Principal Global Investors, LLC |
Delaware |
0 |
1745663 |
0 |
1745663 |
1745663 |
5.42 % |
13/11/2024 |
Rubric Capital Management LP |
State of Delaware |
0 |
1250000 |
0 |
1250000 |
1250000 |
3.88 % |
13/11/2024 |
David Rosen |
United States of America |
0 |
1250000 |
0 |
1250000 |
1250000 |
3.88 % |
13/11/2024 |
Finny Kuruvilla, M.D. Ph. D. |
United States |
0 |
2630478 |
0 |
2630478 |
2630478 |
8.07 % |
14/02/2024 |
Eventide Asset Management, LLC |
Delaware |
2630478 |
0 |
2630478 |
0 |
2630478 |
8.07 % |
14/02/2024 |
Robin C. John |
United States |
0 |
2630478 |
0 |
2630478 |
2630478 |
8.07 % |
14/02/2024 |
David Rosen |
United States of America |
0 |
2758253 |
0 |
2758253 |
2758253 |
8.46 % |
12/02/2024 |
Rubric Capital Management LP |
State of Delaware |
0 |
2758253 |
0 |
2758253 |
2758253 |
8.46 % |
12/02/2024 |
BlackRock, Inc. |
Delaware |
5653206 |
0 |
5786527 |
0 |
5786527 |
17.7 % |
19/01/2024 |
The Vanguard Group |
Pennsylvania |
0 |
57915 |
2121862 |
86249 |
2208111 |
6.58 % |
09/02/2023 |
BlackRock, Inc. |
Delaware |
5647245 |
0 |
0 |
5731305 |
5731305 |
17.1 % |
30/01/2023 |
Robin C. John |
United States |
0 |
2629593 |
0 |
2629593 |
2629593 |
7.6 % |
14/02/2022 |
Finny Kuruvilla, M.D. Ph. D. |
United States |
0 |
2629593 |
0 |
2629593 |
2629593 |
7.6 % |
14/02/2022 |
Eventide Asset Management, LLC |
Delaware |
2629593 |
0 |
2629593 |
0 |
2629593 |
7.6 % |
14/02/2022 |
Camber Capital Management LP |
Delaware xAxAxA |
0 |
1050000 |
0 |
1050000 |
2013 |
3.04 % |
14/02/2022 |
Stephen DuBois Not applicable |
Stephen DuBois x United States xAxAxA |
0 |
1050000 |
0 |
1050000 |
2013 |
3.04 % |
14/02/2022 |
David Rosen |
United States America |
0 |
2606500 |
0 |
2606500 |
2606500 |
7.54 % |
14/02/2022 |
Rubric Capital Management LP |
Delaware |
0 |
2606500 |
0 |
2606500 |
2606500 |
7.54 % |
14/02/2022 |
The Vanguard Group |
Pennsylvania |
0 |
73316 |
2191320 |
96097 |
2287417 |
6.62 % |
09/02/2022 |
BlackRock, Inc. |
Delaware |
5550301 |
0 |
5631660 |
0 |
5631660 |
16.3 % |
28/01/2022 |
BlackRock, Inc. |
Delaware |
5821782 |
0 |
5875672 |
0 |
5875672 |
16.9 % |
09/03/2021 |
Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
2058068 |
0 |
2058068 |
2058068 |
6 % |
16/02/2021 |
Perceptive Advisors LLC |
Delaware |
0 |
2058068 |
0 |
2058068 |
2058068 |
6 % |
16/02/2021 |
Joseph Edelman |
United States of America |
0 |
2058068 |
0 |
2058068 |
2058068 |
6 % |
16/02/2021 |
Rubric Capital Management LP |
State of Delaware |
0 |
1926283 |
0 |
1926283 |
1926283 |
5.57 % |
16/02/2021 |
David Rosen |
United States of America |
0 |
1926283 |
0 |
1926283 |
1926283 |
5.57 % |
16/02/2021 |
Janus Henderson Contrarian Fund |
Massachusetts |
0 |
2264477 |
0 |
2264477 |
2264477 |
6.5 % |
11/02/2021 |
Janus Henderson Group plc EIN #000000000 |
Jersey Channel Islands |
0 |
5087509 |
0 |
5087509 |
5087509 |
14.7 % |
11/02/2021 |
The Vanguard Group |
Pennsylvania |
0 |
78646 |
1627268 |
103584 |
1730852 |
5.01 % |
10/02/2021 |
Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
1255371 |
3.6 % |
01/02/2021 |
Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
1255371 |
3.6 % |
01/02/2021 |
Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
1255371 |
3.6 % |
01/02/2021 |
BlackRock, Inc. |
Delaware |
2795511 |
0 |
2838217 |
0 |
2838217 |
8.2 % |
28/01/2021 |
Perceptive Advisors LLC |
Delaware |
0 |
1721722 |
0 |
1721722 |
1721722 |
5 % |
22/04/2020 |
Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
1721722 |
0 |
1721722 |
1721722 |
5 % |
22/04/2020 |
Joseph Edelman |
United States of America |
0 |
1721722 |
0 |
1721722 |
1721722 |
5 % |
22/04/2020 |
Stephen DuBois Not applicable |
Stephen DuBois – United States |
0 |
2000000 |
0 |
2000000 |
2000000 |
5.97 % |
21/02/2020 |
Camber Capital Management LP |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
5.97 % |
21/02/2020 |
Camber Capital Management LP |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
5.97 % |
21/02/2020 |
Stephen DuBois Not applicable |
Stephen DuBois – United States |
0 |
2000000 |
0 |
2000000 |
2000000 |
5.97 % |
21/02/2020 |
Janus Henderson Group plc EIN #000000000 |
Jersey Channel Islands |
0 |
4502349 |
0 |
4502349 |
4502349 |
13.4 % |
13/02/2020 |
Janus Henderson Contrarian Fund |
Massachusetts |
0 |
2096257 |
0 |
2096257 |
2096257 |
6.3 % |
13/02/2020 |
Macquarie Investment Management Holdings Inc |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Investment Management Business Trust |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Delaware Smid Cap Growth Fund, a series of Delaware Group Equity Funds IV |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Funds Management Hong Kong Limited |
Hong Kong |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Investment Management Holdings Inc |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Bank Limited |
Sydney New South Wales Australia |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Group Limited |
Sydney New South Wales Australia |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Funds Management Hong Kong Limited |
Hong Kong |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Delaware Smid Cap Growth Fund, a series of Delaware Group Equity Funds IV |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Investment Management Business Trust |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Bank Limited |
Sydney New South Wales Australia |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Group Limited |
Sydney New South Wales Australia |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Funds Management Hong Kong Limited |
Hong Kong |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Investment Management Holdings Inc |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Bank Limited |
Sydney New South Wales Australia |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Group Limited |
Sydney New South Wales Australia |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Investment Management Holdings Inc |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Bank Limited |
Sydney New South Wales Australia |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Group Limited |
Sydney New South Wales Australia |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Delaware Smid Cap Growth Fund, a series of Delaware Group Equity Funds IV |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Investment Management Business Trust |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Funds Management Hong Kong Limited |
Hong Kong |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Delaware Smid Cap Growth Fund, a series of Delaware Group Equity Funds IV |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
Macquarie Investment Management Business Trust |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
The Vanguard Group |
Pennsylvania |
66353 |
14300 |
1603050 |
77604 |
1680654 |
5.01 % |
11/02/2020 |
BlackRock, Inc. |
Delaware |
2506740 |
0 |
2565927 |
0 |
2565927 |
7.7 % |
05/02/2020 |
Eventide Asset Management, LLC |
|
2427976 |
|
|
|
2427976 |
7.2 % |
04/02/2020 |
Eventide Asset Management, LLC |
|
2427976 |
|
|
|
2427976 |
7.2 % |
04/02/2020 |
Franklin Advisers, Inc. |
California |
1750452 |
0 |
1750452 |
0 |
1750452 |
5.2 % |
04/02/2020 |
Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
1770152 |
5.3 % |
04/02/2020 |
Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
1770152 |
5.3 % |
04/02/2020 |
Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
1770152 |
5.3 % |
04/02/2020 |
Macquarie Investment Management Holdings Inc |
State of Delaware |
2755656 |
0 |
2755656 |
0 |
2758707 |
8.3 % |
14/02/2019 |
Macquarie Group Limited |
Sydney, New South Wales Australia |
0 |
0 |
0 |
0 |
2758707 |
8.3 % |
14/02/2019 |
Macquarie Bank Limited |
Sydney, New South Wales, Australia |
0 |
0 |
0 |
0 |
2758707 |
8.3 % |
14/02/2019 |
Macquarie Funds Management Hong Kong Limited |
Hong Kong |
300 |
0 |
300 |
0 |
300 |
0.01 % |
14/02/2019 |
Delaware Smid Cap Growth Fund, a series of Delaware Group Equity Funds IV |
State of Delaware |
2560374 |
0 |
2560374 |
0 |
2560374 |
7.7 % |
14/02/2019 |
Macquarie Investment Management Business Trust |
State of Delaware |
2755656 |
0 |
2755656 |
0 |
2758707 |
8.3 % |
14/02/2019 |
Rock Springs Capital Management LP |
Delaware |
0 |
1605105 |
0 |
1605105 |
1605105 |
4.83 % |
14/02/2019 |
Rock Springs Capital LLC |
Delaware |
0 |
1605105 |
0 |
1605105 |
0 |
4.83 % |
14/02/2019 |
Rock Springs Capital Management LP |
Delaware |
0 |
1605105 |
0 |
1605105 |
0 |
4.83 % |
14/02/2019 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1605105 |
0 |
1605105 |
0 |
4.83 % |
14/02/2019 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1605105 |
0 |
1605105 |
1605105 |
4.83 % |
14/02/2019 |
Rock Springs Capital LLC |
Delaware |
0 |
1605105 |
0 |
1605105 |
1605105 |
4.83 % |
14/02/2019 |
Eventide Asset Management, LLC |
Delaware |
2207610 |
0 |
2207610 |
0 |
2207610 |
6.6 % |
13/02/2019 |
Eventide Asset Management, LLC |
Delaware |
2207610 |
0 |
2207610 |
0 |
2207610 |
6.6 % |
13/02/2019 |
Longitude Venture Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2019 |
Patrick G. Enright |
United States America |
158043 |
0 |
158043 |
0 |
158043 |
0.5 % |
12/02/2019 |
Juliet Tammenoms Bakker |
United States America |
158043 |
0 |
158043 |
0 |
158043 |
0.5 % |
12/02/2019 |
David Hch |
United States America |
79088 |
0 |
79088 |
0 |
79088 |
0.2 % |
12/02/2019 |
Longitude Capital Partners, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2019 |
Longitude Capital Associates, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2019 |
Janus Henderson Group plc EIN #000000000 |
Jersey Channel Islands |
0 |
4151719 |
0 |
4151719 |
4151719 |
12.5 % |
12/02/2019 |
BlackRock, Inc. |
Delaware |
2322032 |
0 |
2619718 |
0 |
2619718 |
7.9 % |
04/02/2019 |
Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
1834289 |
5.5 % |
25/01/2019 |
Franklin Advisers, Inc. |
California |
1815989 |
0 |
1815989 |
0 |
1815989 |
5.5 % |
25/01/2019 |
Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
1834289 |
5.5 % |
25/01/2019 |
Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
1834289 |
5.5 % |
25/01/2019 |
Partner Investment Management GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
6 |
0 % |
14/02/2018 |
Partner Investment Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
6 |
0 % |
14/02/2018 |
Brian D. Grossman |
US |
0 |
0 |
0 |
0 |
6 |
0 % |
14/02/2018 |
Partner Fund Management GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
6 |
0 % |
14/02/2018 |
Partner Fund Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
6 |
0 % |
14/02/2018 |
Christopher M. James |
US |
0 |
0 |
0 |
0 |
6 |
0 % |
14/02/2018 |
Rock Springs Capital Management LP |
Delaware |
0 |
1915729 |
0 |
1915729 |
1915729 |
5.9 % |
14/02/2018 |
Rock Springs Capital LLC |
Delaware |
0 |
1915729 |
0 |
1915729 |
1915729 |
5.9 % |
14/02/2018 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1915729 |
0 |
1915729 |
1915729 |
5.9 % |
14/02/2018 |
Michael L. Sjöström |
Swiss |
|
|
|
|
1426862 |
4.4 % |
13/02/2018 |
Jérôme G. Pfund |
Swiss |
|
|
|
|
1426862 |
4.4 % |
13/02/2018 |
Sectoral Asset Management Inc. |
Canada |
|
|
|
|
1426862 |
4.4 % |
13/02/2018 |
Jérôme G. Pfund |
Swiss |
|
|
|
|
1426862 |
4.4 % |
13/02/2018 |
Michael L. Sjöström |
Swiss |
|
|
|
|
1426862 |
4.4 % |
13/02/2018 |
Sectoral Asset Management Inc. |
Canada |
|
|
|
|
1426862 |
4.4 % |
13/02/2018 |
Eventide Asset Management, LLC |
Delaware |
2207610 |
0 |
2207610 |
0 |
2207610 |
6.8 % |
12/02/2018 |
Eventide Asset Management, LLC |
Delaware |
2207610 |
0 |
2207610 |
0 |
2207610 |
6.8 % |
12/02/2018 |
Longitude Venture Partners, L.P. |
Delaware |
0 |
2321842 |
0 |
2321842 |
2321842 |
7.1 % |
12/02/2018 |
Longitude Capital Associates, L.P. |
Delaware |
0 |
2321842 |
0 |
2321842 |
2321842 |
7.1 % |
12/02/2018 |
Juliet Tammenoms Bakker |
United States of America |
0 |
2340230 |
0 |
2340230 |
2340230 |
7.2 % |
12/02/2018 |
Patrick G. Enright |
United States of America |
0 |
2340230 |
0 |
2340230 |
2340230 |
7.2 % |
12/02/2018 |
David Hirsch |
United States of America |
0 |
2340230 |
0 |
2340230 |
2340230 |
7.2 % |
12/02/2018 |
Longitude Capital Partners, LLC |
Delaware |
0 |
2321842 |
0 |
2321842 |
2321842 |
7.1 % |
12/02/2018 |
Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
1511775 |
4.6 % |
06/02/2018 |
Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
1511775 |
4.6 % |
06/02/2018 |
Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
1511775 |
4.6 % |
06/02/2018 |
BlackRock, Inc. |
Delaware |
1915116 |
0 |
1965566 |
0 |
1965566 |
6 % |
01/02/2018 |
Janus Henderson Group plc EIN |
Jersey, Channel Islands |
0 |
3292058 |
0 |
3292058 |
3292058 |
10.1 % |
11/01/2018 |
Partner Fund Management GP, LLC |
Delaware |
0 |
1418141 |
0 |
0 |
6 |
5 % |
14/02/2017 |
Brian D. Grossman |
US |
0 |
1441910 |
0 |
0 |
6 |
5 % |
14/02/2017 |
Partner Investment Management GP, LLC |
Delaware |
0 |
23769 |
0 |
0 |
6 |
0.1 % |
14/02/2017 |
Partner Fund Management, L.P. |
Delaware |
0 |
1418141 |
0 |
0 |
6 |
5 % |
14/02/2017 |
Partner Investment Management, L.P. |
Delaware |
0 |
23769 |
0 |
0 |
6 |
0.1 % |
14/02/2017 |
Christopher M. James |
US |
0 |
1441910 |
0 |
0 |
6 |
5 % |
14/02/2017 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1600000 |
0 |
1600000 |
1600000 |
5.6 % |
14/02/2017 |
Rock Springs Capital Management LP |
Delaware |
0 |
1600000 |
0 |
1600000 |
1600000 |
5.6 % |
14/02/2017 |
Arthur Cohen |
United States |
0 |
1285969 |
0 |
1285969 |
1285969 |
4.5 % |
14/02/2017 |
Joseph Healey |
United States |
0 |
1285969 |
0 |
1285969 |
1285969 |
4.5 % |
14/02/2017 |
HealthCor Sanatate Offshore Master Fund, L.P. |
Cayman Islands |
0 |
459057 |
0 |
459057 |
459057 |
1.6 % |
14/02/2017 |
HealthCor Offshore II GP, LLC |
Delaware |
0 |
459057 |
0 |
459057 |
459057 |
1.6 % |
14/02/2017 |
Joseph Healey |
United States |
0 |
1285969 |
0 |
1285969 |
1285969 |
4.5 % |
14/02/2017 |
HealthCor Sanatate Offshore Master Fund, L.P. |
Cayman Islands |
0 |
459057 |
0 |
459057 |
459057 |
1.6 % |
14/02/2017 |
HealthCor Offshore II GP, LLC |
Delaware |
0 |
459057 |
0 |
459057 |
459057 |
1.6 % |
14/02/2017 |
HealthCor Management, L.P. |
Delaware |
0 |
1285969 |
0 |
1285969 |
1285969 |
4.5 % |
14/02/2017 |
HealthCor Associates, LLC |
Delaware |
0 |
1285969 |
0 |
1285969 |
1285969 |
4.5 % |
14/02/2017 |
HealthCor Offshore Master Fund, L.P. |
Cayman Islands |
0 |
826912 |
0 |
826912 |
826912 |
2.9 % |
14/02/2017 |
HealthCor Offshore GP, LLC |
Delaware |
0 |
826912 |
0 |
826912 |
826912 |
2.9 % |
14/02/2017 |
HealthCor Group, LLC |
Delaware |
0 |
1285969 |
0 |
1285969 |
1285969 |
4.5 % |
14/02/2017 |
HealthCor Management, L.P. |
Delaware |
0 |
1285969 |
0 |
1285969 |
1285969 |
4.5 % |
14/02/2017 |
HealthCor Associates, LLC |
Delaware |
0 |
1285969 |
0 |
1285969 |
1285969 |
4.5 % |
14/02/2017 |
Arthur Cohen |
United States |
0 |
1285969 |
0 |
1285969 |
1285969 |
4.5 % |
14/02/2017 |
HealthCor Offshore GP, LLC |
Delaware |
0 |
826912 |
0 |
826912 |
826912 |
2.9 % |
14/02/2017 |
HealthCor Offshore Master Fund, L.P. |
Cayman Islands |
0 |
826912 |
0 |
826912 |
826912 |
2.9 % |
14/02/2017 |
HealthCor Group, LLC |
Delaware |
0 |
1285969 |
0 |
1285969 |
1285969 |
4.5 % |
14/02/2017 |
Eventide Asset Management, LLC |
Delaware |
2077751 |
0 |
2077751 |
0 |
2077751 |
7.3 % |
13/02/2017 |
Eventide Asset Management, LLC |
Delaware |
2077751 |
0 |
2077751 |
0 |
2077751 |
7.3 % |
13/02/2017 |
James G. Coulter |
United States |
0 |
1389863 |
0 |
1389863 |
1389863 |
4.9 % |
13/02/2017 |
David Bonderman |
United States |
0 |
1389863 |
0 |
1389863 |
1389863 |
4.9 % |
13/02/2017 |
TPG Group Holdings Advisors, Inc. |
Delaware |
0 |
1389863 |
0 |
1389863 |
1389863 |
4.9 % |
13/02/2017 |
Juliet Tammenoms Bakker |
United States America |
0 |
3327470 |
0 |
3327470 |
3327470 |
11.6 % |
10/02/2017 |
Longitude Venture Partners L.P. |
Delaware |
0 |
3321842 |
0 |
3321842 |
3321842 |
11.6 % |
10/02/2017 |
Longitude Capital Associates L.P. |
Delaware |
0 |
3321842 |
0 |
3321842 |
3321842 |
11.6 % |
10/02/2017 |
Longitude Capital Partners, LLC |
Delaware |
0 |
3321842 |
0 |
3321842 |
3321842 |
11.6 % |
10/02/2017 |
Patrick G. Enright |
United States America |
0 |
3327470 |
0 |
3327470 |
3327470 |
11.6 % |
10/02/2017 |
David Hch |
United States America |
0 |
3327470 |
0 |
3327470 |
3327470 |
11.6 % |
10/02/2017 |
Michael L. Sjöström |
Swiss |
|
|
|
|
2104756 |
7.4 % |
10/02/2017 |
Sectoral Asset Management Inc. |
Canada |
|
|
|
|
2104756 |
7.4 % |
10/02/2017 |
Michael L. Sjöström |
Swiss |
|
|
|
|
2104756 |
7.4 % |
10/02/2017 |
Jérôme G. Pfund |
Swiss |
|
|
|
|
2104756 |
7.4 % |
10/02/2017 |
Sectoral Asset Management Inc. |
Canada |
|
|
|
|
2104756 |
7.4 % |
10/02/2017 |
Jérôme G. Pfund |
Swiss |
|
|
|
|
2104756 |
7.4 % |
10/02/2017 |
Franklin Advisers, Inc. |
California |
1778402 |
0 |
1778402 |
0 |
1778402 |
6.2 % |
07/02/2017 |
Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
1797902 |
6.3 % |
07/02/2017 |
Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
1797902 |
6.3 % |
07/02/2017 |
Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
1797902 |
6.3 % |
07/02/2017 |
Boston Millennia Partners Limited Partnership |
Delaware |
0 |
43035 |
0 |
43035 |
43035 |
0.2 % |
19/01/2017 |
Boston Millennia Partners II Limited Partnership |
Delaware |
0 |
898445 |
0 |
898445 |
898445 |
3.1 % |
19/01/2017 |
Glen Partners II Limited Partnership |
Delaware |
0 |
1077494 |
0 |
1077494 |
1077494 |
3.8 % |
19/01/2017 |
Boston Millennia Partners GmbH & Co. KG |
German |
0 |
127937 |
0 |
127937 |
127937 |
0.4 % |
19/01/2017 |
Boston Millennia Verwaltungs GmbH |
German |
0 |
127937 |
0 |
127937 |
127937 |
0.4 % |
19/01/2017 |
Martin J. Hernon |
U.S.A |
0 |
1082160 |
0 |
1082160 |
1082160 |
3.8 % |
19/01/2017 |
Robert S. Sherman |
U.S.A |
0 |
1082160 |
0 |
1082160 |
1082160 |
3.8 % |
19/01/2017 |
Strategic Advisors Fund Limited Partnership |
Delaware |
0 |
8077 |
0 |
8077 |
8077 |
0.1 % |
19/01/2017 |
A. Dana Callow, Jr. |
U.S.A |
0 |
1082160 |
0 |
1082160 |
1082160 |
3.8 % |
19/01/2017 |
Boston Millennia Associates II Partnership |
Delaware general partnership |
0 |
4666 |
0 |
4666 |
4666 |
0.11 % |
19/01/2017 |
Christopher M. James |
U.S. Citizen |
0 |
1441910 |
0 |
1441910 |
1441910 |
5 % |
12/12/2016 |
Partner Fund Management, L.P. |
Delaware |
0 |
1418141 |
0 |
1418141 |
1418141 |
5 % |
12/12/2016 |
Partner Fund Management GP, LLC |
Delaware |
0 |
1418141 |
0 |
1418141 |
1418141 |
5 % |
12/12/2016 |
Brian D. Grossman |
U.S. Citizen |
0 |
1441910 |
0 |
1441910 |
1441910 |
5 % |
12/12/2016 |
Partner Investment Management, L.P. |
Delaware |
0 |
23769 |
0 |
23769 |
23769 |
0.1 % |
12/12/2016 |
Partner Investment Management, L.P. |
Delaware |
0 |
23769 |
0 |
23769 |
23769 |
0.1 % |
12/12/2016 |
Partner Investment Management GP, LLC |
Delaware |
0 |
23769 |
0 |
23769 |
23769 |
0.1 % |
12/12/2016 |
Brian D. Grossman |
U.S. Citizen |
0 |
1441910 |
0 |
1441910 |
1441910 |
5 % |
12/12/2016 |
Partner Investment Management GP, LLC |
Delaware |
0 |
23769 |
0 |
23769 |
23769 |
0.1 % |
12/12/2016 |
Christopher M. James |
U.S. Citizen |
0 |
1441910 |
0 |
1441910 |
1441910 |
5 % |
12/12/2016 |
Partner Fund Management, L.P. |
Delaware |
0 |
1418141 |
0 |
1418141 |
1418141 |
5 % |
12/12/2016 |
Partner Fund Management GP, LLC |
Delaware |
0 |
1418141 |
0 |
1418141 |
1418141 |
5 % |
12/12/2016 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1201400 |
0 |
1201400 |
0 |
5.1 % |
16/05/2016 |
Rock Springs Capital Management LP |
Delaware |
0 |
1201400 |
0 |
1201400 |
0 |
5.1 % |
16/05/2016 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1201400 |
0 |
1201400 |
0 |
5.1 % |
16/05/2016 |
Rock Springs Capital Management LP |
Delaware |
0 |
1201400 |
0 |
1201400 |
0 |
5.1 % |
16/05/2016 |
Peter Kolchinsky |
United States |
0 |
857683 |
0 |
857683 |
857683 |
3.7 % |
16/02/2016 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
857683 |
0 |
857683 |
857683 |
3.7 % |
16/02/2016 |
RA Capital Management, LLC |
Massachusetts |
0 |
857683 |
0 |
857683 |
857683 |
3.7 % |
16/02/2016 |
RA Capital Management, LLC |
Massachusetts |
0 |
857683 |
0 |
857683 |
857683 |
3.7 % |
16/02/2016 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
857683 |
0 |
857683 |
857683 |
3.7 % |
16/02/2016 |
Peter Kolchinsky |
United States |
0 |
857683 |
0 |
857683 |
857683 |
3.7 % |
16/02/2016 |
James G. Coulter |
United States |
0 |
1325263 |
0 |
1325263 |
1325263 |
5.7 % |
12/02/2016 |
David Bonderman |
United States |
0 |
1325263 |
0 |
1325263 |
1325263 |
5.7 % |
12/02/2016 |
James G. Coulter |
United States |
0 |
1325263 |
0 |
1325263 |
1325263 |
5.7 % |
12/02/2016 |
David Bonderman |
United States |
0 |
1325263 |
0 |
1325263 |
1325263 |
5.7 % |
12/02/2016 |
TPG Group Holdings |
Delaware |
0 |
1325263 |
0 |
1325263 |
1325263 |
5.7 % |
12/02/2016 |
TPG Group Holdings Advisors, Inc. |
Delaware |
0 |
1325263 |
0 |
1325263 |
1325263 |
5.7 % |
12/02/2016 |
Eventide Asset Management, LLC |
Delaware |
1401001 |
0 |
1401001 |
0 |
1401001 |
6 % |
12/02/2016 |
Eventide Asset Management, LLC |
Delaware |
1401001 |
0 |
1401001 |
0 |
1401001 |
6 % |
12/02/2016 |
Yasunori Kaneko |
California United States America |
0 |
2949916 |
0 |
2949916 |
2949916 |
14.3 % |
10/02/2016 |
John G. Freund |
California United States America |
0 |
2949916 |
0 |
2949916 |
2949916 |
14.3 % |
10/02/2016 |
Skyline Venture Management V, LLC |
Delaware United States America |
0 |
2949916 |
0 |
2949916 |
2949916 |
14.3 % |
10/02/2016 |
Skyline Venture Partners V, L.P. |
Delaware United States America |
0 |
2949916 |
0 |
2949916 |
2949916 |
14.3 % |
10/02/2016 |
Longitude Capital Partners II, LLC |
Delaware |
0 |
7434630 |
0 |
7434630 |
7434630 |
17.6 % |
29/01/2016 |
Longitude Venture Partners II, L.P. |
Delaware |
0 |
7434630 |
0 |
7434630 |
7434630 |
17.6 % |
29/01/2016 |
Juliet Tammenoms Bakker |
United States of America |
0 |
7552900 |
0 |
7552900 |
7552900 |
17.8 % |
29/01/2016 |
Patrick G. Enright |
United States of America |
0 |
7552900 |
0 |
7552900 |
7552900 |
17.8 % |
29/01/2016 |
Strategic Advisors Fund Limited Partnership |
Delaware |
0 |
8077 |
0 |
8077 |
8077 |
0.1 % |
22/01/2016 |
Boston Millennia Verwaltungs GmbH |
German |
0 |
127937 |
0 |
127937 |
127937 |
0.6 % |
22/01/2016 |
A. Dana Callow, Jr. |
U.S.A |
0 |
1082160 |
0 |
1082160 |
1082160 |
5.2 % |
22/01/2016 |
Boston Millennia Associates II Partnership |
Delaware general partnership |
0 |
4666 |
0 |
4666 |
4666 |
0.1 % |
22/01/2016 |
Boston Millennia Partners II Limited Partnership |
Delaware |
0 |
898445 |
0 |
898445 |
898445 |
4.3 % |
22/01/2016 |
Boston Millennia Partners GmbH & Co. KG |
German |
0 |
127937 |
0 |
127937 |
127937 |
0.6 % |
22/01/2016 |
Glen Partners II Limited Partnership |
Delaware |
0 |
1077494 |
0 |
1077494 |
1077494 |
5.2 % |
22/01/2016 |
Boston Millennia Partners Limited Partnership |
Delaware |
0 |
43035 |
0 |
43035 |
43035 |
0.2 % |
22/01/2016 |
Robert S. Sherman |
U.S.A |
0 |
1082160 |
0 |
1082160 |
1082160 |
5.2 % |
22/01/2016 |
Martin J. Hernon |
U.S.A |
0 |
1082160 |
0 |
1082160 |
1082160 |
5.2 % |
22/01/2016 |
HealthCor Offshore Master Fund, L.P. |
Cayman Islands |
0 |
826954 |
0 |
826954 |
826954 |
3.53 % |
13/01/2016 |
HealthCor Offshore GP, LLC |
Delaware |
0 |
826954 |
0 |
826954 |
826954 |
3.53 % |
13/01/2016 |
HealthCor Group, LLC |
Delaware |
0 |
1200000 |
0 |
1200000 |
1200000 |
5.12 % |
13/01/2016 |
HealthCor Offshore II GP, LLC |
Delaware |
0 |
373046 |
0 |
373046 |
373046 |
1.59 % |
13/01/2016 |
HealthCor Management, L.P. |
Delaware |
0 |
1200000 |
0 |
1200000 |
1200000 |
5.12 % |
13/01/2016 |
HealthCor Associates, LLC |
Delaware |
0 |
1200000 |
0 |
1200000 |
1200000 |
5.12 % |
13/01/2016 |
HealthCor Offshore Master Fund, L.P. |
Cayman Islands |
0 |
826954 |
0 |
826954 |
826954 |
3.53 % |
13/01/2016 |
HealthCor Offshore GP, LLC |
Delaware |
0 |
826954 |
0 |
826954 |
826954 |
3.53 % |
13/01/2016 |
HealthCor Group, LLC |
Delaware |
0 |
1200000 |
0 |
1200000 |
1200000 |
5.12 % |
13/01/2016 |
Arthur Cohen |
United States |
0 |
1200000 |
0 |
1200000 |
1200000 |
5.12 % |
13/01/2016 |
Joseph Healey |
United States |
0 |
1200000 |
0 |
1200000 |
1200000 |
5.12 % |
13/01/2016 |
HealthCor Management, L.P. |
Delaware |
0 |
1200000 |
0 |
1200000 |
1200000 |
5.12 % |
13/01/2016 |
HealthCor Associates, LLC |
Delaware |
0 |
1200000 |
0 |
1200000 |
1200000 |
5.12 % |
13/01/2016 |
Arthur Cohen |
United States |
0 |
1200000 |
0 |
1200000 |
1200000 |
5.12 % |
13/01/2016 |
Joseph Healey |
United States |
0 |
1200000 |
0 |
1200000 |
1200000 |
5.12 % |
13/01/2016 |
HealthCor Sanatate Offshore Master Fund, L.P. |
Cayman Islands |
0 |
373046 |
0 |
373046 |
373046 |
1.59 % |
13/01/2016 |
HealthCor Offshore II GP, LLC |
Delaware |
0 |
373046 |
0 |
373046 |
373046 |
1.59 % |
13/01/2016 |
HealthCor Sanatate Offshore Master Fund, L.P. |
Cayman Islands |
0 |
373046 |
0 |
373046 |
373046 |
1.59 % |
13/01/2016 |
Longitude Venture Partners L.P. |
Delaware |
0 |
3321842 |
0 |
3321842 |
3321842 |
16.06 % |
22/09/2015 |
David Hirsch |
Delaware |
0 |
3321842 |
0 |
3321842 |
3321842 |
16.06 % |
22/09/2015 |
Patrick G. Enright |
Delaware |
0 |
3321842 |
0 |
3321842 |
3321842 |
16.06 % |
22/09/2015 |
Longitude Capital Associates L.P. |
Delaware |
0 |
3321842 |
0 |
3321842 |
3321842 |
16.06 % |
22/09/2015 |
Longitude Capital Partners, LLC |
Delaware |
0 |
3321842 |
0 |
3321842 |
3321842 |
16.06 % |
22/09/2015 |
Juliet Tammenoms Bakker |
Delaware |
0 |
3321842 |
0 |
3321842 |
3321842 |
16.06 % |
22/09/2015 |
Peter Kolchinsky |
United States |
0 |
1545410 |
0 |
1545410 |
1545410 |
7.8 % |
15/05/2015 |
Peter Kolchinsky |
United States |
0 |
1545410 |
0 |
1545410 |
1545410 |
7.8 % |
15/05/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1425193 |
0 |
1425193 |
1425193 |
7.2 % |
15/05/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
1545410 |
0 |
1545410 |
1545410 |
7.8 % |
15/05/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
1545410 |
0 |
1545410 |
1545410 |
7.8 % |
15/05/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1425193 |
0 |
1425193 |
1425193 |
7.2 % |
15/05/2015 |