| Yue Tang |
U.S. |
0 |
3005904 |
0 |
0 |
3005904 |
5.5 % |
14/02/2024 |
| Kynam Capital Management GP, LLC |
Delaware |
0 |
3005904 |
0 |
0 |
3005904 |
5.5 % |
14/02/2024 |
| Kynam Capital Management, LP |
Delaware |
0 |
3005904 |
0 |
0 |
3005904 |
5.5 % |
14/02/2024 |
| Robin C. John |
Delaware |
0 |
3630013 |
0 |
0 |
3630013 |
6.64 % |
14/02/2024 |
| Finny Kuruvilla, M.D. Ph. D. |
Delaware |
0 |
3630013 |
0 |
0 |
3630013 |
6.64 % |
14/02/2024 |
| Eventide Asset Management, LLC |
Delaware |
3630013 |
0 |
3630013 |
0 |
3630013 |
6.64 % |
14/02/2024 |
| Polar Capital Holdings Plc |
United Kingdom |
3135871 |
0 |
3135871 |
0 |
3135871 |
5.73 % |
13/02/2024 |
| Polar Capital LLP |
United Kingdom |
3135871 |
0 |
3135871 |
0 |
3135871 |
5.73 % |
13/02/2024 |
| Steven A. Cohen |
Delaware |
0 |
3622136 |
0 |
0 |
3622136 |
6.6 % |
20/11/2023 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
3622136 |
0 |
0 |
3622136 |
6.6 % |
20/11/2023 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
3622136 |
0 |
0 |
3622136 |
6.6 % |
20/11/2023 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4326037 |
0 |
0 |
4647912 |
9.87 % |
06/02/2023 |
| Wellington Group Holdings LLP |
Delaware |
0 |
4326037 |
0 |
0 |
4647912 |
9.87 % |
06/02/2023 |
| Wellington Management Group LLP |
Massachusetts |
0 |
4326037 |
0 |
0 |
4647912 |
9.87 % |
06/02/2023 |
| Wellington Management Company LLP |
Delaware |
0 |
4298829 |
0 |
0 |
4466182 |
9.48 % |
06/02/2023 |
| Viking Global Investors LP |
Delaware |
0 |
2366385 |
0 |
2366385 |
2366385 |
5.1 % |
10/06/2022 |
| Redmile Group, LLC |
Delaware |
0 |
2165586 |
0 |
0 |
2165586 |
4.6 % |
14/02/2022 |
| Jeremy C. Green |
United Kingdom |
0 |
2165586 |
0 |
0 |
2165586 |
4.6 % |
14/02/2022 |
| STATE STREET CORPORATION |
|
0 |
2291402 |
0 |
2368040 |
2368040 |
5.07 % |
10/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
76323 |
2305232 |
107824 |
2413056 |
5.17 % |
09/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
3048143 |
0 |
3101030 |
0 |
3101030 |
6.6 % |
04/02/2022 |
| FMR LLC |
Delaware |
421707 |
0 |
5615333 |
0 |
5615333 |
12.08 % |
12/10/2021 |
| Jeremy C. Green |
|
0 |
2711616 |
0 |
0 |
2711616 |
6.9 % |
16/02/2021 |
| Redmile Group, LLC |
|
0 |
2711616 |
0 |
0 |
2711616 |
6.9 % |
16/02/2021 |
| Ikarian Capital, LLC |
|
0 |
1364990 |
0 |
1364990 |
1364990 |
3.5 % |
12/02/2021 |
| Ikarian Healthcare Master Fund, L.P. |
|
0 |
1061868 |
0 |
1061868 |
1061868 |
2.7 % |
12/02/2021 |
| Ikarian Healthcare Fund GP, L.P. |
|
0 |
1061868 |
0 |
1061868 |
1061868 |
2.7 % |
12/02/2021 |
| Chart Westcott |
|
0 |
1364990 |
0 |
1364990 |
1364990 |
3.5 % |
12/02/2021 |
| Neil Shahrestani |
|
0 |
1364990 |
0 |
1364990 |
1364990 |
3.5 % |
12/02/2021 |
| S |
|
0 |
2391949 |
0 |
0 |
2391949 |
6.05 % |
12/02/2021 |
| S |
|
0 |
3422855 |
0 |
0 |
3422855 |
8.66 % |
12/02/2021 |
| S |
|
0 |
3422855 |
0 |
0 |
3422855 |
8.66 % |
12/02/2021 |
| BVF Inc. |
|
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| Biotechnology Value Trading Fund OS LP |
|
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| BVF Partners L.P. |
|
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| BVF Partners OS Ltd. |
|
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| Biotechnology Value Fund, L.P. |
|
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| BVF GP HOLDINGS LLC |
|
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| BVF I GP LLC |
|
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| BVF II GP LLC |
|
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| Biotechnology Value Fund II, L.P. |
|
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| Mark N. Lampert |
|
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| Logos Global Master Fund LP |
Delaware |
0 |
1700000 |
0 |
1700000 |
1700000 |
11 % |
22/10/2020 |
| Arsani William |
Delaware |
0 |
1700000 |
0 |
1700000 |
1700000 |
11 % |
22/10/2020 |
| Logos GP LLC |
Delaware |
0 |
1700000 |
0 |
1700000 |
1700000 |
11 % |
22/10/2020 |
| Logos Global Management LP |
Delaware |
0 |
1700000 |
0 |
1700000 |
1700000 |
11 % |
22/10/2020 |
| Logos Global Management GP LLC |
Delaware |
0 |
1700000 |
0 |
1700000 |
1700000 |
11 % |
22/10/2020 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1900000 |
0 |
0 |
1900000 |
5.01 % |
24/07/2020 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1900000 |
0 |
0 |
1900000 |
5.01 % |
24/07/2020 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
1900000 |
0 |
0 |
1900000 |
5.01 % |
24/07/2020 |
| Robert Atchinson |
Delaware |
0 |
1900000 |
0 |
0 |
1900000 |
5.01 % |
24/07/2020 |
| Phillip Gross |
Delaware |
0 |
1900000 |
0 |
0 |
1900000 |
5.01 % |
24/07/2020 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
186317 |
186317 |
1 % |
26/06/2020 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
186317 |
186317 |
1 % |
26/06/2020 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1067616 |
1067616 |
2.8 % |
26/06/2020 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1067616 |
1067616 |
2.8 % |
26/06/2020 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
1430559 |
1430559 |
3.8 % |
26/06/2020 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
2740000 |
2740000 |
7.2 % |
26/06/2020 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
2740000 |
2740000 |
7.2 % |
26/06/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
2498175 |
2498175 |
6.6 % |
26/06/2020 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
2740000 |
2740000 |
7.2 % |
26/06/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1430559 |
1430559 |
3.8 % |
26/06/2020 |
| S |
Delaware |
0 |
1885000 |
0 |
0 |
1885000 |
9.95 % |
19/06/2020 |
| S |
Delaware |
0 |
1327712 |
0 |
0 |
1327712 |
7.01 % |
19/06/2020 |
| S |
Delaware |
0 |
1885000 |
0 |
0 |
1885000 |
9.95 % |
19/06/2020 |
| Ikarian Capital, LLC |
Delaware |
0 |
1592439 |
0 |
0 |
1592439 |
7.1 % |
18/06/2020 |
| Ikarian Healthcare Master Fund, L.P. |
Delaware |
0 |
1236313 |
0 |
0 |
1236313 |
5.5 % |
18/06/2020 |
| Ikarian Healthcare Fund GP, L.P. |
Delaware |
0 |
1236313 |
0 |
0 |
1236313 |
5.5 % |
18/06/2020 |
| Neil Shahrestani |
Delaware |
0 |
1592439 |
0 |
0 |
1592439 |
7.1 % |
18/06/2020 |
| Chart Westcott |
Delaware |
0 |
1592439 |
0 |
0 |
1592439 |
7.1 % |
18/06/2020 |
| 13-3127734 |
Delaware |
1115368 |
0 |
1115368 |
0 |
1115368 |
6.91 % |
12/02/2020 |
| 26-0385758 |
Delaware |
1115368 |
0 |
1115368 |
0 |
1115368 |
6.91 % |
12/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
3475394 |
0 |
3578436 |
0 |
3578436 |
2.5 % |
10/07/2018 |
| FMR LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/05/2018 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/05/2018 |
| (1) BlackRock, Inc. |
Delaware |
9646161 |
0 |
9930701 |
0 |
9930701 |
7.3 % |
29/01/2018 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Page 2 of 8 |
Delaware |
0 |
6865006 |
0 |
6865006 |
6865006 |
5.7 % |
09/12/2016 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
8561225 |
0 |
8561225 |
8561225 |
8.67 % |
08/04/2016 |
| (1) BlackRock, Inc. |
Delaware |
6320840 |
0 |
6547643 |
0 |
6547643 |
6.6 % |
26/01/2016 |
| S.A.C. Capital Advisors, L.P. |
Delaware |
0 |
3506488 |
0 |
0 |
3506488 |
3.9 % |
14/02/2014 |
| S.A.C. Capital Advisors, Inc. |
Delaware |
0 |
3506488 |
0 |
0 |
3506488 |
3.9 % |
14/02/2014 |
| Steven A. Cohen |
Delaware |
0 |
3572057 |
0 |
0 |
3572057 |
4 % |
14/02/2014 |
| Sigma Capital Management, LLC |
Delaware |
0 |
65569 |
0 |
0 |
65569 |
0.1 % |
14/02/2014 |
| BARCLAYS GLOBAL INVESTORS, NA. |
Pennsylvania |
124182 |
|
4854493 |
117782 |
11676560 |
2.77 % |
12/02/2014 |
| Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
7930026 |
9 % |
10/02/2014 |
| Identification #52-2069785 (formerly 13-2631108) |
Delaware |
3981806 |
0 |
0 |
3981806 |
3981806 |
11 % |
06/02/2014 |
| Identification #52-2069785 (formerly 13-2631108) |
Delaware |
3981806 |
0 |
0 |
3981806 |
3981806 |
11 % |
06/02/2014 |
| (1) BlackRock, Inc. |
Delaware |
5641857 |
0 |
5891176 |
0 |
5891176 |
6.7 % |
28/01/2014 |
| FMR LLC |
Delaware |
1450500 |
0 |
8269125 |
0 |
8269125 |
10.21 % |
10/09/2013 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
8269125 |
0 |
8269125 |
10.21 % |
10/09/2013 |
| Steven A. Cohen |
Delaware |
0 |
4319837 |
0 |
0 |
4319837 |
5.4 % |
22/04/2013 |
| Sigma Capital Management, LLC |
Delaware |
0 |
319582 |
0 |
0 |
319582 |
0.4 % |
22/04/2013 |
| S.A.C. Capital Advisors, Inc. |
Delaware |
0 |
4000255 |
0 |
0 |
4000255 |
4.9 % |
22/04/2013 |
| S.A.C. Capital Advisors, L.P. |
Delaware |
0 |
4000255 |
0 |
0 |
4000255 |
4.9 % |
22/04/2013 |
| S.A.C. Capital Advisors, Inc. |
Delaware |
0 |
3931355 |
0 |
0 |
3931355 |
4.9 % |
05/04/2013 |
| Steven A. Cohen |
Delaware |
0 |
3931355 |
0 |
0 |
3931355 |
4.9 % |
05/04/2013 |
| S.A.C. Capital Advisors, L.P. |
Delaware |
0 |
3931355 |
0 |
0 |
3931355 |
4.9 % |
05/04/2013 |
| Identification #52-2069785 (formerly 13-2631108) |
Delaware |
0 |
0 |
0 |
0 |
3538941 |
11 % |
11/02/2013 |
| (1) BlackRock, Inc. |
Delaware |
5361581 |
0 |
5361581 |
0 |
5361581 |
8.65 % |
30/01/2013 |
| Ridgeback Capital Investments L.P. 00-0000000 |
Cayman Islands |
0 |
3804646 |
0 |
3804646 |
3804646 |
6.1 % |
28/12/2012 |
| (1) BlackRock, Inc. |
Delaware |
1887847 |
0 |
1887847 |
0 |
1887847 |
5.89 % |
03/02/2011 |
| Medarex, Inc. |
Delaware |
0 |
2474947 |
0 |
10 |
2474947 |
7.83 % |
09/12/2009 |
| Bristol-Myers Squibb Company |
Delaware |
0 |
2474947 |
0 |
24 |
2474947 |
7.83 % |
09/12/2009 |
| Holdings Limited |
Kingdom |
2811147 |
0 |
2811147 |
10 |
2811147 |
18.8 % |
25/03/2008 |
| TSP Capital Management Group, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
27/02/2008 |
| FGS Advisors, LLC |
New York |
4238504 |
0 |
4238504 |
0 |
4238504 |
5.7 % |
13/02/2008 |
| Investment 10, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
29/01/2008 |
| BVF Investments, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
29/01/2008 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
29/01/2008 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
29/01/2008 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
29/01/2008 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
29/01/2008 |
| FGS Advisors, LLC (2) |
New York |
3818511 |
0 |
3818511 |
0 |
3818511 |
5.15 % |
30/03/2006 |
| Biotechnology Value Fund, L.P.I.R.S. |
Delaware |
0 |
3748148 |
0 |
3748148 |
1122348 |
1.5 % |
07/07/2005 |
| 13-3942422 |
New York |
0 |
3888500 |
0 |
3888500 |
3888500 |
6.8 % |
14/02/2002 |
| 52-2169043 |
Delaware |
0 |
3888500 |
0 |
3888500 |
3888500 |
6.8 % |
14/02/2002 |
| 94-3244780 |
Delaware |
939200 |
0 |
1093700 |
0 |
1093700 |
1.81 % |
01/02/2002 |
| 13-2722082 |
Frankfurt, Germany |
939200 |
0 |
1093700 |
0 |
1093700 |
1.81 % |
01/02/2002 |
| 94-3244780 |
Delaware |
939200 |
0 |
1093700 |
0 |
1093700 |
1.81 % |
01/02/2002 |
| 94-3244780 |
Delaware |
2816200 |
0 |
3155000 |
156700 |
3311700 |
6.02 % |
07/02/2001 |
| 13-2722082 |
Frankfurt, Germany |
2816200 |
0 |
3155000 |
156700 |
3311700 |
6.02 % |
07/02/2001 |
| 94-3244780 |
Delaware |
2816200 |
0 |
3155000 |
156700 |
3311700 |
6.02 % |
07/02/2001 |
| Nomura International plc |
United Kingdom |
2604167 |
0 |
2604167 |
0 |
2604167 |
5.4 % |
01/10/1999 |