| (1)Names of reporting persons. BlackRock, Inc. |
Delaware |
7667904 |
0 |
7692936 |
0 |
7692936 |
5.6 % |
29/01/2024 |
| (1) BlackRock, Inc. |
Delaware |
4298599 |
0 |
4372095 |
0 |
4372095 |
4.6 % |
09/04/2021 |
| Jennifer N. Pritzker |
|
32200 |
14127850 |
32200 |
14127850 |
14160050 |
14.9 % |
11/03/2021 |
| Squadron Capital LLC |
|
0 |
11395045 |
0 |
11395045 |
11395045 |
12 % |
11/03/2021 |
| Squadron Capital Holdings LLC |
|
0 |
11395045 |
0 |
11395045 |
11395045 |
12 % |
11/03/2021 |
| David R. Pelizzon |
|
148837 |
11395045 |
148837 |
11395045 |
11543882 |
12.1 % |
11/03/2021 |
| (1) BlackRock, Inc. |
Delaware |
3873166 |
0 |
3921808 |
0 |
3921808 |
5 % |
02/02/2021 |
| Armistice Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Armistice Capital Master Fund Ltd. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Steven Boyd |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| UBS Group AG directly and on behalf of certain subsidiaries |
Switzerland |
0 |
2965156 |
0 |
0 |
2965156 |
6.86 % |
15/02/2019 |
| Armistice Capital Master Fund Ltd. |
Delaware |
0 |
3338414 |
0 |
3338414 |
3338414 |
7.73 % |
14/02/2019 |
| Steven Boyd |
Delaware |
0 |
3338414 |
0 |
3338414 |
3338414 |
7.73 % |
14/02/2019 |
| Armistice Capital, LLC |
Delaware |
0 |
3338414 |
0 |
3338414 |
3338414 |
7.73 % |
14/02/2019 |
| Niraj Gupta |
United States |
883951 |
0 |
883951 |
0 |
883951 |
2 % |
14/02/2019 |
| Stonepine Capital Management, LLC |
California |
1147802 |
0 |
1147802 |
0 |
1147802 |
11 % |
13/02/2019 |
| Stonepine Capital, L.P. |
California |
1147802 |
0 |
1147802 |
0 |
1147802 |
11 % |
13/02/2019 |
| Jon M. Plexico |
California |
1147802 |
0 |
1147802 |
0 |
1147802 |
11 % |
13/02/2019 |
| Timothy P. Lynch |
California |
1147802 |
0 |
1147802 |
0 |
1147802 |
11 % |
13/02/2019 |
| Armistice Capital Master Fund Ltd. |
Delaware |
0 |
2550361 |
0 |
2550361 |
2550361 |
9.99 % |
19/03/2018 |
| Armistice Capital, LLC |
Delaware |
0 |
2550361 |
0 |
2550361 |
2550361 |
9.99 % |
19/03/2018 |
| Steven Boyd |
Delaware |
0 |
2550361 |
0 |
2550361 |
2550361 |
9.99 % |
19/03/2018 |
| Paul Segal |
United States |
0 |
14682540 |
0 |
10 |
14682540 |
29.66 % |
16/03/2018 |
| L-5 Healthcare Partners, LLC |
Delaware |
0 |
14682540 |
0 |
10 |
14682540 |
29.66 % |
16/03/2018 |
| Niraj Gupta |
United States |
1067469 |
0 |
1067469 |
0 |
1067469 |
6.4 % |
14/02/2018 |
| Kevin Kotler |
Delaware |
0 |
145514 |
0 |
145514 |
145514 |
0.87 % |
13/02/2018 |
| Broadfin Capital, LLC |
Delaware |
0 |
145514 |
0 |
145514 |
145514 |
0.87 % |
13/02/2018 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
145514 |
0 |
145514 |
145514 |
0.87 % |
13/02/2018 |
| MOM, LLC |
Georgia |
0 |
500000 |
0 |
10 |
500000 |
2.5 % |
08/01/2018 |
| Patrick S. Miles |
U.S.A. |
1327434 |
500000 |
1327434 |
10 |
1827434 |
9.1 % |
08/01/2018 |
| Niraj Gupta |
United States |
814459 |
0 |
814459 |
0 |
814459 |
7.5 % |
01/06/2017 |
| GS Mezzanine Partners, L.P. |
Delaware |
0 |
1164618 |
0 |
1164618 |
1069396 |
2.14 % |
29/03/2017 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| James E. Flynn |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Deerfield Mgmt, L.P. |
United States |
0 |
16432738 |
0 |
0 |
16432738 |
9.985 % |
16/02/2016 |
| Deerfield Special Situations International Master Fund, L.P. |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Deerfield Private Design International II, L.P. |
United States |
0 |
4585725 |
0 |
0 |
4585725 |
4.34 % |
16/02/2016 |
| Deerfield Private Design Fund II, L.P. |
United States |
0 |
4001775 |
0 |
0 |
4001775 |
3.81 % |
16/02/2016 |
| Deerfield Special Situations Fund, L.P. |
United States |
0 |
7845238 |
0 |
0 |
7845238 |
7.55 % |
16/02/2016 |
| Deerfield Management Company, L.P. |
United States |
0 |
16432738 |
0 |
0 |
16432738 |
9.985 % |
16/02/2016 |
| James E. Flynn |
United States |
0 |
16432738 |
0 |
0 |
16432738 |
9.985 % |
16/02/2016 |
| Deerfield Management Company, L.P. |
British Virgin Islands |
0 |
15432738 |
0 |
0 |
15432738 |
9.98 % |
17/02/2015 |
| Deerfield Mgmt, L.P. |
British Virgin Islands |
0 |
15432738 |
0 |
0 |
15432738 |
9.98 % |
17/02/2015 |
| Deerfield Special Situations Fund, L.P. |
British Virgin Islands |
0 |
3754675 |
0 |
0 |
3754675 |
3.71 % |
17/02/2015 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
3090563 |
0 |
0 |
3090563 |
3.06 % |
17/02/2015 |
| Deerfield Private Design Fund II, L.P. |
British Virgin Islands |
0 |
4001775 |
0 |
0 |
4001775 |
3.86 % |
17/02/2015 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
4585725 |
0 |
0 |
4585725 |
4.4 % |
17/02/2015 |
| James E. Flynn |
British Virgin Islands |
0 |
15432738 |
0 |
0 |
15432738 |
9.98 % |
17/02/2015 |
| 14-1770168 |
New York |
4474300 |
0 |
4474300 |
0 |
4474300 |
4.56 % |
12/02/2015 |
| James E. Flynn |
United States |
0 |
14232738 |
0 |
0 |
14232738 |
9.98 % |
28/03/2014 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
3612971 |
0 |
0 |
3612971 |
3.65 % |
28/03/2014 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
2932267 |
0 |
0 |
2932267 |
2.97 % |
28/03/2014 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
3582375 |
0 |
0 |
3582375 |
3.54 % |
28/03/2014 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
14232738 |
0 |
0 |
14232738 |
9.98 % |
28/03/2014 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
14232738 |
0 |
0 |
14232738 |
9.98 % |
28/03/2014 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
4105125 |
0 |
0 |
4105125 |
4.04 % |
28/03/2014 |
| 14-1770168 |
New York |
7668800 |
0 |
7668800 |
0 |
7668800 |
7.86 % |
14/02/2014 |
| 14-1770168 |
New York |
6525700 |
0 |
6525700 |
0 |
6525700 |
7.19 % |
12/02/2013 |
| 04-2683227 |
Massachusetts |
0 |
3563581 |
0 |
0 |
3629681 |
4.07 % |
14/02/2012 |
| 14-1770168 |
New York |
5345214 |
0 |
5345214 |
0 |
5345214 |
5.99 % |
13/02/2012 |
| 04-2683227 |
Massachusetts |
0 |
4967000 |
0 |
0 |
5062700 |
5.72 % |
14/02/2011 |
| John H. Foster |
United States |
181300 |
20031646 |
181300 |
20031646 |
20212946 |
39.4 % |
19/06/2009 |
| HealthpointCapital Partners II, L.P. |
Delaware |
0 |
6687007 |
0 |
6687007 |
6687007 |
13 % |
19/06/2009 |
| HGP II, LLC |
Delaware |
0 |
6687007 |
0 |
6687007 |
6687007 |
13 % |
19/06/2009 |
| Mortimer Berkowitz III |
United States |
11200 |
20031646 |
11200 |
20031646 |
20042846 |
39.1 % |
19/06/2009 |