| BlackRock, Inc. |
DELAWARE |
0 |
0 |
0 |
0 |
29483962 |
5.9 % |
23/04/2025 |
| Management division of UBS Group AG (see Item 7) |
Switzerland |
0 |
0 |
0 |
0 |
25782426 |
5.16 % |
13/02/2024 |
| WCM Investment Management, LLC |
Citizenship or Place of Organization |
26016575 |
0 |
26016575 |
0 |
26016575 |
5.21 % |
10/02/2022 |
| 95-1411037 |
Delaware |
6778799 |
0 |
6812420 |
0 |
13 |
1.4 % |
16/02/2021 |
| 52-0556948 |
Maryland |
4520657 |
0 |
11815454 |
0 |
11815454 |
2.4 % |
16/02/2021 |
| 52-0556948 |
Maryland |
9223161 |
0 |
0 |
0 |
24628795 |
5 % |
10/09/2020 |
| Capital Research Global Investors ** |
Delaware |
31808983 |
0 |
31824542 |
0 |
31824542 |
6.5 % |
14/02/2020 |
| 52-0556948 |
Maryland |
17419268 |
0 |
0 |
0 |
49485111 |
10.1 % |
10/01/2020 |
| Novartis AG |
Switzerland |
0 |
0 |
244207279 |
10 |
244207279 |
80.8 % |
24/03/2011 |
| Novartis AG |
Switzerland |
0 |
0 |
240827279 |
10 |
240827279 |
79.6 % |
14/03/2011 |
| Novartis AG |
Switzerland |
0 |
0 |
237357279 |
10 |
237357279 |
78.5 % |
28/02/2011 |
| Novartis AG |
Switzerland |
0 |
0 |
233777279 |
10 |
233777279 |
77.3 % |
09/02/2011 |
| 00-0000000 |
Switzerland |
0 |
0 |
230137500 |
10 |
230137500 |
76.2 % |
15/12/2010 |
| Novartis AG |
Switzerland |
230137500 |
0 |
230137500 |
10 |
230137500 |
76.6 % |
30/08/2010 |
| Novartis AG |
Citizenship or Place of Organization |
74061237 |
0 |
74061237 |
10 |
74061237 |
24.8 % |
04/01/2010 |
| FMR Corp. |
Delaware |
234457 |
0 |
11731167 |
0 |
11731167 |
3.802 % |
14/02/2005 |
| Edward C. Johnson 3d |
United States of America |
28800 |
0 |
11731167 |
0 |
11731167 |
3.802 % |
14/02/2005 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
11731167 |
0 |
11731167 |
3.802 % |
14/02/2005 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
16903242 |
0 |
16903242 |
5.47 % |
17/02/2004 |
| FMR Corp. |
Delaware |
519722 |
0 |
16903242 |
0 |
16903242 |
5.47 % |
17/02/2004 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
16903242 |
0 |
16903242 |
5.47 % |
17/02/2004 |