| Abigail P. Johnson |
United States of America |
0 |
0 |
7734 |
0 |
7734 |
0.01 % |
12/09/2022 |
| FMR LLC |
Delaware |
5554 |
0 |
7734 |
0 |
7734 |
0.01 % |
12/09/2022 |
| Thomas J. Schall, Ph.D. |
United States |
4525787 |
0 |
4525787 |
0 |
4525787 |
6.5 % |
14/02/2022 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| RA Capital Healthcare Fund, L.P. |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Rajeev Shah |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| RA Capital Healthcare Fund, L.P. |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Rajeev Shah |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| The Vanguard Group |
Pennsylvania |
0 |
46258 |
5009145 |
89835 |
5098980 |
7.28 % |
09/02/2022 |
| BlackRock, Inc. |
Delaware |
4146924 |
0 |
4326487 |
0 |
4326487 |
6.2 % |
02/02/2022 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
393973 |
0 |
482747 |
482747 |
0.69 % |
09/06/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
393973 |
0 |
482747 |
482747 |
0.69 % |
09/06/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
393973 |
0 |
482747 |
482747 |
0.69 % |
09/06/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
393973 |
0 |
482747 |
482747 |
0.69 % |
09/06/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
393973 |
0 |
482747 |
482747 |
0.69 % |
09/06/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
393973 |
0 |
482747 |
482747 |
0.69 % |
09/06/2021 |
| Peter Kolchinsky |
United States |
0 |
4776548 |
0 |
4776548 |
4776548 |
6.9 % |
16/02/2021 |
| RA Capital Healthcare Fund, L.P. |
United States |
0 |
4316653 |
0 |
4316653 |
4316653 |
6.2 % |
16/02/2021 |
| Rajeev Shah |
United States |
0 |
4776548 |
0 |
4776548 |
4776548 |
6.9 % |
16/02/2021 |
| Peter Kolchinsky |
United States |
0 |
4776548 |
0 |
4776548 |
4776548 |
6.9 % |
16/02/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
4776548 |
0 |
4776548 |
4776548 |
6.9 % |
16/02/2021 |
| Rajeev Shah |
United States |
0 |
4776548 |
0 |
4776548 |
4776548 |
6.9 % |
16/02/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
4776548 |
0 |
4776548 |
4776548 |
6.9 % |
16/02/2021 |
| RA Capital Healthcare Fund, L.P. |
United States |
0 |
4316653 |
0 |
4316653 |
4316653 |
6.2 % |
16/02/2021 |
| Cormorant Asset Management, LP |
Delaware |
|
|
|
|
1200000 |
1.7 % |
16/02/2021 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
|
|
|
|
1154566 |
1.7 % |
16/02/2021 |
| Bihua Chen |
United States |
0 |
1200000 |
0 |
1200000 |
1200000 |
1.7 % |
16/02/2021 |
| Cormorant Asset Management, LP |
Delaware |
0 |
1200000 |
0 |
1200000 |
1200000 |
1.7 % |
16/02/2021 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
1154566 |
0 |
1154566 |
1154566 |
1.7 % |
16/02/2021 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1154566 |
0 |
1154566 |
1154566 |
1.7 % |
16/02/2021 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
|
|
|
|
1154566 |
1.7 % |
16/02/2021 |
| Bihua Chen |
United States |
|
|
|
|
1200000 |
1.7 % |
16/02/2021 |
| Thomas J. Schall, Ph.D. |
United States citizen |
4337412 |
0 |
4337412 |
0 |
4337412 |
6.3 % |
16/02/2021 |
| Thomas J. Schall, Ph.D. |
United States |
4337412 |
0 |
4337412 |
0 |
4337412 |
6.3 % |
16/02/2021 |
| The Vanguard Group |
Pennsylvania |
0 |
114374 |
4592356 |
155114 |
4747470 |
6.86 % |
10/02/2021 |
| FMR LLC |
Delaware |
2886038 |
0 |
10381262 |
0 |
10381262 |
14.999 % |
08/02/2021 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
10381262 |
0 |
10381262 |
14.999 % |
08/02/2021 |
| FMR LLC |
Delaware |
2886038 |
0 |
10381262 |
0 |
10381262 |
14.999 % |
08/02/2021 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
10381262 |
0 |
10381262 |
14.999 % |
08/02/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
5527133 |
0 |
6057953 |
6057953 |
8.75 % |
03/02/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
5545757 |
0 |
6148679 |
6148679 |
8.88 % |
03/02/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
5527133 |
0 |
6057953 |
6057953 |
8.75 % |
03/02/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5545757 |
0 |
6148679 |
6148679 |
8.88 % |
03/02/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
5545757 |
0 |
6148679 |
6148679 |
8.88 % |
03/02/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
5545757 |
0 |
6148679 |
6148679 |
8.88 % |
03/02/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
5545757 |
0 |
6148679 |
6148679 |
8.88 % |
03/02/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5545757 |
0 |
6148679 |
6148679 |
8.88 % |
03/02/2021 |
| BlackRock, Inc. |
Delaware |
4739576 |
0 |
4804697 |
0 |
4804697 |
6.9 % |
28/01/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
6374881 |
0 |
7014146 |
7014146 |
10.18 % |
10/11/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
6350237 |
0 |
6901632 |
6901632 |
10.02 % |
10/11/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
6374881 |
0 |
7014146 |
7014146 |
10.18 % |
10/11/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
6374881 |
0 |
7014146 |
7014146 |
10.18 % |
10/11/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
6374881 |
0 |
7014146 |
7014146 |
10.18 % |
10/11/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
6374881 |
0 |
7014146 |
7014146 |
10.18 % |
10/11/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
6350237 |
0 |
6901632 |
6901632 |
10.02 % |
10/11/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
6374881 |
0 |
7014146 |
7014146 |
10.18 % |
10/11/2020 |
| Rajeev Shah |
United States |
0 |
3199389 |
0 |
3199389 |
3199389 |
5.5 % |
14/02/2020 |
| Peter Kolchinsky |
United States |
0 |
3199389 |
0 |
3199389 |
3199389 |
5.5 % |
14/02/2020 |
| Peter Kolchinsky |
United States |
0 |
3199389 |
0 |
3199389 |
3199389 |
5.5 % |
14/02/2020 |
| RA Capital Management, L.P. |
Delaware |
0 |
3199389 |
0 |
3199389 |
3199389 |
5.5 % |
14/02/2020 |
| Rajeev Shah |
United States |
0 |
3199389 |
0 |
3199389 |
3199389 |
5.5 % |
14/02/2020 |
| RA Capital Management, L.P. |
Delaware |
0 |
3199389 |
0 |
3199389 |
3199389 |
5.5 % |
14/02/2020 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Mark N. Lampert |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| BVF I GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Thomas J. Schall, Ph.D. |
United States |
4684775 |
0 |
4684775 |
0 |
4684775 |
8 % |
13/02/2020 |
| FMR LLC |
Delaware |
2228338 |
0 |
8740285 |
0 |
8740285 |
14.999 % |
07/02/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
8740285 |
0 |
8740285 |
14.999 % |
07/02/2020 |
| BlackRock, Inc. |
Delaware |
3973787 |
0 |
4113156 |
0 |
4113156 |
7.1 % |
07/02/2020 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
|
|
|
|
2954814 |
5.07 % |
10/01/2020 |
| Cormorant Asset Management, LP |
Delaware |
|
|
|
|
3150000 |
5.41 % |
10/01/2020 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
|
|
|
|
2954814 |
5.07 % |
10/01/2020 |
| Bihua Chen |
United States |
|
|
|
|
3150000 |
5.41 % |
10/01/2020 |
| Cormorant Asset Management, LP |
Delaware |
|
|
|
|
3150000 |
5.41 % |
10/01/2020 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
|
|
|
|
2954814 |
5.07 % |
10/01/2020 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
|
|
|
|
2954814 |
5.07 % |
10/01/2020 |
| Bihua Chen |
United States |
|
|
|
|
3150000 |
5.41 % |
10/01/2020 |
| Cormorant Asset Management, LP |
Delaware |
|
|
|
|
3300000 |
5.66 % |
16/12/2019 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
|
|
|
|
3095416 |
5.31 % |
16/12/2019 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
|
|
|
|
3095416 |
5.31 % |
16/12/2019 |
| Bihua Chen |
United States |
|
|
|
|
3300000 |
5.66 % |
16/12/2019 |
| Cormorant Asset Management, LP |
Delaware |
|
|
|
|
3300000 |
5.66 % |
16/12/2019 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
|
|
|
|
3095416 |
5.31 % |
16/12/2019 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
|
|
|
|
3095416 |
5.31 % |
16/12/2019 |
| Bihua Chen |
United States |
|
|
|
|
3300000 |
5.66 % |
16/12/2019 |
| BlackRock, Inc. |
Delaware |
2569728 |
0 |
2713033 |
0 |
2713033 |
4.7 % |
10/05/2019 |
| FMR LLC |
Delaware |
1512400 |
0 |
5774432 |
0 |
5774432 |
10.984 % |
10/04/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5774432 |
0 |
5774432 |
10.984 % |
10/04/2019 |
| FMR LLC |
Delaware |
1512400 |
0 |
5774432 |
0 |
5774432 |
10.984 % |
10/04/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5774432 |
0 |
5774432 |
10.984 % |
10/04/2019 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
218860 |
0 |
218860 |
218860 |
1 % |
14/02/2019 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1254178 |
0 |
1254178 |
1254178 |
2.5 % |
14/02/2019 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
1512463 |
0 |
1512463 |
1512463 |
3 % |
14/02/2019 |
| Mark N. Lampert |
United States |
0 |
4105215 |
0 |
4105215 |
4105215 |
8.1 % |
14/02/2019 |
| BVF Inc. |
Delaware |
0 |
4105215 |
0 |
4105215 |
4105215 |
8.1 % |
14/02/2019 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
218860 |
0 |
218860 |
218860 |
1 % |
14/02/2019 |
| BVF Partners L.P. |
Delaware |
0 |
4105215 |
0 |
4105215 |
4105215 |
8.1 % |
14/02/2019 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2172757 |
0 |
2172757 |
2172757 |
4.3 % |
14/02/2019 |
| Mark N. Lampert |
United States |
0 |
6687523 |
0 |
6687523 |
6687523 |
13.2 % |
14/02/2019 |
| BVF Inc. |
Delaware |
0 |
6687523 |
0 |
6687523 |
6687523 |
13.2 % |
14/02/2019 |
| BVF Partners L.P. |
Delaware |
0 |
6687523 |
0 |
6687523 |
6687523 |
13.2 % |
14/02/2019 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
308246 |
0 |
308246 |
308246 |
1 % |
14/02/2019 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
308246 |
0 |
308246 |
308246 |
1 % |
14/02/2019 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1708227 |
0 |
1708227 |
1708227 |
3.4 % |
14/02/2019 |
| Thomas J. Schall, Ph.D. |
United States |
4834663 |
0 |
4834663 |
0 |
4834663 |
9.1 % |
13/02/2019 |
| BlackRock, Inc. |
Delaware |
2577503 |
0 |
2729701 |
0 |
2729701 |
5.4 % |
04/02/2019 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2439556 |
0 |
2439556 |
2439556 |
5 % |
14/02/2018 |
| Mark N. Lampert |
United States |
0 |
7587416 |
0 |
7587416 |
7587416 |
15.6 % |
14/02/2018 |
| BVF Inc. |
Delaware |
0 |
7587416 |
0 |
7587416 |
7587416 |
15.6 % |
14/02/2018 |
| BVF Partners L.P. |
Delaware |
0 |
7587416 |
0 |
7587416 |
7587416 |
15.6 % |
14/02/2018 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
430792 |
0 |
430792 |
430792 |
0 % |
14/02/2018 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
430792 |
0 |
430792 |
430792 |
0 % |
14/02/2018 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1570041 |
0 |
1570041 |
1570041 |
3.2 % |
14/02/2018 |
| Mark N. Lampert |
United States |
0 |
7587416 |
0 |
7587416 |
7587416 |
15.6 % |
14/02/2018 |
| BVF Partners L.P. |
Delaware |
0 |
7587416 |
0 |
7587416 |
7587416 |
15.6 % |
14/02/2018 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
430792 |
0 |
430792 |
430792 |
0 % |
14/02/2018 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
430792 |
0 |
430792 |
430792 |
0 % |
14/02/2018 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1570041 |
0 |
1570041 |
1570041 |
3.2 % |
14/02/2018 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2439556 |
0 |
2439556 |
2439556 |
5 % |
14/02/2018 |
| BVF Inc. |
Delaware |
0 |
7587416 |
0 |
7587416 |
7587416 |
15.6 % |
14/02/2018 |
| Thomas J. Schall, Ph.D. |
United States |
4857630 |
0 |
4857630 |
0 |
4857630 |
9.4 % |
13/02/2018 |
| BlackRock, Inc. |
Delaware |
2687478 |
0 |
2742607 |
0 |
2742607 |
5.6 % |
01/02/2018 |
| BVF Inc. |
Delaware |
0 |
7798572 |
0 |
7798572 |
7798572 |
16.3 % |
14/02/2017 |
| BVF Partners L.P. |
Delaware |
0 |
7798572 |
0 |
7798572 |
7798572 |
16.3 % |
14/02/2017 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
503463 |
0 |
503463 |
503463 |
1.1 % |
14/02/2017 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
503463 |
0 |
503463 |
503463 |
1.1 % |
14/02/2017 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2472477 |
0 |
2472477 |
2472477 |
5.2 % |
14/02/2017 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1433473 |
0 |
1433473 |
1433473 |
3 % |
14/02/2017 |
| Mark N. Lampert |
United States |
0 |
7798572 |
0 |
7798572 |
7798572 |
16.3 % |
14/02/2017 |
| Capital World Investors |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2017 |
| Thomas J. Schall, Ph.D. |
United States |
4417876 |
0 |
4417876 |
0 |
4417876 |
8.8 % |
13/02/2017 |
| Vifor (International) Ltd |
Switzerland |
3333333 |
0 |
3333333 |
0 |
3333333 |
7 % |
23/05/2016 |
| Atlas Enhanced Fund, Ltd. |
Cayman |
953478 |
0 |
953478 |
0 |
953478 |
2.16 % |
16/02/2016 |
| Atlas Institutional Fund, LLC |
Delaware |
607932 |
0 |
607932 |
0 |
607932 |
1.38 % |
16/02/2016 |
| Atlas Global Investments, Ltd. |
Cayman |
607932 |
0 |
607932 |
0 |
607932 |
1.38 % |
16/02/2016 |
| Atlas Global, LLC |
Delaware |
607932 |
0 |
607932 |
0 |
607932 |
1.38 % |
16/02/2016 |
| Atlas Master Fund, Ltd. |
Cayman |
607932 |
0 |
607932 |
0 |
607932 |
1.38 % |
16/02/2016 |
| Atlas Global Japan Unit Trust |
Cayman |
607932 |
0 |
607932 |
0 |
607932 |
1.38 % |
16/02/2016 |
| Atlas Institutional Fund II, Ltd. |
Cayman |
607932 |
0 |
607932 |
0 |
607932 |
1.38 % |
16/02/2016 |
| Dmitry Balyasny |
United States |
1631326 |
0 |
1631326 |
0 |
1631326 |
3.7 % |
16/02/2016 |
| Atlas Institutional Fund II, LLC |
Delaware |
607932 |
0 |
607932 |
0 |
607932 |
1.38 % |
16/02/2016 |
| Atlas Institutional Fund, Ltd. |
Cayman |
607932 |
0 |
607932 |
0 |
607932 |
1.38 % |
16/02/2016 |
| Balyasny Asset Management L.P. |
Delaware |
1631326 |
0 |
1631326 |
0 |
1631326 |
3.7 % |
16/02/2016 |
| Atlas Enhanced Master Fund, Ltd. |
Cayman |
953478 |
0 |
953478 |
0 |
953478 |
2.16 % |
16/02/2016 |
| Lyxor/Balyasny Atlas Enhanced Fund Limited |
Jersey |
69916 |
0 |
69916 |
0 |
69916 |
0.16 % |
16/02/2016 |
| Atlas Enhanced Fund, L.P. |
Delaware |
953478 |
0 |
953478 |
0 |
953478 |
2.16 % |
16/02/2016 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1433473 |
0 |
1433473 |
1433473 |
3.3 % |
05/02/2016 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
503463 |
0 |
503463 |
503463 |
1.1 % |
05/02/2016 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
503463 |
0 |
503463 |
503463 |
1.1 % |
05/02/2016 |
| BVF Partners L.P. |
Delaware |
0 |
7229952 |
0 |
7229952 |
7229952 |
16.4 % |
05/02/2016 |
| BVF Inc. |
Delaware |
0 |
7229952 |
0 |
7229952 |
7229952 |
16.4 % |
05/02/2016 |
| Mark N. Lampert |
United States |
0 |
7229952 |
0 |
7229952 |
7229952 |
16.4 % |
05/02/2016 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2472477 |
0 |
2472477 |
2472477 |
5.6 % |
05/02/2016 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2472477 |
0 |
2472477 |
2472477 |
5.6 % |
05/02/2016 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1433473 |
0 |
1433473 |
1433473 |
3.3 % |
05/02/2016 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
503463 |
0 |
503463 |
503463 |
1.1 % |
05/02/2016 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
503463 |
0 |
503463 |
503463 |
1.1 % |
05/02/2016 |
| BVF Partners L.P. |
Delaware |
0 |
7229952 |
0 |
7229952 |
7229952 |
16.4 % |
05/02/2016 |
| BVF Inc. |
Delaware |
0 |
7229952 |
0 |
7229952 |
7229952 |
16.4 % |
05/02/2016 |
| Mark N. Lampert |
United States |
0 |
7229952 |
0 |
7229952 |
7229952 |
16.4 % |
05/02/2016 |
| Samana Capital, L.P. |
Delaware |
0 |
28881 |
0 |
28881 |
28881 |
0.1 % |
13/11/2015 |
| Morton Holdings, Inc. |
Delaware |
0 |
28881 |
0 |
28881 |
28881 |
0.1 % |
13/11/2015 |
| Philip B. Korsant |
United States of America |
0 |
28881 |
0 |
28881 |
28881 |
0.1 % |
13/11/2015 |
| MSI BVF SPV, LLC |
Delaware |
0 |
646327 |
0 |
646327 |
646327 |
1.5 % |
09/11/2015 |
| BVF Partners L.P. |
Delaware |
0 |
4832263 |
0 |
4832263 |
4832263 |
11 % |
09/11/2015 |
| BVF Inc. |
Delaware |
0 |
4832263 |
0 |
4832263 |
4832263 |
11 % |
09/11/2015 |
| Mark N. Lampert |
United States |
0 |
4832263 |
0 |
4832263 |
4832263 |
11 % |
09/11/2015 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2162381 |
0 |
2162381 |
2162381 |
4.9 % |
09/11/2015 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1251914 |
0 |
1251914 |
1251914 |
2.8 % |
09/11/2015 |
| BVF Investments, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/11/2015 |
| Investment 10, L.L.C. |
Illinois |
0 |
414814 |
0 |
414814 |
414814 |
0 % |
09/11/2015 |
| MSI BVF SPV, LLC |
Delaware |
0 |
646327 |
0 |
646327 |
646327 |
1.5 % |
09/11/2015 |
| BVF Partners L.P. |
Delaware |
0 |
4832263 |
0 |
4832263 |
4832263 |
11 % |
09/11/2015 |
| BVF Inc. |
Delaware |
0 |
4832263 |
0 |
4832263 |
4832263 |
11 % |
09/11/2015 |
| Mark N. Lampert |
United States |
0 |
4832263 |
0 |
4832263 |
4832263 |
11 % |
09/11/2015 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1251914 |
0 |
1251914 |
1251914 |
2.8 % |
09/11/2015 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2162381 |
0 |
2162381 |
2162381 |
4.9 % |
09/11/2015 |
| BVF Investments, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/11/2015 |
| Investment 10, L.L.C. |
Illinois |
0 |
414814 |
0 |
414814 |
414814 |
0 % |
09/11/2015 |
| Atlas Institutional Fund II, LLC |
Delaware |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Dmitry Balyasny |
United States |
2193700 |
0 |
2193700 |
0 |
2193700 |
5.02 % |
30/06/2015 |
| Balyasny Asset Management L.P. |
Delaware |
2193700 |
0 |
2193700 |
0 |
2193700 |
5.02 % |
30/06/2015 |
| Lyxor/Balyasny Atlas Enhanced Fund Limited |
Jersey |
94459 |
0 |
94459 |
0 |
94459 |
0.22 % |
30/06/2015 |
| Atlas Institutional Fund, Ltd. |
Cayman |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Institutional Fund, LLC |
Delaware |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Global Investments, Ltd. |
Cayman |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Global, LLC |
Delaware |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Master Fund, Ltd. |
Cayman |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Dmitry Balyasny |
United States |
2193700 |
0 |
2193700 |
0 |
2193700 |
5.02 % |
30/06/2015 |
| Balyasny Asset Management L.P. |
Delaware |
2193700 |
0 |
2193700 |
0 |
2193700 |
5.02 % |
30/06/2015 |
| Lyxor/Balyasny Atlas Enhanced Fund Limited |
Jersey |
94459 |
0 |
94459 |
0 |
94459 |
0.22 % |
30/06/2015 |
| Atlas Enhanced Fund, Ltd. |
Cayman |
1165444 |
0 |
1165444 |
0 |
1165444 |
2.67 % |
30/06/2015 |
| Atlas Enhanced Fund, L.P. |
Delaware |
1165444 |
0 |
1165444 |
0 |
1165444 |
2.67 % |
30/06/2015 |
| Atlas Enhanced Master Fund, Ltd. |
Cayman |
1165444 |
0 |
1165444 |
0 |
1165444 |
2.67 % |
30/06/2015 |
| Atlas Global Japan Unit Trust |
Cayman |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Institutional Fund II, Ltd. |
Cayman |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Institutional Fund II, LLC |
Delaware |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Institutional Fund, Ltd. |
Cayman |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Institutional Fund, LLC |
Delaware |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Global Investments, Ltd. |
Cayman |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Global, LLC |
Delaware |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Master Fund, Ltd. |
Cayman |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Enhanced Fund, Ltd. |
Cayman |
1165444 |
0 |
1165444 |
0 |
1165444 |
2.67 % |
30/06/2015 |
| Atlas Enhanced Fund, L.P. |
Delaware |
1165444 |
0 |
1165444 |
0 |
1165444 |
2.67 % |
30/06/2015 |
| Atlas Enhanced Master Fund, Ltd. |
Cayman |
1165444 |
0 |
1165444 |
0 |
1165444 |
2.67 % |
30/06/2015 |
| Atlas Global Japan Unit Trust |
Cayman |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Atlas Institutional Fund II, Ltd. |
Cayman |
933797 |
0 |
933797 |
0 |
933797 |
2.14 % |
30/06/2015 |
| Thomas J. Schall, Ph.D. |
United States |
3764140 |
0 |
3764140 |
0 |
3764140 |
8.4 % |
17/02/2015 |
| Thomas J. Schall, Ph.D. |
United States citizen |
3764140 |
0 |
3764140 |
0 |
3764140 |
8.4 % |
17/02/2015 |
| Atlas Institutional Fund, Ltd. |
Cayman |
885126 |
0 |
885126 |
0 |
885126 |
2.04 % |
13/02/2015 |
| Atlas Institutional Fund II, LLC |
Delaware |
885126 |
0 |
885126 |
0 |
885126 |
2.04 % |
13/02/2015 |
| Atlas Institutional Fund II, Ltd. |
Cayman |
885126 |
0 |
885126 |
0 |
885126 |
2.04 % |
13/02/2015 |
| Atlas Global Japan Unit Trust |
Cayman |
885126 |
0 |
885126 |
0 |
885126 |
2.04 % |
13/02/2015 |
| Atlas Enhanced Master Fund, Ltd. |
Cayman |
850174 |
0 |
850174 |
0 |
850174 |
1.96 % |
13/02/2015 |
| Atlas Enhanced Fund, L.P. |
Delaware |
850174 |
0 |
850174 |
0 |
850174 |
1.96 % |
13/02/2015 |
| Atlas Enhanced Fund, Ltd. |
Cayman |
850174 |
0 |
850174 |
0 |
850174 |
1.96 % |
13/02/2015 |
| Atlas Global, LLC |
Delaware |
885126 |
0 |
885126 |
0 |
885126 |
2.04 % |
13/02/2015 |
| Atlas Master Fund, Ltd. |
Cayman |
885126 |
0 |
885126 |
0 |
885126 |
2.04 % |
13/02/2015 |
| Atlas Institutional Fund, LLC |
Delaware |
885126 |
0 |
885126 |
0 |
885126 |
2.04 % |
13/02/2015 |
| Atlas Global Investments, Ltd. |
Cayman |
885126 |
0 |
885126 |
0 |
885126 |
2.04 % |
13/02/2015 |
| Balyasny Asset Management L.P. |
Delaware |
1810456 |
0 |
1810456 |
0 |
1810456 |
4.18 % |
13/02/2015 |
| Lyxor/Balyasny Atlas Enhanced Fund Limited |
Jersey |
75156 |
0 |
75156 |
0 |
75156 |
17 % |
13/02/2015 |
| Dmitry Balyasny |
United States |
1810456 |
0 |
1810456 |
0 |
1810456 |
4.18 % |
13/02/2015 |
| Atlas Global Investments, Ltd. |
Cayman |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Fundamental Trading Master Fund, Ltd. |
Cayman |
73396 |
0 |
73396 |
0 |
73396 |
0 % |
02/06/2014 |
| Atlas Enhanced Fund, Ltd. |
Cayman |
789663 |
0 |
789663 |
0 |
789663 |
1.83 % |
02/06/2014 |
| Atlas Enhanced Fund, L.P. |
Delaware |
789663 |
0 |
789663 |
0 |
789663 |
1.83 % |
02/06/2014 |
| Atlas Enhanced Master Fund, Ltd. |
Cayman |
789663 |
0 |
789663 |
0 |
789663 |
1.83 % |
02/06/2014 |
| Atlas Global Japan Unit Trust |
Cayman |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Institutional Fund II, Ltd. |
Cayman |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Institutional Fund II, LLC |
Delaware |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Institutional Fund, Ltd. |
Cayman |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Institutional Fund, LLC |
Delaware |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Fundamental Trading Fund, L.P. |
Delaware |
73396 |
0 |
73396 |
0 |
73396 |
0 % |
02/06/2014 |
| Atlas Global, LLC |
Delaware |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Master Fund, Ltd. |
Cayman |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Dmitry Balyasny |
United States |
2716795 |
0 |
2716795 |
0 |
2716795 |
5.04 % |
02/06/2014 |
| Balyasny Asset Management L.P. |
Delaware |
2716795 |
0 |
2716795 |
0 |
2716795 |
5.04 % |
02/06/2014 |
| Dmitry Balyasny |
United States |
2716795 |
0 |
2716795 |
0 |
2716795 |
5.04 % |
02/06/2014 |
| Balyasny Asset Management L.P. |
Delaware |
2716795 |
0 |
2716795 |
0 |
2716795 |
5.04 % |
02/06/2014 |
| Lyxor/Balyasny Atlas Enhanced Fund Limited |
Jersey |
119949 |
0 |
119949 |
0 |
119949 |
0 % |
02/06/2014 |
| Atlas Fundamental Trading Fund, Ltd. |
Cayman |
73396 |
0 |
73396 |
0 |
73396 |
0 % |
02/06/2014 |
| Atlas Fundamental Trading Fund, L.P. |
Delaware |
73396 |
0 |
73396 |
0 |
73396 |
0 % |
02/06/2014 |
| Atlas Fundamental Trading Master Fund, Ltd. |
Cayman |
73396 |
0 |
73396 |
0 |
73396 |
0 % |
02/06/2014 |
| Atlas Enhanced Fund, Ltd. |
Cayman |
789663 |
0 |
789663 |
0 |
789663 |
1.83 % |
02/06/2014 |
| Atlas Enhanced Fund, L.P. |
Delaware |
789663 |
0 |
789663 |
0 |
789663 |
1.83 % |
02/06/2014 |
| Atlas Enhanced Master Fund, Ltd. |
Cayman |
789663 |
0 |
789663 |
0 |
789663 |
1.83 % |
02/06/2014 |
| Atlas Global Japan Unit Trust |
Cayman |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Institutional Fund II, Ltd. |
Cayman |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Institutional Fund II, LLC |
Delaware |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Institutional Fund, Ltd. |
Cayman |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Institutional Fund, LLC |
Delaware |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Global Investments, Ltd. |
Cayman |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Global, LLC |
Delaware |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Atlas Master Fund, Ltd. |
Cayman |
1193787 |
0 |
1193787 |
0 |
1193787 |
2.77 % |
02/06/2014 |
| Lyxor/Balyasny Atlas Enhanced Fund Limited |
Jersey |
119949 |
0 |
119949 |
0 |
119949 |
0 % |
02/06/2014 |
| Atlas Fundamental Trading Fund, Ltd. |
Cayman |
73396 |
0 |
73396 |
0 |
73396 |
0 % |
02/06/2014 |
| HBM Healthcare Investments Ltd. |
Cayman Islands British West Indies |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2014 |
| Capital World Investors |
Delaware |
3131800 |
0 |
3131800 |
0 |
3131800 |
7.3 % |
13/02/2014 |
| Thomas J. Schall, Ph.D. |
United States |
3531639 |
0 |
3531639 |
0 |
3531639 |
8 % |
12/02/2014 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2345325 |
0 |
2345325 |
2345325 |
5.5 % |
13/09/2013 |
| RA Capital Management, LLC |
Massachusetts |
0 |
3045380 |
0 |
3045380 |
3045380 |
7.1 % |
13/09/2013 |
| Peter Kolchinsky |
United States |
0 |
3045380 |
0 |
3045380 |
3045380 |
7.1 % |
13/09/2013 |
| RA Capital Management, LLC |
Massachusetts |
0 |
3045380 |
0 |
3045380 |
3045380 |
7.1 % |
13/09/2013 |
| Peter Kolchinsky |
United States |
0 |
3045380 |
0 |
3045380 |
3045380 |
7.1 % |
13/09/2013 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2345325 |
0 |
2345325 |
2345325 |
5.5 % |
13/09/2013 |
| HealthCap III Sidefund, K.B. |
Sweden |
0 |
1602429 |
0 |
1602429 |
1602429 |
3.76 % |
15/05/2013 |
| OFCO Club |
Sweden |
0 |
1602429 |
0 |
1602429 |
1602429 |
3.76 % |
15/05/2013 |
| HealthCap 1999 GbR |
Germany |
0 |
1602429 |
0 |
1602429 |
1602429 |
3.76 % |
15/05/2013 |
| HealthCap 1999, K.B. |
Sweden |
0 |
1602429 |
0 |
1602429 |
1602429 |
3.76 % |
15/05/2013 |
| OFCO Club III Sidefund |
Sweden |
0 |
1602429 |
0 |
1602429 |
1602429 |
3.76 % |
15/05/2013 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
376150 |
0 |
376150 |
376150 |
1 % |
31/08/2012 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
651640 |
0 |
651640 |
651640 |
1.8 % |
31/08/2012 |
| Mark N. Lampert |
United States |
0 |
4986766 |
0 |
4986766 |
4986766 |
13.8 % |
31/08/2012 |
| BVF Partners L.P. |
Delaware |
0 |
4986766 |
0 |
4986766 |
4986766 |
13.8 % |
31/08/2012 |
| BVF Inc. |
Delaware |
0 |
4986766 |
0 |
4986766 |
4986766 |
13.8 % |
31/08/2012 |
| Mark N. Lampert |
United States |
0 |
4986766 |
0 |
4986766 |
4986766 |
13.8 % |
31/08/2012 |
| BVF Inc. |
Delaware |
0 |
4986766 |
0 |
4986766 |
4986766 |
13.8 % |
31/08/2012 |
| BVF Partners L.P. |
Delaware |
0 |
4986766 |
0 |
4986766 |
4986766 |
13.8 % |
31/08/2012 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
651640 |
0 |
651640 |
651640 |
1.8 % |
31/08/2012 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
376150 |
0 |
376150 |
376150 |
1 % |
31/08/2012 |
| BVF Investments, L.L.C. |
Delaware |
0 |
3710277 |
0 |
3710277 |
3710277 |
10.3 % |
31/08/2012 |
| Investment 10, L.L.C. |
Illinois |
0 |
248699 |
0 |
248699 |
248699 |
0 % |
31/08/2012 |
| Investment 10, L.L.C. |
Illinois |
0 |
248699 |
0 |
248699 |
248699 |
0 % |
31/08/2012 |
| BVF Investments, L.L.C. |
Delaware |
0 |
3710277 |
0 |
3710277 |
3710277 |
10.3 % |
31/08/2012 |
| Mark N. Lampert |
United States |
0 |
2250899 |
0 |
2250899 |
2250899 |
6.2 % |
29/05/2012 |
| Mark N. Lampert |
United States |
0 |
2250899 |
0 |
2250899 |
2250899 |
6.2 % |
29/05/2012 |
| BVF Inc. |
Delaware |
0 |
2250899 |
0 |
2250899 |
2250899 |
6.2 % |
29/05/2012 |
| BVF Partners L.P. |
Delaware |
0 |
2250899 |
0 |
2250899 |
2250899 |
6.2 % |
29/05/2012 |
| Investment 10, L.L.C. |
Illinois |
0 |
115900 |
0 |
115900 |
115900 |
0 % |
29/05/2012 |
| BVF Investments, L.L.C. |
Delaware |
0 |
1649999 |
0 |
1649999 |
1649999 |
4.6 % |
29/05/2012 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
173500 |
0 |
173500 |
173500 |
0 % |
29/05/2012 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
311500 |
0 |
311500 |
311500 |
0 % |
29/05/2012 |
| BVF Partners L.P. |
Delaware |
0 |
2250899 |
0 |
2250899 |
2250899 |
6.2 % |
29/05/2012 |
| Investment 10, L.L.C. |
Illinois |
0 |
115900 |
0 |
115900 |
115900 |
0 % |
29/05/2012 |
| BVF Investments, L.L.C. |
Delaware |
0 |
1649999 |
0 |
1649999 |
1649999 |
4.6 % |
29/05/2012 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
173500 |
0 |
173500 |
173500 |
0 % |
29/05/2012 |
| BVF Inc. |
Delaware |
0 |
2250899 |
0 |
2250899 |
2250899 |
6.2 % |
29/05/2012 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
311500 |
0 |
311500 |
311500 |
0 % |
29/05/2012 |
| Thomas J. Schall, Ph.D. |
United States citizen |
3380833 |
0 |
3380833 |
0 |
3380833 |
9.1 % |
05/03/2012 |
| Thomas J. Schall, Ph.D. |
United States citizen |
3380833 |
0 |
3380833 |
0 |
3380833 |
9.1 % |
05/03/2012 |
| HBM BioVentures |
Cayman Islands, British West Indies |
2637301 |
0 |
2637301 |
0 |
2637301 |
7.9 % |
16/02/2012 |
| HBM BioVentures |
Cayman Islands, British West Indies |
2637301 |
0 |
2637301 |
0 |
2637301 |
7.9 % |
16/02/2012 |
| Techne Corporation |
Minnesota |
6385056 |
0 |
6385056 |
0 |
6385056 |
18 % |
16/02/2012 |