| Adiumentum Capital Fund I GP LLC |
Delaware |
0 |
8065923 |
0 |
10 |
8065923 |
6.7 % |
22/05/2024 |
| Gregory A. Ciongoli |
United States |
0 |
8065923 |
0 |
10 |
8065923 |
6.7 % |
22/05/2024 |
| Adiumentum Capital Fund I LP |
Delaware |
0 |
8065923 |
0 |
10 |
8065923 |
6.7 % |
22/05/2024 |
| Citadel Advisors Holdings LP |
Delaware |
0 |
6512063 |
0 |
6512063 |
6 |
6.4 % |
18/03/2024 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
0 |
0 |
9503286 |
9503286 |
11 % |
20/11/2023 |
| Oleg Nodelman |
Delaware |
0 |
0 |
0 |
10067043 |
10067043 |
11 % |
20/11/2023 |
| EcoR1 Capital, LLC |
Delaware |
0 |
0 |
0 |
10067043 |
10067043 |
11 % |
20/11/2023 |
| Wasatch Advisors LP 87-0319391 |
|
8391014 |
0 |
0 |
0 |
8391014 |
8.8 % |
08/02/2023 |
| THE GOLDMAN SACHS GROUP, INC. |
New York |
0 |
0 |
13 |
6108260 |
6108260 |
6.4 % |
06/02/2023 |
| GOLDMAN SACHS & CO. LLC |
New York |
0 |
0 |
13 |
6108260 |
6108260 |
6.4 % |
06/02/2023 |
| STATE STREET CORPORATION |
|
0 |
7473863 |
0 |
7649740 |
7649740 |
8.06 % |
03/02/2023 |
| SSGA FUNDS MANAGEMENT, INC. |
|
0 |
5344038 |
0 |
5364638 |
5364638 |
5.65 % |
03/02/2023 |
| III |
Texas |
0 |
7855824 |
0 |
7855824 |
7855824 |
8.4 % |
11/03/2022 |
| 75-2686461 |
Texas |
0 |
7855824 |
0 |
7855824 |
7855824 |
8.4 % |
11/03/2022 |
| 75-2482446 |
Texas |
0 |
7855824 |
0 |
7855824 |
7855824 |
8.4 % |
11/03/2022 |
| Management, LLC – 75-2686461 |
|
0 |
7855824 |
0 |
7855824 |
7855824 |
8.9 % |
14/02/2022 |
| III |
|
0 |
7855824 |
0 |
7855824 |
7855824 |
8.9 % |
14/02/2022 |
| Ltd. – 75-2482446 |
|
0 |
7855824 |
0 |
7855824 |
7855824 |
8.9 % |
14/02/2022 |
| Redmile Group, LLC |
Delaware |
0 |
9098725 |
0 |
0 |
9098725 |
9.9 % |
14/02/2022 |
| Jeremy C. Green |
United Kingdom |
0 |
9098725 |
0 |
0 |
9098725 |
9.9 % |
14/02/2022 |
| Point72 Capital Advisors, Inc. |
Citizenship or place of organization Delaware |
0 |
4613700 |
0 |
4613700 |
4613700 |
4 % |
14/02/2022 |
| Cubist Systematic Strategies, LLC |
Citizenship or place of organization Delaware |
0 |
18823 |
0 |
18823 |
18823 |
4 % |
14/02/2022 |
| Point72 Hong Kong Limited |
Citizenship or place of organization Hong Kong |
0 |
1630 |
0 |
1630 |
1630 |
4 % |
14/02/2022 |
| Steven A. Cohen |
Citizenship or place of organization United States |
0 |
4634153 |
0 |
4634153 |
4634153 |
4 % |
14/02/2022 |
| Point72 Asset Management, L.P. |
Citizenship or place of organization Delaware |
0 |
4613700 |
0 |
4613700 |
4613700 |
4 % |
14/02/2022 |
| Seth A. Klarman |
Delaware |
0 |
8123616 |
0 |
8123616 |
8123616 |
9.19 % |
09/02/2022 |
| Baupost Group GP, L.L.C.82-3254604 |
Delaware |
0 |
8123616 |
0 |
8123616 |
8123616 |
9.19 % |
09/02/2022 |
| The Baupost Group, L.L.C.04-3402144 |
Delaware |
0 |
8123616 |
0 |
8123616 |
8123616 |
9.19 % |
09/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
73993 |
6925898 |
149623 |
7075521 |
8 % |
09/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
7482592 |
0 |
7816552 |
0 |
7816552 |
8.8 % |
03/02/2022 |
| JPMORGAN CHASE & CO.13-2624428 |
Delaware |
6171872 |
0 |
7414275 |
0 |
7425896 |
8.3 % |
07/01/2022 |
| Steven A. Cohen |
Delaware |
0 |
4568034 |
0 |
4568034 |
4568034 |
4 % |
21/12/2021 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
4549516 |
0 |
4549516 |
4549516 |
4 % |
21/12/2021 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
4549516 |
0 |
4549516 |
4549516 |
4 % |
21/12/2021 |
| Point72 Hong Kong Limited |
Delaware |
0 |
2954 |
0 |
2954 |
2954 |
4 % |
21/12/2021 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
15564 |
0 |
15564 |
15564 |
4 % |
21/12/2021 |
| ROBERTO MIGNONE |
Delaware |
0 |
1524760 |
0 |
0 |
1524760 |
1.8 % |
16/02/2021 |
| BRIDGER MANAGEMENT, LLC |
Delaware |
0 |
1524760 |
0 |
0 |
1524760 |
1.8 % |
16/02/2021 |
| Redmile Group, LLC |
Delaware |
0 |
7863613 |
0 |
7863613 |
7863613 |
9.9 % |
16/02/2021 |
| Jeremy C. Green |
Delaware |
0 |
7863613 |
0 |
7863613 |
7863613 |
9.9 % |
16/02/2021 |
| III |
United States America |
7324539 |
0 |
7324539 |
0 |
7324539 |
8.9 % |
16/02/2021 |
| Warford |
United States America |
7324539 |
0 |
7324539 |
0 |
7324539 |
8.9 % |
16/02/2021 |
| 75-2686461 |
United States America |
7324539 |
0 |
7324539 |
0 |
7324539 |
8.9 % |
16/02/2021 |
| 75-2482446 |
United States America |
7324539 |
0 |
7324539 |
0 |
7324539 |
8.9 % |
16/02/2021 |
| The Baupost Group, L.L.C.04-3402144 |
Delaware |
0 |
9108988 |
0 |
9108988 |
9108988 |
11.07 % |
12/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
6288668 |
0 |
6454415 |
0 |
6454415 |
7.8 % |
28/01/2021 |
| JPMORGAN CHASE & CO.13-2624428 |
Delaware |
5136870 |
0 |
6017103 |
0 |
6028503 |
7.3 % |
08/01/2021 |
| Redmile Group, LLC |
Delaware |
0 |
5494109 |
0 |
5494109 |
5494109 |
9.9 % |
14/02/2020 |
| Jeremy C. Green |
United Kingdom |
0 |
5494109 |
0 |
5494109 |
5494109 |
9.9 % |
14/02/2020 |
| Maverick Capital, Ltd. – 75-2482446 |
|
4958431 |
0 |
4958431 |
0 |
4958431 |
9.2 % |
14/02/2020 |
| Andrew H. Warford |
|
4958431 |
0 |
4958431 |
0 |
4958431 |
9.2 % |
14/02/2020 |
| Lee S. Ainslie III |
|
4958431 |
0 |
4958431 |
0 |
4958431 |
9.2 % |
14/02/2020 |
| Maverick Capital Management, LLC – 75-2686461 |
|
4958431 |
0 |
4958431 |
0 |
4958431 |
9.2 % |
14/02/2020 |
| ROBERTO MIGNONE |
Delaware |
0 |
2932865 |
0 |
0 |
2932865 |
5.4 % |
14/02/2020 |
| BRIDGER MANAGEMENT, LLC |
Delaware |
0 |
2932865 |
0 |
0 |
2932865 |
5.4 % |
14/02/2020 |
| Baupost Group GP, L.L.C.82-3254604 |
Delaware |
0 |
8308900 |
0 |
8308900 |
8308900 |
15.34 % |
13/02/2020 |
| The Baupost Group, L.L.C.04-3402144 |
Delaware |
0 |
8308900 |
0 |
8308900 |
8308900 |
15.34 % |
13/02/2020 |
| Seth A. Klarman |
Delaware |
0 |
8308900 |
0 |
8308900 |
8308900 |
15.34 % |
13/02/2020 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
107311 |
9399 |
3570644 |
111057 |
3681701 |
6.79 % |
12/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
4474252 |
0 |
4580414 |
0 |
4580414 |
8.5 % |
05/02/2020 |
| ROBERTO MIGNONE |
Delaware |
0 |
2932865 |
0 |
0 |
2932865 |
5.5 % |
01/11/2019 |
| BRIDGER MANAGEMENT, LLC |
Delaware |
0 |
2932865 |
0 |
0 |
2932865 |
5.5 % |
01/11/2019 |
| ROBERTO MIGNONE |
United States |
0 |
2206917 |
0 |
0 |
2206917 |
4.8 % |
14/02/2019 |
| BRIDGER HEALTHCARE, LTD. |
Cayman Islands |
0 |
835959 |
0 |
0 |
835959 |
1.8 % |
14/02/2019 |
| BLAKE GOODNER |
United States |
0 |
835959 |
0 |
0 |
835959 |
1.8 % |
14/02/2019 |
| BRIDGER MANAGEMENT, LLC |
Delaware |
0 |
2206917 |
0 |
0 |
2206917 |
4.8 % |
14/02/2019 |
| Jeremy C. Green |
Delaware |
0 |
4414617 |
0 |
4414617 |
4414617 |
9.7 % |
14/02/2019 |
| Redmile Group, LLC |
Delaware |
0 |
4414617 |
0 |
4414617 |
4414617 |
9.7 % |
14/02/2019 |
| ArrowMark Colorado Holdings LLC |
Delaware, United States |
1491084 |
0 |
1491084 |
0 |
1491084 |
3.3 % |
14/02/2019 |
| FMR LLC |
Delaware |
151692 |
0 |
5274169 |
0 |
5274169 |
11.553 % |
13/02/2019 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
5274169 |
0 |
5274169 |
11.553 % |
13/02/2019 |
| Morgan Stanley Capital Services LLC |
Delaware. |
0 |
1738800 |
0 |
1738800 |
1738800 |
3.8 % |
12/02/2019 |
| Morgan Stanley |
Delaware. |
0 |
1803459 |
0 |
1830547 |
1830547 |
4 % |
12/02/2019 |
| V-QP, |
Delaware |
0 |
1351916 |
0 |
1351916 |
1351916 |
2.9 % |
07/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
3408051 |
0 |
3513235 |
0 |
3513235 |
7.7 % |
04/02/2019 |
| FMR LLC |
Delaware |
218798 |
0 |
5662210 |
0 |
5662210 |
12.487 % |
10/09/2018 |
| FMR LLC |
Delaware |
316391 |
0 |
6196562 |
0 |
6196562 |
17.696 % |
10/04/2018 |
| Seth A. Klarman |
Delaware |
0 |
6254632 |
0 |
6254632 |
6254632 |
14.51 % |
09/04/2018 |
| The Baupost Group, L.L.C.04-3402144 |
Delaware |
0 |
6254632 |
0 |
6254632 |
6254632 |
14.51 % |
09/04/2018 |
| Baupost Group GP, L.L.C.82-3254604 |
Delaware |
0 |
6254632 |
0 |
6254632 |
6254632 |
14.51 % |
09/04/2018 |
| JEREMY C. GREEN |
UNITED KINGDOM |
0 |
2815988 |
0 |
0 |
2815988 |
9.2 % |
14/02/2018 |
| Redmile Group, LLC |
DELAWARE |
0 |
2815988 |
0 |
0 |
2815988 |
9.2 % |
14/02/2018 |
| BRIDGER HEALTHCARE, LTD. |
Cayman Islands |
0 |
1765986 |
0 |
0 |
1765986 |
5.8 % |
14/02/2018 |
| BLAKE GOODNER |
United States |
0 |
1765986 |
0 |
0 |
1765986 |
5.8 % |
14/02/2018 |
| ROBERTO MIGNONE |
United States |
0 |
2598599 |
0 |
0 |
2598599 |
8.5 % |
14/02/2018 |
| BRIDGER MANAGEMENT, LLC |
Delaware |
0 |
2598599 |
0 |
0 |
2598599 |
8.5 % |
14/02/2018 |
| Morgan Stanley Capital Services LLC |
Delaware. |
0 |
1682627 |
0 |
1682627 |
1682627 |
5.5 % |
13/02/2018 |
| Morgan Stanley |
Delaware. |
0 |
1739038 |
0 |
1736804 |
1739038 |
5.6 % |
13/02/2018 |
| FMR LLC |
Delaware |
87820 |
0 |
4703988 |
0 |
4703988 |
12.511 % |
12/02/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1833868 |
0 |
1833868 |
5.993 % |
09/02/2018 |
| FMR LLC |
Delaware |
0 |
0 |
1833868 |
0 |
1833868 |
5.993 % |
09/02/2018 |
| ArrowMark Colorado Holdings LLC |
Delaware, United States |
3146820 |
0 |
3146820 |
0 |
3146820 |
8.4 % |
09/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
1921238 |
0 |
1962261 |
0 |
1962261 |
6.4 % |
29/01/2018 |
| Stephen DuBois |
Massachusetts |
0 |
2500000 |
0 |
2500000 |
2500000 |
6.65 % |
05/01/2018 |
| CELGENE CORPORATION |
Delaware, U.S.A. |
1154540 |
0 |
1154540 |
0 |
1154540 |
3.8 % |
08/12/2017 |
| Morgan Stanley |
Delaware. |
13 |
0 |
13 |
1526033 |
1530167 |
5 % |
07/12/2017 |
| BLAKE GOODNER |
United States |
0 |
1524191 |
0 |
0 |
1524191 |
5.2 % |
21/04/2017 |
| BRIDGER HEALTHCARE, LTD. |
Cayman Islands |
0 |
1524191 |
0 |
0 |
1524191 |
5.2 % |
21/04/2017 |
| BRIDGER MANAGEMENT, LLC |
Delaware |
0 |
1524191 |
0 |
0 |
1524191 |
5.2 % |
21/04/2017 |
| ROBERTO MIGNONE |
United States |
0 |
1524191 |
0 |
0 |
1524191 |
5.2 % |
21/04/2017 |
| Redmile Group, LLC |
DELAWARE |
0 |
2670942 |
0 |
0 |
2670942 |
9.25 % |
14/02/2017 |
| JEREMY C. GREEN |
UNITED
STATES |
0 |
2670942 |
0 |
0 |
2670942 |
9.25 % |
14/02/2017 |
| Select Biotechnology Portfolio |
Massachusetts |
1979627 |
0 |
0 |
0 |
1979627 |
6.859 % |
14/02/2017 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2782447 |
0 |
2782447 |
9.64 % |
14/02/2017 |
| FMR LLC |
Delaware |
325435 |
0 |
2782447 |
0 |
2782447 |
9.64 % |
14/02/2017 |
| Arrowpoint Asset Management, LLC |
Delaware, United States |
1560612 |
0 |
1560612 |
0 |
1560612 |
5.4 % |
13/02/2017 |
| 4.9% (2) |
Delaware |
550384 |
853117 |
550384 |
853117 |
1403501 |
4.9 % |
07/02/2017 |
| (1) BlackRock, Inc. |
Delaware |
1696781 |
0 |
1740900 |
0 |
1740900 |
6 % |
30/01/2017 |
| FMR LLC |
Delaware |
241835 |
0 |
3125407 |
0 |
3125407 |
10.873 % |
11/07/2016 |
| Carlos Slim Domit |
México |
0 |
616153 |
0 |
0 |
616153 |
2.2 % |
16/02/2016 |
| María Soumaya Slim Domit |
México |
0 |
616153 |
0 |
0 |
616153 |
2.2 % |
16/02/2016 |
| Vanessa Paola Slim Domit |
México |
0 |
616153 |
0 |
0 |
616153 |
2.2 % |
16/02/2016 |
| Carlos Slim Helú |
México |
0 |
616153 |
0 |
0 |
616153 |
2.2 % |
16/02/2016 |
| Marco Antonio Slim Domit |
México |
0 |
616153 |
0 |
0 |
616153 |
2.2 % |
16/02/2016 |
| Patrick Slim Domit |
México |
0 |
616153 |
0 |
0 |
616153 |
2.2 % |
16/02/2016 |
| Johanna Monique Slim Domit |
México |
0 |
616153 |
0 |
0 |
616153 |
2.2 % |
16/02/2016 |
| Inversora Carso, S.A. de C.V., formerly known as Inmobiliaria Carso, S.A. de C.V. |
México |
0 |
616153 |
0 |
0 |
616153 |
2.2 % |
16/02/2016 |
| JEREMY C. GREEN |
UNITED
STATES |
0 |
1534962 |
0 |
0 |
1534962 |
5.36 % |
16/02/2016 |
| Redmile Group, LLC |
DELAWARE |
1534962 |
0 |
1534962 |
0 |
1534962 |
5.36 % |
16/02/2016 |
| The Baupost Group, L.L.C.04-3402144 |
Commonwealth Massachusetts |
0 |
5359632 |
0 |
5359632 |
5359632 |
18.72 % |
12/02/2016 |
| Seth A. Klarman |
Commonwealth Massachusetts |
0 |
5359632 |
0 |
5359632 |
5359632 |
18.72 % |
12/02/2016 |
| SAK Corporation04-3334541 |
Commonwealth Massachusetts |
0 |
5359632 |
0 |
5359632 |
5359632 |
18.72 % |
12/02/2016 |
| DP VIII Associates, L.P. |
Delaware |
15890 |
0 |
15890 |
0 |
15890 |
0.1 % |
19/01/2016 |
| Domain Partners VIII, L.P. |
Delaware |
1641542 |
0 |
1641542 |
0 |
1641542 |
5.7 % |
19/01/2016 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
400933 |
0 |
400933 |
1.645 % |
10/06/2015 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
400933 |
0 |
400933 |
1.645 % |
10/06/2015 |
| FMR LLC |
Delaware |
3300 |
0 |
400933 |
0 |
400933 |
1.645 % |
10/06/2015 |
| The Baupost Group, L.L.C.04-3402144 |
Commonwealth Massachusetts |
0 |
4763265 |
0 |
4763265 |
4763265 |
19.55 % |
09/04/2015 |
| Seth A. Klarman |
Commonwealth Massachusetts |
0 |
4763265 |
0 |
4763265 |
4763265 |
19.55 % |
09/04/2015 |
| SAK Corporation04-3334541 |
Commonwealth Massachusetts |
0 |
4763265 |
0 |
4763265 |
4763265 |
19.55 % |
09/04/2015 |
| 6.0% (2) |
Delaware |
615384 |
853117 |
615384 |
853117 |
1468501 |
12 % |
01/04/2015 |
| S KPCB XV Founders Fund, LLC (“KPCB XV Founders”) |
Delaware |
77622 |
77622 |
77622 |
77622 |
77622 |
0.4 % |
17/02/2015 |
| Kleiner Perkins Caufield & Byers XV, LLC (“KPCB XV”) |
Delaware |
2599028 |
2599028 |
2599028 |
2599028 |
2599028 |
12.9 % |
17/02/2015 |
| KPCB XV Associates, LLC |
Delaware |
2676650 |
2676650 |
2676650 |
2676650 |
2676650 |
13.2 % |
17/02/2015 |
| Inmobiliaria Carso, S.A. de C.V. |
México |
0 |
1335202 |
0 |
0 |
1335202 |
6.6 % |
17/02/2015 |
| Carlos Slim Domit |
México |
0 |
1335202 |
0 |
0 |
1335202 |
6.6 % |
17/02/2015 |
| Carlos Slim Helú |
México |
0 |
1335202 |
0 |
0 |
1335202 |
6.6 % |
17/02/2015 |
| María Soumaya Slim Domit |
México |
0 |
1335202 |
0 |
0 |
1335202 |
6.6 % |
17/02/2015 |
| Vanessa Paola Slim Domit |
México |
0 |
1335202 |
0 |
0 |
1335202 |
6.6 % |
17/02/2015 |
| Johanna Monique Slim Domit |
México |
0 |
1335202 |
0 |
0 |
1335202 |
6.6 % |
17/02/2015 |
| Patrick Slim Domit |
México |
0 |
1335202 |
0 |
0 |
1335202 |
6.6 % |
17/02/2015 |
| Marco Antonio Slim Domit |
México |
0 |
1335202 |
0 |
0 |
1335202 |
6.6 % |
17/02/2015 |
| FMR LLC |
Delaware |
0 |
0 |
1348015 |
0 |
1348015 |
6.669 % |
13/02/2015 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1348015 |
0 |
1348015 |
6.669 % |
13/02/2015 |
| Select Biotechnology Portfolio |
Massachusetts |
1130915 |
0 |
0 |
0 |
1130915 |
5.595 % |
13/02/2015 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1348015 |
0 |
1348015 |
6.669 % |
13/02/2015 |
| Domain Partners VIII, L.P. |
Delaware |
2141542 |
0 |
2141542 |
0 |
2141542 |
10.6 % |
05/02/2015 |
| DP VIII Associates, L.P. |
Delaware |
15890 |
0 |
15890 |
0 |
15890 |
0.1 % |
05/02/2015 |
| SAK Corporation04-3334541 |
United States America |
0 |
2495913 |
0 |
2495913 |
2495913 |
12.86 % |
10/11/2014 |
| The Baupost Group, L.L.C.04-3402144 |
United States America |
0 |
2495913 |
0 |
2495913 |
2495913 |
12.86 % |
10/11/2014 |
| Seth A. Klarman |
United States America |
0 |
2495913 |
0 |
2495913 |
2495913 |
12.86 % |
10/11/2014 |