| Behzad Aghazadeh |
United States |
13050000 |
0 |
13050000 |
0 |
13050000 |
6.4 % |
14/02/2024 |
| Avoro Capital Advisors LLC |
Delaware |
13050000 |
0 |
13050000 |
0 |
13050000 |
6.4 % |
14/02/2024 |
| Felix J. Baker |
United States |
18464744 |
0 |
18464744 |
0 |
18464744 |
9.95 % |
14/02/2022 |
| Baker Bros. Advisors LP |
Delaware |
18386831 |
0 |
18386831 |
0 |
18386831 |
9.91 % |
14/02/2022 |
| Julian C. Baker |
United States |
18464744 |
0 |
18464744 |
0 |
18464744 |
9.95 % |
14/02/2022 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
18386831 |
0 |
18386831 |
0 |
18386831 |
9.91 % |
14/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
170633 |
9092380 |
320525 |
9412905 |
5.23 % |
09/02/2022 |
| STATE STREET CORPORATION |
|
0 |
7876155 |
0 |
0 |
8249029 |
4.58 % |
09/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
14257173 |
0 |
14787395 |
0 |
14787395 |
8.2 % |
01/02/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
6651674 |
0 |
7308816 |
7308816 |
4.13 % |
12/04/2021 |
| Felix J. Baker |
Delaware |
18178881 |
0 |
18178881 |
0 |
18178881 |
9.99 % |
16/02/2021 |
| Baker Bros. Advisors LP |
Delaware |
18100968 |
0 |
18100968 |
0 |
18100968 |
9.95 % |
16/02/2021 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
18100968 |
0 |
18100968 |
0 |
18100968 |
9.95 % |
16/02/2021 |
| Julian C. Baker |
Delaware |
18178881 |
0 |
18178881 |
0 |
18178881 |
9.99 % |
16/02/2021 |
| Kenneth Griffin |
|
0 |
6660717 |
0 |
0 |
10 |
3.8 % |
16/02/2021 |
| Citadel Securities LLC |
|
0 |
475538 |
0 |
0 |
10 |
0.3 % |
16/02/2021 |
| CALC IV LP |
|
0 |
547281 |
0 |
0 |
10 |
0.3 % |
16/02/2021 |
| Citadel Advisors Holdings LP |
|
0 |
6113436 |
0 |
0 |
10 |
3.5 % |
16/02/2021 |
| Citadel Advisors LLC |
|
0 |
6113436 |
0 |
0 |
10 |
3.5 % |
16/02/2021 |
| 2. |
|
0 |
547281 |
0 |
0 |
10 |
0.3 % |
16/02/2021 |
| Citadel GP LLC |
|
0 |
6113436 |
0 |
0 |
10 |
3.5 % |
16/02/2021 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
3230800 |
0 |
3230800 |
3230800 |
4 % |
16/02/2021 |
| Point72 Hong Kong Limited |
Delaware |
0 |
4268 |
0 |
0 |
0 |
4 % |
16/02/2021 |
| Steven A. Cohen |
Delaware |
0 |
3691632 |
0 |
3691632 |
3691632 |
4 % |
16/02/2021 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
456564 |
0 |
456564 |
456564 |
4 % |
16/02/2021 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
3230800 |
0 |
3230800 |
3230800 |
4 % |
16/02/2021 |
| EIN #00-0000000 |
Jersey Channel Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| Israel A. Englander |
|
0 |
286632 |
0 |
286632 |
286632 |
0.2 % |
10/02/2021 |
| Millennium International Management LP |
|
0 |
255502 |
0 |
255502 |
255502 |
0.1 % |
10/02/2021 |
| Integrated Core Strategies (US) LLC |
|
0 |
31130 |
0 |
31130 |
31130 |
0 % |
10/02/2021 |
| Integrated Assets, Ltd. |
|
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
| Integrated Assets II LLC |
|
0 |
104504 |
0 |
104504 |
104504 |
0.1 % |
10/02/2021 |
| ICS Opportunities II LLC |
|
0 |
150998 |
0 |
150998 |
150998 |
0.1 % |
10/02/2021 |
| Millennium Group Management LLC |
|
0 |
286632 |
0 |
286632 |
286632 |
0.2 % |
10/02/2021 |
| Millennium Management LLC |
|
0 |
286632 |
0 |
286632 |
286632 |
0.2 % |
10/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
354760 |
11106569 |
492765 |
11599334 |
6.57 % |
10/02/2021 |
| STATE STREET CORPORATION |
BOSTON MASSACHUSETTS |
0 |
10292691 |
0 |
11056979 |
11056979 |
6.26 % |
05/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
15779719 |
0 |
16259745 |
0 |
16259745 |
9.2 % |
28/01/2021 |
| Sarissa Capital Management LP |
Delaware |
8844000 |
0 |
8844000 |
0 |
8844000 |
5 % |
25/01/2021 |
| Alexander J. Denner, Ph.D. |
Delaware |
0 |
8844000 |
0 |
0 |
8844000 |
5 % |
25/01/2021 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
17191089 |
0 |
17953870 |
17953870 |
10.17 % |
10/12/2020 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
14765296 |
0 |
14817296 |
14817296 |
8.39 % |
10/12/2020 |
| Citadel Advisors LLC |
Delaware |
0 |
8523639 |
0 |
0 |
10 |
4.8 % |
10/06/2020 |
| Kenneth Griffin |
Delaware |
0 |
8895435 |
0 |
0 |
10 |
5 % |
10/06/2020 |
| CALC IV LP |
Delaware |
0 |
371796 |
0 |
0 |
10 |
0.2 % |
10/06/2020 |
| Citadel GP LLC |
Delaware |
0 |
8523639 |
0 |
0 |
10 |
4.8 % |
10/06/2020 |
| Citadel Securities LLC |
Delaware |
0 |
371796 |
0 |
0 |
10 |
0.2 % |
10/06/2020 |
| Citadel Securities GP LLC |
Delaware |
0 |
371796 |
0 |
0 |
10 |
0.2 % |
10/06/2020 |
| Citadel Advisors Holdings LP |
Delaware |
0 |
8523639 |
0 |
0 |
10 |
4.8 % |
10/06/2020 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
1.62 % |
17/04/2020 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
1.62 % |
17/04/2020 |
| Phillip Gross |
Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
1.62 % |
17/04/2020 |
| Robert Atchinson |
Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
1.62 % |
17/04/2020 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
1.62 % |
17/04/2020 |
| Cubist Systematic Strategies, LLC |
|
0 |
2600 |
0 |
2600 |
2600 |
4 % |
14/02/2020 |
| Point72 Hong Kong Limited |
|
0 |
2554 |
0 |
0 |
0 |
4 % |
14/02/2020 |
| Steven A. Cohen |
|
0 |
8388054 |
0 |
8388054 |
8388054 |
4 % |
14/02/2020 |
| Point72 Asset Management, L.P. |
|
0 |
8382900 |
0 |
8382900 |
8382900 |
4 % |
14/02/2020 |
| Point72 Capital Advisors, Inc. |
|
0 |
8382900 |
0 |
8382900 |
8382900 |
4 % |
14/02/2020 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Great Point Partners, LLC |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Mr. David Kroin |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| James E. Flynn |
United States |
0 |
6375143 |
0 |
0 |
6375143 |
4.14 % |
13/02/2020 |
| Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| Company, L.P. |
Delaware |
0 |
6375143 |
0 |
0 |
6375143 |
4.14 % |
13/02/2020 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
6375143 |
0 |
0 |
6375143 |
4.14 % |
13/02/2020 |
| Deerfield Partners, L.P. |
Delaware |
0 |
6375143 |
0 |
0 |
6375143 |
4.14 % |
13/02/2020 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
277298 |
5373 |
7851475 |
270156 |
8121631 |
5.27 % |
12/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
11911615 |
0 |
12150211 |
0 |
12150211 |
7.9 % |
05/02/2020 |
| Integrated Assets II LLC |
|
0 |
3075480 |
0 |
3075480 |
3075480 |
2 % |
22/01/2020 |
| Millennium Group Management LLC |
|
0 |
9975477 |
0 |
9975477 |
9975477 |
6.5 % |
22/01/2020 |
| Millennium Management LLC |
|
0 |
9975477 |
0 |
9975477 |
9975477 |
6.5 % |
22/01/2020 |
| Millennium International Management LP |
|
0 |
3076034 |
0 |
3076034 |
3076034 |
2 % |
22/01/2020 |
| Integrated Assets, Ltd. |
|
0 |
554 |
0 |
554 |
554 |
0 % |
22/01/2020 |
| Integrated Core Strategies (US) LLC |
|
0 |
6899443 |
0 |
6899443 |
6899443 |
4.5 % |
22/01/2020 |
| Israel A. Englander |
|
0 |
9975477 |
0 |
9975477 |
9975477 |
6.5 % |
22/01/2020 |
| Steven A. Cohen |
Delaware |
0 |
9355382 |
0 |
9355382 |
9355382 |
4 % |
19/11/2019 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
55382 |
0 |
55382 |
55382 |
4 % |
19/11/2019 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
9300000 |
0 |
9300000 |
9300000 |
4 % |
19/11/2019 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
0 |
0 |
9300000 |
9300000 |
4 % |
19/11/2019 |
| Koh, Bong |
United States |
0 |
6310255 |
0 |
0 |
6310255 |
5.8 % |
14/02/2019 |
| VHCP Management II, LLC |
Delaware |
0 |
6310255 |
0 |
0 |
6310255 |
5.8 % |
14/02/2019 |
| VHCP Management III, LLC |
Delaware |
0 |
6310255 |
0 |
0 |
6310255 |
5.8 % |
14/02/2019 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
6310255 |
0 |
0 |
6310255 |
5.8 % |
14/02/2019 |
| VHCP Co-Investment Holdings II, LLC |
Delaware |
0 |
6310255 |
0 |
0 |
6310255 |
5.8 % |
14/02/2019 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
6310255 |
0 |
0 |
6310255 |
5.8 % |
14/02/2019 |
| VHCP Co-Investment Holdings III, LLC |
Delaware |
0 |
6310255 |
0 |
0 |
6310255 |
5.8 % |
14/02/2019 |
| Shah, Nimish |
United States |
0 |
6310255 |
0 |
0 |
6310255 |
5.8 % |
14/02/2019 |
| Baker Bros. Advisors LP |
Delaware |
15148081 |
0 |
15148081 |
0 |
15148081 |
13.8 % |
13/02/2019 |
| Julian C. Baker |
United States |
15171540 |
0 |
15171540 |
0 |
15171540 |
13.8 % |
13/02/2019 |
| Felix J. Baker |
United States |
15171540 |
0 |
15171540 |
0 |
15171540 |
13.8 % |
13/02/2019 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
15148081 |
0 |
15148081 |
0 |
15148081 |
13.8 % |
13/02/2019 |
| Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2019 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
6910789 |
0 |
0 |
6910789 |
6.3 % |
12/02/2019 |
| L.P. |
Delaware |
0 |
5860410 |
0 |
0 |
5860410 |
5.35 % |
12/02/2019 |
| James E. Flynn |
United States |
0 |
6910789 |
0 |
0 |
6910789 |
6.3 % |
12/02/2019 |
| Situations Fund, L.P. |
Delaware |
0 |
1050379 |
0 |
0 |
1050379 |
0.96 % |
12/02/2019 |
| Company, L.P. |
Delaware |
0 |
6910789 |
0 |
0 |
6910789 |
6.3 % |
12/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
8650934 |
0 |
8849427 |
0 |
8849427 |
8.1 % |
04/02/2019 |
| Mr. David Kroin |
USA |
0 |
7622256 |
0 |
0 |
7622256 |
6.95 % |
11/01/2019 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
7622256 |
0 |
0 |
7622256 |
6.95 % |
11/01/2019 |
| Great Point Partners, LLC |
USA |
0 |
7622256 |
0 |
0 |
7622256 |
6.95 % |
11/01/2019 |
| Peter Kolchinsky |
Massachusetts |
0 |
0 |
0 |
0 |
9234692 |
8.5 % |
06/08/2018 |
| RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
9234692 |
8.5 % |
06/08/2018 |
| Great Point Partners, LLC |
or Place of Organization Delaware |
0 |
7478275 |
0 |
7478275 |
7478275 |
7.57 % |
31/07/2018 |
| Mr. David Kroin |
or Place of Organization United States |
0 |
7478275 |
0 |
7478275 |
7478275 |
7.57 % |
31/07/2018 |
| Dr. Jeffrey R. Jay, M.D. |
or Place of Organization United States |
0 |
7478275 |
0 |
7478275 |
7478275 |
7.57 % |
31/07/2018 |
| Peter Kolchinsky |
Citizenship or Place of Organization |
0 |
6984692 |
0 |
6984692 |
6984692 |
7.1 % |
14/02/2018 |
| RA Capital Management, LLC |
Massachusetts |
0 |
6984692 |
0 |
6984692 |
6984692 |
7.1 % |
14/02/2018 |
| David E. Shaw |
Delaware |
0 |
938860 |
0 |
939473 |
939473 |
1 % |
14/02/2018 |
| 13-3695715 |
Delaware |
0 |
938860 |
0 |
939473 |
939473 |
1 % |
14/02/2018 |
| Wong |
Delaware |
0 |
3372674 |
0 |
0 |
3372674 |
3.43 % |
14/02/2018 |
| Investments, LP |
Delaware |
0 |
3372674 |
0 |
0 |
3372674 |
3.43 % |
14/02/2018 |
| Master Fund, Ltd. |
Delaware |
0 |
3208664 |
0 |
0 |
3208664 |
3.26 % |
14/02/2018 |
| VHCP Management II, LLC |
Delaware |
0 |
2851385 |
0 |
0 |
2851385 |
2.9 % |
13/02/2018 |
| Koh, Bong |
Delaware |
0 |
2851385 |
0 |
0 |
2851385 |
2.9 % |
13/02/2018 |
| VHCP Co-Investment Holdings II, LLC |
Delaware |
0 |
2851385 |
0 |
0 |
2851385 |
2.9 % |
13/02/2018 |
| Venrock Healthcare Capital Partners, L.P. |
Delaware |
0 |
2851385 |
0 |
0 |
2851385 |
2.9 % |
13/02/2018 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
2851385 |
0 |
0 |
2851385 |
2.9 % |
13/02/2018 |
| VHCP Co-Investment Holdings, LLC |
Delaware |
0 |
2851385 |
0 |
0 |
2851385 |
2.9 % |
13/02/2018 |
| VHCP Management, LLC |
Delaware |
0 |
2851385 |
0 |
0 |
2851385 |
2.9 % |
13/02/2018 |
| Shah, Nimish |
Delaware |
0 |
2851385 |
0 |
0 |
2851385 |
2.9 % |
13/02/2018 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
14057172 |
0 |
14057172 |
0 |
14057172 |
14.3 % |
13/02/2018 |
| Julian C. Baker |
United States |
14080631 |
0 |
14080631 |
0 |
14080631 |
14.3 % |
13/02/2018 |
| Felix J. Baker |
United States |
14080631 |
0 |
14080631 |
0 |
14080631 |
14.3 % |
13/02/2018 |
| Baker Bros. Advisors LP |
Delaware |
14057172 |
0 |
14057172 |
0 |
14057172 |
14.3 % |
13/02/2018 |
| Mazama Capital Management, Inc. |
Jersey Channel Islands |
0 |
6739266 |
0 |
6739266 |
1314579 |
7.64 % |
12/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
7478233 |
0 |
7614280 |
0 |
7614280 |
7.7 % |
29/01/2018 |
| Deerfield International Master Fund, L.P. |
Delaware |
0 |
2860732 |
0 |
0 |
2860732 |
3.56 % |
05/06/2017 |
| Company, L.P. |
Delaware |
0 |
5478719 |
0 |
0 |
5478719 |
6.81 % |
05/06/2017 |
| James E. Flynn |
Delaware |
0 |
5478719 |
0 |
0 |
5478719 |
6.81 % |
05/06/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
5478719 |
0 |
0 |
5478719 |
6.81 % |
05/06/2017 |
| Situations Fund, L.P. |
Delaware |
0 |
375010 |
0 |
0 |
375010 |
0.47 % |
05/06/2017 |
| L.P. |
Delaware |
0 |
2242977 |
0 |
0 |
2242977 |
2.79 % |
05/06/2017 |
| Situations Fund, L.P. |
Delaware |
0 |
375010 |
0 |
0 |
375010 |
0.47 % |
22/05/2017 |
| L.P. |
Delaware |
0 |
1336816 |
0 |
0 |
1336816 |
1.66 % |
22/05/2017 |
| Deerfield International Master Fund, L.P. |
Delaware |
0 |
1708367 |
0 |
0 |
1708367 |
2.12 % |
22/05/2017 |
| James E. Flynn |
Delaware |
0 |
3420193 |
0 |
0 |
3420193 |
4.25 % |
22/05/2017 |
| Company, L.P. |
Delaware |
0 |
3420193 |
0 |
0 |
3420193 |
4.25 % |
22/05/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
3420193 |
0 |
0 |
3420193 |
4.25 % |
22/05/2017 |
| 13-3695715 |
Delaware |
0 |
3665757 |
0 |
3707857 |
3707857 |
5 % |
06/03/2017 |
| Roderick
Wong |
Delaware |
0 |
4078895 |
0 |
4078895 |
4078895 |
5.5 % |
15/02/2017 |
| RTW
Investments, LP |
Delaware |
0 |
4078895 |
0 |
4078895 |
4078895 |
5.5 % |
15/02/2017 |
| RTW
Master Fund, Ltd. |
Delaware |
0 |
3973074 |
0 |
3973074 |
3973074 |
5.4 % |
15/02/2017 |
| Deerfield Partners, L.P. |
Delaware |
0 |
1200442 |
0 |
0 |
1200442 |
1.63 % |
14/02/2017 |
| James E. Flynn |
United States |
0 |
3237734 |
0 |
0 |
3237734 |
4.39 % |
14/02/2017 |
| Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
1540411 |
0 |
0 |
1540411 |
2.09 % |
14/02/2017 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
3237734 |
0 |
0 |
3237734 |
4.39 % |
14/02/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
3237734 |
0 |
0 |
3237734 |
4.39 % |
14/02/2017 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
496881 |
0 |
0 |
496881 |
0.67 % |
14/02/2017 |
| (1) BlackRock, Inc. |
Delaware |
5712748 |
0 |
5849345 |
0 |
5849345 |
7.9 % |
19/01/2017 |
| David E. Shaw |
Delaware |
0 |
3652607 |
0 |
0 |
3690207 |
5 % |
09/01/2017 |
| 13-3695715 |
Delaware |
0 |
3652607 |
0 |
0 |
3690207 |
5 % |
09/01/2017 |
| RTW
Investments, LLC |
Delaware |
0 |
3701460 |
0 |
3701460 |
3701460 |
5.02 % |
26/08/2016 |
| 13-3695715 |
Delaware |
0 |
3698639 |
0 |
0 |
3740239 |
5.1 % |
22/08/2016 |
| David E. Shaw |
Delaware |
0 |
3698639 |
0 |
0 |
3740239 |
5.1 % |
22/08/2016 |
| Felix J. Baker |
Delaware |
11062403 |
0 |
11062403 |
0 |
11062403 |
14.99 % |
17/08/2016 |
| Baker Bros. Advisors LP |
Delaware |
11038944 |
0 |
11038944 |
0 |
11038944 |
14.95 % |
17/08/2016 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
11038944 |
0 |
11038944 |
0 |
11038944 |
14.95 % |
17/08/2016 |
| Julian C. Baker |
Delaware |
11062403 |
0 |
11062403 |
0 |
11062403 |
14.99 % |
17/08/2016 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
4896741 |
0 |
0 |
4896741 |
6.64 % |
12/08/2016 |
| Deerfield Partners, L.P. |
Delaware |
0 |
722700 |
0 |
0 |
722700 |
0.98 % |
12/08/2016 |
| James E. Flynn |
Delaware |
0 |
4896741 |
0 |
0 |
4896741 |
6.64 % |
12/08/2016 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
3246741 |
0 |
0 |
3246741 |
4.41 % |
12/08/2016 |
| Deerfield International Master Fund, L.P. |
Delaware |
0 |
927300 |
0 |
0 |
927300 |
1.26 % |
12/08/2016 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
4896741 |
0 |
0 |
4896741 |
6.64 % |
12/08/2016 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
1496859 |
0 |
0 |
1496859 |
2.03 % |
11/04/2016 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
1496859 |
0 |
0 |
1496859 |
2.03 % |
11/04/2016 |
| Wellington Management Group LLP |
Massachusetts |
0 |
1496859 |
0 |
0 |
1496859 |
2.03 % |
11/04/2016 |
| Venrock Healthcare Capital Partners, L.P. |
Delaware |
0 |
52413782 |
0 |
52413782 |
2 |
3 % |
28/03/2016 |
| 13-3695715 |
Delaware |
0 |
3713161 |
0 |
0 |
3750783 |
5.1 % |
14/03/2016 |
| David E. Shaw |
Delaware |
0 |
3713161 |
0 |
0 |
3750783 |
5.1 % |
14/03/2016 |
| FMR LLC |
United States of America |
201000 |
0 |
1715192 |
0 |
1715192 |
2.329 % |
10/03/2016 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1715192 |
0 |
1715192 |
2.329 % |
10/03/2016 |
| s. |
Massachusetts |
0 |
3094064 |
0 |
3094064 |
3094064 |
4.2 % |
16/02/2016 |
| LLC |
Massachusetts |
0 |
3094064 |
0 |
3094064 |
3094064 |
4.2 % |
16/02/2016 |
| Fund, L.P. |
Massachusetts |
0 |
2460337 |
0 |
2460337 |
2460337 |
3.4 % |
16/02/2016 |
| FMR LLC |
Delaware |
132198 |
0 |
7488027 |
0 |
7488027 |
10.21 % |
12/02/2016 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
7488027 |
0 |
7488027 |
10.21 % |
12/02/2016 |
| Wellington Group Holdings LLP |
Delaware |
0 |
7004719 |
0 |
0 |
7470439 |
10.19 % |
11/02/2016 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
7004719 |
0 |
0 |
7470439 |
10.19 % |
11/02/2016 |
| Wellington Management Group LLP |
Massachusetts |
0 |
7004719 |
0 |
0 |
7470439 |
10.19 % |
11/02/2016 |
| Wellington Management Company LLP |
Delaware |
0 |
6931451 |
0 |
0 |
7255507 |
9.89 % |
11/02/2016 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
15055534 |
0 |
15055534 |
0 |
15055534 |
20.5 % |
04/02/2016 |
| Felix J. Baker |
United States |
15078993 |
0 |
15078993 |
0 |
15078993 |
20.5 % |
04/02/2016 |
| Julian C. Baker |
United States |
15078993 |
0 |
15078993 |
0 |
15078993 |
20.5 % |
04/02/2016 |
| Baker Bros. Advisors LP |
Delaware |
15055534 |
0 |
15055534 |
0 |
15055534 |
20.5 % |
04/02/2016 |
| (1) BlackRock, Inc. |
Delaware |
4757860 |
0 |
4898615 |
0 |
4898615 |
6.7 % |
25/01/2016 |
| Julian C. Baker |
United States |
14331238 |
0 |
14331238 |
0 |
14331238 |
19.5 % |
06/11/2015 |
| Felix J. Baker |
United States |
14331238 |
0 |
14331238 |
0 |
14331238 |
19.5 % |
06/11/2015 |
| Baker Bros. Advisors LP |
Delaware |
14307779 |
0 |
14307779 |
0 |
14307779 |
19.5 % |
06/11/2015 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
14307779 |
0 |
14307779 |
0 |
14307779 |
19.5 % |
06/11/2015 |
| RA Capital Healthcare Fund, L.P. |
Massachusetts |
0 |
5607552 |
0 |
0 |
5607552 |
7.8 % |
17/02/2015 |
| Peter Kolchinsky |
Massachusetts |
0 |
7050356 |
0 |
0 |
7050356 |
9.8 % |
17/02/2015 |
| RA Capital Management,
LLC |
Massachusetts |
0 |
7050356 |
0 |
0 |
7050356 |
9.8 % |
17/02/2015 |
| Julian C. Baker |
Delaware |
10713686 |
0 |
10713686 |
0 |
10713686 |
14.9 % |
17/02/2015 |
| Felix J. Baker |
Delaware |
10713686 |
0 |
10713686 |
0 |
10713686 |
14.9 % |
17/02/2015 |
| 46-3147749 |
Delaware |
10713686 |
0 |
10713686 |
0 |
10713686 |
14.9 % |
17/02/2015 |
| 13-4093645 |
Delaware |
10713686 |
0 |
10713686 |
0 |
10713686 |
14.9 % |
17/02/2015 |
| (1) BlackRock, Inc. |
Delaware |
5351157 |
0 |
5491627 |
0 |
5491627 |
7.6 % |
02/02/2015 |
| Felix J. Baker |
Delaware |
10890872 |
0 |
10890872 |
0 |
10890872 |
15.2 % |
10/06/2014 |
| Julian C. Baker |
Delaware |
10890872 |
0 |
10890872 |
0 |
10890872 |
15.2 % |
10/06/2014 |
| 13-4093645 |
Delaware |
10890872 |
0 |
10890872 |
0 |
10890872 |
15.2 % |
10/06/2014 |
| 46-3147749 |
Delaware |
10890872 |
0 |
10890872 |
0 |
10890872 |
15.2 % |
10/06/2014 |
| 46-3147749 |
Delaware |
6699979 |
0 |
6699979 |
0 |
6699979 |
11.3 % |
25/02/2014 |
| Julian C. Baker |
Delaware |
6699979 |
0 |
6699979 |
0 |
6699979 |
11.3 % |
25/02/2014 |
| Felix J. Baker |
Delaware |
6699979 |
0 |
6699979 |
0 |
6699979 |
11.3 % |
25/02/2014 |
| 13-4093645 |
Delaware |
6699979 |
0 |
6699979 |
0 |
6699979 |
11.3 % |
25/02/2014 |
| 04-2683227 |
Massachusetts |
0 |
3740471 |
0 |
0 |
4791230 |
8.11 % |
14/02/2014 |
| Peter Kolchinsky |
Delaware |
0 |
5850000 |
0 |
0 |
5850000 |
9.9 % |
09/08/2013 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
4493708 |
0 |
0 |
4493708 |
7.6 % |
09/08/2013 |
| RA Capital Management, LLC |
Delaware |
0 |
5850000 |
0 |
0 |
5850000 |
9.9 % |
09/08/2013 |
| Roderick Wong |
Delaware |
0 |
2728709 |
0 |
2728709 |
2728709 |
5.1 % |
02/08/2013 |
| RTW Investments, LLC |
Delaware |
0 |
2728709 |
0 |
2728709 |
2728709 |
5.1 % |
02/08/2013 |
| RTW Master Fund, Ltd. |
Delaware |
0 |
2728709 |
0 |
2728709 |
2728709 |
5.1 % |
02/08/2013 |
| (1) BlackRock, Inc. |
Delaware |
1286925 |
0 |
1286925 |
0 |
1286925 |
2.42 % |
10/07/2013 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| RA Capital Management, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| Peter Kolchinsky |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| (1) BlackRock, Inc. |
Delaware |
3135774 |
0 |
3135774 |
0 |
3135774 |
6.16 % |
30/01/2013 |
| RA Capital Healthcare Fund, L.P. |
Massachusetts |
1634360 |
0 |
1634360 |
0 |
1634360 |
3.6 % |
16/03/2012 |
| Peter Kolchinsky |
Massachusetts |
3008433 |
0 |
3008433 |
0 |
3008433 |
6.5 % |
16/03/2012 |
| RA Capital Management, LLC |
Massachusetts |
3008433 |
0 |
3008433 |
0 |
3008433 |
6.5 % |
16/03/2012 |
| Baker |
States |
0 |
7146948 |
0 |
10 |
7146948 |
17.9 % |
01/06/2009 |
| Felix J. Baker |
States |
0 |
7146948 |
0 |
10 |
7146948 |
17.9 % |
01/06/2009 |
| PAUL
H. STEPHENS |
UNITED
STATES |
286400 |
3411001 |
286400 |
0 |
3411001 |
9.7 % |
12/02/2008 |
| STEPHENS
INVESTMENT MANAGEMENT, LLC |
DELAWARE |
3411001 |
0 |
3411001 |
0 |
3411001 |
9 % |
12/02/2008 |
| P.
BARTLETT STEPHENS |
UNITED
STATES |
0 |
3411001 |
0 |
0 |
3411001 |
9 % |
12/02/2008 |
| W.
BRADFORD STEPHENS |
UNITED
STATES |
0 |
3411001 |
0 |
0 |
3411001 |
9 % |
12/02/2008 |
| STEPHENS
INVESTMENT MANAGEMENT, LLC |
DELAWARE |
3411001 |
0 |
3411001 |
0 |
3411001 |
9 % |
12/02/2008 |
| W.
BRADFORD STEPHENS |
UNITED
STATES |
0 |
3411001 |
0 |
0 |
3411001 |
9 % |
12/02/2008 |
| P.
BARTLETT STEPHENS |
UNITED
STATES |
0 |
3411001 |
0 |
0 |
3411001 |
9 % |
12/02/2008 |
| PAUL
H. STEPHENS |
UNITED
STATES |
286400 |
3411001 |
286400 |
0 |
3411001 |
9.7 % |
12/02/2008 |
| STEPHENS
INVESTMENT MANAGEMENT, LLC |
DELAWARE |
3411001 |
0 |
3411001 |
0 |
3411001 |
9 % |
12/02/2008 |
| P.
BARTLETT STEPHENS |
UNITED
STATES |
0 |
3411001 |
0 |
0 |
3411001 |
9 % |
12/02/2008 |
| W.
BRADFORD STEPHENS |
UNITED
STATES |
0 |
3411001 |
0 |
0 |
3411001 |
9 % |
12/02/2008 |
| PAUL
H. STEPHENS |
UNITED
STATES |
286400 |
3411001 |
286400 |
0 |
3411001 |
9.7 % |
12/02/2008 |
| L. John Doerr III |
States |
371472 |
0 |
371472 |
10 |
371472 |
0.1 % |
20/08/2007 |
| KPCB Pandemic and Bio Defense Fund, LLC |
Delaware |
2883644 |
0 |
2883644 |
10 |
2883644 |
7.5 % |
20/08/2007 |
| KPTV, LLC |
California |
371472 |
0 |
371472 |
10 |
371472 |
0.1 % |
20/08/2007 |
| 52-0556948 |
MARYLAND |
366600 |
0 |
1015100 |
0 |
1015100 |
3.5 % |
13/02/2006 |
| KPTV, LLC |
California |
371472 |
0 |
371472 |
10 |
371472 |
1.3 % |
23/12/2005 |
| Kleiner Perkins Caufield & Byers Holdings, LLC |
Delaware |
1114414 |
0 |
1114414 |
10 |
1114414 |
3.9 % |
23/12/2005 |
| L. John Doerr III |
United States |
371472 |
1114414 |
371472 |
10 |
1485886 |
5.2 % |
23/12/2005 |
| 52-0556948 |
MARYLAND |
390800 |
0 |
1297500 |
0 |
1297500 |
5.9 % |
09/02/2005 |
| 22-2007137 |
New Jersey |
0 |
833836 |
0 |
833836 |
833836 |
4.7 % |
12/02/2004 |
| 22-1024240 |
New Jersey |
0 |
833836 |
0 |
833836 |
833836 |
4.7 % |
12/02/2004 |
| 52-0556948 |
MARYLAND |
371000 |
0 |
1192700 |
0 |
1192700 |
6.7 % |
09/02/2004 |
| Exis Integrated Partners, L.P. |
Cayman
Islands |
0 |
13 |
0 |
13 |
13 |
13 % |
18/12/2003 |
| Exis Capital, LLC |
Delaware |
0 |
13 |
0 |
13 |
13 |
13 % |
18/12/2003 |
| Exis Integrated International Fund, Ltd. |
Cayman
Islands |
0 |
13 |
0 |
13 |
13 |
13 % |
18/12/2003 |
| Exis Capital Management, Inc. |
Delaware |
0 |
13 |
0 |
13 |
13 |
13 % |
18/12/2003 |
| Adam D. Sender |
United States of America |
0 |
13 |
0 |
13 |
13 |
13 % |
18/12/2003 |
| Exis Differential Trading, Ltd. |
British Virgin Islands |
0 |
13 |
0 |
13 |
13 |
13 % |
18/12/2003 |
| Exis Differential Partners, L.P. |
Delaware |
0 |
13 |
0 |
13 |
13 |
13 % |
18/12/2003 |
| Exis Differential Holdings Ltd. |
British
Virgn Islands |
0 |
13 |
0 |
13 |
13 |
13 % |
18/12/2003 |
| Exis Holdings, Ltd. |
Cayman
Islands |
0 |
13 |
0 |
13 |
13 |
13 % |
18/12/2003 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
726900 |
0 |
726900 |
726900 |
4.1 % |
28/06/2002 |
| INVESCO North American Group, Ltd. |
England |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/1997 |
| INVESCO PLC |
England |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/1997 |
| INVESCO, Inc. |
State of Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/1997 |
| INVESCO Funds Group, Inc. |
State of Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/1997 |
| INVESCO North American Holdings, Inc. |
State of Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/1997 |