| Logos GP LLC |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
7.8 % |
27/11/2024 |
| Arsani William |
United States |
0 |
5000000 |
0 |
5000000 |
5000000 |
7.8 % |
27/11/2024 |
| Logos Global Management LP |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
7.8 % |
27/11/2024 |
| Logos Global Management GP LLC |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
7.8 % |
27/11/2024 |
| Logos Global Master Fund LP |
Cayman Islands |
0 |
5000000 |
0 |
5000000 |
5000000 |
7.8 % |
27/11/2024 |
| Siren, L.L.C. |
Delaware |
1965114 |
0 |
1965114 |
0 |
1965114 |
3 % |
12/11/2024 |
| Invus Global Management, LLC |
Delaware |
1965114 |
0 |
1965114 |
0 |
1965114 |
3 % |
12/11/2024 |
| Invus Public Equities, L.P. |
Bermuda |
1965114 |
0 |
1965114 |
0 |
1965114 |
3 % |
12/11/2024 |
| Invus Public Equities Advisors, LLC |
Delaware |
1965114 |
0 |
1965114 |
0 |
1965114 |
3 % |
12/11/2024 |
| Raymond Debbane |
Panama |
1965114 |
0 |
1965114 |
0 |
1965114 |
3 % |
12/11/2024 |
| Rajeev Shah |
United States |
0 |
6383000 |
0 |
6383000 |
6383000 |
9.9 % |
06/11/2024 |
| RA Capital Management, L.P. |
Delaware |
0 |
6383000 |
0 |
6383000 |
6383000 |
9.9 % |
06/11/2024 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
6383000 |
0 |
6383000 |
6383000 |
9.9 % |
06/11/2024 |
| Peter Kolchinsky |
United States |
0 |
6383000 |
0 |
6383000 |
6383000 |
9.9 % |
06/11/2024 |
| Invus Global Management, LLC |
Delaware |
5288508 |
0 |
5288508 |
0 |
5288508 |
8.2 % |
15/08/2024 |
| Siren, L.L.C. |
Delaware |
5288508 |
0 |
5288508 |
0 |
5288508 |
8.2 % |
15/08/2024 |
| Raymond Debbane |
Panama |
5288508 |
0 |
5288508 |
0 |
5288508 |
8.2 % |
15/08/2024 |
| Invus Public Equities, L.P. |
Bermuda |
5288508 |
0 |
5288508 |
0 |
5288508 |
8.2 % |
15/08/2024 |
| Invus Public Equities Advisors, LLC |
Delaware |
5288508 |
0 |
5288508 |
0 |
5288508 |
8.2 % |
15/08/2024 |
| Artal Group S.A. |
Luxembourg |
0 |
0 |
0 |
0 |
0 |
0 % |
29/07/2024 |
| Invus Public Equities, L.P. |
Bermuda |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
29/07/2024 |
| Invus Public Equities Advisors, LLC |
Delaware |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
29/07/2024 |
| Invus Global Management, LLC |
Delaware |
8589064 |
0 |
8589064 |
0 |
85890644 |
13.3 % |
29/07/2024 |
| Siren, L.L.C. |
Delaware |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
29/07/2024 |
| Raymond Debbane |
Panama |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
29/07/2024 |
| Artal International S.C.A. |
Luxembourg |
0 |
0 |
0 |
0 |
0 |
0 % |
29/07/2024 |
| Mr. Amaury Wittouck |
Belgium |
0 |
0 |
0 |
0 |
0 |
0 % |
29/07/2024 |
| Stichting Administratiekantoor Westend |
The Netherlands |
0 |
0 |
0 |
0 |
0 |
0 % |
29/07/2024 |
| Westend S.A. |
Luxembourg |
0 |
0 |
0 |
0 |
0 |
0 % |
29/07/2024 |
| Artal International Management S.A. |
Luxembourg |
0 |
0 |
0 |
0 |
0 |
0 % |
29/07/2024 |
| Artal International Management S.A. |
Luxembourg |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Invus Public Equities Advisors, LLC |
Delaware |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Invus Public Equities, L.P. |
Bermuda |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Mr. Amaury Wittouck |
Belgium |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Stichting Administratiekantoor Westend |
The Netherlands |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Westend S.A. |
Luxembourg |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Artal Group S.A. |
Luxembourg |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Artal International Management S.A. |
Luxembourg |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Artal International S.C.A. |
Luxembourg |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Invus Public Equities Advisors, LLC |
Delaware |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Invus Public Equities, L.P. |
Bermuda |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Mr. Amaury Wittouck |
Belgium |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Stichting Administratiekantoor Westend |
The Netherlands |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Westend S.A. |
Luxembourg |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Artal Group S.A. |
Luxembourg |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| Artal International S.C.A. |
Luxembourg |
8589064 |
0 |
8589064 |
0 |
8589064 |
13.3 % |
09/02/2024 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
630453 |
0 |
630453 |
630453 |
0 % |
29/01/2024 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
630453 |
0 |
630453 |
630453 |
0 % |
29/01/2024 |
| BVF II GP LLC |
Delaware |
0 |
3712350 |
0 |
3712350 |
3712350 |
5.8 % |
29/01/2024 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
3712350 |
0 |
3712350 |
3712350 |
5.8 % |
29/01/2024 |
| BVF I GP LLC |
Delaware |
0 |
4980812 |
0 |
4980812 |
4980812 |
7.7 % |
29/01/2024 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
4980812 |
0 |
4980812 |
4980812 |
7.7 % |
29/01/2024 |
| BVF Partners L.P. |
Delaware |
0 |
9544262 |
0 |
9544262 |
9544262 |
14.8 % |
29/01/2024 |
| Mark N. Lampert |
United States |
0 |
9544262 |
0 |
9544262 |
9544262 |
14.8 % |
29/01/2024 |
| BVF Inc. |
Delaware |
0 |
9544262 |
0 |
9544262 |
9544262 |
14.8 % |
29/01/2024 |
| BVF GP Holdings LLC |
Delaware |
0 |
8693162 |
0 |
8693162 |
8693162 |
13.5 % |
29/01/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
0 |
2224241 |
14312 |
2238553 |
4.33 % |
10/02/2022 |
| The Vanguard Group |
Pennsylvania |
0 |
0 |
2224241 |
14312 |
2238553 |
4.33 % |
10/02/2022 |
| BlackRock, Inc. |
Delaware |
865328 |
0 |
886148 |
0 |
886148 |
1.7 % |
12/07/2021 |
| Stephen DuBois Not applicable |
Stephen DuBois – United States |
0 |
2200000 |
0 |
2200000 |
2200000 |
4.6 % |
16/02/2021 |
| Camber Capital Management LP |
Delaware |
0 |
2200000 |
0 |
2200000 |
2200000 |
4.6 % |
16/02/2021 |
| Stephen DuBois Not applicable |
Stephen DuBois – United States |
0 |
2200000 |
0 |
2200000 |
2200000 |
4.6 % |
16/02/2021 |
| Camber Capital Management LP |
Delaware |
0 |
2200000 |
0 |
2200000 |
2200000 |
4.6 % |
16/02/2021 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
0 |
0 |
0 |
9 |
0 % |
12/02/2021 |
| Oleg Nodelman |
United States |
0 |
0 |
0 |
0 |
9 |
0 % |
12/02/2021 |
| EcoR1 Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
9 |
0 % |
12/02/2021 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
4980812 |
0 |
4980812 |
4980812 |
10.4 % |
11/02/2021 |
| BVF Inc. |
Delaware |
0 |
9544262 |
0 |
9544262 |
9544262 |
19.96 % |
11/02/2021 |
| BVF Partners L.P. |
Delaware |
0 |
9544262 |
0 |
9544262 |
9544262 |
19.96 % |
11/02/2021 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
8693162 |
0 |
8693162 |
8693162 |
18.2 % |
11/02/2021 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
630453 |
0 |
630453 |
630453 |
1.3 % |
11/02/2021 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
630453 |
0 |
630453 |
630453 |
1.3 % |
11/02/2021 |
| BVF II GP LLC |
Delaware |
0 |
3712350 |
0 |
3712350 |
3712350 |
7.8 % |
11/02/2021 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
3712350 |
0 |
3712350 |
3712350 |
7.8 % |
11/02/2021 |
| BVF I GP LLC |
Delaware |
0 |
4980812 |
0 |
4980812 |
4980812 |
10.4 % |
11/02/2021 |
| Mark N. Lampert |
United States |
0 |
9544262 |
0 |
9544262 |
9544262 |
19.96 % |
11/02/2021 |
| The Vanguard Group |
Pennsylvania |
0 |
25325 |
2535357 |
33882 |
2569239 |
5.37 % |
10/02/2021 |
| BlackRock, Inc. |
Delaware |
2563716 |
0 |
2616477 |
0 |
2616477 |
5.5 % |
29/01/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
10/12/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
10/12/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/12/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/12/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/12/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/12/2020 |
| Oleg Nodelman |
United States |
0 |
2909800 |
0 |
2909800 |
2909800 |
6.7 % |
20/07/2020 |
| EcoR1 Capital, LLC |
Delaware |
0 |
2909800 |
0 |
2909800 |
2909800 |
6.7 % |
20/07/2020 |
| Oleg Nodelman |
United States |
0 |
2909800 |
0 |
2909800 |
2909800 |
6.7 % |
20/07/2020 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
2462458 |
0 |
2462458 |
2462458 |
5.7 % |
20/07/2020 |
| EcoR1 Capital, LLC |
Delaware |
0 |
2909800 |
0 |
2909800 |
2909800 |
6.7 % |
20/07/2020 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
2462458 |
0 |
2462458 |
2462458 |
5.7 % |
20/07/2020 |
| Invesco Ltd. |
Bermuda |
36985 |
0 |
39273 |
0 |
39273 |
0.1 % |
10/07/2020 |
| Invesco Ltd. |
Bermuda |
2199609 |
0 |
2388306 |
0 |
2388306 |
5.5 % |
09/04/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
4363466 |
0 |
4522560 |
4522560 |
10.38 % |
09/04/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
4458449 |
0 |
4831896 |
4831896 |
11.09 % |
09/04/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
4458449 |
0 |
4831896 |
4831896 |
11.09 % |
09/04/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
4363466 |
0 |
4522560 |
4522560 |
10.38 % |
09/04/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4458449 |
0 |
4831896 |
4831896 |
11.09 % |
09/04/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
4458449 |
0 |
4831896 |
4831896 |
11.09 % |
09/04/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
4458449 |
0 |
4831896 |
4831896 |
11.09 % |
09/04/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4458449 |
0 |
4831896 |
4831896 |
11.09 % |
09/04/2020 |
| BVF II GP LLC |
Delaware |
0 |
2955440 |
0 |
2955440 |
2955440 |
6.8 % |
14/02/2020 |
| BVF I GP LLC |
Delaware |
0 |
3639935 |
0 |
3639935 |
3639935 |
8.4 % |
14/02/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
3639935 |
0 |
3639935 |
3639935 |
8.4 % |
14/02/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
6595375 |
0 |
6595375 |
6595375 |
15.2 % |
14/02/2020 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
528891 |
0 |
528891 |
528891 |
1.2 % |
14/02/2020 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
528891 |
0 |
528891 |
528891 |
1.2 % |
14/02/2020 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
2955440 |
0 |
2955440 |
2955440 |
6.8 % |
14/02/2020 |
| Mark N. Lampert |
United States |
0 |
7361801 |
0 |
7361801 |
7361801 |
17 % |
14/02/2020 |
| BVF Inc. |
Delaware |
0 |
7361801 |
0 |
7361801 |
7361801 |
17 % |
14/02/2020 |
| BVF Partners L.P. |
Delaware |
0 |
7361801 |
0 |
7361801 |
7361801 |
17 % |
14/02/2020 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
2134 |
0 |
2134 |
0 |
2134 |
0 % |
14/02/2020 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
2134 |
0 |
2134 |
0 |
2134 |
0 % |
14/02/2020 |
| Invesco Ltd. |
Bermuda |
4395572 |
0 |
4772724 |
0 |
4772724 |
11 % |
07/02/2020 |
| BlackRock, Inc. |
Delaware |
2788038 |
0 |
2828511 |
0 |
2828511 |
6.5 % |
05/02/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
3352133 |
0 |
3463104 |
3463104 |
7.99 % |
08/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3435099 |
0 |
3705977 |
3705977 |
8.55 % |
08/01/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
3352133 |
0 |
3463104 |
3463104 |
7.99 % |
08/01/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3435099 |
0 |
3705977 |
3705977 |
8.55 % |
08/01/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3435099 |
0 |
3705977 |
3705977 |
8.55 % |
08/01/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3435099 |
0 |
3705977 |
3705977 |
8.55 % |
08/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3435099 |
0 |
3705977 |
3705977 |
8.55 % |
08/01/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3435099 |
0 |
3705977 |
3705977 |
8.55 % |
08/01/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1809900 |
0 |
1809900 |
4.19 % |
10/09/2019 |
| FMR LLC |
Delaware |
1809900 |
0 |
1809900 |
0 |
1809900 |
4.19 % |
10/09/2019 |
| FMR LLC |
Delaware |
1809900 |
0 |
1809900 |
0 |
1809900 |
4.19 % |
10/09/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1809900 |
0 |
1809900 |
4.19 % |
10/09/2019 |
| Mark N. Lampert |
United States |
0 |
7361801 |
0 |
7361801 |
7361801 |
17 % |
09/09/2019 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
3639935 |
0 |
3639935 |
3639935 |
8.4 % |
09/09/2019 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
2955440 |
0 |
2955440 |
2955440 |
6.8 % |
09/09/2019 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
528891 |
0 |
528891 |
528891 |
1.2 % |
09/09/2019 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
528891 |
0 |
528891 |
528891 |
1.2 % |
09/09/2019 |
| BVF Partners L.P. |
Delaware |
0 |
7361801 |
0 |
7361801 |
7361801 |
17 % |
09/09/2019 |
| BVF Inc. |
Delaware |
0 |
7361801 |
0 |
7361801 |
7361801 |
17 % |
09/09/2019 |
| BVF Partners L.P. |
Delaware |
0 |
7361801 |
0 |
7361801 |
7361801 |
17 % |
09/09/2019 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
528891 |
0 |
528891 |
528891 |
1.2 % |
09/09/2019 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
528891 |
0 |
528891 |
528891 |
1.2 % |
09/09/2019 |
| Mark N. Lampert |
United States |
0 |
7361801 |
0 |
7361801 |
7361801 |
17 % |
09/09/2019 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
2955440 |
0 |
2955440 |
2955440 |
6.8 % |
09/09/2019 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
3639935 |
0 |
3639935 |
3639935 |
8.4 % |
09/09/2019 |
| BVF Inc. |
Delaware |
0 |
7361801 |
0 |
7361801 |
7361801 |
17 % |
09/09/2019 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
318185 |
0 |
318185 |
318185 |
0 % |
15/08/2019 |
| BVF Partners L.P. |
Delaware |
0 |
4436801 |
0 |
4436801 |
4436801 |
10.3 % |
15/08/2019 |
| BVF Inc. |
Delaware |
0 |
4436801 |
0 |
4436801 |
4436801 |
10.3 % |
15/08/2019 |
| Mark N. Lampert |
United States |
0 |
4436801 |
0 |
4436801 |
4436801 |
10.3 % |
15/08/2019 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
318185 |
0 |
318185 |
318185 |
0 % |
15/08/2019 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1783552 |
0 |
1783552 |
1783552 |
4.1 % |
15/08/2019 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2193128 |
0 |
2193128 |
2193128 |
5.1 % |
15/08/2019 |
| Mark N. Lampert |
United States |
0 |
4436801 |
0 |
4436801 |
4436801 |
10.3 % |
15/08/2019 |
| BVF Inc. |
Delaware |
0 |
4436801 |
0 |
4436801 |
4436801 |
10.3 % |
15/08/2019 |
| BVF Partners L.P. |
Delaware |
0 |
4436801 |
0 |
4436801 |
4436801 |
10.3 % |
15/08/2019 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
318185 |
0 |
318185 |
318185 |
0 % |
15/08/2019 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
318185 |
0 |
318185 |
318185 |
0 % |
15/08/2019 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1783552 |
0 |
1783552 |
1783552 |
4.1 % |
15/08/2019 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2193128 |
0 |
2193128 |
2193128 |
5.1 % |
15/08/2019 |
| Camber Capital Management LP |
Delaware |
0 |
3500000 |
0 |
3500000 |
3500000 |
8.1 % |
15/08/2019 |
| Camber Capital Management LP |
Delaware |
0 |
3500000 |
0 |
3500000 |
3500000 |
8.1 % |
15/08/2019 |
| Stephen DuBois Not applicable |
Stephen DuBois – United States |
0 |
3500000 |
0 |
3500000 |
3500000 |
8.1 % |
15/08/2019 |
| Stephen DuBois Not applicable |
Stephen DuBois – United States |
0 |
3500000 |
0 |
3500000 |
3500000 |
8.1 % |
15/08/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
6475154 |
0 |
6475154 |
14.995 % |
12/08/2019 |
| FMR LLC |
Delaware |
3322954 |
0 |
6475154 |
0 |
6475154 |
14.995 % |
12/08/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
6475154 |
0 |
6475154 |
14.995 % |
12/08/2019 |
| FMR LLC |
Delaware |
3322954 |
0 |
6475154 |
0 |
6475154 |
14.995 % |
12/08/2019 |
| Invesco Ltd. |
Bermuda |
4395577 |
0 |
4768257 |
0 |
4768257 |
11 % |
10/06/2019 |
| Redmile Group, LLC |
Delaware |
0 |
1978547 |
0 |
1978547 |
1978547 |
4.6 % |
14/02/2019 |
| Redmile Group, LLC |
Delaware |
0 |
1978547 |
0 |
1978547 |
1978547 |
4.6 % |
14/02/2019 |
| Jeremy C. Green |
United Kingdom |
0 |
1978547 |
0 |
1978547 |
1978547 |
4.6 % |
14/02/2019 |
| Jeremy C. Green |
United Kingdom |
0 |
1978547 |
0 |
1978547 |
1978547 |
4.6 % |
14/02/2019 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
534963 |
0 |
3462573 |
0 |
3462573 |
8 % |
14/02/2019 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
534963 |
0 |
3462573 |
0 |
3462573 |
8 % |
14/02/2019 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4893289 |
0 |
5319265 |
5319265 |
12.33 % |
12/02/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
4893289 |
0 |
5319265 |
5319265 |
12.33 % |
12/02/2019 |
| Wellington Group Holdings LLP |
Delaware |
0 |
4893289 |
0 |
5319265 |
5319265 |
12.33 % |
12/02/2019 |
| Wellington Management Company LLP |
Delaware |
0 |
4791092 |
0 |
5039186 |
5039186 |
11.68 % |
12/02/2019 |
| BlackRock, Inc. |
Delaware |
2774567 |
0 |
2844893 |
0 |
2844893 |
6.6 % |
07/02/2019 |
| Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
1968025 |
4.6 % |
28/01/2019 |
| Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
1968025 |
4.6 % |
28/01/2019 |
| Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
1968025 |
4.6 % |
28/01/2019 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
4743674 |
0 |
4743674 |
4743674 |
11 % |
11/01/2019 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
4426923 |
0 |
4426923 |
4426923 |
10.28 % |
06/09/2018 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
4426923 |
0 |
4426923 |
4426923 |
10.28 % |
06/09/2018 |
| Redmile Group, LLC |
DELAWARE |
0 |
1930668 |
0 |
1930668 |
1930668 |
5.62 % |
14/02/2018 |
| JEREMY C. GREEN |
UNITED KINGDOM |
0 |
1930668 |
0 |
1930668 |
1930668 |
5.62 % |
14/02/2018 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
162772 |
0 |
162772 |
162772 |
1 % |
14/02/2018 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
245349 |
0 |
245349 |
245349 |
1 % |
14/02/2018 |
| Mark N. Lampert |
United States |
0 |
497474 |
0 |
497474 |
497474 |
1.5 % |
14/02/2018 |
| BVF Inc. |
Delaware |
0 |
497474 |
0 |
497474 |
497474 |
1.5 % |
14/02/2018 |
| BVF Partners L.P. |
Delaware |
0 |
497474 |
0 |
497474 |
497474 |
1.5 % |
14/02/2018 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
42124 |
0 |
42124 |
42124 |
1 % |
14/02/2018 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
42124 |
0 |
42124 |
42124 |
1 % |
14/02/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
3221618 |
0 |
3445835 |
3445835 |
10.04 % |
08/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3257285 |
0 |
3578422 |
3578422 |
10.42 % |
08/02/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3257285 |
0 |
3578422 |
3578422 |
10.42 % |
08/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3257285 |
0 |
3578422 |
3578422 |
10.42 % |
08/02/2018 |
| Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
1929379 |
5.6 % |
06/02/2018 |
| Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
1929379 |
5.6 % |
06/02/2018 |
| Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
1929379 |
5.6 % |
06/02/2018 |
| Franklin Advisers, Inc. |
California |
1929379 |
0 |
1929379 |
0 |
1929379 |
5.6 % |
06/02/2018 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
1216873 |
0 |
1216873 |
1216873 |
3.5 % |
13/12/2017 |
| Mark N. Lampert |
United States |
0 |
2454786 |
0 |
2454786 |
2454786 |
7.2 % |
13/12/2017 |
| BVF Inc. |
Delaware |
0 |
2454786 |
0 |
2454786 |
2454786 |
7.2 % |
13/12/2017 |
| BVF Partners L.P. |
Delaware |
0 |
2454786 |
0 |
2454786 |
2454786 |
7.2 % |
13/12/2017 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
130701 |
0 |
130701 |
130701 |
0 % |
13/12/2017 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
130701 |
0 |
130701 |
130701 |
0 % |
13/12/2017 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
768801 |
0 |
768801 |
768801 |
2.2 % |
13/12/2017 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
1216873 |
0 |
1216873 |
1216873 |
3.5 % |
13/12/2017 |
| Mark N. Lampert |
United States |
0 |
2454786 |
0 |
2454786 |
2454786 |
7.2 % |
13/12/2017 |
| BVF Inc. |
Delaware |
0 |
2454786 |
0 |
2454786 |
2454786 |
7.2 % |
13/12/2017 |
| BVF Partners L.P. |
Delaware |
0 |
2454786 |
0 |
2454786 |
2454786 |
7.2 % |
13/12/2017 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
130701 |
0 |
130701 |
130701 |
0 % |
13/12/2017 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
130701 |
0 |
130701 |
130701 |
0 % |
13/12/2017 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
768801 |
0 |
768801 |
768801 |
2.2 % |
13/12/2017 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
1238770 |
0 |
1238770 |
1238770 |
5.4 % |
14/02/2017 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
817019 |
0 |
817019 |
817019 |
3.5 % |
14/02/2017 |
| Mark N. Lampert |
United States |
0 |
2826282 |
0 |
2826282 |
2826282 |
12.3 % |
14/02/2017 |
| BVF Inc. |
Delaware |
0 |
2826282 |
0 |
2826282 |
2826282 |
12.3 % |
14/02/2017 |
| BVF Partners L.P. |
Delaware |
0 |
2826282 |
0 |
2826282 |
2826282 |
12.3 % |
14/02/2017 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
249533 |
0 |
249533 |
249533 |
1.1 % |
14/02/2017 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
249533 |
0 |
249533 |
249533 |
1.1 % |
14/02/2017 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2495669 |
0 |
2799917 |
2799917 |
12.14 % |
09/02/2017 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2495669 |
0 |
2799917 |
2799917 |
12.14 % |
09/02/2017 |
| Wellington Management Company LLP |
Delaware |
0 |
2454229 |
0 |
2678028 |
2678028 |
11.61 % |
09/02/2017 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2495669 |
0 |
2799917 |
2799917 |
12.14 % |
09/02/2017 |
| Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
999979 |
4.3 % |
07/02/2017 |
| Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
999979 |
4.3 % |
07/02/2017 |
| Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
999979 |
4.3 % |
07/02/2017 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
691422 |
0 |
691422 |
691422 |
3.1 % |
27/06/2016 |
| Mark N. Lampert |
United States |
0 |
2447415 |
0 |
2447415 |
2447415 |
10.8 % |
27/06/2016 |
| BVF Partners L.P. |
Delaware |
0 |
2447415 |
0 |
2447415 |
2447415 |
10.8 % |
27/06/2016 |
| BVF Inc. |
Delaware |
0 |
2447415 |
0 |
2447415 |
2447415 |
10.8 % |
27/06/2016 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
206336 |
0 |
206336 |
206336 |
0 % |
27/06/2016 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
206336 |
0 |
206336 |
206336 |
0 % |
27/06/2016 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
691422 |
0 |
691422 |
691422 |
3.1 % |
27/06/2016 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
1053678 |
0 |
1053678 |
1053678 |
4.7 % |
27/06/2016 |
| Mark N. Lampert |
United States |
0 |
2447415 |
0 |
2447415 |
2447415 |
10.8 % |
27/06/2016 |
| BVF Inc. |
Delaware |
0 |
2447415 |
0 |
2447415 |
2447415 |
10.8 % |
27/06/2016 |
| BVF Partners L.P. |
Delaware |
0 |
2447415 |
0 |
2447415 |
2447415 |
10.8 % |
27/06/2016 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
206336 |
0 |
206336 |
206336 |
0 % |
27/06/2016 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
206336 |
0 |
206336 |
206336 |
0 % |
27/06/2016 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
1053678 |
0 |
1053678 |
1053678 |
4.7 % |
27/06/2016 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2375967 |
0 |
2625363 |
2625363 |
13.79 % |
11/02/2016 |
| Wellington Management Company LLP |
Delaware |
0 |
2334527 |
0 |
2512621 |
2512621 |
13.2 % |
11/02/2016 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2375967 |
0 |
2625363 |
2625363 |
13.79 % |
11/02/2016 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2375967 |
0 |
2625363 |
2625363 |
13.79 % |
11/02/2016 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2352707 |
0 |
2599011 |
2599011 |
13.76 % |
12/02/2015 |
| S Wellington Management Company, LLP |
Massachusetts |
0 |
1737980 |
0 |
2007580 |
2007580 |
10.79 % |
10/02/2014 |