| Vanguard Capital Management |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
77965099 |
5.02 % |
28/04/2026 |
| AstraZeneca PLC |
UNITED KINGDOM |
0 |
0 |
0 |
0 |
522667 |
7.8 % |
06/02/2026 |
| MedImmune Limited |
X0 |
7825501 |
0 |
7825501 |
0 |
7825501 |
8.3 % |
06/02/2026 |
| AstraZeneca PLC |
X0 |
7825501 |
0 |
7825501 |
0 |
7825501 |
8.3 % |
06/02/2026 |
| BlackRock, Inc. |
DELAWARE |
0 |
0 |
0 |
0 |
117761076 |
7.6 % |
23/04/2025 |
| AstraZeneca PLC |
UNITED KINGDOM |
0 |
0 |
0 |
0 |
73892 |
1.1 % |
10/04/2025 |
| AstraZeneca Holdings B.V. |
P7 |
44000000 |
0 |
44000000 |
0 |
44000000 |
44 % |
24/01/2025 |
| AstraZeneca PLC |
X0 |
44000000 |
0 |
44000000 |
0 |
44000000 |
44 % |
24/01/2025 |
| Alexion Pharmaceuticals, Inc. |
United Kingdom |
387329 |
0 |
387329 |
0 |
387329 |
9.9 % |
28/10/2024 |
| AstraZeneca PLC |
United Kingdom |
387329 |
0 |
387329 |
0 |
387329 |
9.9 % |
28/10/2024 |
| Name of Reporting Person |
United Kingdom |
9504465 |
0 |
9504465 |
0 |
7 |
8 % |
11/10/2024 |
| Name of Reporting Person |
United Kingdom |
9504465 |
0 |
9504465 |
0 |
3 |
4 % |
11/10/2024 |
| AstraZeneca PLC |
United Kingdom |
16000000 |
0 |
16000000 |
10 |
16000000 |
22.4 % |
09/11/2023 |
| AstraZeneca Holdings B.V. |
Netherlands |
16000000 |
0 |
16000000 |
10 |
16000000 |
22.4 % |
09/11/2023 |
| (1)Names of reporting persons. BlackRock, Inc. |
Delaware |
140995048 |
0 |
157391306 |
0 |
157391306 |
10.2 % |
08/07/2022 |
| Wellington Management Group LLP |
Massachusetts |
0 |
61516761 |
0 |
0 |
65542362 |
4.23 % |
04/02/2022 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
61516761 |
0 |
0 |
65542362 |
4.23 % |
04/02/2022 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
61516761 |
0 |
0 |
65542362 |
4.23 % |
04/02/2022 |
| AstraZeneca PLC |
United Kingdom |
884956 |
0 |
884956 |
0 |
884956 |
7.3 % |
27/07/2021 |
| AstraZeneca UK Limited |
United Kingdom |
4011215 |
0 |
4011215 |
0 |
4011215 |
5.23 % |
10/02/2021 |
| AstraZeneca PLC |
United Kingdom |
4011215 |
0 |
4011215 |
0 |
4011215 |
5.23 % |
10/02/2021 |
| AstraZeneca PLC |
United Kingdom |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
| Zeneca Inc. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
64086893 |
0 |
0 |
68525329 |
5.22 % |
03/02/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
64086893 |
0 |
0 |
68525329 |
5.22 % |
03/02/2021 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
64086893 |
0 |
0 |
68525329 |
5.22 % |
03/02/2021 |
| MedImmune Limited |
United Kingdom |
12946900 |
0 |
12946900 |
10 |
12946900 |
16.7 % |
07/02/2020 |
| AstraZeneca PLC |
United Kingdom |
12946900 |
0 |
12946900 |
10 |
12946900 |
16.7 % |
07/02/2020 |
| AstraZeneca PLC |
United Kingdom |
14650334 |
0 |
14650334 |
0 |
14650334 |
28.7 % |
30/01/2020 |
| AstraZeneca UK Limited |
United Kingdom |
14650334 |
0 |
14650334 |
0 |
14650334 |
28.7 % |
30/01/2020 |
| Wellington Management Group LLP |
Delaware |
0 |
73319750 |
0 |
0 |
77503889 |
5.91 % |
27/01/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
70695336 |
0 |
0 |
72145886 |
5.5 % |
27/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
73319750 |
0 |
0 |
77503889 |
5.91 % |
27/01/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
73319750 |
0 |
0 |
77503889 |
5.91 % |
27/01/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
22943288 |
0 |
0 |
77136557 |
6.09 % |
12/02/2019 |
| Wellington Group Holdings LLP |
Delaware |
0 |
25584193 |
0 |
0 |
83554462 |
6.6 % |
12/02/2019 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
25584193 |
0 |
0 |
83554462 |
6.6 % |
12/02/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
25584193 |
0 |
0 |
83554462 |
6.6 % |
12/02/2019 |
| Zeneca Inc. |
Delaware |
25499325 |
0 |
25499325 |
0 |
25499325 |
7.75 % |
30/01/2019 |
| AstraZeneca PLC |
United Kingdom |
25499325 |
0 |
25499325 |
0 |
25499325 |
7.75 % |
30/01/2019 |
| in Row (9) |
United Kingdom |
2950630 |
0 |
2950630 |
0 |
2950630 |
10.4 % |
08/02/2018 |
| in Row (9) |
United Kingdom |
2950630 |
0 |
2950630 |
0 |
2950630 |
10.4 % |
08/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
21706377 |
0 |
0 |
81428036 |
6.43 % |
08/02/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
21706377 |
0 |
0 |
81428036 |
6.43 % |
08/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
21706377 |
0 |
0 |
81428036 |
6.43 % |
08/02/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
19718931 |
0 |
0 |
76925030 |
6.08 % |
08/02/2018 |
| 10. |
England and Wales |
0 |
1632652 |
0 |
1632652 |
1632652 |
8.8 % |
10/02/2017 |
| 10. |
England and Wales |
0 |
1632652 |
0 |
1632652 |
1632652 |
8.8 % |
10/02/2017 |
| Wellington Management Company LLP |
Delaware |
0 |
16573628 |
0 |
0 |
71462611 |
5.65 % |
09/02/2017 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
18305031 |
0 |
0 |
74620419 |
5.9 % |
09/02/2017 |
| Wellington Group Holdings LLP |
Delaware |
0 |
18305031 |
0 |
0 |
74620419 |
5.9 % |
09/02/2017 |
| Wellington Management Group LLP |
Massachusetts |
0 |
18305031 |
0 |
0 |
74620419 |
5.9 % |
09/02/2017 |
| Page 2 of 7 Pages |
ENGLAND AND WALES |
0 |
1917906 |
0 |
1917906 |
1917906 |
7.3 % |
16/02/2016 |
| Page 3 of 7 Pages |
ENGLAND AND WALES |
0 |
1917906 |
0 |
1917906 |
1917906 |
7.3 % |
16/02/2016 |
| Wellington Group Holdings LLP |
Delaware |
0 |
24850511 |
0 |
0 |
85633978 |
6.77 % |
11/02/2016 |
| Wellington Management Group LLP |
Massachusetts |
0 |
24850511 |
0 |
0 |
85633978 |
6.77 % |
11/02/2016 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
24850511 |
0 |
0 |
85633978 |
6.77 % |
11/02/2016 |
| Wellington Management Company LLP |
Delaware |
0 |
21934618 |
0 |
0 |
80595016 |
6.38 % |
11/02/2016 |
| (1) BlackRock, Inc. |
Delaware |
112782109 |
0 |
128757300 |
0 |
128757300 |
10.2 % |
10/02/2016 |
| EIN # 06-1641145 |
ENGLAND AND WALES |
0 |
1114092 |
0 |
1114092 |
1114092 |
6.8 % |
17/02/2015 |
| ASTRAZENECA PLC |
ENGLAND AND WALES |
0 |
1114092 |
0 |
1114092 |
1114092 |
6.8 % |
17/02/2015 |
| Mario J. Gabelli |
Massachusetts |
0 |
29430520 |
0 |
81298442 |
438426 |
24.78 % |
12/02/2015 |
| (1) BlackRock, Inc. |
Delaware |
81345820 |
0 |
81345820 |
0 |
81345820 |
6.53 % |
06/02/2013 |
| AstraZeneca Holdings BV |
The Netherlands |
0 |
1000 |
0 |
10 |
1000 |
100 % |
19/06/2012 |
| AstraZeneca UK Limited |
United Kingdom |
0 |
1000 |
0 |
10 |
1000 |
100 % |
19/06/2012 |
| AstraZeneca Treasury Limited |
United Kingdom |
0 |
1000 |
0 |
10 |
1000 |
100 % |
19/06/2012 |
| Zeneca Inc. |
Delaware |
0 |
1000 |
0 |
10 |
1000 |
100 % |
19/06/2012 |
| AstraZeneca PLC |
United Kingdom |
0 |
1000 |
0 |
10 |
1000 |
100 % |
19/06/2012 |
| AstraZeneca Intermediate Holdings Limited |
United Kingdom |
0 |
1000 |
0 |
10 |
1000 |
100 % |
19/06/2012 |
| Zeneca Holdings Inc. |
Delaware |
0 |
1000 |
0 |
10 |
1000 |
100 % |
19/06/2012 |
| AstraZeneca Holdings BV |
The Netherlands |
0 |
10886949 |
0 |
10 |
12181075 |
32 % |
01/05/2012 |
| Zeneca Holdings Inc. |
Delaware |
0 |
10886949 |
0 |
10 |
12181075 |
32 % |
01/05/2012 |
| AstraZeneca UK Limited |
United Kingdom |
0 |
10886949 |
0 |
10 |
12181075 |
32 % |
01/05/2012 |
| AstraZeneca Treasury Limited |
United Kingdom |
0 |
10886949 |
0 |
10 |
12181075 |
32 % |
01/05/2012 |
| AstraZeneca PLC |
United Kingdom |
0 |
10886949 |
0 |
10 |
12181075 |
32 % |
01/05/2012 |
| AstraZeneca Intermediate Holdings Limited |
United Kingdom |
0 |
10886949 |
0 |
10 |
12181075 |
32 % |
01/05/2012 |
| Zeneca Inc. |
Delaware |
0 |
10886949 |
0 |
10 |
12181075 |
32 % |
01/05/2012 |
| (1) BlackRock, Inc. |
Delaware |
83372880 |
0 |
83372880 |
0 |
83372880 |
6.45 % |
13/02/2012 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
95095116 |
0 |
95095116 |
6.75 % |
02/02/2011 |
| BlackRock for purposes of Schedule 13G filings. |
Delaware |
99580239 |
0 |
99580239 |
0 |
99580239 |
6.87 % |
29/01/2010 |
| Biopharmaceuticals Inc. |
Delaware |
0 |
219463013 |
0 |
219463013 |
219463013 |
91.9 % |
13/06/2007 |
| PLC |
and Wales |
0 |
219463013 |
0 |
219463013 |
219463013 |
91.9 % |
13/06/2007 |
| S |
KINGDOM OF SWEDEN |
63465810 |
0 |
63465810 |
10 |
63465810 |
3.75 % |
17/02/2004 |
| AstraZeneca PLC |
Citizenship or Place of Organization |
1951098 |
0 |
0 |
0 |
1951098 |
7.3 % |
14/11/2003 |
| AstraZeneca AB |
Citizenship or Place of Organization |
1951098 |
0 |
0 |
0 |
1951098 |
7.3 % |
14/11/2003 |
| AstraZeneca Treasury Limited |
Citizenship or Place of Organization |
1951098 |
0 |
0 |
0 |
1951098 |
7.3 % |
14/11/2003 |
| AstraZeneca UK Limited |
Citizenship or Place of Organization |
1951098 |
0 |
0 |
0 |
1951098 |
7.3 % |
14/11/2003 |
| AstraZeneca Holding AB |
Citizenship or Place of Organization |
1951098 |
0 |
0 |
0 |
1951098 |
7.3 % |
14/11/2003 |
| (on behalf of Merrill Lynch Asset Management Group ("AMG"))** |
Delaware |
0 |
37330335 |
0 |
37330335 |
37330335 |
2.1 % |
04/02/2000 |
| (on behalf of Merrill Lynch Asset Management Group ("AMG"))** |
Delaware |
0 |
48870155 |
0 |
48870155 |
48870155 |
5.1 % |
05/02/1999 |