| EIN #00-0000000 |
Jersey, Channel Islands |
0 |
4158110 |
0 |
4158110 |
4158110 |
5.3 % |
22/05/2024 |
| 00-0000000 |
Cayman Islands |
0 |
4158110 |
0 |
4158110 |
4158110 |
5.3 % |
22/05/2024 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
5750000 |
0 |
0 |
5750000 |
7.38 % |
13/05/2024 |
| Cormorant Global Healthcare GP, LLC |
Cayman Islands |
0 |
5750000 |
0 |
0 |
5750000 |
7.38 % |
13/05/2024 |
| Cormorant Asset Management, LP |
Cayman Islands |
0 |
5750000 |
0 |
0 |
5750000 |
7.38 % |
13/05/2024 |
| Bihua Chen |
Cayman Islands |
0 |
5750000 |
0 |
0 |
5750000 |
7.38 % |
13/05/2024 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
3544303 |
3544303 |
5.4 % |
29/07/2022 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
2622422 |
2622422 |
4 % |
29/07/2022 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
3544303 |
3544303 |
5.4 % |
29/07/2022 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
319691 |
319691 |
1 % |
29/07/2022 |
| BVF GP Holdings LLC |
Delaware |
0 |
0 |
0 |
6166725 |
6166725 |
9.4 % |
29/07/2022 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
6595801 |
6595801 |
10.1 % |
29/07/2022 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
2622422 |
2622422 |
4 % |
29/07/2022 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
319691 |
319691 |
1 % |
29/07/2022 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
6595801 |
6595801 |
10.1 % |
29/07/2022 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
6595801 |
6595801 |
10.1 % |
29/07/2022 |
| (1) BlackRock, Inc. |
Delaware |
1825198 |
0 |
1826591 |
0 |
1826591 |
2.8 % |
08/07/2022 |
| Steven A. Cohen |
Citizenship or place of organization United States |
0 |
6312371 |
0 |
6312371 |
6312371 |
4 % |
14/02/2022 |
| Cubist Systematic Strategies, LLC |
Citizenship or place of organization Delaware |
0 |
9346 |
0 |
9346 |
9346 |
4 % |
14/02/2022 |
| Point72 Asset Management, L.P. |
Citizenship or place of organization Delaware |
0 |
6303025 |
0 |
6303025 |
6303025 |
4 % |
14/02/2022 |
| Point72 Capital Advisors, Inc. |
Citizenship or place of organization Delaware |
0 |
6303025 |
0 |
6303025 |
6303025 |
4 % |
14/02/2022 |
| Rajeev Shah |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Peter Kolchinsky |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Roderick Wong |
United States |
0 |
6029700 |
0 |
0 |
6029700 |
9.2 % |
14/02/2022 |
| RTW Investments, LP |
Delaware |
0 |
6029700 |
0 |
0 |
6029700 |
9.2 % |
14/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
99477 |
4985704 |
122287 |
5107991 |
7.83 % |
09/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
4891148 |
0 |
4962362 |
0 |
4962362 |
7.6 % |
03/02/2022 |
| 2. |
New York |
8828 |
0 |
0 |
0 |
8828 |
12 % |
01/02/2022 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
3002559 |
3002559 |
4.6 % |
03/01/2022 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
319691 |
319691 |
1 % |
03/01/2022 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
5374624 |
5374624 |
8.2 % |
03/01/2022 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
5803700 |
5803700 |
8.9 % |
03/01/2022 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
5803700 |
5803700 |
8.9 % |
03/01/2022 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
3002559 |
3002559 |
4.6 % |
03/01/2022 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
2372065 |
2372065 |
3.6 % |
03/01/2022 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
2372065 |
2372065 |
3.6 % |
03/01/2022 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
319691 |
319691 |
1 % |
03/01/2022 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
5803700 |
5803700 |
8.9 % |
03/01/2022 |
| Roderick
Wong |
Delaware |
0 |
5868326 |
0 |
5868326 |
5868326 |
8.99 % |
08/12/2021 |
| RTW
Master Fund, Ltd. |
Delaware |
0 |
3881954 |
0 |
3881954 |
3881954 |
5.95 % |
08/12/2021 |
| RTW
Investments, LP |
Delaware |
0 |
5868326 |
0 |
5868326 |
5868326 |
8.99 % |
08/12/2021 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
2919471 |
2919471 |
4.5 % |
03/05/2021 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
179569 |
179569 |
1 % |
03/05/2021 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
2690013 |
2690013 |
4.1 % |
03/05/2021 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1135004 |
1135004 |
1.8 % |
03/05/2021 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1135004 |
1135004 |
1.8 % |
03/05/2021 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1555009 |
1555009 |
2.4 % |
03/05/2021 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
179569 |
179569 |
1 % |
03/05/2021 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
2919471 |
2919471 |
4.5 % |
03/05/2021 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
1555009 |
1555009 |
2.4 % |
03/05/2021 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
2919471 |
2919471 |
4.5 % |
03/05/2021 |
| Joseph Edelman |
Delaware |
0 |
2577043 |
0 |
2577043 |
2577043 |
4.3 % |
16/02/2021 |
| Perceptive Life Sciences Master Fund, Ltd. |
Delaware |
0 |
2577043 |
0 |
2577043 |
2577043 |
4.3 % |
16/02/2021 |
| Perceptive Advisors LLC |
Delaware |
0 |
2577043 |
0 |
2577043 |
2577043 |
4.3 % |
16/02/2021 |
| Biotechnology Value Trading Fund OS LP |
|
0 |
0 |
0 |
358450 |
358450 |
1 % |
11/02/2021 |
| BVF II GP LLC |
|
0 |
0 |
0 |
2164406 |
2164406 |
4.7 % |
11/02/2021 |
| BVF Partners OS Ltd. |
|
0 |
0 |
0 |
358450 |
358450 |
1 % |
11/02/2021 |
| BVF GP HOLDINGS LLC |
|
0 |
0 |
0 |
5110149 |
5110149 |
11.1 % |
11/02/2021 |
| BVF Partners L.P. |
|
0 |
0 |
0 |
5576471 |
5576471 |
12.1 % |
11/02/2021 |
| BVF Inc. |
|
0 |
0 |
0 |
5576471 |
5576471 |
12.1 % |
11/02/2021 |
| Mark N. Lampert |
|
0 |
0 |
0 |
5576471 |
5576471 |
12.1 % |
11/02/2021 |
| Biotechnology Value Fund, L.P. |
|
0 |
0 |
0 |
2945743 |
2945743 |
6.4 % |
11/02/2021 |
| BVF I GP LLC |
|
0 |
0 |
0 |
2945743 |
2945743 |
6.4 % |
11/02/2021 |
| Biotechnology Value Fund II, L.P. |
|
0 |
0 |
0 |
2164406 |
2164406 |
4.7 % |
11/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
100301 |
2800222 |
134202 |
2934424 |
6.35 % |
10/02/2021 |
| 2. |
New York |
2643517 |
0 |
2728037 |
0 |
2728037 |
7.11 % |
02/02/2021 |
| Rajeev Shah |
United States of America |
0 |
3500000 |
0 |
0 |
3500000 |
5.8 % |
29/01/2021 |
| RA Capital Healthcare Fund, L.P. |
United States of America |
0 |
3203941 |
0 |
3203941 |
3203941 |
5.3 % |
29/01/2021 |
| RA Capital Management, L.P. |
United States of America |
0 |
3500000 |
0 |
3500000 |
3500000 |
5.8 % |
29/01/2021 |
| Peter Kolchinsky |
United States of America |
0 |
3500000 |
0 |
0 |
3500000 |
5.8 % |
29/01/2021 |
| (1) BlackRock, Inc. |
Delaware |
3752970 |
0 |
3805179 |
0 |
3805179 |
8.2 % |
29/01/2021 |
| Point72 Asset Management, L.P. |
United States |
0 |
5500300 |
0 |
5500300 |
5500300 |
4 % |
26/01/2021 |
| Point72 Capital Advisors, Inc. |
United States |
0 |
5500300 |
0 |
5500300 |
5500300 |
4 % |
26/01/2021 |
| Cubist Systematic Strategies, LLC |
United States |
0 |
23606 |
0 |
23606 |
23606 |
4 % |
26/01/2021 |
| Steven A. Cohen |
United States |
0 |
5523906 |
0 |
5523906 |
5523906 |
4 % |
26/01/2021 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
4626411 |
4626411 |
10 % |
10/11/2020 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1798908 |
1798908 |
3.9 % |
10/11/2020 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
305795 |
305795 |
1 % |
10/11/2020 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
305795 |
305795 |
1 % |
10/11/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
4214171 |
4214171 |
9.1 % |
10/11/2020 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
4626411 |
4626411 |
10 % |
10/11/2020 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
4626411 |
4626411 |
10 % |
10/11/2020 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1798908 |
1798908 |
3.9 % |
10/11/2020 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
2415263 |
2415263 |
5.2 % |
10/11/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
2415263 |
2415263 |
5.2 % |
10/11/2020 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
1640852 |
1640852 |
3.6 % |
06/03/2020 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1226415 |
1226415 |
2.7 % |
06/03/2020 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1226415 |
1226415 |
2.7 % |
06/03/2020 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
3188948 |
3188948 |
7 % |
06/03/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
2867267 |
2867267 |
6.3 % |
06/03/2020 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
221566 |
221566 |
1 % |
06/03/2020 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
221566 |
221566 |
1 % |
06/03/2020 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
3188948 |
3188948 |
7 % |
06/03/2020 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
3188948 |
3188948 |
7 % |
06/03/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1640852 |
1640852 |
3.6 % |
06/03/2020 |
| Perceptive Advisors LLC |
Delaware |
0 |
3253923 |
0 |
3253923 |
3253923 |
7.2 % |
14/02/2020 |
| Perceptive Life Sciences Master Fund, Ltd. |
Delaware |
0 |
3253923 |
0 |
3253923 |
3253923 |
7.2 % |
14/02/2020 |
| Joseph Edelman |
Delaware |
0 |
3253923 |
0 |
3253923 |
3253923 |
7.2 % |
14/02/2020 |
| 52-0556948 |
Maryland |
52770 |
0 |
686188 |
0 |
686188 |
1.5 % |
14/02/2020 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
93682 |
2900 |
2596647 |
92957 |
2689604 |
5.91 % |
11/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
3902727 |
0 |
4016048 |
0 |
4016048 |
8.8 % |
05/02/2020 |
| 2. |
New York |
2719431 |
0 |
2813451 |
0 |
2813451 |
6.19 % |
31/01/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
130332 |
0 |
0 |
130332 |
0.29 % |
27/01/2020 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
130332 |
0 |
0 |
130332 |
0.29 % |
27/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
130332 |
0 |
0 |
130332 |
0.29 % |
27/01/2020 |
| 10 |
Cayman Islands |
0 |
2991715 |
0 |
2991715 |
2991715 |
6.5 % |
14/02/2019 |
| 10 |
Cayman Islands |
0 |
2991715 |
0 |
2991715 |
2991715 |
6.5 % |
14/02/2019 |
| 10 |
Cayman Islands |
0 |
2991715 |
0 |
2991715 |
2991715 |
6.5 % |
14/02/2019 |
| 52-0556948 |
Maryland |
730166 |
0 |
4091526 |
0 |
4091526 |
9 % |
14/02/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2420775 |
0 |
0 |
2677658 |
5.95 % |
12/02/2019 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2420775 |
0 |
0 |
2677658 |
5.95 % |
12/02/2019 |
| Wellington Management Company LLP |
Delaware |
0 |
2351887 |
0 |
0 |
2461278 |
5.47 % |
12/02/2019 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2420775 |
0 |
0 |
2677658 |
5.95 % |
12/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
3729784 |
0 |
3860928 |
0 |
3860928 |
8.6 % |
04/02/2019 |
| 10 |
Delaware |
0 |
2490381 |
0 |
2490381 |
2490381 |
6.5 % |
14/02/2018 |
| 10 |
Delaware |
0 |
2490381 |
0 |
2490381 |
2490381 |
6.5 % |
14/02/2018 |
| ( 13-5315170 |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2018 |
| 10. |
United States |
0 |
3320348 |
0 |
3320348 |
3320348 |
8.6 % |
13/02/2018 |
| 10. |
United States |
0 |
3320348 |
0 |
3320348 |
3320348 |
8.6 % |
13/02/2018 |
| 10. |
United States |
85509 |
3320348 |
85509 |
3320348 |
3405857 |
8.9 % |
13/02/2018 |
| 10. |
United States |
0 |
3320348 |
0 |
3320348 |
3320348 |
8.6 % |
13/02/2018 |
| 10. |
United States |
0 |
3320348 |
0 |
3320348 |
3320348 |
8.6 % |
13/02/2018 |
| 10. |
United States |
145286 |
3320348 |
145286 |
3320348 |
3465634 |
9 % |
13/02/2018 |
| FMR LLC |
Delaware |
738438 |
0 |
5761294 |
0 |
5761294 |
15 % |
13/02/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5761294 |
0 |
5761294 |
15 % |
13/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
2575961 |
0 |
2646599 |
0 |
2646599 |
6.9 % |
01/02/2018 |
| 10 |
Delaware |
0 |
2165381 |
0 |
2165381 |
2165381 |
5.6 % |
18/12/2017 |
| 10 |
Delaware |
0 |
2165381 |
0 |
2165381 |
2165381 |
5.6 % |
18/12/2017 |
| 10 |
Delaware |
0 |
2165381 |
0 |
2165381 |
2165381 |
5.6 % |
18/12/2017 |
| (10) |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
07/07/2017 |
| (10) |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
07/07/2017 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
608749 |
608749 |
1.7 % |
29/06/2017 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
171334 |
171334 |
1 % |
29/06/2017 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
941783 |
941783 |
2.6 % |
29/06/2017 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
171334 |
171334 |
1 % |
29/06/2017 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
2026998 |
2026998 |
5.5 % |
29/06/2017 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
2026998 |
2026998 |
5.5 % |
29/06/2017 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
2026998 |
2026998 |
5.5 % |
29/06/2017 |
| FMR LLC |
Delaware |
566095 |
0 |
5460352 |
0 |
5460352 |
15 % |
14/02/2017 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5460352 |
0 |
5460352 |
15 % |
14/02/2017 |
| 10. |
Delaware |
3244381 |
0 |
3244381 |
0 |
3244381 |
8.9 % |
26/01/2017 |
| 10. |
Delaware |
3244381 |
0 |
3244381 |
0 |
3244381 |
8.9 % |
26/01/2017 |
| ( 13-5315170 |
Delaware |
2017604 |
0 |
2017604 |
0 |
2017604 |
11 % |
21/10/2015 |
| James E. Flynn |
Delaware |
0 |
946024 |
0 |
0 |
946024 |
2.71 % |
14/10/2015 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
671024 |
0 |
0 |
671024 |
1.92 % |
14/10/2015 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
275000 |
0 |
0 |
275000 |
0.79 % |
14/10/2015 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
671024 |
0 |
0 |
671024 |
1.92 % |
14/10/2015 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
275000 |
0 |
0 |
275000 |
0.79 % |
14/10/2015 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
946024 |
0 |
0 |
946024 |
2.71 % |
14/10/2015 |