TANG CAPITAL PARTNERS, LP |
DELAWARE |
|
1330879 |
0 |
1330879 |
1330879 |
4.4 % |
14/11/2024 |
Tang Capital Management, LLC |
DELAWARE |
|
1330879 |
0 |
1330879 |
1330879 |
4.4 % |
14/11/2024 |
Kevin Tang |
united states |
|
1330879 |
0 |
1330879 |
1330879 |
4.4 % |
14/11/2024 |
Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
Deep Track Capital, LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
David Kroin |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2870618 |
0 |
2870618 |
10.507 % |
10/07/2024 |
FMR LLC |
Delaware |
2869767 |
0 |
2870618 |
0 |
2870618 |
10.507 % |
10/07/2024 |
KEVIN TANG |
united states |
0 |
1950609 |
0 |
1950609 |
1950609 |
7.3 % |
14/02/2024 |
Tang Capital Management, LLC |
DELAWARE |
0 |
1950609 |
0 |
1950609 |
1950609 |
7.3 % |
14/02/2024 |
TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
1950609 |
0 |
1950609 |
1950609 |
7.3 % |
14/02/2024 |
Steven A. Cohen |
United States |
0 |
788545 |
0 |
788545 |
788545 |
3 % |
14/02/2024 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
788545 |
0 |
788545 |
788545 |
3 % |
14/02/2024 |
Point72 Asset Management, L.P. |
Delaware |
0 |
788545 |
0 |
788545 |
788545 |
3 % |
14/02/2024 |
David Kroin |
United States |
0 |
2036990 |
0 |
2036990 |
0 |
7.67 % |
14/02/2024 |
Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
2036990 |
0 |
2036990 |
0 |
7.67 % |
14/02/2024 |
Deep Track Capital, LP |
Delaware |
0 |
2036990 |
0 |
2036990 |
0 |
7.67 % |
14/02/2024 |
The Vanguard Group |
Pennsylvania |
0 |
29018 |
1334532 |
45583 |
1380115 |
5.19 % |
13/02/2024 |
BlackRock, Inc. |
Delaware |
1771357 |
0 |
1799823 |
0 |
1799823 |
6.8 % |
26/01/2024 |
Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
1360176 |
0 |
1360176 |
0 |
5.12 % |
02/10/2023 |
Deep Track Capital, LP |
Delaware |
0 |
1360176 |
0 |
1360176 |
0 |
5.12 % |
02/10/2023 |
David Kroin |
United States |
0 |
1360176 |
0 |
1360176 |
0 |
5.12 % |
02/10/2023 |
Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
1360176 |
0 |
1360176 |
0 |
5.12 % |
02/10/2023 |
Deep Track Capital, LP |
Delaware |
0 |
1360176 |
0 |
1360176 |
0 |
5.12 % |
02/10/2023 |
David Kroin |
United States |
0 |
1360176 |
0 |
1360176 |
0 |
5.12 % |
02/10/2023 |
The Vanguard Group |
Pennsylvania |
0 |
12814 |
1747529 |
29379 |
1776908 |
6.25 % |
09/02/2023 |
Federated Hermes, Inc. |
Pennsylvania |
2373023 |
|
2373023 |
|
2373023 |
8.35 % |
01/02/2023 |
Thomas R. Donahue |
United States |
|
2373023 |
|
2373023 |
2373023 |
8.35 % |
01/02/2023 |
J. Christopher Donahue |
United States |
|
2373023 |
|
2373023 |
2373023 |
8.35 % |
01/02/2023 |
Voting Shares Irrevocable Trust |
Pennsylvania |
2373023 |
|
2373023 |
|
2373023 |
8.35 % |
01/02/2023 |
BlackRock, Inc. |
Delaware |
1805439 |
0 |
1856266 |
0 |
1856266 |
6.5 % |
31/01/2023 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2281200 |
0 |
2281200 |
2281200 |
8.1 % |
09/09/2022 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2281200 |
0 |
2281200 |
2281200 |
8.1 % |
09/09/2022 |
Steven A. Cohen |
United States |
0 |
2281200 |
0 |
2281200 |
2281200 |
8.1 % |
09/09/2022 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
1466600 |
0 |
1466600 |
1466600 |
5.19 % |
15/08/2022 |
Deerfield Partners, L.P. |
Delaware |
0 |
1466600 |
0 |
1466600 |
1466600 |
5.19 % |
15/08/2022 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1466600 |
0 |
1466600 |
1466600 |
5.19 % |
15/08/2022 |
James E. Flynn |
United States |
0 |
1466600 |
0 |
1466600 |
1466600 |
5.19 % |
15/08/2022 |
James E. Flynn |
United States |
0 |
1466600 |
0 |
1466600 |
1466600 |
5.19 % |
15/08/2022 |
Deerfield Partners, L.P. |
Delaware |
0 |
1466600 |
0 |
1466600 |
1466600 |
5.19 % |
15/08/2022 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1466600 |
0 |
1466600 |
1466600 |
5.19 % |
15/08/2022 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
1466600 |
0 |
1466600 |
1466600 |
5.19 % |
15/08/2022 |
Voting Shares Irrevocable Trust |
|
1319173 |
|
1319173 |
|
1319173 |
4.68 % |
10/05/2022 |
J. Christopher Donahue |
|
|
1319173 |
|
1319173 |
1319173 |
4.68 % |
10/05/2022 |
Rhodora J. Donahue |
|
|
1319173 |
|
1319173 |
1319173 |
4.68 % |
10/05/2022 |
Thomas R. Donahue |
|
|
1319173 |
|
1319173 |
1319173 |
4.68 % |
10/05/2022 |
(entities only Federated Hermes, Inc. |
|
1319173 |
|
1319173 |
|
1319173 |
4.68 % |
10/05/2022 |
Point72 Asset Management, L.P. |
Delaware |
0 |
257145 |
0 |
257145 |
257145 |
1 % |
14/02/2022 |
Steven A. Cohen |
United States |
0 |
271229 |
0 |
271229 |
271229 |
1 % |
14/02/2022 |
Point72 Hong Kong Limited |
Hong Kong |
0 |
366 |
0 |
366 |
366 |
0.1 % |
14/02/2022 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
13718 |
0 |
13718 |
13718 |
0.1 % |
14/02/2022 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
257145 |
0 |
257145 |
257145 |
1 % |
14/02/2022 |
Point72 Asset Management, L.P. |
Delaware |
0 |
257145 |
0 |
257145 |
257145 |
1 % |
14/02/2022 |
Steven A. Cohen |
United States |
0 |
271229 |
0 |
271229 |
271229 |
1 % |
14/02/2022 |
Point72 Hong Kong Limited |
Hong Kong |
0 |
366 |
0 |
366 |
366 |
0.1 % |
14/02/2022 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
13718 |
0 |
13718 |
13718 |
0.1 % |
14/02/2022 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
257145 |
0 |
257145 |
257145 |
1 % |
14/02/2022 |
J. Christopher Donahue |
|
|
1604287 |
|
1604287 |
1604287 |
5.8 % |
14/02/2022 |
(entities only Federated Hermes, Inc. |
|
1604287 |
|
1604287 |
|
1604287 |
5.8 % |
14/02/2022 |
Voting Shares Irrevocable Trust |
|
1604287 |
|
1604287 |
|
1604287 |
5.8 % |
14/02/2022 |
Rhodora J. Donahue |
|
|
1604287 |
|
1604287 |
1604287 |
5.8 % |
14/02/2022 |
Thomas R. Donahue |
|
|
1604287 |
|
1604287 |
1604287 |
5.8 % |
14/02/2022 |
The Vanguard Group |
Pennsylvania |
0 |
14814 |
1814169 |
28514 |
1842683 |
6.67 % |
09/02/2022 |
BlackRock, Inc. |
Delaware |
1806960 |
0 |
1865288 |
0 |
1865288 |
6.8 % |
02/02/2022 |
Tang Capital Management, LLC |
DELAWARE |
0 |
2628678 |
0 |
2628678 |
2628678 |
9.6 % |
16/02/2021 |
TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
2628678 |
0 |
2628678 |
2628678 |
9.6 % |
16/02/2021 |
Tang Capital Management, LLC |
DELAWARE |
0 |
2628678 |
0 |
2628678 |
2628678 |
9.6 % |
16/02/2021 |
KEVIN TANG |
united states |
0 |
2628678 |
0 |
2628678 |
2628678 |
9.6 % |
16/02/2021 |
TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
2628678 |
0 |
2628678 |
2628678 |
9.6 % |
16/02/2021 |
KEVIN TANG |
united states |
0 |
2628678 |
0 |
2628678 |
2628678 |
9.6 % |
16/02/2021 |
The Vanguard Group |
Pennsylvania |
0 |
20514 |
2181478 |
38843 |
2220321 |
8.12 % |
10/02/2021 |
BlackRock, Inc. |
Delaware |
1870223 |
0 |
1907834 |
0 |
1907834 |
7 % |
28/01/2021 |
EcoR1 Capital, LLC |
Delaware |
0 |
3813324 |
0 |
3813324 |
3813324 |
13.9 % |
14/01/2021 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
3212344 |
0 |
3212344 |
3212344 |
11.8 % |
14/01/2021 |
EcoR1 Capital, LLC |
Delaware |
0 |
3813324 |
0 |
3813324 |
3813324 |
13.9 % |
14/01/2021 |
Oleg Nodelman |
United States |
0 |
3813324 |
0 |
3813324 |
3813324 |
13.9 % |
14/01/2021 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
3212344 |
0 |
3212344 |
3212344 |
11.8 % |
14/01/2021 |
Oleg Nodelman |
United States |
0 |
3813324 |
0 |
3813324 |
3813324 |
13.9 % |
14/01/2021 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
1358000 |
0 |
1358000 |
1358000 |
5 % |
13/01/2021 |
Point72 Asset Management, L.P. |
Delaware |
0 |
1358000 |
0 |
1358000 |
1358000 |
5 % |
13/01/2021 |
Point72 Asset Management, L.P. |
Delaware |
0 |
1358000 |
0 |
1358000 |
1358000 |
5 % |
13/01/2021 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
1358000 |
0 |
1358000 |
1358000 |
5 % |
13/01/2021 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
19942 |
0 |
19942 |
19942 |
0.1 % |
13/01/2021 |
Steven A. Cohen |
United States |
0 |
1377942 |
0 |
1377942 |
1377942 |
5 % |
13/01/2021 |
Steven A. Cohen |
United States |
0 |
1377942 |
0 |
1377942 |
1377942 |
5 % |
13/01/2021 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
19942 |
0 |
19942 |
19942 |
0.1 % |
13/01/2021 |
EcoR1 Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
9 |
7.2 % |
14/02/2020 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
0 |
0 |
0 |
9 |
6 % |
14/02/2020 |
Oleg Nodelman |
United States |
0 |
0 |
0 |
0 |
9 |
7.2 % |
14/02/2020 |
(entities only Federated Hermes, Inc. |
|
2378300 |
|
2378300 |
|
2378300 |
8.77 % |
13/02/2020 |
J. Christopher Donahue |
|
|
2378300 |
|
2378300 |
2378300 |
8.77 % |
13/02/2020 |
Thomas R. Donahue |
|
|
2378300 |
|
2378300 |
2378300 |
8.77 % |
13/02/2020 |
Rhodora J. Donahue |
|
|
2378300 |
|
2378300 |
2378300 |
8.77 % |
13/02/2020 |
Voting Shares Irrevocable Trust |
|
2378300 |
|
2378300 |
|
2378300 |
8.77 % |
13/02/2020 |
SSGA FUNDS MANAGEMENT, INC. NO. OF THE ABOVE PERSON: |
BOSTON MASSACHUSETTS |
0 |
1485162 |
0 |
1493076 |
1493076 |
5.5 % |
13/02/2020 |
STATE STREET CORPORATION NO. OF THE ABOVE PERSON: |
BOSTON MASSACHUSETTS |
0 |
1850359 |
0 |
1945009 |
1945009 |
7.17 % |
13/02/2020 |
Robert Atchinson |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2020 |
Adage Capital Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2020 |
Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2020 |
Phillip Gross |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2020 |
Adage Capital Advisors, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2020 |
The Vanguard Group |
Pennsylvania |
47214 |
3374 |
2146947 |
47714 |
2194661 |
8.08 % |
12/02/2020 |
BVF I GP LLC |
Delaware |
0 |
733882 |
0 |
733882 |
733882 |
2.7 % |
03/02/2020 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
733882 |
0 |
733882 |
733882 |
2.7 % |
03/02/2020 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
564092 |
0 |
564092 |
564092 |
2.1 % |
03/02/2020 |
BVF II GP LLC. |
Delaware |
0 |
564092 |
0 |
564092 |
564092 |
2.1 % |
03/02/2020 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
99383 |
0 |
99383 |
99383 |
0 % |
03/02/2020 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
99383 |
0 |
99383 |
99383 |
0 % |
03/02/2020 |
BVF GP HOLDINGS LLC |
Delaware |
0 |
1297974 |
0 |
1297974 |
1297974 |
4.8 % |
03/02/2020 |
BVF Partners L.P. |
Delaware |
0 |
1441565 |
0 |
1441565 |
1441565 |
5.3 % |
03/02/2020 |
BVF Inc. |
Delaware |
0 |
1441565 |
0 |
1441565 |
1441565 |
5.3 % |
03/02/2020 |
Mark N. Lampert |
United States |
0 |
1441565 |
0 |
1441565 |
1441565 |
5.3 % |
03/02/2020 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
733882 |
0 |
733882 |
733882 |
2.7 % |
03/02/2020 |
BVF I GP LLC |
Delaware |
0 |
733882 |
0 |
733882 |
733882 |
2.7 % |
03/02/2020 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
564092 |
0 |
564092 |
564092 |
2.1 % |
03/02/2020 |
BVF II GP LLC. |
Delaware |
0 |
564092 |
0 |
564092 |
564092 |
2.1 % |
03/02/2020 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
99383 |
0 |
99383 |
99383 |
0 % |
03/02/2020 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
99383 |
0 |
99383 |
99383 |
0 % |
03/02/2020 |
BVF GP HOLDINGS LLC |
Delaware |
0 |
1297974 |
0 |
1297974 |
1297974 |
4.8 % |
03/02/2020 |
BVF Partners L.P. |
Delaware |
0 |
1441565 |
0 |
1441565 |
1441565 |
5.3 % |
03/02/2020 |
BVF Inc. |
Delaware |
0 |
1441565 |
0 |
1441565 |
1441565 |
5.3 % |
03/02/2020 |
Mark N. Lampert |
United States |
0 |
1441565 |
0 |
1441565 |
1441565 |
5.3 % |
03/02/2020 |
Millennium International Management LP |
|
|
|
|
|
622969 |
2.3 % |
27/01/2020 |
Integrated Core Strategies (US) LLC |
|
|
|
|
|
73947 |
0.3 % |
27/01/2020 |
Israel A. Englander |
|
|
|
|
|
696916 |
2.6 % |
27/01/2020 |
Millennium Group Management LLC |
|
|
|
|
|
696916 |
2.6 % |
27/01/2020 |
ICS Opportunities II LLC |
|
|
|
|
|
0 |
0 % |
27/01/2020 |
Integrated Assets II LLC |
|
|
|
|
|
622969 |
2.3 % |
27/01/2020 |
Millennium Management LLC |
|
|
|
|
|
696916 |
2.6 % |
27/01/2020 |
Janus Henderson Group plc EIN |
Jersey, Channel Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
10/12/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
177739 |
0 |
177739 |
0.655 % |
10/12/2019 |
FMR LLC |
Delaware |
66281 |
0 |
177739 |
0 |
177739 |
0.655 % |
10/12/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
177739 |
0 |
177739 |
0.655 % |
10/12/2019 |
FMR LLC |
Delaware |
66281 |
0 |
177739 |
0 |
177739 |
0.655 % |
10/12/2019 |
Tang Capital Management, LLC |
DELAWARE |
0 |
1843814 |
0 |
1843814 |
1843814 |
6.8 % |
22/11/2019 |
KEVIN TANG |
united states |
0 |
1843814 |
0 |
1843814 |
1843814 |
6.8 % |
22/11/2019 |
Tang Capital Management, LLC |
DELAWARE |
0 |
1843814 |
0 |
1843814 |
1843814 |
6.8 % |
22/11/2019 |
TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
1843814 |
0 |
1843814 |
1843814 |
6.8 % |
22/11/2019 |
KEVIN TANG |
united states |
0 |
1843814 |
0 |
1843814 |
1843814 |
6.8 % |
22/11/2019 |
TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
1843814 |
0 |
1843814 |
1843814 |
6.8 % |
22/11/2019 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
1432144 |
0 |
1432144 |
1432144 |
5.3 % |
18/11/2019 |
Oleg Nodelman |
United States |
0 |
1720500 |
0 |
1720500 |
1720500 |
6.3 % |
18/11/2019 |
EcoR1 Capital, LLC |
Delaware |
0 |
1720500 |
0 |
1720500 |
1720500 |
6.3 % |
18/11/2019 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
1432144 |
0 |
1432144 |
1432144 |
5.3 % |
18/11/2019 |
Oleg Nodelman |
United States |
0 |
1720500 |
0 |
1720500 |
1720500 |
6.3 % |
18/11/2019 |
EcoR1 Capital, LLC |
Delaware |
0 |
1720500 |
0 |
1720500 |
1720500 |
6.3 % |
18/11/2019 |
Millennium International Management LP |
|
|
|
|
|
16370 |
0.1 % |
19/08/2019 |
ICS Opportunities II LLC |
|
|
|
|
|
16370 |
0.1 % |
19/08/2019 |
Millennium Management LLC |
|
|
|
|
|
1367728 |
5.1 % |
19/08/2019 |
Millennium Group Management LLC |
|
|
|
|
|
1367728 |
5.1 % |
19/08/2019 |
Israel A. Englander |
|
|
|
|
|
1367728 |
5.1 % |
19/08/2019 |
Integrated Core Strategies (US) LLC |
|
|
|
|
|
1264976 |
4.7 % |
19/08/2019 |
Integrated Assets II LLC |
|
|
|
|
|
86382 |
0.3 % |
19/08/2019 |
Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
1025273 |
0 |
1025273 |
1025273 |
3.83 % |
14/02/2019 |
Cormorant Asset Management, LP |
Delaware |
0 |
1105557 |
0 |
1105557 |
1105557 |
4.13 % |
14/02/2019 |
Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1025273 |
0 |
1025273 |
1025273 |
3.83 % |
14/02/2019 |
Bihua Chen |
United States |
0 |
1105557 |
0 |
1105557 |
1105557 |
4.13 % |
14/02/2019 |
Bihua Chen |
United States |
0 |
1105557 |
0 |
1105557 |
1105557 |
4.13 % |
14/02/2019 |
Cormorant Asset Management, LP |
Delaware |
0 |
1105557 |
0 |
1105557 |
1105557 |
4.13 % |
14/02/2019 |
Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
1025273 |
0 |
1025273 |
1025273 |
3.83 % |
14/02/2019 |
Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1025273 |
0 |
1025273 |
1025273 |
3.83 % |
14/02/2019 |
Adage Capital Advisors, L.L.C. |
Delaware |
0 |
2295000 |
0 |
2295000 |
2295000 |
8.58 % |
13/02/2019 |
Phillip Gross |
United States |
0 |
2295000 |
0 |
2295000 |
2295000 |
8.58 % |
13/02/2019 |
Adage Capital Partners, L.P. |
Delaware |
0 |
2295000 |
0 |
2295000 |
2295000 |
8.58 % |
13/02/2019 |
Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
2295000 |
0 |
2295000 |
2295000 |
8.58 % |
13/02/2019 |
Robert Atchinson |
United States |
0 |
2295000 |
0 |
2295000 |
2295000 |
8.58 % |
13/02/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
4012735 |
0 |
4012735 |
14.999 % |
13/02/2019 |
FMR LLC |
Delaware |
486207 |
0 |
4012735 |
0 |
4012735 |
14.999 % |
13/02/2019 |
FMR LLC |
Delaware |
486207 |
0 |
4012735 |
0 |
4012735 |
14.999 % |
13/02/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
4012735 |
0 |
4012735 |
14.999 % |
13/02/2019 |
The Vanguard Group |
Pennsylvania |
43772 |
2748 |
1844335 |
44866 |
1889201 |
7.06 % |
11/02/2019 |
BlackRock, Inc. |
Delaware |
1772955 |
0 |
1816825 |
0 |
1816825 |
6.8 % |
04/02/2019 |
Janus Henderson Group plc EIN |
Jersey, Channel Islands |
0 |
2353880 |
0 |
2353880 |
2353880 |
10 % |
08/06/2018 |
Cormorant Asset Management, LLC |
Delaware |
0 |
1254185 |
0 |
1254185 |
1254185 |
5.34 % |
14/02/2018 |
Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
1046502 |
0 |
1046502 |
1046502 |
4.45 % |
14/02/2018 |
Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1046502 |
0 |
1046502 |
1046502 |
4.45 % |
14/02/2018 |
Bihua Chen |
United States |
0 |
1254185 |
0 |
1254185 |
1254185 |
5.34 % |
14/02/2018 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
180043 |
0 |
180043 |
180043 |
1 % |
14/02/2018 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
49182 |
0 |
49182 |
49182 |
1 % |
14/02/2018 |
BVF Partners L.P. |
Delaware |
0 |
594397 |
0 |
594397 |
594397 |
2.5 % |
14/02/2018 |
BVF Inc. |
Delaware |
0 |
594397 |
0 |
594397 |
594397 |
2.5 % |
14/02/2018 |
Mark N. Lampert |
United States |
0 |
594397 |
0 |
594397 |
594397 |
2.5 % |
14/02/2018 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
278511 |
0 |
278511 |
278511 |
1.2 % |
14/02/2018 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
49182 |
0 |
49182 |
49182 |
1 % |
14/02/2018 |
Deerfield Management Company, L.P. |
Delaware |
0 |
812484 |
0 |
812484 |
812484 |
3.46 % |
14/02/2018 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
812484 |
0 |
812484 |
812484 |
3.46 % |
14/02/2018 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
197647 |
0 |
197647 |
197647 |
0.84 % |
14/02/2018 |
Deerfield Partners, L.P. |
Delaware |
0 |
391111 |
0 |
391111 |
391111 |
1.66 % |
14/02/2018 |
Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
223726 |
0 |
223726 |
223726 |
0.95 % |
14/02/2018 |
James E. Flynn |
United States |
0 |
812484 |
0 |
812484 |
812484 |
3.46 % |
14/02/2018 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
812484 |
0 |
812484 |
812484 |
3.46 % |
14/02/2018 |
Deerfield Management Company, L.P. |
Delaware |
0 |
812484 |
0 |
812484 |
812484 |
3.46 % |
14/02/2018 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
197647 |
0 |
197647 |
197647 |
0.84 % |
14/02/2018 |
Deerfield Partners, L.P. |
Delaware |
0 |
391111 |
0 |
391111 |
391111 |
1.66 % |
14/02/2018 |
Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
223726 |
0 |
223726 |
223726 |
0.95 % |
14/02/2018 |
James E. Flynn |
United States |
0 |
812484 |
0 |
812484 |
812484 |
3.46 % |
14/02/2018 |
Robert Atchinson |
United States |
0 |
1250000 |
0 |
1250000 |
1250000 |
5.32 % |
13/02/2018 |
Phillip Gross |
United States |
0 |
1250000 |
0 |
1250000 |
1250000 |
5.32 % |
13/02/2018 |
Adage Capital Partners, L.P. |
Delaware |
0 |
1250000 |
0 |
1250000 |
1250000 |
5.32 % |
13/02/2018 |
Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1250000 |
0 |
1250000 |
1250000 |
5.32 % |
13/02/2018 |
Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1250000 |
0 |
1250000 |
1250000 |
5.32 % |
13/02/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
3324468 |
0 |
3324468 |
14.148 % |
13/02/2018 |
FMR LLC |
Delaware |
114370 |
0 |
3324468 |
0 |
3324468 |
14.148 % |
13/02/2018 |
BlackRock, Inc. |
Delaware |
1361106 |
0 |
1393305 |
0 |
1393305 |
5.9 % |
01/02/2018 |
Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1044252 |
0 |
1044252 |
1044252 |
4.48 % |
20/10/2017 |
Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1044252 |
0 |
1044252 |
1044252 |
4.48 % |
20/10/2017 |
Bihua Chen |
United States |
0 |
1168394 |
0 |
1168394 |
1168394 |
5.02 % |
20/10/2017 |
Cormorant Asset Management, LLC |
Delaware |
0 |
1168394 |
0 |
1168394 |
1168394 |
5.02 % |
20/10/2017 |
Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
1044252 |
0 |
1044252 |
1044252 |
4.48 % |
20/10/2017 |
Bihua Chen |
United States |
0 |
1168394 |
0 |
1168394 |
1168394 |
5.02 % |
20/10/2017 |
Cormorant Asset Management, LLC |
Delaware |
0 |
1168394 |
0 |
1168394 |
1168394 |
5.02 % |
20/10/2017 |
Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
1044252 |
0 |
1044252 |
1044252 |
4.48 % |
20/10/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2192030 |
0 |
2192030 |
10.775 % |
10/10/2017 |
FMR LLC |
Delaware |
30000 |
0 |
2192030 |
0 |
2192030 |
10.775 % |
10/10/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2192030 |
0 |
2192030 |
10.775 % |
10/10/2017 |
FMR LLC |
Delaware |
30000 |
0 |
2192030 |
0 |
2192030 |
10.775 % |
10/10/2017 |
Adage Capital Partners, L.P. |
Delaware |
0 |
1231486 |
0 |
1231486 |
1231486 |
6.05 % |
02/10/2017 |
Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1231486 |
0 |
1231486 |
1231486 |
6.05 % |
02/10/2017 |
Robert Atchinson |
United States |
0 |
1231486 |
0 |
1231486 |
1231486 |
6.05 % |
02/10/2017 |
Phillip Gross |
United States |
0 |
1231486 |
0 |
1231486 |
1231486 |
6.05 % |
02/10/2017 |
Adage Capital Partners, L.P. |
Delaware |
0 |
1231486 |
0 |
1231486 |
1231486 |
6.05 % |
02/10/2017 |
Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1231486 |
0 |
1231486 |
1231486 |
6.05 % |
02/10/2017 |
Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1231486 |
0 |
1231486 |
1231486 |
6.05 % |
02/10/2017 |
Robert Atchinson |
United States |
0 |
1231486 |
0 |
1231486 |
1231486 |
6.05 % |
02/10/2017 |
Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1231486 |
0 |
1231486 |
1231486 |
6.05 % |
02/10/2017 |
Phillip Gross |
United States |
0 |
1231486 |
0 |
1231486 |
1231486 |
6.05 % |
02/10/2017 |
HBM Healthcare Investments |
Cayman Islands, British West Indies |
942835 |
0 |
942835 |
0 |
942835 |
4.67 % |
13/03/2017 |
HBM Healthcare Investments |
Cayman Islands, British West Indies |
942835 |
0 |
942835 |
0 |
942835 |
4.67 % |
13/03/2017 |
Deerfield Partners, L.P. |
Delaware |
0 |
388621 |
0 |
388621 |
388621 |
1.95 % |
08/02/2017 |
Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
490614 |
0 |
490614 |
490614 |
2.46 % |
08/02/2017 |
Deerfield Partners, L.P. |
Delaware |
0 |
388621 |
0 |
388621 |
388621 |
1.95 % |
08/02/2017 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
130511 |
0 |
130511 |
130511 |
0.66 % |
08/02/2017 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1009746 |
0 |
1009746 |
1009746 |
5.07 % |
08/02/2017 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
1009746 |
0 |
1009746 |
1009746 |
5.07 % |
08/02/2017 |
James E. Flynn |
United States |
0 |
1009746 |
0 |
1009746 |
1009746 |
5.07 % |
08/02/2017 |
Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
490614 |
0 |
490614 |
490614 |
2.46 % |
08/02/2017 |
James E. Flynn |
United States |
0 |
1009746 |
0 |
1009746 |
1009746 |
5.07 % |
08/02/2017 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
130511 |
0 |
130511 |
130511 |
0.66 % |
08/02/2017 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1009746 |
0 |
1009746 |
1009746 |
5.07 % |
08/02/2017 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
1009746 |
0 |
1009746 |
1009746 |
5.07 % |
08/02/2017 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
551019 |
0 |
551019 |
551019 |
2.8 % |
03/02/2017 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
74064 |
0 |
74064 |
74064 |
0 % |
03/02/2017 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
907116 |
0 |
907116 |
907116 |
4.6 % |
03/02/2017 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
74064 |
0 |
74064 |
74064 |
0 % |
03/02/2017 |
BVF Partners L.P. |
Delaware |
0 |
1904600 |
0 |
1904600 |
1904600 |
9.6 % |
03/02/2017 |
BVF Inc. |
Delaware |
0 |
1904600 |
0 |
1904600 |
1904600 |
9.6 % |
03/02/2017 |
Mark N. Lampert |
United States |
0 |
1904600 |
0 |
1904600 |
1904600 |
9.6 % |
03/02/2017 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
907116 |
0 |
907116 |
907116 |
4.6 % |
03/02/2017 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
551019 |
0 |
551019 |
551019 |
2.8 % |
03/02/2017 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
74064 |
0 |
74064 |
74064 |
0 % |
03/02/2017 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
74064 |
0 |
74064 |
74064 |
0 % |
03/02/2017 |
BVF Partners L.P. |
Delaware |
0 |
1904600 |
0 |
1904600 |
1904600 |
9.6 % |
03/02/2017 |
BVF Inc. |
Delaware |
0 |
1904600 |
0 |
1904600 |
1904600 |
9.6 % |
03/02/2017 |
Mark N. Lampert |
United States |
0 |
1904600 |
0 |
1904600 |
1904600 |
9.6 % |
03/02/2017 |