| Brown Capital Management, LLC |
State of Maryland |
3757142 |
0 |
5804501 |
0 |
5804501 |
14.31 % |
14/02/2022 |
| The Brown Capital Management Small Company Fund |
State of Maryland |
3138112 |
0 |
3138112 |
0 |
3138112 |
7.74 % |
14/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
74709 |
2594698 |
105680 |
2700378 |
6.66 % |
09/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
6882994 |
0 |
7007264 |
0 |
7007264 |
17.3 % |
28/01/2022 |
| Brown Capital Management, LLC |
Maryland |
3879318 |
0 |
5990470 |
0 |
5990470 |
14.93 % |
12/02/2021 |
| The Brown Capital Management Small Company Fund |
Maryland |
3138112 |
0 |
3138112 |
0 |
3138112 |
7.82 % |
12/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
89537 |
2396970 |
119711 |
2516681 |
6.27 % |
10/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
6838389 |
0 |
6969889 |
0 |
6969889 |
17.4 % |
25/01/2021 |
| The Brown Capital Management Small Company Fund |
State of Delaware |
3138112 |
0 |
3138112 |
0 |
3138112 |
8.92 % |
14/02/2020 |
| Brown Capital Management, LLC |
State of Maryland |
3758925 |
0 |
5868827 |
0 |
5868827 |
16.67 % |
14/02/2020 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
0 |
2157715 |
75187 |
2232902 |
6.34 % |
11/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
5353432 |
0 |
5431129 |
0 |
5431129 |
15.4 % |
04/02/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
1467918 |
0 |
0 |
1632232 |
4.64 % |
28/01/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
1467918 |
0 |
0 |
1632232 |
4.64 % |
28/01/2020 |
| Wellington Management Group LLP |
Delaware |
0 |
1467918 |
0 |
0 |
1632232 |
4.64 % |
28/01/2020 |
| Brown Capital Management, LLC |
State of Maryland |
3683000 |
0 |
5790301 |
0 |
5790301 |
16.42 % |
09/09/2019 |
| The Brown Capital Management Small Company Fund |
State of Maryland |
3053787 |
0 |
3053787 |
0 |
3053787 |
8.66 % |
09/09/2019 |
| (1) BlackRock, Inc. |
Delaware |
5350966 |
0 |
5449176 |
0 |
5449176 |
15.6 % |
10/04/2019 |
| The Brown Capital Management Small Company Fund |
State of Maryland |
1866766 |
0 |
1866766 |
0 |
1866766 |
5.42 % |
10/04/2019 |
| Brown Capital Management, LLC |
State of Maryland |
2434269 |
0 |
3750757 |
0 |
3750757 |
10.77 % |
10/04/2019 |
| Brown Capital Management, LLC |
Maryland |
2337637 |
0 |
3609369 |
0 |
3609369 |
10.4 % |
14/02/2019 |
| Wellington Management Company LLP |
Massachusetts |
0 |
1903835 |
0 |
0 |
2026703 |
5.84 % |
12/02/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
1918266 |
0 |
0 |
2102965 |
6.06 % |
12/02/2019 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
1918266 |
0 |
0 |
2102965 |
6.06 % |
12/02/2019 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
1918266 |
0 |
0 |
2102965 |
6.06 % |
12/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
2810351 |
0 |
2901471 |
0 |
2901471 |
8.4 % |
04/02/2019 |
| Capital Management, LLC |
State of Maryland |
2315425 |
0 |
3387259 |
0 |
3387259 |
10.11 % |
10/09/2018 |
| Brown Capital Management Small Company Fund |
State of Maryland |
1719510 |
0 |
1719510 |
0 |
1719510 |
5.13 % |
10/09/2018 |
| Capital Management, LLC |
State of Maryland |
1597675 |
0 |
2659509 |
0 |
2659509 |
7.79 % |
14/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
2541834 |
0 |
0 |
2984421 |
8.75 % |
08/02/2018 |
| Wellington Management Company LLP |
Massachusetts |
0 |
2527784 |
0 |
0 |
2857763 |
8.38 % |
08/02/2018 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
2541834 |
0 |
0 |
2984421 |
8.75 % |
08/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2541834 |
0 |
0 |
2984421 |
8.75 % |
08/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
2196615 |
0 |
2265706 |
0 |
2265706 |
6.6 % |
29/01/2018 |
| Brown Capital Management, LLC |
State of Maryland |
1510874 |
0 |
2471674 |
0 |
2471674 |
7.56 % |
10/07/2017 |
| Wellington Management Company LLP |
Massachusetts |
0 |
2121817 |
0 |
0 |
2378354 |
7.19 % |
09/02/2017 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
2121817 |
0 |
0 |
2503410 |
7.57 % |
09/02/2017 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2121817 |
0 |
0 |
2503410 |
7.57 % |
09/02/2017 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
2121817 |
0 |
0 |
2503410 |
7.57 % |
09/02/2017 |
| (1) BlackRock, Inc. |
Delaware |
2196049 |
0 |
2267546 |
0 |
2267546 |
6.9 % |
23/01/2017 |
| Ivy Investment Management Company Tax ID No. 03-0481447 |
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH: |
882942 |
0 |
0 |
0 |
882942 |
11 % |
12/02/2016 |
| Waddell & Reed Financial Services, Inc. Tax ID No. 43-1414157 |
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH: |
0 |
0 |
635500 |
0 |
635500 |
11 % |
12/02/2016 |
| Waddell & Reed Financial, Inc. Tax ID No. 51-0261715 |
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH: |
1518442 |
0 |
1518442 |
0 |
1518442 |
11 % |
12/02/2016 |
| Waddell & Reed Investment Management Company Tax ID No. 48-1106973 |
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH: |
0 |
0 |
635500 |
0 |
635500 |
11 % |
12/02/2016 |
| Waddell & Reed, Inc. Tax ID No. 43-1235675 |
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH: |
0 |
0 |
635500 |
0 |
635500 |
11 % |
12/02/2016 |
| The Vanguard Group |
Vermont |
1392270 |
0 |
1962310 |
11 |
1953526 |
5.68 % |
11/02/2016 |
| Mitchell Blutt |
Delaware |
0 |
0 |
0 |
0 |
10 |
12 % |
11/02/2016 |
| Consonance Capman GP LLC |
Delaware |
0 |
0 |
0 |
0 |
10 |
12 % |
11/02/2016 |
| Consonance Capital Management LP |
Delaware |
0 |
0 |
0 |
0 |
10 |
12 % |
11/02/2016 |
| Wellington Group Holdings LLP |
Delaware |
0 |
1933330 |
0 |
0 |
2365897 |
7.28 % |
11/02/2016 |
| Wellington Management Group LLP |
Delaware |
0 |
1933330 |
0 |
0 |
2365897 |
7.28 % |
11/02/2016 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
1933330 |
0 |
0 |
2365897 |
7.28 % |
11/02/2016 |
| Wellington Management Company LLP |
Delaware |
0 |
1933330 |
0 |
0 |
2140976 |
6.59 % |
11/02/2016 |
| (1) BlackRock, Inc. |
Delaware |
1785298 |
0 |
1852152 |
0 |
1852152 |
5.7 % |
28/01/2016 |
| Charles B. Johnson |
Massachusetts |
0 |
2000000 |
0 |
2000000 |
16251000 |
9.2 % |
02/11/2015 |
| Consonance Capman GP LLC |
Delaware |
0 |
2135200 |
0 |
0 |
2135200 |
6.8 % |
17/02/2015 |
| Consonance Capital Management LP |
Delaware |
0 |
2135200 |
0 |
0 |
2135200 |
6.8 % |
17/02/2015 |
| Mitchell Blutt |
Delaware |
0 |
2135200 |
0 |
0 |
2135200 |
6.8 % |
17/02/2015 |
| ( ) |
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH: |
1138542 |
0 |
1138542 |
0 |
1138542 |
11 % |
13/02/2015 |
| ( ) |
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH: |
844400 |
0 |
0 |
0 |
844400 |
11 % |
13/02/2015 |
| ( ) |
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH: |
1982942 |
0 |
1982942 |
0 |
1982942 |
11 % |
13/02/2015 |
| ( ) |
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH: |
844400 |
0 |
0 |
0 |
844400 |
11 % |
13/02/2015 |
| ( ) |
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH: |
844400 |
0 |
0 |
0 |
844400 |
11 % |
13/02/2015 |
| 2.7%(2) |
United States America |
815577 |
0 |
815577 |
0 |
815577 |
2.7 % |
13/02/2014 |
| Massachusetts Financial Services Company ("MFS") |
Delaware |
1535540 |
0 |
1627140 |
0 |
1627140 |
5.8 % |
07/02/2014 |
| Michael R. Murphy |
United States of America |
0 |
1102132 |
0 |
10 |
1102132 |
5.2 % |
08/04/2013 |
| Discovery Equity Partners, L.P. |
Illinois |
0 |
1102132 |
0 |
10 |
1102132 |
5.2 % |
08/04/2013 |
| Daniel J. Donoghue |
United States of America |
0 |
1102132 |
0 |
10 |
1102132 |
5.2 % |
08/04/2013 |
| Discovery Group I, LLC |
Delaware |
0 |
1102132 |
0 |
10 |
1102132 |
5.2 % |
08/04/2013 |
| Glen D. Nelson, M.D. |
U.S.A. |
1414473 |
0 |
1414473 |
10 |
1414473 |
6.6 % |
30/01/2013 |
| Glen D. Nelson 2012 Family Trust |
U.S.A. |
28500 |
0 |
28500 |
10 |
28500 |
1 % |
30/01/2013 |
| GDN Holdings, LLC |
Minnesota |
939257 |
0 |
939257 |
10 |
939257 |
4.4 % |
30/01/2013 |
| David L. Martin |
United States of America |
1179293 |
0 |
1179293 |
0 |
1179293 |
5.5 % |
30/01/2013 |
| Daniel J. Donoghue |
United States of America |
0 |
1327542 |
0 |
10 |
1327542 |
6.4 % |
21/12/2012 |
| Discovery Equity Partners, L.P. |
Illinois |
0 |
1265370 |
0 |
10 |
1265370 |
6.1 % |
21/12/2012 |
| Discovery Group I, LLC |
Delaware |
0 |
1327542 |
0 |
10 |
1327542 |
6.4 % |
21/12/2012 |
| Michael R. Murphy |
United States of America |
0 |
1327542 |
0 |
10 |
1327542 |
6.4 % |
21/12/2012 |
| Discovery Equity Partners, L.P. |
Illinois |
0 |
1358527 |
0 |
10 |
1358527 |
6.6 % |
13/11/2012 |
| Discovery Group I, LLC |
Delaware |
0 |
1567539 |
0 |
10 |
1567539 |
7.6 % |
13/11/2012 |
| Daniel J. Donoghue |
United States of America |
0 |
1567539 |
0 |
10 |
1567539 |
7.6 % |
13/11/2012 |
| Michael R. Murphy |
United States of America |
0 |
1567539 |
0 |
10 |
1567539 |
7.6 % |
13/11/2012 |
| Discovery Equity Partners, L.P. |
Illinois |
0 |
1543150 |
0 |
10 |
1543150 |
7.5 % |
22/10/2012 |
| Discovery Group I, LLC |
Delaware |
0 |
1777786 |
0 |
10 |
1777786 |
8.7 % |
22/10/2012 |
| Daniel J. Donoghue |
United States of America |
0 |
1777786 |
0 |
10 |
1777786 |
8.7 % |
22/10/2012 |
| Michael R. Murphy |
United States of America |
0 |
1777786 |
0 |
10 |
1777786 |
8.7 % |
22/10/2012 |
| Daniel J. Donoghue |
United States of America |
0 |
2009832 |
0 |
10 |
2009832 |
9.8 % |
26/09/2012 |
| Discovery Equity Partners, L.P. |
Illinois |
0 |
1754072 |
0 |
10 |
1754072 |
8.6 % |
26/09/2012 |
| Discovery Group I, LLC |
Delaware |
0 |
2009832 |
0 |
10 |
2009832 |
9.8 % |
26/09/2012 |
| Michael R. Murphy |
United States of America |
0 |
2009832 |
0 |
10 |
2009832 |
9.8 % |
26/09/2012 |
| David L. Martin |
United States America |
1120905 |
0 |
1120905 |
0 |
1120905 |
6.5 % |
08/02/2012 |
| Discovery Equity Partners, L.P. |
Illinois |
0 |
1677764 |
0 |
10 |
1677764 |
9.5 % |
12/10/2011 |
| Daniel J. Donoghue |
United States of America |
0 |
1920123 |
0 |
10 |
1920123 |
10.9 % |
12/10/2011 |
| Michael R. Murphy |
United States of America |
0 |
1920123 |
0 |
10 |
1920123 |
10.9 % |
12/10/2011 |
| Discovery Group I, LLC |
Delaware |
0 |
1920123 |
0 |
10 |
1920123 |
10.9 % |
12/10/2011 |
| Michael R. Murphy |
United States of America |
0 |
1668935 |
0 |
10 |
1668935 |
9.4 % |
06/10/2011 |
| Discovery Equity Partners, L.P. |
Illinois |
0 |
1458807 |
0 |
10 |
1458807 |
8.2 % |
06/10/2011 |
| Discovery Group I, LLC |
Delaware |
0 |
1668935 |
0 |
10 |
1668935 |
9.4 % |
06/10/2011 |
| Daniel J. Donoghue |
United States of America |
0 |
1668935 |
0 |
10 |
1668935 |
9.4 % |
06/10/2011 |
| ECP GP, Inc. |
Delaware |
572640 |
58229 |
572640 |
0 |
630869 |
3.5 % |
09/09/2011 |
| EHC GP, LP |
Delaware |
680473 |
58229 |
680473 |
0 |
738702 |
4.1 % |
09/09/2011 |
| John Friedman |
Delaware |
66229 |
1253113 |
66229 |
0 |
1319342 |
7.3 % |
09/09/2011 |
| ECP GP, LLC |
Delaware |
572640 |
58229 |
572640 |
0 |
630869 |
3.5 % |
09/09/2011 |
| Easton Capital Partners, LP |
Delaware |
572640 |
58229 |
572640 |
0 |
630869 |
3.5 % |
09/09/2011 |
| EHC, Inc. |
Delaware |
680473 |
58229 |
680473 |
0 |
738702 |
4.1 % |
09/09/2011 |
| Easton Hunt Capital Partners, L.P. |
Delaware |
680473 |
58229 |
680473 |
0 |
738702 |
4.1 % |
09/09/2011 |
| Daniel J. Donoghue |
United States of America |
0 |
1149751 |
0 |
10 |
1149751 |
7 % |
29/08/2011 |
| Discovery Equity Partners, L.P. |
Illinois |
0 |
1006537 |
0 |
10 |
1006537 |
6.2 % |
29/08/2011 |
| Discovery Group I, LLC |
Delaware |
0 |
1149751 |
0 |
10 |
1149751 |
7 % |
29/08/2011 |
| Michael R. Murphy |
United States of America |
0 |
1149751 |
0 |
10 |
1149751 |
7 % |
29/08/2011 |
| Discovery Equity Partners, L.P. |
Illinois |
0 |
864268 |
0 |
10 |
864268 |
5.3 % |
17/08/2011 |
| Discovery Group I, LLC |
Delaware |
0 |
986525 |
0 |
10 |
986525 |
6 % |
17/08/2011 |
| Daniel J. Donoghue |
United States of America |
0 |
986525 |
0 |
10 |
986525 |
6 % |
17/08/2011 |
| Michael R. Murphy |
United States of America |
0 |
986525 |
0 |
10 |
986525 |
6 % |
17/08/2011 |
| Maverick Capital, Ltd. - 75-2482446 |
Texas |
1528563 |
0 |
1528563 |
0 |
1528563 |
9.6 % |
14/02/2011 |
| Maverick Capital Management, LLC - 75-2686461 |
Texas |
1528563 |
0 |
1528563 |
0 |
1528563 |
9.6 % |
14/02/2011 |
| Lee S. Ainslie III |
Texas |
1528563 |
0 |
1528563 |
0 |
1528563 |
9.6 % |
14/02/2011 |
| David L. Martin |
United States America |
0 |
0 |
0 |
0 |
1090872 |
6.6 % |
09/02/2011 |
| GDN Holdings, LLC |
United States of America |
0 |
0 |
0 |
0 |
1254634 |
7.6 % |
09/12/2010 |
| Glen D. Nelson, M.D. |
United States of America |
0 |
0 |
0 |
0 |
1254634 |
7.6 % |
09/12/2010 |
| Maverick Capital, Ltd. - 75-2482446 |
Texas |
2183152 |
0 |
2183152 |
0 |
2183152 |
14.1 % |
16/02/2010 |
| Maverick Capital Management, LLC - 75-2686461 |
Texas |
2183152 |
0 |
2183152 |
0 |
2183152 |
14.1 % |
16/02/2010 |
| Lee S. Ainslie III |
Texas |
2183152 |
0 |
2183152 |
0 |
2183152 |
14.1 % |
16/02/2010 |
| ECP GP, Inc. (1) |
Delaware |
0 |
0 |
0 |
58229 |
665136 |
4.4 % |
16/02/2010 |
| Easton Hunt Capital Partners, L.P. (1) |
Delaware |
0 |
0 |
0 |
58229 |
772969 |
5.1 % |
16/02/2010 |
| ECP GP, LLC (1) |
Delaware |
0 |
0 |
0 |
58229 |
665136 |
4.4 % |
16/02/2010 |
| Easton Capital Partners, LP (1) |
Delaware |
0 |
0 |
0 |
58229 |
665136 |
4.4 % |
16/02/2010 |
| EHC, Inc. (1) |
Delaware |
0 |
0 |
0 |
58229 |
772969 |
5.1 % |
16/02/2010 |
| EHC GP, LP (1) |
Delaware |
0 |
0 |
0 |
58229 |
772969 |
5.1 % |
16/02/2010 |
| Advisors, Inc. |
Texas |
0 |
275290 |
0 |
0 |
275290 |
1.9 % |
12/02/2010 |
| Bonderman |
States |
0 |
275290 |
0 |
0 |
275290 |
1.9 % |
12/02/2010 |
| G. Coulter |
States |
0 |
275290 |
0 |
0 |
275290 |
1.9 % |
12/02/2010 |
| Partnres VI, L.P. |
USA |
0 |
0 |
0 |
361235 |
361235 |
2.5 % |
10/02/2010 |
| Ph.D. |
USA |
0 |
0 |
0 |
435905 |
435905 |
3 % |
10/02/2010 |
| Ventures VIII, L.P. |
USA |
0 |
0 |
0 |
74670 |
74670 |
0.51 % |
10/02/2010 |
| Ventures VI, L.P. |
USA |
0 |
0 |
0 |
361235 |
361235 |
2.5 % |
10/02/2010 |
| Crouse |
USA |
0 |
0 |
0 |
361235 |
361235 |
2.5 % |
10/02/2010 |
| W. Littlechild |
USA |
0 |
0 |
0 |
435905 |
435905 |
3 % |
10/02/2010 |
| R. Werner |
USA |
0 |
0 |
0 |
435905 |
435905 |
3 % |
10/02/2010 |
| Partners VIII, L.P. |
USA |
0 |
0 |
0 |
74670 |
74670 |
0.51 % |
10/02/2010 |
| Partners VIII, LLC |
USA |
0 |
0 |
0 |
74670 |
74670 |
0.51 % |
10/02/2010 |
| H. Cavanaugh, Ph.D. |
USA |
0 |
0 |
0 |
435905 |
435905 |
3 % |
10/02/2010 |
| Lawlor |
USA |
9791 |
0 |
0 |
435905 |
445696 |
3 % |
10/02/2010 |
| Mitsui & Co. Ltd. |
Japan |
0 |
776861 |
0 |
776861 |
776861 |
5.7 % |
26/03/2009 |
| Mitsui & Co. Venture Partners, Inc. |
Delaware |
7767 |
0 |
7767 |
0 |
7767 |
0.06 % |
26/03/2009 |
| Mitsui & Co. (U.S.A.), Inc. |
New York |
384547 |
0 |
384547 |
0 |
384547 |
2.8 % |
26/03/2009 |
| MCVP Holding, Inc. |
Delaware |
384547 |
0 |
384547 |
0 |
384547 |
2.8 % |
26/03/2009 |
| HealthCare Partners VIII, LLC |
USA |
0 |
746707 |
0 |
0 |
746707 |
2.75 % |
11/02/2009 |
| HealthCare Ventures VIII, L.P. |
USA |
0 |
746707 |
0 |
0 |
746707 |
2.75 % |
11/02/2009 |
| HealthCare Partners VIII, L.P. |
USA |
0 |
746707 |
0 |
0 |
746707 |
2.75 % |
11/02/2009 |
| William Crouse |
USA |
0 |
3612362 |
0 |
0 |
3612362 |
13.33 % |
11/02/2009 |
| John W. Littlechild |
USA |
0 |
4359069 |
0 |
0 |
4359069 |
16.08 % |
11/02/2009 |
| HealthCare Partners VI, L.P. |
USA |
0 |
3612362 |
0 |
0 |
3612362 |
13.33 % |
11/02/2009 |
| Augustine Lawlor |
USA |
24469 |
4359069 |
24469 |
0 |
4383538 |
16.16 % |
11/02/2009 |
| Christopher Mirabelli, Ph.D. |
USA |
0 |
4359069 |
0 |
0 |
4359069 |
16.08 % |
11/02/2009 |
| HealthCare Ventures VI, L.P. |
USA |
0 |
3612362 |
0 |
0 |
3612362 |
13.33 % |
11/02/2009 |
| James H. Cavanaugh, Ph.D. |
USA |
0 |
4359069 |
0 |
0 |
4359069 |
16.08 % |
11/02/2009 |
| Harold R. Werner |
USA |
0 |
4359069 |
0 |
0 |
4359069 |
16.08 % |
11/02/2009 |
| 13-3695715 |
Delaware |
0 |
2420153 |
0 |
0 |
2420153 |
8.9 % |
11/01/2008 |
| E. Shaw |
States |
0 |
2420153 |
0 |
0 |
2420153 |
8.9 % |
11/01/2008 |
| 13-3799946 |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/01/2008 |
| 13-4046559 |
Delaware |
0 |
2420153 |
0 |
0 |
2420153 |
8.9 % |
11/01/2008 |
| 13-4152438 |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/01/2008 |
| tion No. of Above Person |
United States |
0 |
1504121 |
0 |
1504121 |
1504121 |
11 % |
11/05/2007 |
| tion No. of Above Person |
Delaware |
0 |
1487808 |
0 |
1487808 |
1487808 |
11 % |
11/05/2007 |
| tion No. of Above Person |
Delaware |
0 |
1487808 |
0 |
1487808 |
1487808 |
11 % |
11/05/2007 |
| tion No. of Above Person |
Delaware |
0 |
1487808 |
0 |
1487808 |
1487808 |
11 % |
11/05/2007 |
| tion No. of Above Person |
Delaware |
0 |
1487808 |
0 |
1487808 |
1487808 |
11 % |
11/05/2007 |
| tion No. of Above Person |
Delaware |
0 |
1504121 |
0 |
1504121 |
1504121 |
11 % |
11/05/2007 |
| tion No. of Above Person |
Delaware |
1487808 |
0 |
1487808 |
0 |
1487808 |
11 % |
11/05/2007 |
| tion No. of Above Person |
United States |
0 |
1504121 |
0 |
1504121 |
1504121 |
11 % |
11/05/2007 |
| tion No. of Above Person |
Delaware |
1487808 |
0 |
1487808 |
0 |
1487808 |
11 % |
11/05/2007 |
| 13-3695715 |
Delaware |
0 |
2313722 |
0 |
0 |
2313722 |
8.6 % |
10/05/2007 |
| 13-3799946 |
Delaware |
0 |
2215820 |
0 |
0 |
2215820 |
8.2 % |
10/05/2007 |
| E. Shaw |
States |
0 |
2313722 |
0 |
0 |
2313722 |
8.6 % |
10/05/2007 |
| 13-4152438 |
Delaware |
0 |
2215820 |
0 |
0 |
2215820 |
8.2 % |
10/05/2007 |
| 51-0481096 |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/05/2007 |
| 13-3695715 |
Delaware |
0 |
1624301 |
0 |
0 |
1624301 |
6 % |
14/02/2007 |
| 51-0481096 |
Delaware |
0 |
1471761 |
0 |
0 |
1471761 |
5.5 % |
14/02/2007 |
| E. Shaw |
States |
0 |
1624301 |
0 |
0 |
1624301 |
6 % |
14/02/2007 |
| 13-3799946 |
Delaware |
0 |
1471761 |
0 |
0 |
1471761 |
5.5 % |
14/02/2007 |
| 84-1561872 |
: |
0 |
0 |
0 |
0 |
1459459 |
5.4 % |
14/02/2007 |
| 84-1568047 |
: |
0 |
0 |
0 |
0 |
39459 |
0.1 % |
14/02/2007 |
| John T. Greff (“JTG”) |
: |
0 |
0 |
0 |
1459459 |
1459459 |
5.4 % |
14/02/2007 |
| Kinney L. Johnson (“KLJ”) |
: |
0 |
0 |
0 |
1459459 |
1459459 |
5.4 % |
14/02/2007 |
| Thomas G. Washing (“TGW”) |
: |
0 |
0 |
0 |
1459459 |
1459459 |
5.4 % |
14/02/2007 |
| Daniel J. Mitchell (“DJM”) |
: |
0 |
0 |
0 |
1459459 |
1492443 |
5.5 % |
14/02/2007 |
| Timothy H. Connor (“THC”) |
: |
0 |
0 |
0 |
1459459 |
1459459 |
5.4 % |
14/02/2007 |
| 84-1561871 |
: |
0 |
0 |
0 |
0 |
1420000 |
5.3 % |
14/02/2007 |
| tion No. of Above Person |
Delaware |
0 |
1368382 |
0 |
1368382 |
1368382 |
11 % |
14/02/2007 |
| tion No. of Above Person |
Delaware |
1368382 |
0 |
1368382 |
0 |
1368382 |
11 % |
14/02/2007 |
| tion No. of Above Person |
United States |
0 |
1384695 |
0 |
1384695 |
1384695 |
11 % |
14/02/2007 |
| tion No. of Above Person |
Delaware |
0 |
1368382 |
0 |
1368382 |
1368382 |
11 % |
14/02/2007 |
| tion No. of Above Person |
Delaware |
0 |
1368382 |
0 |
1368382 |
1368382 |
11 % |
14/02/2007 |
| tion No. of Above Person |
Delaware |
0 |
1368382 |
0 |
1368382 |
1368382 |
11 % |
14/02/2007 |
| tion No. of Above Person |
United States |
0 |
1384695 |
0 |
1384695 |
1384695 |
11 % |
14/02/2007 |
| tion No. of Above Person |
Delaware |
1368382 |
0 |
1368382 |
0 |
1368382 |
11 % |
14/02/2007 |
| tion No. of Above Person |
Delaware |
0 |
1384695 |
0 |
1384695 |
1384695 |
11 % |
14/02/2007 |
| Tarrant Advisors, Inc. |
Delaware |
2752914 |
0 |
2752914 |
0 |
2752914 |
10.2 % |
14/02/2007 |
| Duquesne Capital Management, L.L.C. |
Pennsylvania |
0 |
1383918 |
0 |
1383918 |
1383918 |
5.1 % |
09/02/2007 |
| Windmill Master Fund L.P. |
Cayman Islands |
0 |
1097509 |
0 |
1097509 |
1097509 |
4.1 % |
09/02/2007 |
| Stanley F. Druckenmiller |
United States |
0 |
1383918 |
0 |
1383918 |
1383918 |
5.1 % |
09/02/2007 |
| HealthCare Partners VIII, LLC |
United States |
0 |
746707 |
0 |
0 |
746707 |
2.77 % |
02/02/2007 |
| John W. Littlechild |
United States |
0 |
4359069 |
0 |
0 |
4359069 |
16.18 % |
02/02/2007 |
| HealthCare Ventures VI, L.P. |
United States |
0 |
3612362 |
0 |
0 |
3612362 |
13.41 % |
02/02/2007 |
| HealthCare Ventures VIII, L.P. |
United States |
0 |
746707 |
0 |
0 |
746707 |
2.77 % |
02/02/2007 |
| Eric Aguiar, Ph.D. |
United States |
0 |
4359069 |
0 |
0 |
4359069 |
16.18 % |
02/02/2007 |
| Christopher Mirabelli, Ph.D. |
United States |
0 |
4359069 |
0 |
0 |
4359069 |
16.18 % |
02/02/2007 |
| Augustine Lawlor |
United States |
16313 |
4359069 |
16313 |
0 |
4375382 |
16.23 % |
02/02/2007 |
| James H. Cavanaugh, Ph.D. |
United States |
0 |
4359069 |
0 |
0 |
4359069 |
16.18 % |
02/02/2007 |
| William Crouse |
United States |
0 |
3612362 |
0 |
0 |
3612362 |
13.41 % |
02/02/2007 |
| HealthCare Partners VIII, L.P. |
United States |
0 |
746707 |
0 |
0 |
746707 |
2.77 % |
02/02/2007 |
| HealthCare Partners VI, L.P. |
United States |
0 |
3612362 |
0 |
0 |
3612362 |
13.41 % |
02/02/2007 |
| Harold R. Werner |
United States |
0 |
4359069 |
0 |
0 |
4359069 |
16.18 % |
02/02/2007 |
| D.
E. Shaw & Co., L.P. |
or Place of Organization |
0 |
0 |
0 |
1398200 |
1398200 |
5.3 % |
07/08/2006 |
| David
E. Shaw |
or Place of Organization |
0 |
0 |
0 |
1398200 |
1398200 |
5.3 % |
07/08/2006 |
| Windmill Master Fund L.P. |
Cayman Islands |
0 |
1390309 |
0 |
1390309 |
1390309 |
5.3 % |
07/07/2006 |
| Stanley F. Druckenmiller |
United States |
0 |
1683918 |
0 |
1683918 |
1683918 |
6.4 % |
07/07/2006 |
| Duquesne Capital Management, L.L.C. |
Pennsylvania |
0 |
1683918 |
0 |
1683918 |
1683918 |
6.4 % |
07/07/2006 |