| Morgan Stanley |
|
0 |
21724566 |
0 |
22052095 |
22052095 |
5.5 % |
08/02/2023 |
| Felix J. Baker |
United States |
21293177 |
0 |
21293177 |
0 |
21293177 |
5.4 % |
14/02/2022 |
| Julian C. Baker |
United States |
21293177 |
0 |
21293177 |
0 |
21293177 |
5.4 % |
14/02/2022 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
21169805 |
0 |
21169805 |
0 |
21169805 |
5.3 % |
14/02/2022 |
| Baker Bros. Advisors LP |
Delaware |
21169805 |
0 |
21169805 |
0 |
21169805 |
5.3 % |
14/02/2022 |
| Alexander J. Denner, Ph.D. |
United States |
0 |
24000000 |
0 |
10 |
24000000 |
6.06 % |
24/01/2022 |
| Sarissa Capital Management LP |
Delaware |
0 |
24000000 |
0 |
10 |
24000000 |
6.06 % |
24/01/2022 |
| Julian C. Baker |
United States |
42592824 |
0 |
42592824 |
0 |
42592824 |
13.2 % |
13/02/2019 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
42592824 |
0 |
42592824 |
0 |
42592824 |
13.2 % |
13/02/2019 |
| Baker Bros. Advisors LP |
Delaware |
42592824 |
0 |
42592824 |
0 |
42592824 |
13.2 % |
13/02/2019 |
| Felix J. Baker |
United States |
42592824 |
0 |
42592824 |
0 |
42592824 |
13.2 % |
13/02/2019 |
| Stonepine Capital, L.P. |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2016 |
| Timothy P. Lynch |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2016 |
| Jon M. Plexico |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2016 |
| Stonepine Capital Management, LLC |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2016 |
| Timothy P. Lynch |
U.S.A. |
11334295 |
0 |
11334295 |
0 |
11334295 |
6.5 % |
09/02/2015 |
| Jon M. Plexico |
U.S.A. |
11334295 |
0 |
11334295 |
0 |
11334295 |
6.5 % |
09/02/2015 |
| Stonepine Capital Management, LLC |
California |
11334295 |
0 |
11334295 |
0 |
11334295 |
6.5 % |
09/02/2015 |
| Stonepine Capital, L.P. |
Delaware |
11334295 |
0 |
11334295 |
0 |
11334295 |
6.5 % |
09/02/2015 |
| Timothy P. Lynch |
California |
9000000 |
0 |
9000000 |
0 |
9000000 |
5.2 % |
19/11/2014 |
| Stonepine Capital, L.P. |
California |
9000000 |
0 |
9000000 |
0 |
9000000 |
5.2 % |
19/11/2014 |
| Jon M. Plexico |
California |
9000000 |
0 |
9000000 |
0 |
9000000 |
5.2 % |
19/11/2014 |
| Stonepine Capital Management, LLC |
California |
9000000 |
0 |
9000000 |
0 |
9000000 |
5.2 % |
19/11/2014 |
| Sigma Capital Management, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| S.A.C. Capital Advisors, L.P. |
Delaware |
0 |
969117 |
0 |
0 |
969117 |
0.6 % |
14/02/2013 |
| Steven A. Cohen |
United States |
0 |
1078514 |
0 |
0 |
1078514 |
0.7 % |
14/02/2013 |
| S.A.C. Global Investors LLP |
England and Wales |
0 |
109397 |
0 |
0 |
109397 |
0.1 % |
14/02/2013 |
| S.A.C. Capital Associates, LLC |
Anguilla, British West Indies |
0 |
946400 |
0 |
0 |
946400 |
0.6 % |
14/02/2013 |
| S.A.C. Capital Advisors, Inc. |
Delaware |
0 |
969117 |
0 |
0 |
969117 |
0.6 % |
14/02/2013 |
| FMR LLC |
Delaware |
2016332 |
0 |
4958462 |
0 |
4958462 |
4.475 % |
14/02/2013 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
4958462 |
0 |
4958462 |
4.475 % |
14/02/2013 |
| Abingworth Bioequities Master Fund Limited |
Cayman Islands |
0 |
0 |
0 |
11 |
1625708 |
1.12 % |
16/04/2012 |
| Abingworth Bioventures V Co-Invest Growth Equity Fund LP |
England |
0 |
0 |
0 |
11 |
6264901 |
4.6 % |
16/04/2012 |
| Abingworth LLP |
England |
0 |
0 |
0 |
11 |
14155509 |
10.4 % |
16/04/2012 |
| Abingworth Bioventures V L.P. |
England |
0 |
0 |
0 |
11 |
6264900 |
4.6 % |
16/04/2012 |
| Ardsley Advisory Partners |
Delaware |
0 |
5810000 |
0 |
0 |
5810000 |
4.28 % |
14/11/2011 |
| Ardsley Offshore Fund, Ltd. |
Delaware |
0 |
194700 |
0 |
0 |
194700 |
0.14 % |
14/11/2011 |
| Ardsley Partners Institutional Fund, L.P. |
Delaware |
0 |
2384500 |
0 |
0 |
2384500 |
1.76 % |
14/11/2011 |
| Ardsley Partners Fund II, L.P. |
Delaware |
0 |
3020800 |
0 |
0 |
3020800 |
2.22 % |
14/11/2011 |
| Ardsley Partners Renewable Energy Fund, L.P. |
Delaware |
0 |
148600 |
0 |
0 |
148600 |
0.11 % |
14/11/2011 |
| Ardsley Renewable Energy Offshore Fund, Ltd. |
Delaware |
0 |
10700 |
0 |
0 |
10700 |
0.01 % |
14/11/2011 |
| Ardsley Partners I |
Delaware |
0 |
5553900 |
0 |
0 |
5553900 |
4.09 % |
14/11/2011 |
| Philip J. Hempleman |
Delaware |
0 |
7195000 |
0 |
0 |
7195000 |
5.3 % |
14/11/2011 |
| STICHTING PENSIOENFONDS ABP |
Kingdom Nerlands |
10150000 |
0 |
10150000 |
0 |
10150000 |
9.98 % |
06/12/2010 |
| D. Isaly |
States |
14410872 |
0 |
14410872 |
10 |
14410872 |
14.38 % |
25/02/2010 |
| Advisors LLC |
Delaware |
135521 |
0 |
135521 |
10 |
135521 |
0.14 % |
25/02/2010 |
| Capital GP III LLC |
Delaware |
14275351 |
0 |
14275351 |
10 |
14275351 |
14.25 % |
25/02/2010 |
| Advisors LLC |
Delaware |
133121 |
0 |
133121 |
10 |
133121 |
0.13 % |
17/02/2010 |
| Capital GP III LLC |
Delaware |
13977751 |
0 |
13977751 |
10 |
13977751 |
13.95 % |
17/02/2010 |
| D. Isaly |
States |
14110872 |
0 |
14110872 |
10 |
14110872 |
14.08 % |
17/02/2010 |
| Capital GP III LLC |
Delaware |
13977751 |
0 |
13977751 |
10 |
13977751 |
13.95 % |
17/02/2010 |
| Advisors LLC |
Delaware |
133121 |
0 |
133121 |
10 |
133121 |
0.13 % |
17/02/2010 |
| D. Isaly |
States |
14110872 |
0 |
14110872 |
10 |
14110872 |
14.08 % |
17/02/2010 |
| OrbiMed Capital GP III LLC |
Delaware |
0 |
3230107 |
0 |
10 |
3230107 |
11.9 % |
08/07/2009 |
| Dr. James I. Healy |
U.S. Citizen |
0 |
3586957 |
0 |
10 |
3586957 |
13.2 % |
08/07/2009 |
| Samuel D. Isaly |
U.S. Citizen |
0 |
3260870 |
0 |
0 |
3260870 |
12.1 % |
08/07/2009 |
| Longitude Capital Partners, LLC |
Delaware |
0 |
1086957 |
0 |
10 |
1086957 |
4 % |
08/07/2009 |
| Patrick Enright |
U.S. Citizen |
0 |
1086957 |
0 |
10 |
1086957 |
4 % |
08/07/2009 |
| Fountain Healthcare Partners Ltd. |
Ireland |
0 |
217391 |
0 |
10 |
217391 |
0.8 % |
08/07/2009 |
| Aidan King |
Ireland |
0 |
217391 |
0 |
10 |
217391 |
0.8 % |
08/07/2009 |
| Manus Rogan |
Ireland |
0 |
217391 |
0 |
10 |
217391 |
0.8 % |
08/07/2009 |
| ”) |
Delaware |
3586957 |
0 |
3586957 |
0 |
3586957 |
13.2 % |
08/07/2009 |
| ”) |
Ireland |
0 |
217391 |
0 |
10 |
217391 |
0.8 % |
08/07/2009 |
| ”) |
Delaware |
1086957 |
0 |
1086957 |
0 |
1086957 |
4 % |
08/07/2009 |
| ”) |
Delaware |
30763 |
0 |
30763 |
0 |
30763 |
0.1 % |
08/07/2009 |
| ”) |
Delaware |
3230107 |
0 |
3230107 |
0 |
3230107 |
11.9 % |
08/07/2009 |
| Sofinnova Management VII, L.L.C. |
Delaware |
0 |
3586957 |
0 |
10 |
3586957 |
13.2 % |
08/07/2009 |
| Michael F. Powell, Ph.D. |
U.S. Citizen |
0 |
3586957 |
0 |
10 |
3586957 |
13.2 % |
08/07/2009 |
| Juliet Tammenoms Bakker |
Dutch Citizen |
0 |
1086957 |
0 |
10 |
1086957 |
4 % |
08/07/2009 |
| Longitude Capital Associates, L.P. |
Delaware |
0 |
1086957 |
0 |
10 |
1086957 |
4 % |
08/07/2009 |
| Justin Lynch |
Ireland |
0 |
217391 |
0 |
10 |
217391 |
0.8 % |
08/07/2009 |
| Eric P. Buatois |
U.S. Citizen |
0 |
3586957 |
0 |
10 |
3586957 |
13.2 % |
08/07/2009 |
| OrbiMed Advisors LLC |
Delaware |
0 |
30763 |
0 |
10 |
30763 |
0.1 % |
08/07/2009 |
| Ena Prosser |
Ireland |
0 |
217391 |
0 |
10 |
217391 |
0.8 % |
08/07/2009 |
| James Thomas |
U.S. Citizen |
0 |
2173913 |
0 |
10 |
2173913 |
7.12 % |
29/05/2008 |
| ”) |
Delaware |
1847826 |
0 |
1847826 |
0 |
1847826 |
6 % |
29/05/2008 |
| ”) |
Delaware |
2143913 |
0 |
2143913 |
0 |
2143913 |
7 % |
29/05/2008 |
| ”) |
Delaware |
7609 |
0 |
7609 |
0 |
7609 |
0.02 % |
29/05/2008 |
| Michael F. Powell, Ph.D. |
U.S. Citizen |
0 |
3586957 |
0 |
10 |
3586957 |
11.7 % |
29/05/2008 |
| Eric P. Buatois |
U.S. Citizen |
0 |
3586957 |
0 |
10 |
3586957 |
11.7 % |
29/05/2008 |
| OrbiMed Capital GP III LLC |
Delaware |
0 |
3230107 |
0 |
10 |
3230107 |
10.5 % |
29/05/2008 |
| Panorama Capital Management, LLC |
Delaware |
0 |
1847826 |
0 |
10 |
1847826 |
6 % |
29/05/2008 |
| Dr. Srinivas Akkaraju |
U.S. Citizen |
0 |
1847826 |
0 |
10 |
1847826 |
6 % |
29/05/2008 |
| Rodney A. Ferguson |
U.S. Citizen |
0 |
1847826 |
0 |
10 |
1847826 |
6 % |
29/05/2008 |
| Thomas, McNerney & Partners II, LLC |
Delaware |
0 |
2151522 |
0 |
10 |
2151522 |
7.02 % |
29/05/2008 |
| Pratik Shah |
U.S. Citizen |
0 |
2151522 |
0 |
10 |
2151522 |
7.02 % |
29/05/2008 |
| Patrick Enright |
U.S. Citizen |
0 |
1086957 |
0 |
10 |
1086957 |
3.5 % |
29/05/2008 |
| Juliet Tammenoms Bakker |
Dutch Citizen |
0 |
1086957 |
0 |
10 |
1086957 |
3.5 % |
29/05/2008 |
| Longitude Capital Associates, L.P. |
Delaware |
0 |
1086957 |
0 |
10 |
1086957 |
3.5 % |
29/05/2008 |
| ”) |
Delaware |
3586957 |
0 |
3586957 |
0 |
3586957 |
11.7 % |
29/05/2008 |
| ”) |
Delaware |
3230107 |
0 |
3230107 |
0 |
3230107 |
10.5 % |
29/05/2008 |
| Dr. James I. Healy |
U.S. Citizen |
0 |
3586957 |
0 |
10 |
3586957 |
11.7 % |
29/05/2008 |
| OrbiMed Advisors LLC |
Delaware |
0 |
30763 |
0 |
10 |
30763 |
0.1 % |
29/05/2008 |
| Samuel D. Isaly |
U.S. Citizen |
0 |
3260870 |
0 |
0 |
3260870 |
10.6 % |
29/05/2008 |
| Christopher J. Albinson |
U.S. Citizen |
0 |
1847826 |
0 |
10 |
1847826 |
6 % |
29/05/2008 |
| Shahan D. Soghikian |
U.S. Citizen |
0 |
1847826 |
0 |
10 |
1847826 |
6 % |
29/05/2008 |
| Damion Wicker |
U.S. Citizen |
0 |
1847826 |
0 |
10 |
1847826 |
6 % |
29/05/2008 |
| ”) |
Delaware |
22391 |
0 |
22391 |
10 |
22391 |
0.1 % |
29/05/2008 |
| ”) |
Delaware |
30763 |
0 |
30763 |
0 |
30763 |
0.1 % |
29/05/2008 |
| Alex Zisson |
U.S. Citizen |
0 |
2151522 |
0 |
10 |
2151522 |
7.02 % |
29/05/2008 |
| Dr. Eric Aguiar |
U.S. Citizen |
0 |
2151522 |
0 |
10 |
2151522 |
7.02 % |
29/05/2008 |
| ”) |
Delaware |
1086957 |
0 |
1086957 |
0 |
1086957 |
3.5 % |
29/05/2008 |
| Longitude Capital Partners, LLC |
Delaware |
0 |
1086957 |
0 |
10 |
1086957 |
3.5 % |
29/05/2008 |
| Sofinnova Management VII, L.L.C. |
Delaware |
0 |
3586957 |
0 |
10 |
3586957 |
11.7 % |
29/05/2008 |
| Pete McNerney |
U.S. Citizen |
0 |
2173913 |
0 |
10 |
2173913 |
7.12 % |
29/05/2008 |
| Medica II Management L.P. |
Cayman Islands |
5728929 |
0 |
5728929 |
0 |
5728929 |
11 % |
17/12/2007 |
| Medica Investments (Israel) L.P. |
Israel |
2333448 |
0 |
2333448 |
0 |
2333448 |
11 % |
17/12/2007 |
| Medica II/Baxter L.P. |
Israel |
277171 |
0 |
277171 |
0 |
277171 |
11 % |
17/12/2007 |
| Medica II Investments (Israel) L.P. |
Israel |
1219208 |
0 |
1219208 |
0 |
1219208 |
11 % |
17/12/2007 |
| Medica II Investments (International), L.P. |
Cayman Islands |
3273308 |
0 |
3273308 |
0 |
3273308 |
11 % |
17/12/2007 |
| Medica II Investment GP Co. Ltd. |
Cayman Islands |
5728929 |
0 |
5728929 |
0 |
5728929 |
11 % |
17/12/2007 |
| Medica II Investments (P.F.) (Israel), L.P. |
Israel |
628309 |
0 |
628309 |
0 |
628309 |
11 % |
17/12/2007 |
| Ehud Geller |
Israel |
8062377 |
0 |
8062377 |
0 |
8062377 |
11 % |
17/12/2007 |
| John S. Clark II |
: |
0 |
0 |
0 |
0 |
8098820 |
9.6 % |
30/12/2005 |
| Robert W. Butts |
: |
0 |
0 |
0 |
0 |
8098820 |
9.6 % |
30/12/2005 |
| 20-1064783 |
: |
0 |
0 |
0 |
0 |
8098820 |
9.6 % |
30/12/2005 |
| 20-0975910 |
: |
0 |
0 |
0 |
0 |
8098820 |
9.6 % |
30/12/2005 |
| 20-0975900 |
: |
0 |
0 |
0 |
0 |
8098820 |
9.6 % |
30/12/2005 |
| 20-1095514 |
: |
0 |
0 |
0 |
0 |
8098820 |
9.6 % |
30/12/2005 |