| Armistice Capital Master Fund Ltd. |
Delaware |
0 |
768915 |
0 |
768915 |
768915 |
5.6 % |
03/11/2017 |
| Steven Boyd |
Delaware |
0 |
768915 |
0 |
768915 |
768915 |
5.6 % |
03/11/2017 |
| Armistice Capital, LLC |
Delaware |
0 |
768915 |
0 |
768915 |
768915 |
5.6 % |
03/11/2017 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
1301622 |
0 |
1301622 |
1301622 |
5.7 % |
03/10/2014 |
| Broadfin Capital, LLC |
Delaware |
0 |
1301622 |
0 |
1301622 |
1301622 |
5.7 % |
03/10/2014 |
| Kevin Kotler |
Delaware |
0 |
1301622 |
0 |
1301622 |
1301622 |
5.7 % |
03/10/2014 |
| KEVIN C. TANG |
DELAWARE |
0 |
5500000 |
0 |
0 |
5500000 |
7.4 % |
30/07/2012 |
| TANG CAPITAL MANAGEMENT, LLC |
DELAWARE |
0 |
5500000 |
0 |
0 |
5500000 |
7.4 % |
30/07/2012 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
5500000 |
0 |
0 |
5500000 |
7.4 % |
30/07/2012 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
2677500 |
0 |
2677500 |
0 |
2677500 |
3.6 % |
27/07/2012 |
| Peter Kolchinsky |
United States |
4500000 |
0 |
4500000 |
0 |
4500000 |
6.1 % |
27/07/2012 |
| RA Capital Management, LLC |
Massachusetts |
4500000 |
0 |
4500000 |
0 |
4500000 |
6.1 % |
27/07/2012 |
| 04-3519872 |
Delaware |
0 |
0 |
0 |
0 |
1894600 |
5.7 % |
10/02/2011 |
| Jacob Gottlieb |
Cayman Islands |
1910728 |
0 |
1910728 |
0 |
1910728 |
5.74 % |
01/10/2010 |
| Visium Balanced Master Fund, Ltd |
Cayman Islands |
1910728 |
0 |
1910728 |
0 |
1910728 |
5.74 % |
01/10/2010 |
| Visium Asset Management, LP |
Cayman Islands |
1910728 |
0 |
1910728 |
0 |
1910728 |
5.74 % |
01/10/2010 |
| JG Asset, LLC |
Cayman Islands |
1910728 |
0 |
1910728 |
0 |
1910728 |
5.74 % |
01/10/2010 |
| Samuel D. Isaly |
United States |
0 |
4763168 |
0 |
10 |
4763168 |
13.95 % |
28/09/2010 |
| OrbiMed Advisors LLC |
Delaware |
0 |
4763168 |
0 |
10 |
4763168 |
13.95 % |
28/09/2010 |
| OrbiMed Capital GP IV LLC |
Delaware |
0 |
4763168 |
0 |
10 |
4763168 |
13.95 % |
28/09/2010 |
| HBM BioCapital Ltd. |
Cayman Islands, British West Indies |
0 |
1521851 |
0 |
0 |
1521851 |
7 % |
15/03/2010 |
| HBM BioCapital (EUR) L.P. |
Cayman Islands, British West Indies |
0 |
1521851 |
0 |
0 |
1521851 |
7 % |
15/03/2010 |
| HBM BioCapital (USD) L.P. |
Cayman Islands, British West Indies |
0 |
1521851 |
0 |
0 |
1521851 |
7 % |
15/03/2010 |
| VantagePoint Venture Partners IV Principals Fund, L.P. |
Delaware |
21277 |
0 |
21277 |
10 |
21277 |
0.1 % |
12/03/2010 |
| VantagePoint Venture Partners IV (Q), L.P. |
Delaware |
5843089 |
0 |
5843089 |
10 |
5843089 |
26.8 % |
12/03/2010 |
| VantagePoint Venture Partners IV, L.P. |
Delaware |
584948 |
0 |
584948 |
10 |
584948 |
2.7 % |
12/03/2010 |
| VantagePoint Venture Associates IV, L.L.C. |
Delaware |
6459961 |
0 |
6459961 |
10 |
6459961 |
29.6 % |
12/03/2010 |
| Alan E. Salzman |
Canada |
6459961 |
0 |
6459961 |
10 |
6459961 |
29.6 % |
12/03/2010 |
| Arthur M. Pappas |
DELAWARE |
0 |
1159806 |
0 |
0 |
1159806 |
5.4 % |
11/03/2010 |
| III, LP |
DELAWARE |
0 |
1091939 |
0 |
0 |
1091939 |
5.1 % |
11/03/2010 |
| LP |
DELAWARE |
0 |
67867 |
0 |
0 |
67867 |
0.3 % |
11/03/2010 |
| LLC |
DELAWARE |
0 |
1159806 |
0 |
0 |
1159806 |
5.4 % |
11/03/2010 |