| Point72 Asset Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
| Steven A. Cohen |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
| Parag Shah |
United States of America |
0 |
2873 |
0 |
2873 |
2873 |
0.02 % |
14/11/2024 |
| Anup Arora |
United States of America |
0 |
2873 |
0 |
2873 |
2873 |
0.02 % |
14/11/2024 |
| K2 HealthVentures Equity Trust LLC |
Delaware |
0 |
2873 |
0 |
2873 |
2873 |
0.02 % |
14/11/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
11938 |
629017 |
16633 |
645650 |
5.36 % |
12/11/2024 |
| Adage Capital Management, L.P. |
Delaware |
0 |
528937 |
0 |
528937 |
528937 |
4.39 % |
12/11/2024 |
| Robert Atchinson |
United States |
0 |
528937 |
0 |
528937 |
528937 |
4.39 % |
12/11/2024 |
| Phillip Gross |
United States |
0 |
528937 |
0 |
528937 |
528937 |
4.39 % |
12/11/2024 |
| BlackRock, Inc. |
Delaware |
0 |
0 |
802721 |
0 |
802721 |
6.7 % |
22/10/2024 |
| Millennium Management LLC |
Delaware |
0 |
122751 |
0 |
122751 |
122751 |
1 % |
15/10/2024 |
| Millennium Group Management LLC |
Delaware |
0 |
122751 |
0 |
122751 |
122751 |
1 % |
15/10/2024 |
| Israel A. Englander |
United States |
0 |
122751 |
0 |
122751 |
122751 |
1 % |
15/10/2024 |
| Octagon Investments Master Fund LP |
Cayman Islands |
0 |
1115000 |
0 |
1115000 |
1115000 |
9.3 % |
11/10/2024 |
| Ting Jia |
China |
0 |
1115000 |
0 |
1115000 |
1115000 |
9.3 % |
11/10/2024 |
| Octagon Capital Advisors LP |
Delaware |
0 |
1115000 |
0 |
1115000 |
1115000 |
9.3 % |
11/10/2024 |
| Cormorant Asset Management, LP |
Delaware |
0 |
1475000 |
0 |
1475000 |
1475000 |
14.27 % |
05/02/2024 |
| Bihua Chen |
United States |
0 |
1475000 |
0 |
1475000 |
1475000 |
14.27 % |
05/02/2024 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
1475000 |
0 |
1475000 |
1475000 |
14.27 % |
05/02/2024 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1475000 |
0 |
1475000 |
1475000 |
14.27 % |
05/02/2024 |
| Paradigm BioCapital Advisors GP LLC |
Delaware |
399658 |
0 |
399658 |
0 |
399658 |
9 % |
05/02/2024 |
| Paradigm BioCapital Advisors LP |
Delaware |
399658 |
0 |
399658 |
0 |
399658 |
9 % |
05/02/2024 |
| Paradigm BioCapital International Fund Ltd. |
Cayman Islands |
340756 |
0 |
340756 |
0 |
340756 |
7.7 % |
05/02/2024 |
| Senai Asefaw, M.D. |
United States of America |
399658 |
0 |
399658 |
0 |
399658 |
9 % |
05/02/2024 |
| Steven A. Cohen |
United States |
0 |
388676 |
0 |
388676 |
388676 |
8.8 % |
29/01/2024 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
388676 |
0 |
388676 |
388676 |
8.8 % |
29/01/2024 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
388676 |
0 |
388676 |
388676 |
8.8 % |
29/01/2024 |
| ETF Managers Group LLC |
Delaware |
6194679 |
|
6194679 |
|
6194679 |
4.95 % |
24/08/2022 |
| ETF Managers Group LLC |
Delaware |
6194679 |
|
6194679 |
|
6194679 |
4.95 % |
24/08/2022 |
| ETF Managers Group LLC |
Delaware |
10995143 |
|
10995143 |
|
10995143 |
8.78 % |
14/02/2022 |
| ETF Managers Group LLC |
Delaware |
10995143 |
|
10995143 |
|
10995143 |
8.78 % |
14/02/2022 |
| ETF Managers Group LLC |
Delaware |
14240357 |
|
14240357 |
|
14240357 |
11.39 % |
01/06/2021 |
| ETF Managers Group LLC |
Delaware |
14240357 |
|
14240357 |
|
14240357 |
11.39 % |
01/06/2021 |
| ETF Managers Group LLC |
Delaware |
6673458 |
|
6673458 |
|
6673458 |
5.34 % |
11/05/2021 |
| ETF Managers Group LLC |
Delaware |
6673458 |
|
6673458 |
|
6673458 |
5.34 % |
11/05/2021 |
| BlackRock, Inc. |
Delaware |
5621171 |
0 |
5673664 |
0 |
5673664 |
4.5 % |
09/04/2021 |
| ETF Managers Group LLC |
Delaware |
5997343 |
|
5997343 |
|
5997343 |
4.8 % |
17/03/2021 |
| ETF Managers Group LLC |
Delaware |
5997343 |
|
5997343 |
|
5997343 |
4.8 % |
17/03/2021 |
| ETF Managers Group LLC |
Delaware |
5851347 |
|
5851347 |
|
5851347 |
6.96 % |
16/02/2021 |
| ETF Managers Group LLC |
Delaware |
5851347 |
|
5851347 |
|
5851347 |
6.96 % |
16/02/2021 |
| ETF Managers Group LLC |
Delaware |
7796166 |
|
7796166 |
|
7796166 |
9.28 % |
12/02/2021 |
| ETF Managers Group LLC |
Delaware |
7796166 |
|
7796166 |
|
7796166 |
9.28 % |
12/02/2021 |
| BlackRock, Inc. |
Delaware |
5173531 |
0 |
5220525 |
0 |
5220525 |
6.2 % |
28/01/2021 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
1081734 |
0 |
1333546 |
1333546 |
1.59 % |
11/01/2021 |
| ETF Managers Group LLC |
Delaware |
8935647 |
|
8935647 |
|
8935647 |
10.63 % |
08/01/2021 |
| ETF Managers Group LLC |
Delaware |
8935647 |
|
8935647 |
|
8935647 |
10.63 % |
08/01/2021 |
| ETF Managers Group LLC |
Delaware |
8116550 |
|
8116550 |
|
8116550 |
9.66 % |
11/12/2020 |
| ETF Managers Group LLC |
Delaware |
8116550 |
|
8116550 |
|
8116550 |
9.66 % |
11/12/2020 |
| ETF Managers Group LLC |
Delaware |
7051869 |
|
7051869 |
|
7051869 |
8.39 % |
16/11/2020 |
| ETF Managers Group LLC |
Delaware |
7051869 |
|
7051869 |
|
7051869 |
8.39 % |
16/11/2020 |
| ETF Managers Group LLC |
Delaware |
4192462 |
|
4192462 |
|
4192462 |
5.13 % |
06/11/2020 |
| ETF Managers Group LLC |
Delaware |
4192462 |
|
4192462 |
|
4192462 |
5.13 % |
06/11/2020 |
| SSgA Funds Management, Inc. |
BOSTON, MASSACHUSETTS |
0 |
15345185 |
0 |
15360985 |
15360985 |
18.8 % |
13/10/2020 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
16334488 |
0 |
16618149 |
16618149 |
20.34 % |
13/10/2020 |
| Gakasa Holdings, LLC |
Florida |
0 |
1316364 |
0 |
1316364 |
1316364 |
5.9 % |
14/08/2020 |
| Fred Knoll |
USA |
0 |
1316364 |
0 |
1316364 |
1316364 |
5.9 % |
14/08/2020 |
| Knoll Capital Management, LP |
Delaware |
0 |
1316364 |
0 |
1316364 |
1316364 |
5.9 % |
14/08/2020 |
| ETF Managers Group LLC |
Delaware |
3771557 |
|
3771557 |
|
3771557 |
4.62 % |
07/08/2020 |
| ETF Managers Group LLC |
Delaware |
3771557 |
|
3771557 |
|
3771557 |
4.62 % |
07/08/2020 |
| ETF Managers Group LLC |
Delaware |
3632418 |
|
3632418 |
|
3632418 |
5.01 % |
24/04/2020 |
| ETF Managers Group LLC |
Delaware |
3632418 |
|
3632418 |
|
3632418 |
5.01 % |
24/04/2020 |
| ETF Managers Group LLC |
Delaware |
3594019 |
|
3594019 |
|
3594019 |
4.96 % |
19/03/2020 |
| ETF Managers Group LLC |
Delaware |
3594019 |
|
3594019 |
|
3594019 |
4.96 % |
19/03/2020 |
| Knoll Capital Management, LP |
Delaware |
0 |
5045870 |
0 |
5045870 |
5045870 |
7.06 % |
14/02/2020 |
| Fred Knoll |
USA |
0 |
5045870 |
0 |
5045870 |
5045870 |
7.06 % |
14/02/2020 |
| Gakasa Holdings, LLC |
Florida |
0 |
5045870 |
0 |
5045870 |
5045870 |
7.06 % |
14/02/2020 |
| ETF Managers Group LLC |
Delaware |
5461597 |
|
5461597 |
|
5461597 |
8.44 % |
02/12/2019 |
| ETF Managers Group LLC |
Delaware |
5461597 |
|
5461597 |
|
5461597 |
8.44 % |
02/12/2019 |
| ETF Managers Group LLC |
Delaware |
6953210 |
|
6953210 |
|
6953210 |
10.79 % |
03/06/2019 |
| ETF Managers Group LLC |
Delaware |
6953210 |
|
6953210 |
|
6953210 |
10.79 % |
03/06/2019 |
| ETF Managers Group LLC |
Delaware |
6335867 |
|
6335867 |
|
6335867 |
9.83 % |
29/04/2019 |
| ETF Managers Group LLC |
Delaware |
6335867 |
|
6335867 |
|
6335867 |
9.83 % |
29/04/2019 |
| ETF Managers Group LLC |
Delaware |
5501467 |
|
5501467 |
|
5501467 |
8.67 % |
19/02/2019 |
| ETF Managers Group LLC |
Delaware |
5501467 |
|
5501467 |
|
5501467 |
8.67 % |
19/02/2019 |
| Mark Tepper |
States |
3170285 |
0 |
3170285 |
0 |
3170285 |
5.4 % |
14/02/2019 |
| Fred Knoll |
USA |
0 |
4985870 |
0 |
4985870 |
4985870 |
7.9 % |
14/02/2019 |
| Knoll Capital Management, LP |
Delaware |
0 |
4985870 |
0 |
4985870 |
4985870 |
7.9 % |
14/02/2019 |
| Gakasa Holdings, LLC |
Florida |
0 |
4985870 |
0 |
4985870 |
4985870 |
7.9 % |
14/02/2019 |
| BlackRock, Inc. |
Delaware |
5064770 |
0 |
5139893 |
0 |
5139893 |
9 % |
04/02/2019 |
| ETF Managers Group LLC |
Delaware |
4167349 |
|
|
|
4167349 |
7.28 % |
29/10/2018 |
| Fred Knoll |
USA |
0 |
3856985 |
0 |
3856985 |
3856985 |
6.9 % |
14/02/2018 |
| Knoll Capital Management, LP |
Delaware |
0 |
3856985 |
0 |
3856985 |
3856985 |
6.9 % |
14/02/2018 |
| Gakasa Holdings, LLC |
Florida |
0 |
3856985 |
0 |
3856985 |
3856985 |
6.9 % |
14/02/2018 |
| Mark Tepper |
States |
2960322 |
0 |
2960322 |
0 |
2960322 |
5.4 % |
14/02/2018 |
| Gakasa Holdings, LLC |
Florida |
0 |
3563925 |
0 |
3563925 |
3563925 |
7.3 % |
06/03/2017 |
| Fred Knoll |
USA |
0 |
3563925 |
0 |
3563925 |
3563925 |
7.3 % |
06/03/2017 |
| Knoll Capital Management, LP |
Delaware |
0 |
3563925 |
0 |
3563925 |
3563925 |
7.3 % |
06/03/2017 |
| Adam K. Stern |
USA |
1127250 |
1300000 |
1127250 |
1300000 |
2427250 |
4.9 % |
02/03/2017 |
| A.K.S. Family Partners, L.P. |
Nevada |
0 |
1150000 |
0 |
1150000 |
1150000 |
2.4 % |
02/03/2017 |
| AKS Family Foundation |
Delaware |
0 |
150000 |
0 |
150000 |
150000 |
0.3 % |
02/03/2017 |
| Adam K. Stern |
USA |
1127250 |
1300000 |
1127250 |
1300000 |
2427250 |
4.9 % |
02/03/2017 |
| A.K.S. Family Partners, L.P. |
Nevada |
0 |
1150000 |
0 |
1150000 |
1150000 |
2.4 % |
02/03/2017 |
| AKS Family Foundation |
Delaware |
0 |
150000 |
0 |
150000 |
150000 |
0.3 % |
02/03/2017 |
| Knoll Capital Management, LP |
Delaware |
0 |
2563925 |
0 |
2563925 |
2563925 |
5.8 % |
14/02/2017 |
| Fred Knoll |
USA |
0 |
2563925 |
0 |
2563925 |
2563925 |
5.8 % |
14/02/2017 |
| Gakasa Holdings, LLC |
Florida |
0 |
2563925 |
0 |
2563925 |
2563925 |
5.8 % |
14/02/2017 |
| Bihua Chen |
United States |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.17 % |
14/02/2017 |
| Cormorant Asset Management, LLC |
Delaware |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.17 % |
14/02/2017 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
2078750 |
0 |
2078750 |
2078750 |
4.3 % |
14/02/2017 |
| Bihua Chen |
United States |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.17 % |
14/02/2017 |
| Cormorant Asset Management, LLC |
Delaware |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.17 % |
14/02/2017 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
2078750 |
0 |
2078750 |
2078750 |
4.3 % |
14/02/2017 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
2078750 |
0 |
2078750 |
2078750 |
4.3 % |
14/02/2017 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
2078750 |
0 |
2078750 |
2078750 |
4.3 % |
14/02/2017 |
| Sumner Burstein |
States |
3058519 |
0 |
3058519 |
0 |
3058519 |
6.9 % |
14/02/2017 |
| Mark Tepper |
States |
2701172 |
0 |
2701172 |
0 |
2701172 |
6 % |
14/02/2017 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
|
|
|
|
1954600 |
4.47 % |
29/09/2016 |
| Bihua Chen |
United States |
|
|
|
|
2350700 |
5.37 % |
29/09/2016 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
|
|
|
|
1954600 |
4.47 % |
29/09/2016 |
| Cormorant Asset Management, LLC |
Delaware |
|
|
|
|
2350700 |
5.37 % |
29/09/2016 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
|
|
|
|
1954600 |
4.47 % |
29/09/2016 |
| Cormorant Asset Management, LLC |
Delaware |
|
|
|
|
2350700 |
5.37 % |
29/09/2016 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
|
|
|
|
1954600 |
4.47 % |
29/09/2016 |
| Bihua Chen |
United States |
|
|
|
|
2350700 |
5.37 % |
29/09/2016 |
| Knoll Capital Management, LP |
Delaware |
0 |
2563925 |
0 |
2563925 |
2563925 |
5.96 % |
01/03/2016 |
| Gakasa Holdings, LLC |
Florida |
0 |
2563925 |
0 |
2563925 |
2563925 |
5.96 % |
01/03/2016 |
| Knoll Capital Management, LP |
Delaware |
0 |
2563925 |
0 |
2563925 |
2563925 |
5.96 % |
01/03/2016 |
| Fred Knoll |
USA |
0 |
2563925 |
0 |
2563925 |
2563925 |
5.96 % |
01/03/2016 |
| Gakasa Holdings, LLC |
Florida |
0 |
2563925 |
0 |
2563925 |
2563925 |
5.96 % |
01/03/2016 |
| Fred Knoll |
USA |
0 |
2563925 |
0 |
2563925 |
2563925 |
5.96 % |
01/03/2016 |
| Europa International, Inc. |
British Virgin Islands |
0 |
2750000 |
0 |
2750000 |
2750000 |
8.5 % |
05/08/2015 |
| Europa International, Inc. |
British Virgin Islands |
0 |
2750000 |
0 |
2750000 |
2750000 |
8.5 % |
05/08/2015 |
| Knoll Capital Management, LP |
Delaware |
0 |
2750000 |
0 |
2750000 |
2750000 |
8.5 % |
05/08/2015 |
| Fred Knoll |
USA |
0 |
2750000 |
0 |
2750000 |
2750000 |
8.5 % |
05/08/2015 |
| Knoll Capital Management, LP |
Delaware |
0 |
2750000 |
0 |
2750000 |
2750000 |
8.5 % |
05/08/2015 |
| Fred Knoll |
USA |
0 |
2750000 |
0 |
2750000 |
2750000 |
8.5 % |
05/08/2015 |
| Adam K. Stern |
USA |
1612917 |
1200500 |
1612917 |
1200500 |
2813417 |
8.7 % |
29/07/2015 |
| Adam K. Stern |
USA |
1612917 |
1200500 |
1612917 |
1200500 |
2813417 |
8.7 % |
29/07/2015 |
| AKS Family Foundation |
Delaware |
0 |
200500 |
0 |
200500 |
200500 |
0.6 % |
29/07/2015 |
| A.K.S. Family Partners, L.P. |
Nevada |
0 |
1000000 |
0 |
1000000 |
1000000 |
3.2 % |
29/07/2015 |
| A.K.S. Family Partners, L.P. |
Nevada |
0 |
1000000 |
0 |
1000000 |
1000000 |
3.2 % |
29/07/2015 |
| AKS Family Foundation |
Delaware |
0 |
200500 |
0 |
200500 |
200500 |
0.6 % |
29/07/2015 |
| Sumner Burstein |
United States |
3825546 |
0 |
3825546 |
0 |
3825546 |
14.8 % |
21/07/2015 |
| Mark Tepper |
United States |
2251289 |
0 |
2251289 |
0 |
2251289 |
8.7 % |
17/02/2015 |