Albireo Pharma, Inc. ALBO
Trading inactive
| Déclarant | Citoyenneté ou lieu d'organisation | Pouvoir de vote unique | Pouvoir de vote partagé | Pouvoir de disposition unique | Pouvoir de disposition partagé | Montant en propriété effective | Pourcentage détenu | Date d'achat |
|---|---|---|---|---|---|---|---|---|
| RA Capital Management, L.P. | Delaware | 0 | 9695228 | 0 | 0 | 9695228 | 9.9 % | 06/12/2024 |
| Peter Kolchinsky | Delaware | 0 | 9695228 | 0 | 0 | 9695228 | 9.9 % | 06/12/2024 |
| RA Capital Healthcare Fund, L.P. | Delaware | 0 | 9695228 | 0 | 0 | 9695228 | 9.9 % | 06/12/2024 |
| Rajeev Shah | Delaware | 0 | 9695228 | 0 | 0 | 9695228 | 9.9 % | 06/12/2024 |
| T. ROWE PRICE ASSOCIATES, INC. | States | 3355398 | 3930375 | 3355398 | 3930375 | 8512674 | 5.4 % | 08/02/2024 |
| J. Christopher Donahue | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 10/04/2023 |
| Ann C. Donahue | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 10/04/2023 |
| Thomas R. Donahue | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 10/04/2023 |
| Voting Shares Irrevocable Trust | Pennsylvania | 0 | 0 | 0 | 0 | 0 | 0 % | 10/04/2023 |
| Federated Hermes, Inc. | Pennsylvania | 0 | 0 | 0 | 0 | 0 | 0 % | 10/04/2023 |
| (1) BlackRock, Inc. | Delaware | 478937 | 0 | 506425 | 0 | 506425 | 2.4 % | 08/03/2023 |
| Millennium Group Management LLC | 0 | 999363 | 0 | 999363 | 999363 | 4.8 % | 02/03/2023 | |
| ICS Opportunities, Ltd. | 0 | 893869 | 0 | 893869 | 893869 | 4.3 % | 02/03/2023 | |
| Millennium Management LLC | 0 | 999363 | 0 | 999363 | 999363 | 4.8 % | 02/03/2023 | |
| Israel A. Englander | 0 | 999363 | 0 | 999363 | 999363 | 4.8 % | 02/03/2023 | |
| Beryl Capital Management LLC | Delaware | 0 | 1483599 | 0 | 1483599 | 9 | 7.1 % | 27/02/2023 |
| EDCA 2019 Fund, L.P. | United States | 0 | 208795 | 0 | 208795 | 208795 | 1 % | 24/02/2023 |
| Black Diamond Arbitrage Offshore Ltd. | United States | 0 | 632155 | 0 | 632155 | 632155 | 3 % | 24/02/2023 |
| Corbin Hedged Equity Fund, L.P. | United States | 0 | 55904 | 0 | 55904 | 55904 | 0.3 % | 24/02/2023 |
| Asgard Investment Corp. II | United States | 0 | 1075000 | 0 | 1075000 | 1075000 | 5.2 % | 24/02/2023 |
| Clint D. Carlson | United States | 0 | 1075000 | 0 | 1075000 | 1075000 | 5.2 % | 24/02/2023 |
| Carlson Capital, L.P. | United States | 0 | 1075000 | 0 | 1075000 | 1075000 | 5.2 % | 24/02/2023 |
| Double Black Diamond Offshore Ltd. | United States | 0 | 178146 | 0 | 178146 | 178146 | 1 % | 24/02/2023 |
| Deep Track Biotechnology Master Fund, Ltd. | Cayman Islands | 0 | 1704000 | 0 | 0 | 1704000 | 8.23 % | 14/02/2023 |
| David Kroin | United States | 0 | 1704000 | 0 | 0 | 1704000 | 8.23 % | 14/02/2023 |
| Deep Track Capital, LP | Delaware | 0 | 1704000 | 0 | 0 | 1704000 | 8.23 % | 14/02/2023 |
| (1) BlackRock, Inc. | Delaware | 1312963 | 0 | 1344897 | 0 | 1344897 | 6.5 % | 31/01/2023 |
| Chicago Capital LLC | Illinois | 1362484 | 0 | 1362484 | 0 | 1362484 | 6.6 % | 23/01/2023 |
| David Kroin | Delaware | 0 | 1124421 | 0 | 0 | 1124421 | 5.46 % | 03/10/2022 |
| Deep Track Biotechnology Master Fund, Ltd. | Delaware | 0 | 1124421 | 0 | 0 | 1124421 | 5.46 % | 03/10/2022 |
| Deep Track Capital, LP | Delaware | 0 | 1124421 | 0 | 0 | 1124421 | 5.46 % | 03/10/2022 |
| Chicago Capital LLC | Illinois | 971885 | 0 | 971885 | 0 | 971885 | 5.1 % | 07/03/2022 |
| 2 | 2630134 | 0 | 2630134 | 3930375 | 6560509 | 8 % | 14/02/2022 | |
| Perceptive Advisors LLC | Delaware | 0 | 2360139 | 0 | 2360139 | 2360139 | 12.2 % | 14/02/2022 |
| EcoR1 Capital Fund Qualified, L.P. | 0 | 4542952 | 0 | 4542952 | 4542952 | 11 % | 14/02/2022 | |
| EcoR1 Capital, LLC | 0 | 4994970 | 0 | 4994970 | 4994970 | 11 % | 14/02/2022 | |
| Oleg Nodelman | 0 | 4994970 | 0 | 4994970 | 4994970 | 11 % | 14/02/2022 | |
| Federated Hermes, Inc. | Citizenship or place of Organization | 2358624 | 0 | 2358624 | 0 | 2358624 | 12.23 % | 14/02/2022 |
| J. Christopher Donahue | Citizenship or place of Organization | 0 | 2358624 | 0 | 2358624 | 2358624 | 12.23 % | 14/02/2022 |
| Rhodora J. Donahue | Citizenship or place of Organization | 0 | 2358624 | 0 | 2358624 | 2358624 | 12.23 % | 14/02/2022 |
| Voting Shares Irrevocable Trust | Citizenship or place of Organization | 2358624 | 0 | 2358624 | 0 | 2358624 | 12.23 % | 14/02/2022 |
| Thomas R. Donahue | Citizenship or place of Organization | 0 | 2358624 | 0 | 2358624 | 2358624 | 12.23 % | 14/02/2022 |
| STATE STREET CORPORATION | 0 | 0 | 0 | 0 | 992832 | 5.15 % | 09/02/2022 | |
| (1) BlackRock, Inc. | Delaware | 1152646 | 0 | 1168783 | 0 | 1168783 | 6.1 % | 02/02/2022 |
| EcoR1 Capital Fund Qualified, L.P. | Delaware | 0 | 0 | 0 | 4143794 | 4143794 | 11 % | 12/07/2021 |
| EcoR1 Capital, LLC | Delaware | 0 | 0 | 0 | 4742634 | 4742634 | 11 % | 12/07/2021 |
| Oleg Nodelman | Delaware | 0 | 0 | 0 | 4742634 | 4742634 | 11 % | 12/07/2021 |
| Perceptive Life Sciences Master Fund, Ltd. | Delaware | 0 | 2360139 | 0 | 2360139 | 2360139 | 12.4 % | 16/02/2021 |
| Joseph Edelman | Delaware | 0 | 2360139 | 0 | 2360139 | 2360139 | 12.4 % | 16/02/2021 |
| Perceptive Advisors LLC | Delaware | 0 | 2360139 | 0 | 2360139 | 2360139 | 12.4 % | 16/02/2021 |
| ArrowMark Colorado Holdings, LLC | Delaware, United States | 751495 | 0 | 751495 | 0 | 751495 | 3.9 % | 16/02/2021 |
| Voting Shares Irrevocable Trust | Citizenship or place of Organization | 2447000 | 0 | 2447000 | 0 | 2447000 | 12.83 % | 12/02/2021 |
| J. Christopher Donahue | Citizenship or place of Organization | 0 | 2447000 | 0 | 2447000 | 2447000 | 12.83 % | 12/02/2021 |
| Rhodora J. Donahue | Citizenship or place of Organization | 0 | 2447000 | 0 | 2447000 | 2447000 | 12.83 % | 12/02/2021 |
| Thomas R. Donahue | Citizenship or place of Organization | 0 | 2447000 | 0 | 2447000 | 2447000 | 12.83 % | 12/02/2021 |
| Federated Hermes, Inc. | Citizenship or place of Organization | 2447000 | 0 | 2447000 | 0 | 2447000 | 12.83 % | 12/02/2021 |
| Page 2 of 6 Pages | 0 | 0 | 0 | 0 | 0 | 0 % | 12/02/2021 | |
| The Vanguard Group - 23-1945930 | Pennsylvania | 0 | 0 | 0 | 140763 | 5002859 | 6.31 % | 10/02/2021 |
| (1) BlackRock, Inc. | Delaware | 1221745 | 0 | 1242780 | 0 | 1242780 | 6.5 % | 02/02/2021 |
| TVM Life Science Ventures Management VI L.P. | 0 | 0 | 0 | 10 | 0 | 0 % | 23/10/2020 | |
| Stefan Fischer | 0 | 0 | 0 | 10 | 0 | 0 % | 23/10/2020 | |
| TVM Life Science Ventures VI L.P. | 0 | 0 | 0 | 10 | 0 | 0 % | 23/10/2020 | |
| TVM Life Science Ventures VI GmbH & Co. KG | 0 | 0 | 0 | 10 | 0 | 0 % | 23/10/2020 | |
| Hubert Birner | 0 | 0 | 0 | 10 | 0 | 0 % | 23/10/2020 | |
| ArrowMark Colorado Holdings, LLC | Delaware, United States | 867050 | 0 | 867050 | 0 | 867050 | 6.83 % | 14/02/2020 |
| Perceptive Advisors LLC | Delaware | 0 | 1704330 | 0 | 1704330 | 1704330 | 13.4 % | 14/02/2020 |
| Joseph Edelman | Delaware | 0 | 1704330 | 0 | 1704330 | 1704330 | 13.4 % | 14/02/2020 |
| Perceptive Life Sciences Master Fund, Ltd. | Delaware | 0 | 1704330 | 0 | 1704330 | 1704330 | 13.4 % | 14/02/2020 |
| Voting Shares Irrevocable Trust | Citizenship or place of Organization | 1437000 | 0 | 1437000 | 0 | 1437000 | 11.33 % | 14/02/2020 |
| Thomas R. Donahue | Citizenship or place of Organization | 0 | 1437000 | 0 | 1437000 | 1437000 | 11.33 % | 14/02/2020 |
| Rhodora J. Donahue | Citizenship or place of Organization | 0 | 1437000 | 0 | 1437000 | 1437000 | 11.33 % | 14/02/2020 |
| J. Christopher Donahue | Citizenship or place of Organization | 0 | 1437000 | 0 | 1437000 | 1437000 | 11.33 % | 14/02/2020 |
| Federated Hermes, Inc. | Citizenship or place of Organization | 1437000 | 0 | 1437000 | 0 | 1437000 | 11.33 % | 14/02/2020 |
| PVP VI (AIV) Feeder Corp. Holding Partnership, L.P. | 2298932 | 0 | 2298932 | 0 | 2298932 | 3.3 % | 12/02/2020 | |
| David Barrett | 0 | 12858194 | 0 | 12858194 | 12858194 | 18.7 % | 12/02/2020 | |
| Polaris Venture Management Co VI, L.L.C. | 12858194 | 0 | 12858194 | 0 | 12858194 | 18.7 % | 12/02/2020 | |
| Polaris Venture Partners VI, L.P. | 498468 | 0 | 498468 | 0 | 498468 | 0.7 % | 12/02/2020 | |
| Polaris Venture Partners Founders’ Fund VI, L.P. | 709917 | 0 | 709917 | 0 | 709917 | 1 % | 12/02/2020 | |
| Polaris Venture Partners VI (AIV), L.P. | 9350877 | 0 | 9350877 | 0 | 9350877 | 13.6 % | 12/02/2020 | |
| Jonathan A. Flint | 0 | 12858194 | 0 | 12858194 | 12858194 | 18.7 % | 12/02/2020 | |
| Bryce Youngren | 0 | 12858194 | 0 | 12858194 | 12858194 | 18.7 % | 12/02/2020 | |
| Amir Nashat | 0 | 12858194 | 0 | 12858194 | 12858194 | 18.7 % | 12/02/2020 | |
| Terrance G. McGuire | 15000 | 12858194 | 15000 | 12858194 | 12873194 | 18.7 % | 12/02/2020 | |
| Brian Chee | 0 | 12858194 | 0 | 12858194 | 12858194 | 18.7 % | 12/02/2020 | |
| Page 2 of 6 Pages | United States America | 0 | 13 | 832000 | 0 | 832000 | 5.59 % | 12/02/2020 |
| (1) BlackRock, Inc. | Delaware | 0 | 0 | 686456 | 0 | 686456 | 4.6 % | 10/02/2020 |
| (1) BlackRock, Inc. | Delaware | 697288 | 0 | 709381 | 0 | 709381 | 5.6 % | 07/02/2020 |
| James G. Coulter | United States of America | 0 | 566381 | 0 | 0 | 566381 | 4.5 % | 30/10/2019 |
| David Bonderman | United States of America | 0 | 566381 | 0 | 0 | 566381 | 4.5 % | 30/10/2019 |
| TPG Group Holdings (SBS) Advisors, Inc. | Delaware | 0 | 566381 | 0 | 0 | 566381 | 4.5 % | 30/10/2019 |
| Rhodora J. Donahue | Citizenship or place of Organization | 0 | 1437000 | 0 | 1437000 | 1437000 | 11.94 % | 07/06/2019 |
| Voting Shares Irrevocable Trust | Citizenship or place of Organization | 1437000 | 0 | 1437000 | 0 | 1437000 | 11.94 % | 07/06/2019 |
| Federated Investors, Inc. | Citizenship or place of Organization | 1437000 | 0 | 1437000 | 0 | 1437000 | 11.94 % | 07/06/2019 |
| Thomas R. Donahue | Citizenship or place of Organization | 0 | 1437000 | 0 | 1437000 | 1437000 | 11.94 % | 07/06/2019 |
| J. Christopher Donahue | Citizenship or place of Organization | 0 | 1437000 | 0 | 1437000 | 1437000 | 11.94 % | 07/06/2019 |
| Perceptive Life Sciences Master Fund, Ltd. | Delaware | 0 | 1704330 | 0 | 1704330 | 1704330 | 14.2 % | 14/02/2019 |
| Joseph Edelman | Delaware | 0 | 1704330 | 0 | 1704330 | 1704330 | 14.2 % | 14/02/2019 |
| Perceptive Advisors LLC | Delaware | 0 | 1704330 | 0 | 1704330 | 1704330 | 14.2 % | 14/02/2019 |
| ArrowMark Colorado Holdings, LLC | Delaware United States | 611992 | 0 | 611992 | 0 | 611992 | 5.11 % | 14/02/2019 |
| Page 2 of 6 Pages | United States America | 832000 | 0 | 832000 | 0 | 832000 | 7 % | 13/02/2019 |
| Deerfield Mgmt IV, L.P. | Delaware | 0 | 527596 | 0 | 0 | 527596 | 0.77 % | 11/02/2019 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 901731 | 0 | 0 | 901731 | 1.32 % | 11/02/2019 |
| Deerfield Partners, L.P. | Delaware | 0 | 550000 | 0 | 0 | 550000 | 0.8 % | 11/02/2019 |
| James E. Flynn | Delaware | 0 | 1956923 | 0 | 0 | 1956923 | 2.86 % | 11/02/2019 |
| Deerfield Private Design Fund III, L.P. | Delaware | 0 | 527596 | 0 | 0 | 527596 | 0.77 % | 11/02/2019 |
| Situations Fund, L.P. | Delaware | 0 | 351731 | 0 | 0 | 351731 | 0.51 % | 11/02/2019 |
| III, L.P. | Delaware | 0 | 527596 | 0 | 0 | 527596 | 0.77 % | 11/02/2019 |
| Deerfield Private Design Fund IV, L.P. | Delaware | 0 | 527596 | 0 | 0 | 527596 | 0.77 % | 11/02/2019 |
| Deerfield Management Company, L.P. | Delaware | 0 | 1956923 | 0 | 0 | 1956923 | 2.86 % | 11/02/2019 |
| Page 2 of 6 Pages | United States America | 0 | 13 | 832000 | 0 | 832000 | 7.7 % | 09/02/2018 |
| 1,320,000 | Delaware | 0 | 0 | 0 | 1320000 | 1320000 | 14.8 % | 04/12/2017 |
| 1,320,000 | Delaware | 0 | 0 | 0 | 1320000 | 1320000 | 14.8 % | 04/12/2017 |
| 1,320,000 | Delaware | 0 | 0 | 0 | 1320000 | 1320000 | 14.8 % | 04/12/2017 |
| Joseph Edelman | Delaware, United States of America | 0 | 845000 | 0 | 0 | 845000 | 9.94 % | 05/06/2017 |
| Advisors LLC | Delaware, United States of America | 0 | 845000 | 0 | 0 | 845000 | 9.94 % | 05/06/2017 |
| Sciences Master Fund, Ltd. | Delaware, United States of America | 0 | 803764 | 0 | 0 | 803764 | 9.46 % | 05/06/2017 |
| Page 2 of 6 Pages | United States of America | 830000 | 0 | 830000 | 0 | 830000 | 9.77 % | 30/05/2017 |
| Abigail P. Johnson | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| FMR LLC | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| David Bonderman | United States of America | 0 | 777096 | 0 | 0 | 777096 | 12.3 % | 14/11/2016 |
| TPG Group Holdings (SBS) Advisors, Inc. | Delaware | 0 | 777096 | 0 | 0 | 777096 | 12.3 % | 14/11/2016 |
| James G. Coulter | United States of America | 0 | 777096 | 0 | 0 | 777096 | 12.3 % | 14/11/2016 |
| Julian C. Baker | United States | 871500 | 0 | 871500 | 0 | 871500 | 1.3 % | 16/02/2016 |
| Baker Bros. Advisors (GP) LLC | United States | 871500 | 0 | 871500 | 0 | 871500 | 1.3 % | 16/02/2016 |
| Baker Bros. Advisors LP | United States | 871500 | 0 | 871500 | 0 | 871500 | 1.3 % | 16/02/2016 |
| Felix J. Baker | United States | 871500 | 0 | 871500 | 0 | 871500 | 1.3 % | 16/02/2016 |
| Great Point Partners, LLC | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Dr. Jeffrey R. Jay, M.D. | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Mr. David Kroin | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Rock Springs Capital Management LP | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Rock Springs Capital Master Fund LP | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| S | ONTARIO CANADA | 0 | 193649 | 0 | 0 | 193649 | 0.3 % | 12/02/2016 |
| S | ONTARIO CANADA | 0 | 590590 | 0 | 0 | 590590 | 0.9 % | 12/02/2016 |
| S | ONTARIO CANADA | 0 | 590590 | 0 | 0 | 590590 | 0.9 % | 12/02/2016 |
| S | ONTARIO CANADA | 0 | 396940 | 0 | 0 | 396940 | 0.6 % | 12/02/2016 |
| Abigail P. Johnson | United States of America | 0 | 0 | 4000000 | 0 | 4000000 | 6.235 % | 12/02/2016 |
| FMR LLC | Delaware | 0 | 0 | 4000000 | 0 | 4000000 | 6.235 % | 12/02/2016 |
| Select Biotechnology Portfolio | Massachusetts | 3281200 | 0 | 0 | 0 | 3281200 | 5.115 % | 12/02/2016 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 2000000 | 0 | 2000000 | 2000000 | 3.1 % | 11/02/2016 |
| Kevin Kotler | Delaware | 0 | 2000000 | 0 | 2000000 | 2000000 | 3.1 % | 11/02/2016 |
| Broadfin Capital, LLC | Delaware | 0 | 2000000 | 0 | 2000000 | 2000000 | 3.1 % | 11/02/2016 |
| Wellington Management Group LLP | Massachusetts | 0 | 0 | 0 | 0 | 0 | 0 % | 11/01/2016 |
| S | ONTARIO, CANADA | 0 | 2314344 | 0 | 2314344 | 2314344 | 3.7 % | 25/08/2015 |
| S | ONTARIO, CANADA | 0 | 1278545 | 0 | 1278545 | 1278545 | 2.1 % | 25/08/2015 |
| S | ONTARIO, CANADA | 0 | 3592889 | 0 | 3592889 | 3592889 | 5.8 % | 25/08/2015 |
| S | ONTARIO, CANADA | 0 | 3592889 | 0 | 3592889 | 3592889 | 5.8 % | 25/08/2015 |
| Wellington Investment Advisors Holdings LLP | Massachusetts | 0 | 6707575 | 0 | 0 | 6994875 | 12.22 % | 11/05/2015 |
| Wellington Management Company LLP | Massachusetts | 0 | 6303325 | 0 | 0 | 6515925 | 11.39 % | 11/05/2015 |
| Wellington Management Group LLP | Massachusetts | 0 | 6707575 | 0 | 0 | 6994875 | 12.22 % | 11/05/2015 |
| Wellington Group Holdings LLP | Massachusetts | 0 | 6707575 | 0 | 0 | 6994875 | 12.22 % | 11/05/2015 |
| Great Point Partners, LLC | USA | 0 | 5430855 | 0 | 0 | 5430855 | 9.32 % | 28/04/2015 |
| Mr. David Kroin | USA | 0 | 5430855 | 0 | 0 | 5430855 | 9.32 % | 28/04/2015 |
| Dr. Jeffrey R. Jay, M.D. | USA | 0 | 5430855 | 0 | 0 | 5430855 | 9.32 % | 28/04/2015 |
| Dr. Jeffrey R. Jay, M.D. | USA | 0 | 5430855 | 0 | 0 | 5430855 | 9.32 % | 27/04/2015 |
| Great Point Partners, LLC | USA | 0 | 5430855 | 0 | 0 | 5430855 | 9.32 % | 27/04/2015 |
| Mr. David Kroin | USA | 0 | 5430855 | 0 | 0 | 5430855 | 9.32 % | 27/04/2015 |
| Hilltop Holdings Inc. | Delaware | 0 | 4000000 | 0 | 4000000 | 8695652 | 21.1 % | 23/04/2015 |
| S | ONTARIO, CANADA | 0 | 2883313 | 0 | 2883313 | 2883313 | 4.6 % | 23/04/2015 |
| S | ONTARIO, CANADA | 0 | 1064106 | 0 | 1064106 | 1064106 | 1.7 % | 23/04/2015 |
| S | ONTARIO, CANADA | 0 | 1819207 | 0 | 1819207 | 1819207 | 2.9 % | 23/04/2015 |
| S | ONTARIO, CANADA | 0 | 2883313 | 0 | 2883313 | 2883313 | 4.6 % | 23/04/2015 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 1330034 | 0 | 1330034 | 1330034 | 5.5 % | 17/02/2015 |
| Kevin Kotler | Delaware | 0 | 1330034 | 0 | 1330034 | 1330034 | 5.5 % | 17/02/2015 |
| Broadfin Capital, LLC | Delaware | 0 | 1330034 | 0 | 1330034 | 1330034 | 5.5 % | 17/02/2015 |
| S | ONTARIO, CANADA | 0 | 1265492 | 0 | 1265492 | 1265492 | 5.4 % | 23/10/2014 |
| S | ONTARIO, CANADA | 0 | 444011 | 0 | 444011 | 444011 | 1.9 % | 23/10/2014 |
| S | ONTARIO, CANADA | 0 | 821481 | 0 | 821481 | 821481 | 3.5 % | 23/10/2014 |
| S | ONTARIO, CANADA | 0 | 1265492 | 0 | 1265492 | 1265492 | 5.4 % | 23/10/2014 |
| American Express Financial Corporation | Cayman Islands | 0 | 1803760 | 0 | 1803760 | 3355344 | 5.9 % | 29/07/2014 |
| Hove, Anders | Delaware | 0 | 1642392 | 0 | 0 | 1642392 | 7.6 % | 14/02/2014 |
| Roberts, Bryan | Delaware | 0 | 1642392 | 0 | 0 | 1642392 | 7.6 % | 14/02/2014 |
| VHCP Management, LLC | Delaware | 0 | 1642392 | 0 | 0 | 1642392 | 7.6 % | 14/02/2014 |
| VHCP Co-Investment Holdings, LLC | Delaware | 0 | 1642392 | 0 | 0 | 1642392 | 7.6 % | 14/02/2014 |
| Venrock Healthcare Capital Partners, L.P. | Delaware | 0 | 1642392 | 0 | 0 | 1642392 | 7.6 % | 14/02/2014 |
| Felix J. Baker | United States | 2336500 | 0 | 2336500 | 0 | 2336500 | 9.98 % | 14/02/2014 |
| Julian C. Baker | United States | 2336500 | 0 | 2336500 | 0 | 2336500 | 9.98 % | 14/02/2014 |
| 13-4093645 | Delaware | 2336500 | 0 | 2336500 | 0 | 2336500 | 9.98 % | 14/02/2014 |
| 46-3147749 | Delaware | 2336500 | 0 | 2336500 | 0 | 2336500 | 9.98 % | 14/02/2014 |
| Great Point Partners, LLC | USA | 0 | 1048024 | 0 | 0 | 1048024 | 4.74 % | 14/02/2014 |
| Mr. David Kroin | USA | 0 | 1048024 | 0 | 0 | 1048024 | 4.74 % | 14/02/2014 |
| Dr. Jeffrey R. Jay, M.D. | USA | 0 | 1048024 | 0 | 0 | 1048024 | 4.74 % | 14/02/2014 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 4.7 % | 13/02/2014 |
| Broadfin Capital, LLC | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 4.7 % | 13/02/2014 |
| Kevin Kotler | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 4.7 % | 13/02/2014 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 5.23 % | 07/10/2013 |
| Kevin Kotler | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 5.23 % | 07/10/2013 |
| Broadfin Capital, LLC | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 5.23 % | 07/10/2013 |
| Hove, Anders | United States | 0 | 1408954 | 0 | 0 | 1408954 | 9.8 % | 14/02/2013 |
| Venrock Healthcare Capital Partners, L.P. | United States | 0 | 1408954 | 0 | 0 | 1408954 | 9.8 % | 14/02/2013 |
| VHCP Co-Investment Holdings, LLC | United States | 0 | 1408954 | 0 | 0 | 1408954 | 9.8 % | 14/02/2013 |
| VHCP Management, LLC | United States | 0 | 1408954 | 0 | 0 | 1408954 | 9.8 % | 14/02/2013 |
| Roberts, Bryan | United States | 0 | 1408954 | 0 | 0 | 1408954 | 9.8 % | 14/02/2013 |
| 13-4093645 | Delaware | 1511500 | 0 | 1511500 | 0 | 1511500 | 9.98 % | 01/02/2013 |
| Julian C. Baker | United States | 1511500 | 0 | 1511500 | 0 | 1511500 | 9.98 % | 01/02/2013 |
| Felix J. Baker | United States | 1511500 | 0 | 1511500 | 0 | 1511500 | 9.98 % | 01/02/2013 |
| VHCP Co-Investment Holdings, LLC | Delaware | 0 | 1408954 | 0 | 0 | 1408954 | 9.98 % | 06/07/2012 |
| VHCP Management, LLC | Delaware | 0 | 1408954 | 0 | 0 | 1408954 | 9.98 % | 06/07/2012 |
| Hove, Anders | Delaware | 0 | 1408954 | 0 | 0 | 1408954 | 9.98 % | 06/07/2012 |
| Venrock Healthcare Capital Partners, L.P. | Delaware | 0 | 1408954 | 0 | 0 | 1408954 | 9.8 % | 06/07/2012 |
| Roberts, Bryan | Delaware | 0 | 1408954 | 0 | 0 | 1408954 | 9.98 % | 06/07/2012 |
| Sabby Management, LLC | Delaware USA | 0 | 1395511 | 0 | 1395511 | 1395511 | 9.98 % | 25/06/2012 |
| Jay Venkatesan | Delaware USA | 0 | 541666 | 0 | 541666 | 541666 | 1.38 % | 03/04/2012 |
| Ayer Capital Management, LP | Delaware USA | 0 | 541666 | 0 | 541666 | 541666 | 1.38 % | 03/04/2012 |
| ACM Capital Partners, LLC | Delaware USA | 0 | 541666 | 0 | 541666 | 541666 | 1.38 % | 03/04/2012 |
| Ayer Capital Management, LP | Delaware USA | 0 | 2574099 | 0 | 2574099 | 2574099 | 6.39 % | 23/05/2011 |
| Jay Venkatesan | Delaware USA | 0 | 2574099 | 0 | 2574099 | 2574099 | 6.39 % | 23/05/2011 |
| ACM Capital Partners, LLC | Delaware USA | 0 | 2574099 | 0 | 2574099 | 2574099 | 6.39 % | 23/05/2011 |
| BAM Management, LLC | Delaware, U.S.A. | 0 | 1204000 | 0 | 1204000 | 1204000 | 4.55 % | 12/01/2011 |
| Hal Mintz | Delaware, U.S.A. | 0 | 1204000 | 0 | 1204000 | 1204000 | 4.55 % | 12/01/2011 |
| Ross Berman | Delaware, U.S.A. | 0 | 1204000 | 0 | 1204000 | 1204000 | 4.55 % | 12/01/2011 |
| BAM Opportunity Fund, L.P. | Delaware, U.S.A. | 0 | 1204000 | 0 | 1204000 | 1204000 | 4.55 % | 12/01/2011 |
| BAM Capital, LLC | Delaware, U.S.A. | 0 | 1204000 | 0 | 1204000 | 1204000 | 4.55 % | 12/01/2011 |
| Michael M. Rothenberg | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 23/11/2010 |
| David A. Sackler | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 23/11/2010 |
| 20-4093001 | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 23/11/2010 |
| 20-4092810 | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 23/11/2010 |
| Ross Berman | United States of America | 0 | 1392100 | 0 | 0 | 1392100 | 5.27 % | 13/10/2010 |
| BAM Capital, LLC | Delaware, U.S.A. | 0 | 1392100 | 0 | 0 | 1392100 | 5.27 % | 13/10/2010 |
| BAM Opportunity Fund, L.P. | Delaware, U.S.A. | 0 | 1392100 | 0 | 0 | 1392100 | 5.27 % | 13/10/2010 |
| Hal Mintz | United States of America | 0 | 1392100 | 0 | 0 | 1392100 | 5.27 % | 13/10/2010 |
| BAM Management, LLC | Delaware, U.S.A. | 0 | 1392100 | 0 | 0 | 1392100 | 5.27 % | 13/10/2010 |
| FMR LLC | Delaware | 194420 | 0 | 1500187 | 0 | 1500187 | 6.279 % | 09/07/2010 |
| Edward C. Johnson 3d | Delaware | 0 | 0 | 1500187 | 0 | 1500187 | 6.279 % | 09/07/2010 |
| Moab Capital Partners, LLC | Delaware | 0 | 0 | 0 | 107000 | 2386869 | 9.9 % | 16/02/2010 |
| Moab Partners, L.P. | Delaware | 0 | 0 | 0 | 0 | 2279869 | 9.5 % | 16/02/2010 |
| David A. Sackler | Delaware | 0 | 0 | 0 | 107000 | 2386869 | 9.9 % | 16/02/2010 |
| Michael M. Rothenberg | Delaware | 0 | 0 | 0 | 107000 | 2386869 | 9.9 % | 16/02/2010 |
| FMR LLC | Delaware | 206120 | 0 | 2956757 | 0 | 2956757 | 12.38 % | 16/02/2010 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 2956757 | 0 | 2956757 | 12.38 % | 16/02/2010 |
| Great Point Partners I, L.P. | USA | 0 | 1161642 | 0 | 1161642 | 1161642 | 4.86 % | 16/02/2010 |
| Poco Bay Company | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 31/12/2009 |
| FMR LLC | Delaware | 500 | 0 | 2439617 | 0 | 2439617 | 10.288 % | 17/02/2009 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 2439617 | 0 | 2439617 | 10.288 % | 17/02/2009 |
| LLC 42-1684320 | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 17/02/2009 |
| Capital Investments Ltd. 00-0000000 | Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 17/02/2009 |
| Capital Investments L.P. 00-0000000 | Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 17/02/2009 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 2379217 | 0 | 2379217 | 10.053 % | 10/09/2008 |
| FMR LLC | Delaware | 7600 | 0 | 2379217 | 0 | 2379217 | 10.053 % | 10/09/2008 |
| D. Isaly | States | 0 | 1812892 | 0 | 10 | 1812892 | 7.69 % | 22/02/2008 |
| Advisors LLC | Delaware | 0 | 149994 | 0 | 10 | 149994 | 0.64 % | 22/02/2008 |
| Capital GP II LLC | Delaware | 0 | 1662898 | 0 | 10 | 1662898 | 7.05 % | 22/02/2008 |
| Advisors LLC | Delaware | 0 | 149994 | 0 | 10 | 149994 | 0.64 % | 22/02/2008 |
| Capital GP II LLC | Delaware | 0 | 1662898 | 0 | 10 | 1662898 | 7.05 % | 22/02/2008 |
| D. Isaly | States | 0 | 1812892 | 0 | 10 | 1812892 | 7.69 % | 22/02/2008 |
| Advisors LLC | Delaware | 0 | 149994 | 0 | 10 | 149994 | 0.64 % | 22/02/2008 |
| Capital GP II LLC | Delaware | 0 | 1662898 | 0 | 10 | 1662898 | 7.05 % | 22/02/2008 |
| D. Isaly | States | 0 | 1812892 | 0 | 10 | 1812892 | 7.69 % | 22/02/2008 |
| 20-3704605 | USA | 0 | 1812574 | 0 | 1812574 | 1812574 | 7.7 % | 14/02/2008 |
| FMR LLC | Delaware | 0 | 0 | 1606896 | 0 | 1606896 | 7.97 % | 14/02/2008 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 1606896 | 0 | 1606896 | 7.97 % | 14/02/2008 |
| Wayne Holman | USA | 0 | 1848000 | 0 | 0 | 1848000 | 9.2 % | 14/02/2008 |
| 00-0000000 | Cayman Islands | 0 | 1848000 | 0 | 0 | 1848000 | 9.2 % | 14/02/2008 |
| LLC 42-1684320 | Delaware | 0 | 1848000 | 0 | 0 | 1848000 | 9.2 % | 14/02/2008 |
| 00-0000000 | Cayman Islands | 0 | 1848000 | 0 | 0 | 1848000 | 9.2 % | 14/02/2008 |
| LLC 42-1684320 | USA | 0 | 1530000 | 0 | 0 | 1530000 | 7.6 % | 26/11/2007 |
| Wayne Holman | USA | 0 | 1530000 | 0 | 0 | 1530000 | 7.6 % | 26/11/2007 |
| 00-0000000 | USA | 0 | 1530000 | 0 | 0 | 1530000 | 7.6 % | 26/11/2007 |