventures VI GP, L.P. |
|
0 |
777727 |
0 |
777727 |
777727 |
2.2 % |
12/02/2021 |
| Panayotis D. Sparaggis |
U.S.A. |
0 |
2287630 |
0 |
2287630 |
2287630 |
11 % |
11/02/2021 |
| Alkeon Capital Management, LLC |
Delaware |
0 |
2287630 |
0 |
2287630 |
2287630 |
11 % |
11/02/2021 |
| EIN #00-0000000 |
Jersey, Channel Islands |
0 |
3493419 |
0 |
3493419 |
3493419 |
10.1 % |
11/02/2021 |
| in Item 9 |
Delaware |
1508375 |
0 |
0 |
0 |
1508375 |
4.344 % |
05/02/2021 |
| Janus Henderson Group plc |
Jersey, Channel Islands |
0 |
3507228 |
0 |
0 |
3507228 |
10.1 % |
10/09/2020 |
| Robert Adelman |
|
0 |
2668717 |
0 |
2668717 |
2668717 |
7.7 % |
09/09/2020 |
| venBio Global Strategic GP II, Ltd. |
|
0 |
2668717 |
0 |
2668717 |
2668717 |
7.7 % |
09/09/2020 |
| Corey Goodman |
|
0 |
2668717 |
0 |
2668717 |
2668717 |
7.7 % |
09/09/2020 |
| venBio Global Strategic GP II, L.P. |
|
0 |
2668717 |
0 |
2668717 |
2668717 |
7.7 % |
09/09/2020 |
| venBio Global Strategic Fund II, L.P. |
|
0 |
2668717 |
0 |
2668717 |
2668717 |
7.7 % |
09/09/2020 |
| ATP III GP, Ltd. |
|
0 |
5830203 |
0 |
11 |
5830203 |
17.2 % |
14/07/2020 |
| Apple Tree Partners IV, L.P. |
|
0 |
5830203 |
0 |
11 |
5830203 |
17.2 % |
14/07/2020 |
| Seth L. Harrison |
|
0 |
5838869 |
0 |
11 |
5838869 |
17.2 % |
14/07/2020 |
| venBio Global Strategic GP II, L.P. |
|
0 |
3033552 |
0 |
3033552 |
3033552 |
10.6 % |
08/07/2020 |
| venBio Global Strategic Fund II, L.P. |
|
0 |
3033552 |
0 |
3033552 |
3033552 |
10.6 % |
08/07/2020 |
| Robert Adelman |
|
0 |
3033552 |
0 |
3033552 |
3033552 |
10.6 % |
08/07/2020 |
| Corey Goodman |
|
0 |
3033552 |
0 |
3033552 |
3033552 |
10.6 % |
08/07/2020 |
| venBio Global Strategic GP II, Ltd. |
|
0 |
3033552 |
0 |
3033552 |
3033552 |
10.6 % |
08/07/2020 |
| Janus Henderson Group plc |
Jersey Channel Islands |
0 |
2409533 |
0 |
2409533 |
2409533 |
8.4 % |
14/02/2020 |
| Versant Ventures VI GP-GP, LLC |
Delaware |
0 |
3656585 |
0 |
0 |
3656585 |
12.8 % |
14/02/2020 |
| Versant Venture Capital VI, L.P. |
Delaware |
3656585 |
0 |
3656585 |
0 |
3656585 |
12.8 % |
14/02/2020 |
| Versant Ventures VI GP, L.P. |
Delaware |
0 |
3656585 |
0 |
0 |
3656585 |
12.8 % |
14/02/2020 |
| Atlas Venture Opportunity Fund I, L.P. |
Delaware |
0 |
454589 |
0 |
454589 |
454589 |
1.6 % |
13/02/2020 |
| Atlas Venture Associates Opportunity I, LLC |
Delaware |
0 |
454589 |
0 |
454589 |
454589 |
1.6 % |
13/02/2020 |
| Atlas Venture Associates XI, L.P. |
Delaware |
0 |
2706412 |
0 |
2706412 |
2706412 |
9.5 % |
13/02/2020 |
| Atlas Venture Associates XI, LLC |
Delaware |
0 |
2706412 |
0 |
2706412 |
2706412 |
9.5 % |
13/02/2020 |
| Atlas Venture Associates Opportunity I, L.P. |
Delaware |
0 |
454589 |
0 |
454589 |
454589 |
1.6 % |
13/02/2020 |
| Atlas Venture Fund XI, L.P. |
Delaware |
0 |
2706412 |
0 |
2706412 |
2706412 |
9.5 % |
13/02/2020 |
| 1,905,698 |
Delaware |
1905698 |
0 |
0 |
0 |
1905698 |
6.67 % |
07/02/2020 |
| venBio Global Strategic GP II, L.P. |
|
0 |
3322138 |
0 |
11 |
3322138 |
11.6 % |
15/01/2020 |
| Robert Adelman |
|
0 |
3322138 |
0 |
11 |
3322138 |
11.6 % |
15/01/2020 |
| venBio Global Strategic GP II, Ltd. |
|
0 |
3322138 |
0 |
11 |
3322138 |
11.6 % |
15/01/2020 |
| venBio Global Strategic Fund II, L.P. |
|
0 |
3322138 |
0 |
11 |
3322138 |
11.6 % |
15/01/2020 |
| Corey Goodman |
|
0 |
3322138 |
0 |
11 |
3322138 |
11.6 % |
15/01/2020 |
| Versant Ventures VI GP, L.P. |
Delaware |
0 |
4104858 |
0 |
0 |
4104858 |
14.7 % |
05/07/2019 |
| Versant Venture Capital VI, L.P. |
Delaware |
4104858 |
0 |
4104858 |
0 |
4104858 |
14.7 % |
05/07/2019 |
| Versant Ventures VI GP-GP, LLC |
Delaware |
0 |
4104858 |
0 |
0 |
4104858 |
14.7 % |
05/07/2019 |