| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
23630 |
0 |
38105 |
1288972 |
6.31 % |
13/02/2024 |
| LP |
State of Delaware |
0 |
1125000 |
0 |
0 |
1125000 |
5.51 % |
12/02/2024 |
| David Rosen |
United States of America |
0 |
1125000 |
0 |
0 |
1125000 |
5.51 % |
12/02/2024 |
| Muthusamy Shanmugam |
United States |
1346080 |
0 |
1346080 |
0 |
1346080 |
8.04 % |
02/03/2022 |
| Esjay LLC |
Delaware |
1332620 |
0 |
1332620 |
0 |
1332620 |
7.96 % |
02/03/2022 |
| (1) BlackRock, Inc. |
Delaware |
1662969 |
0 |
1686613 |
0 |
1686613 |
11.8 % |
07/02/2022 |
| ALLIANZ GLOBAL INVESTORS U.S. HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
0 |
73388 |
0.6 % |
14/02/2018 |
| ALLIANZ GLOBAL INVESTORS U.S. LLC |
Delaware |
59781 |
0 |
72733 |
0 |
72733 |
0.6 % |
14/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
1159052 |
0 |
1175529 |
0 |
1175529 |
10.1 % |
10/08/2017 |
| ALLIANZ GLOBAL INVESTORS U.S. HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
0 |
684306 |
5.7 % |
14/02/2017 |
| ALLIANZ GLOBAL INVESTORS U.S. LLC |
Delaware |
553286 |
0 |
636825 |
0 |
636825 |
5.3 % |
14/02/2017 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
491608 |
0 |
0 |
491608 |
4.25 % |
13/02/2017 |
| Consonance Capital Management LP |
Delaware USA |
0 |
480422 |
0 |
0 |
480422 |
4.15 % |
13/02/2017 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
11186 |
0 |
0 |
11186 |
0.1 % |
13/02/2017 |
| Mitchell Blutt |
USA |
0 |
491608 |
0 |
0 |
491608 |
4.25 % |
13/02/2017 |
| (1) BlackRock, Inc. |
Delaware |
1056313 |
0 |
1070224 |
0 |
1070224 |
9.2 % |
19/01/2017 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
32988 |
0 |
0 |
32988 |
0.3 % |
11/02/2016 |
| Consonance Capital Management LP |
Delaware USA |
0 |
913501 |
0 |
0 |
913501 |
7.9 % |
11/02/2016 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
946489 |
0 |
0 |
946489 |
8.2 % |
11/02/2016 |
| Mitchell Blutt |
USA |
0 |
946489 |
0 |
0 |
946489 |
8.2 % |
11/02/2016 |
| James E. Flynn |
United States |
0 |
13211 |
0 |
0 |
13211 |
0.12 % |
17/02/2015 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
4756 |
0 |
0 |
4756 |
0.04 % |
17/02/2015 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
8455 |
0 |
0 |
8455 |
0.07 % |
17/02/2015 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
13211 |
0 |
0 |
13211 |
0.12 % |
17/02/2015 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
13211 |
0 |
0 |
13211 |
0.12 % |
17/02/2015 |
| Consonance Capman GP LLC |
Delaware |
0 |
1090067 |
0 |
0 |
1090067 |
9.6 % |
17/02/2015 |
| Consonance Capital Opportunity Fund Management LP |
Delaware |
0 |
43050 |
0 |
0 |
43050 |
0.4 % |
17/02/2015 |
| Consonance Capital Management LP |
Delaware |
0 |
1047017 |
0 |
0 |
1047017 |
9.3 % |
17/02/2015 |
| Mitchell Blutt |
USA |
0 |
1090067 |
0 |
0 |
1090067 |
9.6 % |
17/02/2015 |
| (1) BlackRock, Inc. |
Delaware |
581223 |
0 |
591083 |
0 |
591083 |
5.2 % |
03/02/2015 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
294289 |
0 |
0 |
294289 |
2.61 % |
29/04/2014 |
| James E. Flynn |
United States |
0 |
659470 |
0 |
0 |
659470 |
5.85 % |
29/04/2014 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
659470 |
0 |
0 |
659470 |
5.85 % |
29/04/2014 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
659470 |
0 |
0 |
659470 |
5.85 % |
29/04/2014 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
365181 |
0 |
0 |
365181 |
3.24 % |
29/04/2014 |
| 36-4432547 |
DE |
552494 |
0 |
552494 |
0 |
552494 |
5.8 % |
13/02/2014 |
| Foreign |
DE |
23015 |
0 |
23015 |
0 |
23015 |
0.2 % |
13/02/2014 |
| 45-6899983 |
DE |
8629 |
0 |
8629 |
0 |
8629 |
0.1 % |
13/02/2014 |
| ###-##-#### |
DE |
8310 |
808440 |
0 |
0 |
816750 |
8.6 % |
13/02/2014 |
| 45-6899967 |
DE |
224302 |
0 |
224302 |
0 |
224302 |
2.4 % |
13/02/2014 |
| Thomas A. Penn |
United States of America |
0 |
2819744 |
0 |
10 |
2819744 |
29.7 % |
25/11/2013 |
| Robert E. Brown, Jr. |
United States of America |
0 |
2819744 |
0 |
10 |
2819744 |
29.7 % |
25/11/2013 |
| Meridian Venture Partners II, L.P. (“MVP II”), |
Delaware |
0 |
2819744 |
0 |
10 |
2819744 |
29.7 % |
25/11/2013 |
| Meridian Venture Partners II GP, L.P. (“GP”) |
Delaware, United States of America |
0 |
2819744 |
0 |
10 |
2819744 |
29.7 % |
25/11/2013 |
| Meridian Venture Partners II, Co. (“MVP Corp.”) |
Delaware |
0 |
2819744 |
0 |
10 |
2819744 |
29.7 % |
25/11/2013 |
| Robert E. Brown, Jr. |
United States of America |
0 |
16918469 |
0 |
10 |
16918469 |
29.6 % |
01/07/2013 |
| Meridian Venture Partners II, L.P. (“MVP II”), |
Delaware |
0 |
16918469 |
0 |
10 |
16918469 |
29.6 % |
01/07/2013 |
| Thomas A. Penn |
United States of America |
0 |
16918469 |
0 |
10 |
16918469 |
29.6 % |
01/07/2013 |
| Meridian Venture Partners II, Co. (“MVP Corp.”) |
Delaware |
0 |
16918469 |
0 |
10 |
16918469 |
29.6 % |
01/07/2013 |
| Meridian Venture Partners II GP, L.P. (“GP”) |
Delaware, United States of America |
0 |
16918469 |
0 |
10 |
16918469 |
29.6 % |
01/07/2013 |
| (1) BlackRock, Inc. |
Delaware |
5655478 |
0 |
5655478 |
0 |
5655478 |
4.68 % |
08/06/2012 |
| Great Point Partners, LLC |
USA |
0 |
882353 |
0 |
882353 |
882353 |
0.8 % |
14/02/2012 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
882353 |
0 |
882353 |
882353 |
0.8 % |
14/02/2012 |
| Mr. David Kroin |
USA |
0 |
882353 |
0 |
882353 |
882353 |
0.8 % |
14/02/2012 |
| (1) BlackRock, Inc. |
Delaware |
0 |
6453146 |
6453146 |
0 |
6453146 |
5.89 % |
09/02/2012 |
| Harel PIA Mutual Funds Management Ltd |
Israel |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2011 |
| Harel Insurance Investments & Financial Services Ltd. |
Israel |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2011 |
| BAM Capital, LLC |
Delaware, U.S.A. |
0 |
0 |
0 |
0 |
0 |
0 % |
07/01/2010 |
| BAM Opportunity Fund SPV, LLC |
Delaware, U.S.A. |
0 |
1000000 |
0 |
0 |
1000000 |
1.84 % |
07/01/2010 |
| BAM Management, LLC |
Delaware, U.S.A. |
0 |
1000000 |
0 |
0 |
1000000 |
1.84 % |
07/01/2010 |
| Ross Berman |
United States of America |
0 |
1000000 |
0 |
0 |
1000000 |
1.84 % |
07/01/2010 |
| BAM Opportunity Fund, L.P. |
Delaware, U.S.A. |
0 |
0 |
0 |
0 |
0 |
0 % |
07/01/2010 |
| Hal Mintz |
United States of America |
0 |
1000000 |
0 |
0 |
1000000 |
1.84 % |
07/01/2010 |
| Hal Mintz |
United States of America |
0 |
2500000 |
0 |
0 |
2500000 |
7.57 % |
17/08/2009 |
| BAM Capital, LLC |
Delaware, U.S.A. |
0 |
2500000 |
0 |
0 |
2500000 |
7.57 % |
17/08/2009 |
| BAM Opportunity Fund, L.P. |
Delaware, U.S.A. |
0 |
2500000 |
0 |
0 |
2500000 |
7.57 % |
17/08/2009 |
| Ross Berman |
United States of America |
0 |
2500000 |
0 |
0 |
2500000 |
7.57 % |
17/08/2009 |
| BAM Management, LLC |
Delaware, U.S.A. |
0 |
2500000 |
0 |
0 |
2500000 |
7.57 % |
17/08/2009 |
| Ross Mangano |
: |
0 |
0 |
0 |
0 |
2034314 |
10.7 % |
13/02/2006 |
| FEIN #35-1876627 |
: |
0 |
0 |
0 |
0 |
1644861 |
8.65 % |
13/02/2006 |
| FEIN #35-6220339 |
: |
0 |
0 |
0 |
0 |
30000 |
0.16 % |
13/02/2006 |
| Joseph Edelman |
United States |
709819 |
0 |
709819 |
0 |
709819 |
3.81 % |
13/12/2004 |
| Joseph Edelman |
United States |
2715500 |
0 |
2715500 |
0 |
2715500 |
15.04 % |
20/08/2004 |
| Michael Cho |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
20/08/2004 |
| Joseph Edelman |
United States |
2279900 |
0 |
2279900 |
0 |
2279900 |
16.12 % |
13/08/2003 |
| persons (: |
With |
1721501 |
0 |
1721501 |
0 |
1721501 |
20.1 % |
14/02/2003 |
| persons (: |
With |
0 |
0 |
1396004 |
0 |
1721501 |
20.1 % |
14/02/2003 |
| Joseph Edelman |
United States |
500000 |
0 |
500000 |
0 |
500000 |
5.83 % |
13/09/2002 |