Albireo Pharma, Inc. ALBO
Trading inactive
| Déclarant | Citoyenneté ou lieu d'organisation | Pouvoir de vote unique | Pouvoir de vote partagé | Pouvoir de disposition unique | Pouvoir de disposition partagé | Montant en propriété effective | Pourcentage détenu | Date d'achat |
|---|---|---|---|---|---|---|---|---|
| David Kroin | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2024 |
| Deep Track Capital, LP | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2024 |
| Deep Track Biotechnology Master Fund, Ltd. | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2024 |
| Federated Hermes, Inc. | Pennsylvania | 0 | 0 | 0 | 0 % | 10/04/2023 | ||
| Voting Shares Irrevocable Trust | Pennsylvania | 0 | 0 | 0 | 0 % | 10/04/2023 | ||
| Ann C. Donahue | United States | 0 | 0 | 0 | 0 % | 10/04/2023 | ||
| Thomas R. Donahue | United States | 0 | 0 | 0 | 0 % | 10/04/2023 | ||
| J. Christopher Donahue | United States | 0 | 0 | 0 | 0 % | 10/04/2023 | ||
| BlackRock, Inc. | Delaware | 478937 | 0 | 506425 | 0 | 506425 | 2.4 % | 08/03/2023 |
| Israel A. Englander | 999363 | 4.8 % | 02/03/2023 | |||||
| ICS Opportunities, Ltd. | 893869 | 4.3 % | 02/03/2023 | |||||
| Millennium Management LLC | 999363 | 4.8 % | 02/03/2023 | |||||
| Israel A. Englander | 999363 | 4.8 % | 02/03/2023 | |||||
| Millennium Group Management LLC | 999363 | 4.8 % | 02/03/2023 | |||||
| ICS Opportunities, Ltd. | 893869 | 4.3 % | 02/03/2023 | |||||
| Millennium Management LLC | 999363 | 4.8 % | 02/03/2023 | |||||
| Millennium Group Management LLC | 999363 | 4.8 % | 02/03/2023 | |||||
| David A. Witkin | U.S.A. | 0 | 1483599 | 0 | 1483599 | 1483599 | 7.1 % | 27/02/2023 |
| Beryl Capital Management LLC | Delaware | 0 | 1483599 | 0 | 1483599 | 1483599 | 7.1 % | 27/02/2023 |
| Beryl Capital Management LP | Delaware | 0 | 1483599 | 0 | 1483599 | 1483599 | 7.1 % | 27/02/2023 |
| Beryl Capital Partners II LP | Delaware | 0 | 1337293 | 0 | 1337293 | 1337293 | 6.4 % | 27/02/2023 |
| Double Black Diamond Offshore Ltd. | Cayman Islands | 0 | 178146 | 0 | 178146 | 178146 | 1 % | 24/02/2023 |
| Corbin Hedged Equity Fund, L.P. | Delaware | 0 | 55904 | 0 | 55904 | 55904 | 0.3 % | 24/02/2023 |
| EDCA 2019 Fund, L.P. | Delaware | 0 | 208795 | 0 | 208795 | 208795 | 1 % | 24/02/2023 |
| Carlson Capital, L.P. | Delaware | 0 | 1075000 | 0 | 1075000 | 1075000 | 5.2 % | 24/02/2023 |
| Clint D. Carlson | United States | 0 | 1075000 | 0 | 1075000 | 1075000 | 5.2 % | 24/02/2023 |
| Asgard Investment Corp. II | Delaware | 0 | 1075000 | 0 | 1075000 | 1075000 | 5.2 % | 24/02/2023 |
| Corbin Hedged Equity Fund, L.P. | Delaware | 0 | 55904 | 0 | 55904 | 55904 | 0.3 % | 24/02/2023 |
| EDCA 2019 Fund, L.P. | Delaware | 0 | 208795 | 0 | 208795 | 208795 | 1 % | 24/02/2023 |
| Black Diamond Arbitrage Offshore Ltd. | Cayman Islands | 0 | 632155 | 0 | 632155 | 632155 | 3 % | 24/02/2023 |
| Double Black Diamond Offshore Ltd. | Cayman Islands | 0 | 178146 | 0 | 178146 | 178146 | 1 % | 24/02/2023 |
| Clint D. Carlson | United States | 0 | 1075000 | 0 | 1075000 | 1075000 | 5.2 % | 24/02/2023 |
| Carlson Capital, L.P. | Delaware | 0 | 1075000 | 0 | 1075000 | 1075000 | 5.2 % | 24/02/2023 |
| Black Diamond Arbitrage Offshore Ltd. | Cayman Islands | 0 | 632155 | 0 | 632155 | 632155 | 3 % | 24/02/2023 |
| Asgard Investment Corp. II | Delaware | 0 | 1075000 | 0 | 1075000 | 1075000 | 5.2 % | 24/02/2023 |
| STATE STREET CORPORATION | BOSTON, MASSACHUSETTS | 0 | 313531 | 0 | 348114 | 348114 | 1.68 % | 01/02/2023 |
| Federated Hermes, Inc. | Pennsylvania | 1956488 | 1956488 | 1956488 | 9.45 % | 01/02/2023 | ||
| Voting Shares Irrevocable Trust | Pennsylvania | 1956488 | 1956488 | 1956488 | 9.45 % | 01/02/2023 | ||
| J. Christopher Donahue | United States | 1956488 | 1956488 | 1956488 | 9.45 % | 01/02/2023 | ||
| Thomas R. Donahue | United States | 1956488 | 1956488 | 1956488 | 9.45 % | 01/02/2023 | ||
| BlackRock, Inc. | Delaware | 1312963 | 0 | 1344897 | 0 | 1344897 | 6.5 % | 31/01/2023 |
| Chicago Capital LLC | Illinois | 1362484 | 0 | 1362484 | 0 | 1362484 | 6.6 % | 23/01/2023 |
| Chicago Capital LLC | Illinois | 1362484 | 0 | 1362484 | 0 | 1362484 | 6.6 % | 23/01/2023 |
| Deep Track Capital, LP | Delaware | 0 | 1124421 | 0 | 1124421 | 0 | 5.46 % | 03/10/2022 |
| Deep Track Biotechnology Master Fund, Ltd. | Cayman Islands | 0 | 1124421 | 0 | 1124421 | 0 | 5.46 % | 03/10/2022 |
| David Kroin | United States | 0 | 1124421 | 0 | 1124421 | 0 | 5.46 % | 03/10/2022 |
| David Kroin | United States | 0 | 1124421 | 0 | 1124421 | 0 | 5.46 % | 03/10/2022 |
| Deep Track Capital, LP | Delaware | 0 | 1124421 | 0 | 1124421 | 0 | 5.46 % | 03/10/2022 |
| Deep Track Biotechnology Master Fund, Ltd. | Cayman Islands | 0 | 1124421 | 0 | 1124421 | 0 | 5.46 % | 03/10/2022 |
| Kevin Tang | united states | 1099516 | 0 | 1099516 | 1099516 | 5.6 % | 26/09/2022 | |
| TANG CAPITAL PARTNERS, LP | DELAWARE | 1099516 | 0 | 1099516 | 1099516 | 5.6 % | 26/09/2022 | |
| Tang Capital Management, LLC | DELAWARE | 1099516 | 0 | 1099516 | 1099516 | 5.6 % | 26/09/2022 | |
| Kevin Tang | united states | 1099516 | 0 | 1099516 | 1099516 | 5.6 % | 26/09/2022 | |
| TANG CAPITAL PARTNERS, LP | DELAWARE | 1099516 | 0 | 1099516 | 1099516 | 5.6 % | 26/09/2022 | |
| Tang Capital Management, LLC | DELAWARE | 1099516 | 0 | 1099516 | 1099516 | 5.6 % | 26/09/2022 | |
| Chicago Capital LLC | Illinois | 971885 | 0 | 971885 | 0 | 971885 | 5.1 % | 07/03/2022 |
| Chicago Capital LLC | Illinois | 971885 | 0 | 971885 | 0 | 971885 | 5.1 % | 07/03/2022 |
| Thomas R. Donahue | 2358624 | 2358624 | 2358624 | 12.23 % | 14/02/2022 | |||
| Rhodora J. Donahue | 2358624 | 2358624 | 2358624 | 12.23 % | 14/02/2022 | |||
| Voting Shares Irrevocable Trust | 2358624 | 2358624 | 2358624 | 12.23 % | 14/02/2022 | |||
| J. Christopher Donahue | 2358624 | 2358624 | 2358624 | 12.23 % | 14/02/2022 | |||
| (entities only Federated Hermes, Inc. | 2358624 | 2358624 | 2358624 | 12.23 % | 14/02/2022 | |||
| BlackRock, Inc. | Delaware | 1152646 | 0 | 1168783 | 0 | 1168783 | 6.1 % | 02/02/2022 |
| Joseph Edelman | United States of America | 0 | 2360139 | 0 | 2360139 | 2360139 | 12.4 % | 16/02/2021 |
| Perceptive Advisors LLC | Delaware | 0 | 2360139 | 0 | 2360139 | 2360139 | 12.4 % | 16/02/2021 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 2360139 | 0 | 2360139 | 2360139 | 12.4 % | 16/02/2021 |
| ArrowMark Colorado Holdings, LLC | Delaware, United States | 751495 | 0 | 751495 | 0 | 0 | 3.9 % | 16/02/2021 |
| ArrowMark Colorado Holdings, LLC | Delaware United States | 751495 | 0 | 751495 | 0 | 751495 | 3.9 % | 16/02/2021 |
| Rhodora J. Donahue | 2447000 | 2447000 | 2447000 | 12.83 % | 12/02/2021 | |||
| (entities only Federated Hermes, Inc. | 2447000 | 2447000 | 2447000 | 12.83 % | 12/02/2021 | |||
| J. Christopher Donahue | 2447000 | 2447000 | 2447000 | 12.83 % | 12/02/2021 | |||
| Voting Shares Irrevocable Trust | 2447000 | 2447000 | 2447000 | 12.83 % | 12/02/2021 | |||
| Thomas R. Donahue | 2447000 | 2447000 | 2447000 | 12.83 % | 12/02/2021 | |||
| BlackRock, Inc. | Delaware | 1221745 | 0 | 1242780 | 0 | 1242780 | 6.5 % | 02/02/2021 |
| ArrowMark Colorado Holdings, LLC | Delaware, United States | 867050 | 0 | 867050 | 0 | 0 | 6.83 % | 14/02/2020 |
| Muneer A. Satter | United States America | 832000 | 0 | 832000 | 0 | 832000 | 5.59 % | 12/02/2020 |
| Muneer A. Satter | United States America | 832000 | 0 | 832000 | 0 | 832000 | 5.59 % | 12/02/2020 |
| BlackRock, Inc. | Delaware | 677196 | 0 | 686456 | 0 | 686456 | 4.6 % | 10/02/2020 |
| BlackRock, Inc. | Delaware | 697288 | 0 | 709381 | 0 | 709381 | 5.6 % | 07/02/2020 |
| ArrowMark Colorado Holdings, LLC | Delaware United States | 611992 | 0 | 611992 | 0 | 611992 | 5.11 % | 14/02/2019 |
| Muneer A. Satter | United States America | 832000 | 0 | 832000 | 0 | 832000 | 7 % | 13/02/2019 |
| Muneer A. Satter | United States America | 832000 | 0 | 832000 | 0 | 832000 | 7 % | 13/02/2019 |
| Muneer A. Satter | United States America | 832000 | 0 | 832000 | 0 | 832000 | 7.7 % | 09/02/2018 |
| Muneer A. Satter | United States America | 832000 | 0 | 832000 | 0 | 832000 | 7.7 % | 09/02/2018 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 1320000 | 0 | 1320000 | 1320000 | 14.8 % | 04/12/2017 |
| Joseph Edelman | United States of America | 0 | 1320000 | 0 | 1320000 | 1320000 | 14.8 % | 04/12/2017 |
| Perceptive Advisors LLC | Delaware | 0 | 1320000 | 0 | 1320000 | 1320000 | 14.8 % | 04/12/2017 |
| Joseph Edelman | United States of America | 0 | 845000 | 0 | 845000 | 845000 | 9.94 % | 05/06/2017 |
| Perceptive Advisors LLC | Delaware, United States of America | 0 | 845000 | 0 | 845000 | 845000 | 9.94 % | 05/06/2017 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 803764 | 0 | 803764 | 803764 | 9.46 % | 05/06/2017 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 803764 | 0 | 803764 | 803764 | 9.46 % | 05/06/2017 |
| Perceptive Advisors LLC | Delaware, United States of America | 0 | 845000 | 0 | 845000 | 845000 | 9.94 % | 05/06/2017 |
| Joseph Edelman | United States of America | 0 | 845000 | 0 | 845000 | 845000 | 9.94 % | 05/06/2017 |
| Muneer A. Satter | United States of America | 830000 | 0 | 830000 | 0 | 830000 | 9.77 % | 30/05/2017 |
| Muneer A. Satter | United States of America | 830000 | 0 | 830000 | 0 | 830000 | 9.77 % | 30/05/2017 |
| Abigail P. Johnson | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| FMR LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| FMR LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Abigail P. Johnson | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Julian C. Baker | United States | 871500 | 0 | 871500 | 0 | 871500 | 1.3 % | 16/02/2016 |
| Felix J. Baker | United States | 871500 | 0 | 871500 | 0 | 871500 | 1.3 % | 16/02/2016 |
| Baker Bros. Advisors | Delaware | 871500 | 0 | 871500 | 0 | 871500 | 1.3 % | 16/02/2016 |
| Baker Bros. Advisors LP | Delaware | 871500 | 0 | 871500 | 0 | 871500 | 1.3 % | 16/02/2016 |
| OrbiMed Advisors LLC | Delaware | 0 | 1133592 | 0 | 0 | 1133592 | 1.77 % | 16/02/2016 |
| Samuel D. Isaly | United States | 0 | 1133592 | 0 | 1133592 | 1133592 | 1.77 % | 16/02/2016 |
| OrbiMed Capital GP IV LLC | Delaware | 0 | 1133592 | 0 | 1133592 | 1133592 | 1.77 % | 16/02/2016 |
| Mr. David Kroin | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Great Point Partners, LLC | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Dr. Jeffrey R. Jay, M.D. | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Rock Springs Capital Management LP | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Rock Springs Capital Master Fund LP | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Rosalind Master Fund L.P. | CAYMAN ISLANDS | 0 | 193649 | 0 | 193649 | 193649 | 0.3 % | 12/02/2016 |
| Rosalind Capital Partners L.P. | ONTARIO CANADA | 0 | 396940 | 0 | 396940 | 396940 | 0.6 % | 12/02/2016 |
| Steven Salamon | ONTARIO CANADA | 0 | 590590 | 0 | 590590 | 590590 | 0.9 % | 12/02/2016 |
| Rosalind Advisors, Inc. | ONTARIO CANADA | 0 | 590590 | 0 | 590590 | 590590 | 0.9 % | 12/02/2016 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 2000000 | 0 | 2000000 | 2000000 | 3.1 % | 11/02/2016 |
| Broadfin Capital, LLC | Delaware | 0 | 2000000 | 0 | 2000000 | 2000000 | 3.1 % | 11/02/2016 |
| Kevin Kotler | United States America | 0 | 2000000 | 0 | 2000000 | 2000000 | 3.1 % | 11/02/2016 |
| Sabby Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1926560 | 0 | 1926560 | 1926560 | 3 % | 11/01/2016 |
| Sabby Management, LLC | Delaware, USA | 0 | 2017066 | 0 | 2017066 | 2017066 | 3.14 % | 11/01/2016 |
| Hal Mintz | USA | 0 | 2017066 | 0 | 2017066 | 2017066 | 3.14 % | 11/01/2016 |
| Sabby Volatility Warrant Master Fund, Ltd. | Cayman Islands | 0 | 90506 | 0 | 90506 | 90506 | 0.14 % | 11/01/2016 |
| Wellington Management Group LLP | Massachusetts | 0 | 0 | 0 | 0 | 0 | 0 % | 11/01/2016 |
| Rosalind Advisors, Inc. | ONTARIO, CANADA | 0 | 3592889 | 0 | 3592889 | 3592889 | 5.8 % | 25/08/2015 |
| Steven Salamon | ONTARIO, CANADA | 0 | 3592889 | 0 | 3592889 | 3592889 | 5.8 % | 25/08/2015 |
| Rosalind Capital Partners L.P. | ONTARIO, CANADA | 0 | 2314344 | 0 | 2314344 | 2314344 | 3.7 % | 25/08/2015 |
| Rosalind Master Fund L.P. | CAYMAN ISLANDS | 0 | 1278545 | 0 | 1278545 | 1278545 | 2.1 % | 25/08/2015 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 6707575 | 0 | 6994875 | 6994875 | 12.22 % | 11/05/2015 |
| Wellington Management Group LLP | Massachusetts | 0 | 6707575 | 0 | 6994875 | 6994875 | 12.22 % | 11/05/2015 |
| Wellington Management Company LLP | Delaware | 0 | 6303325 | 0 | 6515925 | 6515925 | 11.39 % | 11/05/2015 |
| Wellington Group Holdings LLP | Delaware | 0 | 6707575 | 0 | 6994875 | 6994875 | 12.22 % | 11/05/2015 |
| 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | USA | 0 | 54308551 | 0 | 54308551 | 54308551 | 9.32 % | 28/04/2015 |
| Great Point Partners, LLC | USA | 0 | 54308551 | 0 | 54308551 | 54308551 | 9.32 % | 28/04/2015 |
| Mr. David Kroin | USA | 0 | 54308551 | 0 | 54308551 | 54308551 | 9.32 % | 28/04/2015 |
| Mr. David Kroin | USA | 0 | 54308551 | 0 | 54308551 | 54308551 | 9.32 % | 27/04/2015 |
| Dr. Jeffrey R. Jay, M.D. | USA | 0 | 54308551 | 0 | 54308551 | 54308551 | 9.32 % | 27/04/2015 |
| Great Point Partners, LLC | USA | 0 | 54308551 | 0 | 54308551 | 54308551 | 9.32 % | 27/04/2015 |
| Rock Springs Capital Master Fund LP | Cayman Islands | 0 | 4000000 | 0 | 4000000 | 4000000 | 6.99 % | 23/04/2015 |
| Rock Springs Capital Management LP | Delaware | 0 | 4000000 | 0 | 4000000 | 4000000 | 6.99 % | 23/04/2015 |
| Rosalind Capital Partners L.P. | ONTARIO, CANADA | 0 | 1819207 | 0 | 1819207 | 1819207 | 2.9 % | 23/04/2015 |
| Rosalind Master Fund L.P. | CAYMAN ISLANDS | 0 | 1064106 | 0 | 1064106 | 1064106 | 1.7 % | 23/04/2015 |
| Steven Salamon | ONTARIO, CANADA | 0 | 2883313 | 0 | 2883313 | 2883313 | 4.6 % | 23/04/2015 |
| Rosalind Advisors, Inc. | ONTARIO, CANADA | 0 | 2883313 | 0 | 2883313 | 2883313 | 4.6 % | 23/04/2015 |
| Broadfin Capital, LLC | Delaware | 0 | 1330034 | 0 | 1330034 | 1330034 | 5.5 % | 17/02/2015 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1330034 | 0 | 1330034 | 1330034 | 5.5 % | 17/02/2015 |
| Kevin Kotler | United States of America | 0 | 1330034 | 0 | 1330034 | 1330034 | 5.5 % | 17/02/2015 |
| Hal Mintz | USA | 0 | 2151509 | 0 | 2151509 | 2151509 | 9.18 % | 12/01/2015 |
| Sabby Volatility Warrant Master Fund, Ltd. | Cayman Islands | 0 | 90506 | 0 | 90506 | 90506 | 0.39 % | 12/01/2015 |
| Sabby Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 2061003 | 0 | 2061003 | 2061003 | 8.79 % | 12/01/2015 |
| Sabby Management, LLC | Delaware, USA | 0 | 2151509 | 0 | 2151509 | 2151509 | 9.18 % | 12/01/2015 |
| Rosalind Capital Partners L.P. | ONTARIO, CANADA | 0 | 821481 | 0 | 821481 | 821481 | 3.5 % | 23/10/2014 |
| Rosalind Master Fund L.P. | CAYMAN ISLANDS | 0 | 444011 | 0 | 444011 | 444011 | 1.9 % | 23/10/2014 |
| Rosalind Advisors, Inc. | ONTARIO, CANADA | 0 | 1265492 | 0 | 1265492 | 1265492 | 5.4 % | 23/10/2014 |
| Steven Salamon | ONTARIO, CANADA | 0 | 1265492 | 0 | 1265492 | 1265492 | 5.4 % | 23/10/2014 |
| Sabby Volatility Warrant Master Fund, Ltd. | Cayman Islands | 0 | 90506 | 0 | 90506 | 90506 | 0.4 % | 29/07/2014 |
| Hal Mintz | USA | 0 | 1894266 | 0 | 1894266 | 1894266 | 8.38 % | 29/07/2014 |
| Sabby Healthcare Volatility Master Fund, Ltd. | Cayman Islands | 0 | 1803760 | 0 | 1803760 | 1803760 | 7.98 % | 29/07/2014 |
| Sabby Management, LLC | Delaware, USA | 0 | 1894266 | 0 | 1894266 | 1894266 | 8.38 % | 29/07/2014 |
| VHCP Holdings, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 16423922 | 0 | 16423922 | 16423922 | 7.6 % | 14/02/2014 |
| Venrock Healthcare Capital Partners, L.P. | Delaware | 0 | 16423922 | 0 | 16423922 | 16423922 | 7.6 % | 14/02/2014 |
| VHCP Management, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 16423922 | 0 | 16423922 | 16423922 | 7.6 % | 14/02/2014 |
| Roberts, Bryan 2. Check the Appropriate Box if a Member of a Group | United States | 0 | 16423922 | 0 | 16423922 | 16423922 | 7.6 % | 14/02/2014 |
| Hove, Anders 2. Check the Appropriate Box if a Member of a Group | United States | 0 | 16423922 | 0 | 16423922 | 16423922 | 7.6 % | 14/02/2014 |
| Julian C. Baker | United States | 2336500 | 0 | 2336500 | 0 | 2336500 | 9.98 % | 14/02/2014 |
| Felix J. Baker | United States | 2336500 | 0 | 2336500 | 0 | 2336500 | 9.98 % | 14/02/2014 |
| Baker Bros. Advisors | Delaware | 2336500 | 0 | 2336500 | 0 | 2336500 | 9.98 % | 14/02/2014 |
| Baker Bros. Advisors LP | Delaware | 2336500 | 0 | 2336500 | 0 | 2336500 | 9.98 % | 14/02/2014 |
| Kevin Kotler | United States America | 0 | 1000000 | 0 | 1000000 | 1000000 | 4.7 % | 13/02/2014 |
| Broadfin Capital, LLC | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 4.7 % | 13/02/2014 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1000000 | 0 | 1000000 | 1000000 | 4.7 % | 13/02/2014 |
| Hal Mintz | USA | 0 | 536366 | 0 | 536366 | 536366 | 2.54 % | 07/01/2014 |
| Sabby Management, LLC | Delaware USA | 0 | 536366 | 0 | 536366 | 536366 | 2.54 % | 07/01/2014 |
| Sabby Volatility Warrant Master Fund, Ltd. | Cayman Islands | 0 | 90506 | 0 | 90506 | 90506 | 0.43 % | 07/01/2014 |
| Sabby Healthcare Volatility Master Fund, Ltd. | Cayman Islands | 0 | 445860 | 0 | 445860 | 445860 | 2.12 % | 07/01/2014 |
| Broadfin Capital, LLC | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 5.23 % | 07/10/2013 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1000000 | 0 | 1000000 | 1000000 | 5.23 % | 07/10/2013 |
| Kevin Kotler | United States of America | 0 | 1000000 | 0 | 1000000 | 1000000 | 5.23 % | 07/10/2013 |
| Venrock Healthcare Capital Partners, L.P. | Delaware, United States | 0 | 14089542 | 0 | 14089542 | 14089542 | 9.8 % | 14/02/2013 |
| Hove, Anders 2. Check the Appropriate Box if a Member of a Group | United States | 0 | 14089542 | 0 | 14089542 | 14089542 | 9.8 % | 14/02/2013 |
| VHCP Management, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware, United States | 0 | 14089542 | 0 | 14089542 | 14089542 | 9.8 % | 14/02/2013 |
| Roberts, Bryan 2. Check the Appropriate Box if a Member of a Group | United States | 0 | 14089542 | 0 | 14089542 | 14089542 | 9.8 % | 14/02/2013 |
| VHCP Holdings, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware, United States | 0 | 14089542 | 0 | 14089542 | 14089542 | 9.8 % | 14/02/2013 |
| Great Point Partners, LLC | USA | 0 | 13504001 | 0 | 13504001 | 13504001 | 9.531 % | 14/02/2013 |
| Mr. David Kroin | USA | 0 | 137422813 | 0 | 137422813 | 137422813 | 9.681 % | 14/02/2013 |
| Dr. Jeffrey R. Jay, M.D. | USA | 0 | 13504001 | 0 | 13504001 | 13504001 | 9.531 % | 14/02/2013 |
| Baker Bros. Advisors, LLC | Delaware | 1511500 | 0 | 1511500 | 0 | 1511500 | 9.98 % | 01/02/2013 |
| Felix J. Baker | United States | 1511500 | 0 | 1511500 | 0 | 1511500 | 9.98 % | 01/02/2013 |
| Julian C. Baker | United States | 1511500 | 0 | 1511500 | 0 | 1511500 | 9.98 % | 01/02/2013 |
| Sabby Volatility Warrant Master Fund, Ltd. | Cayman Islands | 0 | 133728 | 0 | 133728 | 133728 | 0.94 % | 28/01/2013 |
| Sabby Healthcare Volatility Master Fund, Ltd. | Cayman Islands | 0 | 1414887 | 0 | 1414887 | 1414887 | 9.98 % | 28/01/2013 |
| Hal Mintz | USA | 0 | 1414887 | 0 | 1414887 | 1414887 | 9.98 % | 28/01/2013 |
| Sabby Management, LLC | Delaware USA | 0 | 1414887 | 0 | 1414887 | 1414887 | 9.98 % | 28/01/2013 |
| VHCP Holdings, LLC 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | Delaware | 0 | 1408954 | 0 | 1408954 | 1408954 | 9.98 % | 06/07/2012 |
| Venrock Healthcare Capital Partners, L.P. | Delaware | 0 | 1408954 | 0 | 1408954 | 1408954 | 9.8 % | 06/07/2012 |
| Roberts, Bryan 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | United States | 0 | 1408954 | 0 | 1408954 | 1408954 | 9.98 % | 06/07/2012 |
| Hove, Anders 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | United States | 0 | 1408954 | 0 | 1408954 | 1408954 | 9.98 % | 06/07/2012 |
| VHCP Management, LLC 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | Delaware | 0 | 1408954 | 0 | 1408954 | 1408954 | 9.98 % | 06/07/2012 |
| Hal Mintz | USA | 0 | 1395511 | 0 | 1395511 | 1395511 | 9.98 % | 25/06/2012 |
| Sabby Healthcare Volatility Master Fund, Ltd. | Cayman Islands | 0 | 1136922 | 0 | 1136922 | 1136922 | 8.13 % | 25/06/2012 |
| Sabby Volatility Warrant Master Fund, Ltd. | Cayman Islands | 0 | 258589 | 0 | 258589 | 258589 | 1.85 % | 25/06/2012 |
| Sabby Management, LLC | Delaware USA | 0 | 1395511 | 0 | 1395511 | 1395511 | 9.98 % | 25/06/2012 |
| Ayer Capital Management, LP | Delaware USA | 0 | 541666 | 0 | 541666 | 541666 | 1.38 % | 03/04/2012 |
| ACM Capital Partners, LLC | Delaware USA | 0 | 541666 | 0 | 541666 | 541666 | 1.38 % | 03/04/2012 |
| Jay Venkatesan | USA | 0 | 541666 | 0 | 541666 | 541666 | 1.38 % | 03/04/2012 |
| OrbiMed Advisors LLC | Delaware | 0 | 3968197 | 0 | 3968197 | 3968197 | 9.98 % | 10/06/2011 |
| Samuel D. Isaly | United States | 0 | 3968197 | 0 | 3968197 | 3968197 | 9.98 % | 10/06/2011 |
| OrbiMed Capital GP IV LLC | Delaware | 0 | 3968197 | 0 | 3968197 | 3968197 | 9.98 % | 10/06/2011 |
| Dr. Jeffrey R. Jay, M.D. | USA | 0 | 38273751 | 0 | 38273751 | 38273751 | 9.901 % | 31/05/2011 |
| Great Point Partners, LLC | USA | 0 | 38273751 | 0 | 38273751 | 38273751 | 9.901 % | 31/05/2011 |
| Mr. David Kroin | USA | 0 | 38273751 | 0 | 38273751 | 38273751 | 9.901 % | 31/05/2011 |
| ACM Capital Partners, LLC | Delaware USA | 0 | 2574099 | 0 | 2574099 | 2574099 | 6.39 % | 23/05/2011 |
| Ayer Capital Management, LP | Delaware USA | 0 | 2574099 | 0 | 2574099 | 2574099 | 6.39 % | 23/05/2011 |
| Jay Venkatesan | USA | 0 | 2574099 | 0 | 2574099 | 2574099 | 6.39 % | 23/05/2011 |
| Hal Mintz | United States of America | 0 | 1204000 | 0 | 1204000 | 1204000 | 4.55 % | 12/01/2011 |
| BAM Opportunity Fund, L.P. | Delaware, U.S.A. | 0 | 1204000 | 0 | 1204000 | 1204000 | 4.55 % | 12/01/2011 |
| Ross Berman | United States of America | 0 | 1204000 | 0 | 1204000 | 1204000 | 4.55 % | 12/01/2011 |
| BAM Management, LLC | Delaware, U.S.A. | 0 | 1204000 | 0 | 1204000 | 1204000 | 4.55 % | 12/01/2011 |
| BAM Capital, LLC | Delaware, U.S.A. | 0 | 1204000 | 0 | 1204000 | 1204000 | 4.55 % | 12/01/2011 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 10/12/2010 |
| FMR LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 10/12/2010 |
| Moab Partners, | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 23/11/2010 |
| David A. Sackler | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 23/11/2010 |
| Moab Capital Partners, | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 23/11/2010 |
| Michael M. Rothenberg | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 23/11/2010 |
| Ross Berman | United States of America | 0 | 1392100 | 0 | 1392100 | 1392100 | 5.27 % | 13/10/2010 |
| BAM Opportunity Fund, L.P. | Delaware, U.S.A. | 0 | 1392100 | 0 | 1392100 | 1392100 | 5.27 % | 13/10/2010 |
| BAM Capital, LLC | Delaware, U.S.A. | 0 | 1392100 | 0 | 1392100 | 1392100 | 5.27 % | 13/10/2010 |
| BAM Management, LLC | Delaware, U.S.A. | 0 | 1392100 | 0 | 1392100 | 1392100 | 5.27 % | 13/10/2010 |
| Hal Mintz | United States of America | 0 | 1392100 | 0 | 1392100 | 1392100 | 5.27 % | 13/10/2010 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 1500187 | 0 | 1500187 | 6.279 % | 09/07/2010 |
| FMR LLC | Delaware | 194420 | 0 | 1500187 | 0 | 1500187 | 6.279 % | 09/07/2010 |
| Moab Partners, L.P. | Delaware | 2279869 | 0 | 2279869 | 0 | 2279869 | 9.5 % | 16/02/2010 |
| David A. Sackler | United States America | 2279869 | 107000 | 2279869 | 107000 | 2386869 | 9.9 % | 16/02/2010 |
| Michael M. Rothenberg | United States America | 2279869 | 107000 | 2279869 | 107000 | 2386869 | 9.9 % | 16/02/2010 |
| Moab Capital Partners, LLC | Delaware | 2279869 | 107000 | 2279869 | 107000 | 2386869 | 9.9 % | 16/02/2010 |
| Great Point Partners I, L.P. : | USA | 0 | 1161642 | 0 | 1161642 | 1161642 | 4.86 % | 16/02/2010 |
| Solomon S. Steiners . | United States | 0 | 4320395 | 0 | 4320395 | 4320395 | 18.1 % | 16/02/2010 |
| Steiner Ventures, LLCs .510459630 | Connecticut | 0 | 4044266 | 0 | 4044266 | 4044266 | 16.9 % | 16/02/2010 |
| Poco Bay Company | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 31/12/2009 |
| I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) | USA | 0 | 1530000 | 0 | 1530000 | 1530000 | 7.6 % | 26/11/2007 |