CYTK

Cytokinetics, Incorporated CYTK

Bénéficiaire Individuel

Déclarant Citoyenneté ou lieu d'organisation Pouvoir de vote unique Pouvoir de vote partagé Pouvoir de disposition unique Pouvoir de disposition partagé Montant en propriété effective Pourcentage détenu Date d'achat
T. Rowe Price Investment Management, Inc. Maryland 9667286 0 9689987 0 9689987 8.2 % 14/11/2024
The Vanguard Group Pennsylvania 0 87684 11544717 216888 11761605 9.99 % 12/11/2024
BlackRock, Inc. Delaware 15059304 0 15252905 0 15252905 13 % 12/11/2024
FMR LLC Delaware 12216482 0 12415642 0 12415642 10.518 % 12/11/2024
Abigail P. Johnson United States of America 0 0 12415642 0 12415642 10.518 % 12/11/2024
The Vanguard Group Pennsylvania 0 87684 11544717 216888 11761605 9.99 % 04/11/2024
BlackRock, Inc. Delaware 0 0 15252905 0 15252905 13 % 23/10/2024
The Vanguard Group Pennsylvania 0 162357 10758222 258667 11016889 11.24 % 13/02/2024
Abigail P. Johnson United States of America 0 0 13007783 0 13007783 13.265 % 09/02/2024
FMR LLC Delaware 12991435 0 13007783 0 13007783 13.265 % 09/02/2024
Wellington Management Company LLP Delaware 0 5998852 0 6325032 6325032 6.45 % 08/02/2024
Wellington Management Group LLP Massachusetts 0 6036013 0 6530884 6530884 6.66 % 08/02/2024
Wellington Group Holdings LLP Delaware 0 6036013 0 6530884 6530884 6.66 % 08/02/2024
Wellington Investment Advisors Holdings LLP Delaware 0 6036013 0 6530884 6530884 6.66 % 08/02/2024
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 5614958 0 5893358 5893358 6.01 % 25/01/2024
BlackRock, Inc. Delaware 16300541 0 16102070 0 16102070 16.4 % 22/01/2024
BlackRock, Inc. Delaware 15639426 0 15767874 0 15767874 16.7 % 10/02/2023
The Vanguard Group Pennsylvania 0 135263 9849052 224042 10073094 10.64 % 09/02/2023
Wellington Investment Advisors Holdings LLP Delaware 0 6054676 0 6542724 6542724 6.91 % 06/02/2023
Wellington Management Group LLP Massachusetts 0 6054676 0 6542724 6542724 6.91 % 06/02/2023
Wellington Group Holdings LLP Delaware 0 6054676 0 6542724 6542724 6.91 % 06/02/2023
Wellington Management Company LLP Delaware 0 6016885 0 6312435 6312435 6.67 % 06/02/2023
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 4855518 0 5044914 5044914 5.33 % 03/02/2023
BlackRock, Inc. Delaware 15639426 0 15767874 0 14967317 16 % 26/01/2023
The Vanguard Group Pennsylvania 0 132640 8533656 207468 8741124 10.3 % 08/04/2022
DRIEHAUS CAPITAL MANAGEMENT LLC Delaware USA 0 2327112 0 2327112 2327112 2.77 % 14/02/2022
The Vanguard Group Pennsylvania 0 145350 6784630 205089 6989719 8.33 % 09/02/2022
STATE STREET CORPORATION NO. OF THE ABOVE PERSON: BOSTON MASSACHUSETTS 0 3825027 0 3985227 3985227 4.75 % 09/02/2022
BlackRock, Inc. Delaware 12841809 0 12950964 0 12950964 15.4 % 27/01/2022
BlackRock, Inc. Delaware 12854369 0 12950964 0 12950964 15.4 % 25/01/2022
Abigail P. Johnson United States of America 0 0 8488682 0 8488682 11.832 % 12/07/2021
Abigail P. Johnson United States of America 0 0 8488682 0 8488682 11.832 % 12/07/2021
FMR LLC Delaware 353600 0 8488682 0 8488682 11.832 % 12/07/2021
FMR LLC Delaware 353600 0 8488682 0 8488682 11.832 % 12/07/2021
PORTFOLIO SERVICES LTD. 3062748 4.3 % 19/02/2021
EASTERN CAPITAL LIMITED 3062748 4.3 % 19/02/2021
KENNETH B. DART 3062748 4.3 % 19/02/2021
EASTERN CAPITAL LIMITED 3062748 4.3 % 19/02/2021
KENNETH B. DART 3062748 4.3 % 19/02/2021
PORTFOLIO SERVICES LTD. 3062748 4.3 % 19/02/2021
Point72 Asset Management, L.P. Delaware 0 1166294 0 1166294 1166294 1.6 % 16/02/2021
Cubist Systematic Strategies, LLC Delaware 0 9921 0 9921 9921 0.1 % 16/02/2021
Point72 Asset Management, L.P. Delaware 0 1166294 0 1166294 1166294 1.6 % 16/02/2021
Cubist Systematic Strategies, LLC Delaware 0 9921 0 9921 9921 0.1 % 16/02/2021
Point72 Hong Kong Limited Hong Kong 0 438 0 438 438 0.1 % 16/02/2021
Steven A. Cohen United States 0 1176653 0 1176653 1176653 1.7 % 16/02/2021
Steven A. Cohen United States 0 1176653 0 1176653 1176653 1.7 % 16/02/2021
Point72 Capital Advisors, Inc. Delaware 0 1166294 0 1166294 1166294 1.6 % 16/02/2021
Point72 Hong Kong Limited Hong Kong 0 438 0 438 438 0.1 % 16/02/2021
Point72 Capital Advisors, Inc. Delaware 0 1166294 0 1166294 1166294 1.6 % 16/02/2021
The Vanguard Group Pennsylvania 0 142419 4628234 193756 4821990 6.81 % 10/02/2021
The Vanguard Group Pennsylvania 0 142419 4628234 193756 4821990 6.81 % 10/02/2021
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 4384539 0 4640923 4640923 6.56 % 08/02/2021
BlackRock, Inc. Delaware 11501601 0 11611079 0 11611079 16.4 % 25/01/2021
Biotechnology Value Fund II, L.P. Delaware 0 1060631 0 1060631 1060631 1.5 % 13/01/2021
Biotechnology Value Fund, L.P. Delaware 0 1439986 0 1439986 1439986 2 % 13/01/2021
BVF Inc. Delaware 0 2728035 0 2728035 2728035 3.9 % 13/01/2021
BVF Partners L.P. Delaware 0 2728035 0 2728035 2728035 3.9 % 13/01/2021
BVF GP HOLDINGS LLC Delaware 0 2500617 0 2500617 2500617 3.5 % 13/01/2021
BVF Partners OS Ltd. Cayman Islands 0 174220 0 174220 174220 0 % 13/01/2021
BVF GP HOLDINGS LLC Delaware 0 2500617 0 2500617 2500617 3.5 % 13/01/2021
BVF Partners L.P. Delaware 0 2728035 0 2728035 2728035 3.9 % 13/01/2021
BVF Inc. Delaware 0 2728035 0 2728035 2728035 3.9 % 13/01/2021
Mark N. Lampert United States 0 2728035 0 2728035 2728035 3.9 % 13/01/2021
Mark N. Lampert United States 0 2728035 0 2728035 2728035 3.9 % 13/01/2021
Biotechnology Value Fund, L.P. Delaware 0 1439986 0 1439986 1439986 2 % 13/01/2021
BVF I GP LLC Delaware 0 1439986 0 1439986 1439986 2 % 13/01/2021
Biotechnology Value Fund II, L.P. Delaware 0 1060631 0 1060631 1060631 1.5 % 13/01/2021
BVF II GP LLC Delaware 0 1060631 0 1060631 1060631 1.5 % 13/01/2021
Biotechnology Value Trading Fund OS LP Cayman Islands 0 174220 0 174220 174220 0 % 13/01/2021
BVF Partners OS Ltd. Cayman Islands 0 174220 0 174220 174220 0 % 13/01/2021
Biotechnology Value Trading Fund OS LP Cayman Islands 0 174220 0 174220 174220 0 % 13/01/2021
BVF II GP LLC Delaware 0 1060631 0 1060631 1060631 1.5 % 13/01/2021
BVF I GP LLC Delaware 0 1439986 0 1439986 1439986 2 % 13/01/2021
BVF Partners L.P. Delaware 0 7358019 0 7358019 7358019 10.4 % 16/11/2020
Biotechnology Value Fund, L.P. Delaware 0 3896766 0 3896766 3896766 5.5 % 16/11/2020
BVF I GP LLC Delaware 0 3896766 0 3896766 3896766 5.5 % 16/11/2020
BVF II GP LLC Delaware 0 2832420 0 2832420 2832420 4 % 16/11/2020
Biotechnology Value Fund, L.P. Delaware 0 3896766 0 3896766 3896766 5.5 % 16/11/2020
BVF I GP LLC Delaware 0 3896766 0 3896766 3896766 5.5 % 16/11/2020
Biotechnology Value Fund II, L.P. Delaware 0 2832420 0 2832420 2832420 4 % 16/11/2020
BVF II GP LLC Delaware 0 2832420 0 2832420 2832420 4 % 16/11/2020
Biotechnology Value Trading Fund OS LP Cayman Islands 0 475224 0 475224 475224 0 % 16/11/2020
BVF Partners OS Ltd. Cayman Islands 0 475224 0 475224 475224 0 % 16/11/2020
BVF GP HOLDINGS LLC Delaware 0 6729186 0 6729186 6729186 9.5 % 16/11/2020
BVF Partners L.P. Delaware 0 7358019 0 7358019 7358019 10.4 % 16/11/2020
BVF Inc. Delaware 0 7358019 0 7358019 7358019 10.4 % 16/11/2020
Mark N. Lampert United States 0 7358019 0 7358019 7358019 10.4 % 16/11/2020
BVF Inc. Delaware 0 7358019 0 7358019 7358019 10.4 % 16/11/2020
Biotechnology Value Fund II, L.P. Delaware 0 2832420 0 2832420 2832420 4 % 16/11/2020
Biotechnology Value Trading Fund OS LP Cayman Islands 0 475224 0 475224 475224 0 % 16/11/2020
BVF Partners OS Ltd. Cayman Islands 0 475224 0 475224 475224 0 % 16/11/2020
BVF GP HOLDINGS LLC Delaware 0 6729186 0 6729186 6729186 9.5 % 16/11/2020
Mark N. Lampert United States 0 7358019 0 7358019 7358019 10.4 % 16/11/2020
BVF Inc. Delaware 0 3938280 0 3938280 3938280 6.6 % 01/04/2020
BVF GP HOLDINGS LLC Delaware 0 3600466 0 3600466 3600466 6.1 % 01/04/2020
BVF I GP LLC Delaware 0 2057150 0 2057150 2057150 3.5 % 01/04/2020
Biotechnology Value Fund II, L.P. Delaware 0 1543316 0 1543316 1543316 2.6 % 01/04/2020
BVF II GP LLC Delaware 0 1543316 0 1543316 1543316 2.6 % 01/04/2020
Biotechnology Value Trading Fund OS LP Cayman Islands 0 263921 0 263921 263921 0 % 01/04/2020
BVF Partners OS Ltd. Cayman Islands 0 263921 0 263921 263921 0 % 01/04/2020
Mark N. Lampert United States 0 3938280 0 3938280 3938280 6.6 % 01/04/2020
BVF Inc. Delaware 0 3938280 0 3938280 3938280 6.6 % 01/04/2020
BVF Partners L.P. Delaware 0 3938280 0 3938280 3938280 6.6 % 01/04/2020
BVF GP HOLDINGS LLC Delaware 0 3600466 0 3600466 3600466 6.1 % 01/04/2020
BVF Partners OS Ltd. Cayman Islands 0 263921 0 263921 263921 0 % 01/04/2020
Biotechnology Value Trading Fund OS LP Cayman Islands 0 263921 0 263921 263921 0 % 01/04/2020
BVF II GP LLC Delaware 0 1543316 0 1543316 1543316 2.6 % 01/04/2020
Biotechnology Value Fund, L.P. Delaware 0 2057150 0 2057150 2057150 3.5 % 01/04/2020
Biotechnology Value Fund II, L.P. Delaware 0 1543316 0 1543316 1543316 2.6 % 01/04/2020
BVF I GP LLC Delaware 0 2057150 0 2057150 2057150 3.5 % 01/04/2020
Biotechnology Value Fund, L.P. Delaware 0 2057150 0 2057150 2057150 3.5 % 01/04/2020
Mark N. Lampert United States 0 3938280 0 3938280 3938280 6.6 % 01/04/2020
BVF Partners L.P. Delaware 0 3938280 0 3938280 3938280 6.6 % 01/04/2020
Point72 Capital Advisors, Inc. Delaware 0 3028751 0 3028751 3028751 5.1 % 14/02/2020
Point72 Asset Management, L.P. Delaware 0 3028751 0 3028751 3028751 5.1 % 14/02/2020
Steven A. Cohen United States 0 3031849 0 3031849 3031849 5.1 % 14/02/2020
Cubist Systematic Strategies, LLC Delaware 0 3098 0 3098 3098 0.1 % 14/02/2020
Mr. David Kroin USA 0 160073 0 160073 0 0.27 % 14/02/2020
Great Point Partners, LLC USA 0 160073 0 160073 0 0.27 % 14/02/2020
Mr. David Kroin USA 0 160073 0 160073 0 0.27 % 14/02/2020
Dr. Jeffrey R. Jay, M.D. USA 0 160073 0 160073 0 0.27 % 14/02/2020
Great Point Partners, LLC USA 0 160073 0 160073 0 0.27 % 14/02/2020
Dr. Jeffrey R. Jay, M.D. USA 0 160073 0 160073 0 0.27 % 14/02/2020
Mark N. Lampert United States 0 7206458 0 7206458 7206458 12.2 % 14/02/2020
BVF Partners L.P. Delaware 0 7206458 0 7206458 7206458 12.2 % 14/02/2020
BVF GP HOLDINGS LLC Delaware 0 6479398 0 6479398 6479398 11 % 14/02/2020
Biotechnology Value Fund, L.P. Delaware 0 3617776 0 3617776 3617776 6.1 % 14/02/2020
BVF Inc. Delaware 0 7206458 0 7206458 7206458 12.2 % 14/02/2020
BVF I GP LLC Delaware 0 3617776 0 3617776 3617776 6.1 % 14/02/2020
Biotechnology Value Trading Fund OS LP Cayman Islands 0 499312 0 499312 499312 0 % 14/02/2020
BVF Partners OS Ltd. Cayman Islands 0 499312 0 499312 499312 0 % 14/02/2020
BVF II GP LLC Delaware 0 2861622 0 2861622 2861622 4.8 % 14/02/2020
Biotechnology Value Fund II, L.P. Delaware 0 2861622 0 2861622 2861622 4.8 % 14/02/2020
The Vanguard Group Pennsylvania 112427 3500 4437833 108157 4545990 7.68 % 12/02/2020
DRIEHAUS CAPITAL MANAGEMENT LLC Delaware USA 0 3039256 0 3039256 3039256 5.14 % 12/02/2020
BlackRock, Inc. Delaware 9475184 0 9560602 0 9560602 16.2 % 04/02/2020
Millennium International Management LP 378471 0.6 % 23/01/2020
ICS Opportunities, Ltd. 3959 0 % 23/01/2020
Millennium Group Management LLC 2571557 4.3 % 23/01/2020
Integrated Assets II LLC 374512 0.6 % 23/01/2020
Millennium Group Management LLC 2571557 4.3 % 23/01/2020
Millennium Management LLC 2571557 4.3 % 23/01/2020
Millennium Management LLC 2571557 4.3 % 23/01/2020
Millennium International Management LP 378471 0.6 % 23/01/2020
ICS Opportunities, Ltd. 3959 0 % 23/01/2020
Integrated Core Strategies (US) LLC 2193086 3.7 % 23/01/2020
Integrated Assets II LLC 374512 0.6 % 23/01/2020
Integrated Core Strategies (US) LLC 2193086 3.7 % 23/01/2020
Israel A. Englander 2571557 4.3 % 23/01/2020
Israel A. Englander 2571557 4.3 % 23/01/2020
Steven A. Cohen United States 0 2985508 0 2985508 2985508 5 % 27/12/2019
Point72 Capital Advisors, Inc. Delaware 0 2973941 0 2973941 2973941 5 % 27/12/2019
Point72 Asset Management, L.P. Delaware 0 2973941 0 2973941 2973941 5 % 27/12/2019
Steven A. Cohen United States 0 2985508 0 2985508 2985508 5 % 27/12/2019
Point72 Asset Management, L.P. Delaware 0 2973941 0 2973941 2973941 5 % 27/12/2019
Point72 Capital Advisors, Inc. Delaware 0 2973941 0 2973941 2973941 5 % 27/12/2019
Cubist Systematic Strategies, LLC Delaware 0 11567 0 11567 11567 0.1 % 27/12/2019
Cubist Systematic Strategies, LLC Delaware 0 11567 0 11567 11567 0.1 % 27/12/2019
Israel A. Englander 3076955 5.3 % 02/08/2019
Millennium Group Management LLC 3076955 5.3 % 02/08/2019
Israel A. Englander 3076955 5.3 % 02/08/2019
Millennium Management LLC 3076955 5.3 % 02/08/2019
Integrated Assets II LLC 160608 0.3 % 02/08/2019
Integrated Assets II LLC 160608 0.3 % 02/08/2019
Millennium Management LLC 3076955 5.3 % 02/08/2019
Millennium Group Management LLC 3076955 5.3 % 02/08/2019
Integrated Core Strategies (US) LLC 2916347 5.1 % 02/08/2019
Integrated Core Strategies (US) LLC 2916347 5.1 % 02/08/2019
Great Point Partners, LLC USA 0 3173288 0 3173288 3173288 5.8 % 14/02/2019
Mr. David Kroin USA 0 3173288 0 3173288 3173288 5.8 % 14/02/2019
Dr. Jeffrey R. Jay, M.D. USA 0 3173288 0 3173288 3173288 5.8 % 14/02/2019
Great Point Partners, LLC USA 0 3173288 0 3173288 3173288 5.8 % 14/02/2019
Mr. David Kroin USA 0 3173288 0 3173288 3173288 5.8 % 14/02/2019
Dr. Jeffrey R. Jay, M.D. USA 0 3173288 0 3173288 3173288 5.8 % 14/02/2019
Biotechnology Value Trading Fund OS LP Cayman Islands 0 294043 0 294043 294043 0 % 14/02/2019
Biotechnology Value Fund, L.P. Delaware 0 2038086 0 2038086 2038086 3.7 % 14/02/2019
BVF Partners OS Ltd. Cayman Islands 0 294043 0 294043 294043 0 % 14/02/2019
Biotechnology Value Fund II, L.P. Delaware 0 1597353 0 1597353 1597353 2.9 % 14/02/2019
BVF Partners L.P. Delaware 0 4150639 0 4150639 4150639 7.6 % 14/02/2019
BVF Inc. Delaware 0 4150639 0 4150639 4150639 7.6 % 14/02/2019
Mark N. Lampert United States 0 4150639 0 4150639 4150639 7.6 % 14/02/2019
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 1692380 0 1915962 1915962 3.5 % 12/02/2019
The Vanguard Group Pennsylvania 91962 3500 3511100 90812 3601912 6.58 % 11/02/2019
BlackRock, Inc. Delaware 8644486 0 8726571 0 8726571 16 % 24/01/2019
Mark N. Lampert United States 0 5515256 0 5515256 5515256 10.1 % 10/01/2019
BVF Partners L.P. Delaware 0 5515256 0 5515256 5515256 10.1 % 10/01/2019
BVF Partners OS Ltd. Cayman Islands 0 388725 0 388725 388725 0 % 10/01/2019
Biotechnology Value Trading Fund OS LP Cayman Islands 0 388725 0 388725 388725 0 % 10/01/2019
Biotechnology Value Fund II, L.P. Delaware 0 2123166 0 2123166 2123166 3.9 % 10/01/2019
Biotechnology Value Fund, L.P. Delaware 0 2705329 0 2705329 2705329 4.9 % 10/01/2019
Biotechnology Value Fund II, L.P. Delaware 0 2123166 0 2123166 2123166 3.9 % 10/01/2019
Biotechnology Value Fund, L.P. Delaware 0 2705329 0 2705329 2705329 4.9 % 10/01/2019
BVF Inc. Delaware 0 5515256 0 5515256 5515256 10.1 % 10/01/2019
Biotechnology Value Trading Fund OS LP Cayman Islands 0 388725 0 388725 388725 0 % 10/01/2019
BVF Partners OS Ltd. Cayman Islands 0 388725 0 388725 388725 0 % 10/01/2019
BVF Partners L.P. Delaware 0 5515256 0 5515256 5515256 10.1 % 10/01/2019
Mark N. Lampert United States 0 5515256 0 5515256 5515256 10.1 % 10/01/2019
BVF Inc. Delaware 0 5515256 0 5515256 5515256 10.1 % 10/01/2019
Dr. Jeffrey R. Jay, M.D. USA 0 3173288 0 3173288 3173288 5.81 % 15/11/2018
Mr. David Kroin USA 0 3173288 0 3173288 3173288 5.81 % 15/11/2018
Great Point Partners, LLC USA 0 3173288 0 3173288 3173288 5.81 % 15/11/2018
Dr. Jeffrey R. Jay, M.D. USA 0 3173288 0 3173288 3173288 5.81 % 15/11/2018
Great Point Partners, LLC USA 0 3173288 0 3173288 3173288 5.81 % 15/11/2018
Mr. David Kroin USA 0 3173288 0 3173288 3173288 5.81 % 15/11/2018
Biotechnology Value Trading Fund OS LP Cayman Islands 0 459326 0 459326 459326 0 % 14/02/2018
BVF Partners L.P. Delaware 0 5721888 0 5721888 5721888 9.6 % 14/02/2018
BVF Inc. Delaware 0 5721888 0 5721888 5721888 9.6 % 14/02/2018
Mark N. Lampert United States 0 5721888 0 5721888 5721888 9.6 % 14/02/2018
Biotechnology Value Fund II, L.P. Delaware 0 1769797 0 1769797 1769797 3 % 14/02/2018
BVF Partners OS Ltd. Cayman Islands 0 459326 0 459326 459326 0 % 14/02/2018
Biotechnology Value Fund, L.P. Delaware 0 2734215 0 2734215 2734215 4.6 % 14/02/2018
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 2715972 0 2715972 2715972 5.04 % 14/02/2018
The Vanguard Group Pennsylvania 84728 3500 3366990 83578 3450568 6.4 % 08/02/2018
LANSDOWNE PARTNERS ENGLAND 0 2647981 0 2647981 2647981 4.91 % 30/01/2018
LANSDOWNE DEVELOPED MARKETS MASTER FUND LIMITED CAYMAN ISLANDS 0 2647981 0 2647981 2647981 4.91 % 30/01/2018
LANSDOWNE DEVELOPED MARKETS MASTER FUND LIMITED CAYMAN ISLANDS 0 2647981 0 2647981 2647981 4.91 % 30/01/2018
LANSDOWNE DEVELOPED MARKETS STRATEGIC INVESTMENT MASTER FUND LIMITED CAYMAN ISLANDS 0 0 0 0 0 0 % 30/01/2018
LANSDOWNE PARTNERS ENGLAND 0 2647981 0 2647981 2647981 4.91 % 30/01/2018
LANSDOWNE DEVELOPED MARKETS STRATEGIC INVESTMENT MASTER FUND LIMITED CAYMAN ISLANDS 0 0 0 0 0 0 % 30/01/2018
BlackRock, Inc. Delaware 7171417 0 7239394 0 7239394 13.4 % 19/01/2018
FMR LLC Delaware 2073 0 2623725 0 2623725 4.869 % 11/12/2017
Abigail P. Johnson United States of America 0 0 2623725 0 2623725 4.869 % 11/12/2017
FMR LLC Delaware 2073 0 2623725 0 2623725 4.869 % 11/12/2017
Abigail P. Johnson United States of America 0 0 2623725 0 2623725 4.869 % 11/12/2017
BVF Inc. Delaware 0 5427313 0 5427313 5427313 10.1 % 30/11/2017
Mark N. Lampert United States 0 5427313 0 5427313 5427313 10.1 % 30/11/2017
BVF Partners L.P. Delaware 0 5427313 0 5427313 5427313 10.1 % 30/11/2017
BVF Partners OS Ltd. Cayman Islands 0 459326 0 459326 459326 0 % 30/11/2017
Mark N. Lampert United States 0 5427313 0 5427313 5427313 10.1 % 30/11/2017
BVF Partners L.P. Delaware 0 5427313 0 5427313 5427313 10.1 % 30/11/2017
BVF Partners OS Ltd. Cayman Islands 0 459326 0 459326 459326 0 % 30/11/2017
Biotechnology Value Trading Fund OS LP Cayman Islands 0 459326 0 459326 459326 0 % 30/11/2017
Biotechnology Value Fund II, L.P. Delaware 0 1718193 0 1718193 1718193 3.2 % 30/11/2017
Biotechnology Value Fund, L.P. Delaware 0 2691120 0 2691120 2691120 5 % 30/11/2017
Biotechnology Value Trading Fund OS LP Cayman Islands 0 459326 0 459326 459326 0 % 30/11/2017
Biotechnology Value Fund II, L.P. Delaware 0 1718193 0 1718193 1718193 3.2 % 30/11/2017
Biotechnology Value Fund, L.P. Delaware 0 2691120 0 2691120 2691120 5 % 30/11/2017
BVF Inc. Delaware 0 5427313 0 5427313 5427313 10.1 % 30/11/2017
Mark N. Lampert United States 0 3266321 0 3266321 3266321 6.4 % 15/05/2017
BVF Inc. Delaware 0 3266321 0 3266321 3266321 6.4 % 15/05/2017
BVF Partners L.P. Delaware 0 3266321 0 3266321 3266321 6.4 % 15/05/2017
Biotechnology Value Fund, L.P. Delaware 0 1458738 0 1458738 1458738 2.9 % 15/05/2017
BVF Partners OS Ltd. Cayman Islands 0 260404 0 260404 260404 0 % 15/05/2017
Biotechnology Value Trading Fund OS LP Cayman Islands 0 260404 0 260404 260404 0 % 15/05/2017
Biotechnology Value Fund II, L.P. Delaware 0 953260 0 953260 953260 1.9 % 15/05/2017
BlackRock, Inc. Delaware 5457387 0 5509198 0 5509198 12.7 % 09/05/2017
BVF Inc. Delaware 0 4851691 0 4851691 4851691 12 % 14/02/2017
Mark N. Lampert United States 0 4851691 0 4851691 4851691 12 % 14/02/2017
Biotechnology Value Fund II, L.P. Delaware 0 1403420 0 1403420 1403420 3.5 % 14/02/2017
Biotechnology Value Trading Fund OS LP Cayman Islands 0 455226 0 455226 455226 1.1 % 14/02/2017
Biotechnology Value Fund, L.P. Delaware 0 2109086 0 2109086 2109086 5.2 % 14/02/2017
BVF Partners OS Ltd. Cayman Islands 0 455226 0 455226 455226 1.1 % 14/02/2017
BVF Partners L.P. Delaware 0 4851691 0 4851691 4851691 12 % 14/02/2017
Abigail P. Johnson United States of America 0 0 5199414 0 5199414 12.801 % 14/02/2017
FMR LLC Delaware 48834 0 5199414 0 5199414 12.801 % 14/02/2017
Select Biotechnology Portfolio Massachusetts 2415778 0 0 0 2415778 5.947 % 14/02/2017
BlackRock, Inc. Delaware 2951791 0 2998800 0 2998800 7.4 % 23/01/2017
Abigail P. Johnson United States of America 0 0 4169760 0 4169760 10.524 % 10/08/2016
FMR LLC Delaware 700 0 4169760 0 4169760 10.524 % 10/08/2016
FMR LLC Delaware 700 0 4169760 0 4169760 10.524 % 10/08/2016
Abigail P. Johnson United States of America 0 0 4169760 0 4169760 10.524 % 10/08/2016
Biotechnology Value Trading Fund OS LP Cayman Islands 0 342985 0 342985 342985 0 % 03/03/2016
Mark N. Lampert United States 0 3908329 0 3908329 3908329 10.1 % 03/03/2016
BVF Inc. Delaware 0 3908329 0 3908329 3908329 10.1 % 03/03/2016
BVF Partners L.P. Delaware 0 3908329 0 3908329 3908329 10.1 % 03/03/2016
BVF Partners OS Ltd. Cayman Islands 0 342985 0 342985 342985 0 % 03/03/2016
Biotechnology Value Fund II, L.P. Delaware 0 1042344 0 1042344 1042344 2.7 % 03/03/2016
Biotechnology Value Fund, L.P. Delaware 0 1712889 0 1712889 1712889 4.4 % 03/03/2016
Biotechnology Value Fund II, L.P. Delaware 0 967054 0 967054 967054 2.5 % 16/02/2016
Mark N. Lampert United States 0 3841680 0 3841680 3841680 9.7 % 16/02/2016
Biotechnology Value Fund, L.P. Delaware 0 1682579 0 1682579 1682579 4.3 % 16/02/2016
Biotechnology Value Trading Fund OS LP Cayman Islands 0 304472 0 304472 304472 0 % 16/02/2016
BVF Partners OS Ltd. Cayman Islands 0 304472 0 304472 304472 0 % 16/02/2016
BVF Partners L.P. Delaware 0 3841680 0 3841680 3841680 9.7 % 16/02/2016
BVF Inc. Delaware 0 3841680 0 3841680 3841680 9.7 % 16/02/2016
Deerfield Mgmt, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 16/02/2016
Deerfield Management Company, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
Deerfield Partners, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
S Deerfield International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 16/02/2016
S Deerfield Special Situations Fund, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
S Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 16/02/2016
S Deerfield Private Design Fund II, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
S Deerfield Private Design International II, L.P. British Virgin Islands 0 0 0 0 0 0 % 16/02/2016
S James E. Flynn United States 0 0 0 0 0 0 % 16/02/2016
James E. Flynn United States 0 0 0 0 0 0 % 16/02/2016
Deerfield Private Design International II, L.P. British Virgin Islands 0 0 0 0 0 0 % 16/02/2016
Deerfield Private Design Fund II, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
Deerfield International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 16/02/2016
S Deerfield Partners, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
S Deerfield Management Company, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
S Deerfield Mgmt, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
Deerfield Special Situations Fund, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
LANSDOWNE DEVELOPED MARKETS MASTER FUND LIMITED CAYMAN ISLANDS 0 2848181 0 2848181 2848181 7.2 % 12/02/2016
LANSDOWNE DEVELOPED MARKETS STRATEGIC INVESTMENT MASTER FUND LIMITED CAYMAN ISLANDS 0 0 0 0 0 0 % 12/02/2016
LANSDOWNE PARTNERS ENGLAND 0 2848181 0 2848181 2848181 7.2 % 12/02/2016
FMR LLC Delaware 700 0 3198699 0 3198699 8.017 % 12/02/2016
Select Biotechnology Portfolio Massachusetts 2108359 0 0 0 2108359 5.284 % 12/02/2016
Abigail P. Johnson United States of America 0 0 3198699 0 3198699 8.017 % 12/02/2016
BlackRock, Inc. Delaware 2434952 0 2497737 0 2497737 6.4 % 26/01/2016
Steven A. Cohen United States 0 0 0 0 0 0 % 17/02/2015
EverPoint Asset Management, LLC Delaware 0 0 0 0 0 0 % 17/02/2015
Point72 Capital Advisors, Inc. Delaware 0 0 0 0 0 0 % 17/02/2015
Point72 Asset Management, L.P. Delaware 0 0 0 0 0 0 % 17/02/2015
Steven A. Cohen United States 0 0 0 0 0 0 % 17/02/2015
EverPoint Asset Management, LLC Delaware 0 0 0 0 0 0 % 17/02/2015
Cubist Systematic Strategies, LLC Delaware 0 0 0 0 0 0 % 17/02/2015
Point72 Capital Advisors, Inc. Delaware 0 0 0 0 0 0 % 17/02/2015
Point72 Asset Management, L.P. Delaware 0 0 0 0 0 0 % 17/02/2015
Cubist Systematic Strategies, LLC Delaware 0 0 0 0 0 0 % 17/02/2015
BVF Inc. Delaware 0 3364152 0 3364152 3364152 9 % 13/02/2015
BVF Partners L.P. Delaware 0 3364152 0 3364152 3364152 9 % 13/02/2015
Biotechnology Value Fund, L.P. Delaware 0 1550980 0 1550980 1550980 4.2 % 13/02/2015
Biotechnology Value Fund II, L.P. Delaware 0 811003 0 811003 811003 2.2 % 13/02/2015
Investment 10, L.L.C. Illinois 0 436650 0 436650 436650 1.2 % 13/02/2015
MSI BVF SPV, LLC Delaware 0 565519 0 565519 565519 1.5 % 13/02/2015
Mark N. Lampert United States 0 3364152 0 3364152 3364152 9 % 13/02/2015
PORTFOLIO SERVICES LTD. CAYMAN ISLANDS 0 3607529 0 3607529 3607529 9.7 % 13/02/2015
KENNETH B. DART CAYMAN ISLANDS 0 3607529 0 3607529 3607529 9.7 % 13/02/2015
EASTERN CAPITAL LIMITED CAYMAN ISLANDS 0 3607529 0 3607529 3607529 9.7 % 13/02/2015
FMR LLC Delaware 1486704 0 3755596 0 3755596 9.98 % 13/02/2015
Edward C. Johnson 3d United States of America 0 0 3755596 0 3755596 9.98 % 13/02/2015
Abigail P. Johnson United States of America 0 0 3755596 0 3755596 9.98 % 13/02/2015
BlackRock, Inc. Delaware 2738205 0 2775949 0 2775949 7.6 % 26/01/2015
Astellas Pharma Inc. Japan 2040816 0 2040816 0 2040816 5.28 % 29/12/2014
Astellas Pharma Inc. Japan 2040816 0 2040816 0 2040816 5.28 % 29/12/2014
LANSDOWNE PARTNERS ENGLAND 0 2848181 0 2848181 2848181 7.7 % 10/07/2014
LANSDOWNE PARTNERS AUSTRIA GMBH AUSTRIA 0 0 0 0 0 0 % 10/07/2014
LANSDOWNE PARTNERS LIMITED PARTNERSHIP ENGLAND 0 0 0 0 0 0 % 10/07/2014
LANSDOWNE DEVELOPED MARKETS MASTER FUND LIMITED CAYMAN ISLANDS 0 2505957 0 2505957 2505957 6.8 % 10/07/2014
LANSDOWNE DEVELOPED MARKETS STRATEGIC INVESTMENT MASTER FUND LIMITED CAYMAN ISLANDS 0 342224 0 342224 342224 0.9 % 10/07/2014
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) ENGLAND 0 2848181 0 2848181 2848181 7.7 % 10/07/2014
Mark N. Lampert United States 0 2238052 0 2238052 2238052 6 % 08/05/2014
BVF Inc. Delaware 0 2238052 0 2238052 2238052 6 % 08/05/2014
BVF Partners L.P. Delaware 0 2238052 0 2238052 2238052 6 % 08/05/2014
Biotechnology Value Fund II, L.P. Delaware 0 600106 0 600106 600106 1.6 % 08/05/2014
Magnitude Special Investments Portfolio Fund, Ltd. Cayman Islands 0 224536 0 224536 224536 0 % 08/05/2014
Investment 10, L.L.C. Illinois 0 344664 0 344664 344664 0 % 08/05/2014
Biotechnology Value Fund, L.P. Delaware 0 1068746 0 1068746 1068746 2.9 % 08/05/2014
Steven A. Cohen United States 0 2000500 0 2000500 2000500 5.5 % 07/04/2014
Point72 Capital Advisors, Inc. Delaware 0 1200000 0 1200000 1200000 3.3 % 07/04/2014
Cubist Systematic Strategies, LLC Delaware 0 500 0 500 500 0.1 % 07/04/2014
EverPoint Asset Management, LLC Delaware 0 800000 0 800000 800000 2.2 % 07/04/2014
S.A.C. Capital Advisors, L.P. Delaware 0 0 0 0 0 0 % 07/04/2014
Sigma Capital Management, LLC Delaware 0 0 0 0 0 0 % 07/04/2014
Point72 Asset Management, L.P. Delaware 0 1200000 0 1200000 1200000 3.3 % 07/04/2014
Point72 Capital Advisors, Inc. Delaware 0 1200000 0 1200000 1200000 3.3 % 07/04/2014
Cubist Systematic Strategies, LLC Delaware 0 500 0 500 500 0.1 % 07/04/2014
EverPoint Asset Management, LLC Delaware 0 800000 0 800000 800000 2.2 % 07/04/2014
Steven A. Cohen United States 0 2000500 0 2000500 2000500 5.5 % 07/04/2014
S.A.C. Capital Advisors, L.P. Delaware 0 0 0 0 0 0 % 07/04/2014
Sigma Capital Management, LLC Delaware 0 0 0 0 0 0 % 07/04/2014
Point72 Asset Management, L.P. Delaware 0 1200000 0 1200000 1200000 3.3 % 07/04/2014
Sigma Capital Management, LLC Delaware 0 800000 0 800000 800000 2.2 % 07/04/2014
Point72 Capital Advisors, Inc. Delaware 0 1200500 0 1200500 1200500 3.3 % 07/04/2014
S.A.C. Capital Advisors, L.P. Delaware 0 1200500 0 1200500 1200500 3.3 % 07/04/2014
S.A.C. Capital Advisors, L.P. Delaware 0 1200500 0 1200500 1200500 3.3 % 07/04/2014
Steven A. Cohen United States 0 2000500 0 2000500 2000500 5.5 % 07/04/2014
Point72 Capital Advisors, Inc. Delaware 0 1200500 0 1200500 1200500 3.3 % 07/04/2014
Sigma Capital Management, LLC Delaware 0 800000 0 800000 800000 2.2 % 07/04/2014
Steven A. Cohen United States 0 2000500 0 2000500 2000500 5.5 % 07/04/2014
Investment 10, L.L.C. Illinois 0 311396 0 311396 311396 0 % 25/03/2014
Mark N. Lampert United States 0 1796557 0 1796557 1796557 4.9 % 25/03/2014
BVF Inc. Delaware 0 1796557 0 1796557 1796557 4.9 % 25/03/2014
BVF Partners L.P. Delaware 0 1796557 0 1796557 1796557 4.9 % 25/03/2014
Biotechnology Value Fund II, L.P. Delaware 0 531830 0 531830 531830 1.5 % 25/03/2014
Biotechnology Value Fund, L.P. Delaware 0 953331 0 953331 953331 2.6 % 25/03/2014
Biotechnology Value Fund, L.P. Delaware 0 1740251 0 1740251 1740251 5.8 % 14/02/2014
Investment 10, L.L.C. Illinois 0 551592 0 551592 551592 1.9 % 14/02/2014
BVF Partners L.P. Delaware 0 3289957 0 3289957 3289957 9.98 % 14/02/2014
BVF Inc. Delaware 0 3289957 0 3289957 3289957 9.98 % 14/02/2014
Mark N. Lampert United States 0 3289957 0 3289957 3289957 9.98 % 14/02/2014
Biotechnology Value Fund II, L.P. Delaware 0 998114 0 998114 998114 3.4 % 14/02/2014
James E. Flynn United States 0 2416769 0 2416769 2416769 7.57 % 14/02/2014
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 223312 0 223312 223312 0.75 % 14/02/2014
Deerfield Private Design Fund II, L.P. Delaware 0 598342 0 598342 598342 1.99 % 14/02/2014
Deerfield Private Design International II, L.P. British Virgin Islands 0 685592 0 685592 685592 2.27 % 14/02/2014
Deerfield Special Situations Fund, L.P. Delaware 0 149623 0 149623 149623 0.5 % 14/02/2014
Deerfield Mgmt, L.P. Delaware 0 2416769 0 2416769 2416769 7.57 % 14/02/2014
Deerfield Management Company, L.P. Delaware 0 2416769 0 2416769 2416769 7.57 % 14/02/2014
Deerfield Partners, L.P. Delaware 0 326766 0 326766 326766 1.1 % 14/02/2014
Deerfield International Master Fund, L.P. British Virgin Islands 0 433134 0 433134 433134 1.45 % 14/02/2014
Edward C. Johnson 3d United States of America 0 0 2927805 0 2927805 9.583 % 14/02/2014
FMR LLC Delaware 745922 0 2927805 0 2927805 9.583 % 14/02/2014
LANSDOWNE DEVELOPED MARKETS STRATEGIC INVESTMENT MASTER FUND LIMITED CAYMAN ISLANDS 0 286046 0 286046 286046 0.95 % 13/02/2014
LANSDOWNE DEVELOPED MARKETS MASTER FUND LIMITED CAYMAN ISLANDS 0 2261181 0 2261181 2261181 7.53 % 13/02/2014
LANSDOWNE PARTNERS AUSTRIA GMBH AUSTRIA 0 286046 0 286046 286046 0.95 % 13/02/2014
LANSDOWNE PARTNERS LIMITED PARTNERSHIP ENGLAND 0 2547227 0 2547227 2547227 8.48 % 13/02/2014
LANSDOWNE DEVELOPED MARKETS MASTER FUND LIMITED CAYMAN ISLANDS 0 2261181 0 2261181 2261181 7.53 % 13/02/2014
LANSDOWNE PARTNERS AUSTRIA GMBH AUSTRIA 0 286046 0 286046 286046 0.95 % 13/02/2014
LANSDOWNE PARTNERS LIMITED PARTNERSHIP ENGLAND 0 2547227 0 2547227 2547227 8.48 % 13/02/2014
LANSDOWNE DEVELOPED MARKETS STRATEGIC INVESTMENT MASTER FUND LIMITED CAYMAN ISLANDS 0 286046 0 286046 286046 0.95 % 13/02/2014
T. ROWE PRICE ASSOCIATES, INC. MARYLAND 0 0 0 0 0 0 % 12/02/2014
BlackRock, Inc. Delaware 2007691 0 2046065 0 2046065 6.9 % 28/01/2014
T. ROWE PRICE ASSOCIATES, INC. MARYLAND 0 0 0 0 9082458 6.2 % 10/05/2013
T. ROWE PRICE NEW HORIZONS FUND, INC. Maryland 0 0 0 0 5623605 3.8 % 10/05/2013
Deerfield International Master Fund, L.P. British Virgin Islands 0 5544201 0 5544201 5544201 3.76 % 14/02/2013
Deerfield Private Design Fund II, L.P. Delaware 0 6977583 0 6977583 6977583 4.78 % 14/02/2013
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 4712804 0 4712804 4712804 3.25 % 14/02/2013
Deerfield Partners, L.P. Delaware 0 4182658 0 4182658 4182658 2.86 % 14/02/2013
Deerfield Management Company, L.P. Delaware 0 32573325 0 32573325 32573325 9.98 % 14/02/2013
Deerfield Mgmt, L.P. Delaware 0 32573325 0 32573325 32573325 9.98 % 14/02/2013
James E. Flynn United States 0 32573325 0 32573325 32573325 9.98 % 14/02/2013
Deerfield Private Design International II, L.P. British Virgin Islands 0 7994520 0 7994520 7994520 5.46 % 14/02/2013
Deerfield Special Situations Fund, L.P. Delaware 0 3161559 0 3161559 3161559 2.2 % 14/02/2013
Biotechnology Value Fund II, L.P. Delaware 0 4616516 0 4616516 4616516 3.2 % 14/02/2013
Biotechnology Value Fund, L.P. Delaware 0 8151158 0 8151158 8151158 5.6 % 14/02/2013
BVF Inc. Delaware 0 15839746 0 15839746 15839746 9.98 % 14/02/2013
Mark N. Lampert United States 0 15839746 0 15839746 15839746 9.98 % 14/02/2013
BVF Partners L.P. Delaware 0 15839746 0 15839746 15839746 9.98 % 14/02/2013
Investment 10, L.L.C. Illinois 0 3072072 0 3072072 3072072 2.1 % 14/02/2013
Edward C. Johnson 3d United States of America 0 0 14856480 0 14856480 9.99 % 14/02/2013
FMR LLC Delaware 0 0 14856480 0 14856480 9.99 % 14/02/2013
Wellington Management Company, LLP Massachusetts 0 3101642 0 3101642 3101642 2.18 % 14/02/2013
QVT Fund LP Cayman Islands 0 0 0 0 0 0 % 14/02/2013
QVT Financial LP Delaware 0 0 0 0 0 0 % 14/02/2013
QVT Associates GP LLC Delaware 0 0 0 0 0 0 % 14/02/2013
QVT Financial GP LLC Delaware 0 0 0 0 0 0 % 14/02/2013
LANSDOWNE PARTNERS LIMITED PARTNERSHIP ENGLAND 0 13567083 0 13567083 13567083 9.32 % 13/02/2013
LANSDOWNE DEVELOPED MARKETS MASTER FUND LIMITED CAYMAN ISLANDS 0 13567083 0 13567083 13567083 9.32 % 13/02/2013
T. ROWE PRICE NEW HORIZONS FUND, INC. Maryland 0 0 0 0 13075600 8.6 % 06/02/2013
T. ROWE PRICE ASSOCIATES, INC. MARYLAND 0 0 0 0 21047624 14 % 06/02/2013
T. ROWE PRICE NEW HORIZONS FUND, INC. Maryland 0 0 0 0 13076800 9.2 % 10/07/2012
T. ROWE PRICE ASSOCIATES, INC. MARYLAND 0 0 0 0 20940304 14.8 % 10/07/2012
Biotechnology Value Fund, L.P. Delaware 0 7681248 0 7681248 7681248 5.6 % 03/07/2012
Biotechnology Value Fund II, L.P. Delaware 0 4224657 0 4224657 4224657 3.1 % 03/07/2012
BVF Partners L.P. Delaware 0 13771847 0 13771847 13771847 9.98 % 03/07/2012
Investment 10, L.L.C. Illinois 0 2830926 0 2830926 2830926 2.1 % 03/07/2012
Mark N. Lampert United States 0 13771847 0 13771847 13771847 9.98 % 03/07/2012
BVF Inc. Delaware 0 13771847 0 13771847 13771847 9.98 % 03/07/2012
PORTFOLIO SERVICES LTD. CAYMAN ISLANDS 0 14303071 0 14303071 14303071 10.72 % 29/06/2012
EASTERN CAPITAL LIMITED CAYMAN ISLANDS 0 14303071 0 14303071 14303071 10.72 % 29/06/2012
KENNETH B. DART CAYMAN ISLANDS 0 14303071 0 14303071 14303071 10.72 % 29/06/2012
LANSDOWNE PARTNERS LIMITED PARTNERSHIP ENGLAND 0 4322680 0 4322680 4322680 5.66 % 12/04/2012
LANSDOWNE DEVELOPED MARKETS MASTER FUND LIMITED CAYMAN ISLANDS 0 4262959 0 4262959 4262959 5.58 % 12/04/2012
QVT Financial LP . Delaware 133 133 133 133 133 6.91 % 14/02/2012
QVT Associates GP LLC . Delaware 133 133 133 133 133 6.91 % 14/02/2012
QVT Fund LP . Cayman Islands 133 133 133 133 133 6.27 % 14/02/2012
QVT Financial GP LLC . Delaware 133 133 133 133 133 6.91 % 14/02/2012
Wellington Management Company, LLP Massachusetts 0 2984013 0 4025519 4025519 5.57 % 14/02/2012
KENNETH B. DART CAYMAN ISLANDS 0 7066236 0 7066236 7066236 9.78 % 14/02/2012
EASTERN CAPITAL LIMITED CAYMAN ISLANDS 0 7066236 0 7066236 7066236 9.78 % 14/02/2012
PORTFOLIO SERVICES LTD. CAYMAN ISLANDS 0 7066236 0 7066236 7066236 9.78 % 14/02/2012
LANSDOWNE UK EQUITY FUND LIMITED CAYMAN ISLANDS 0 3629804 0 3629804 3629804 5.02 % 13/02/2012
LANSDOWNE PARTNERS LIMITED PARTNERSHIP ENGLAND 0 4322680 0 4322680 4322680 5.98 % 13/02/2012
Deerfield Special Situations Fund International Limited British Virgin Islands 0 4195893 0 4195893 4195893 5.59 % 07/02/2012
Deerfield Private Design International II, L.P. British Virgin Islands 0 7408650 0 7408650 7408650 9.52 % 07/02/2012
Deerfield Capital, L.P. Delaware 0 16691158 0 16691158 16691158 9.98 % 07/02/2012
Deerfield Special Situations Fund, L.P. Delaware 0 2816158 0 2816158 2816158 3.8 % 07/02/2012
Deerfield Private Design Fund II, L.P. Delaware 0 6466350 0 6466350 6466350 8.39 % 07/02/2012
Deerfield Management Company, L.P. Delaware 0 4195893 0 4195893 4195893 5.59 % 07/02/2012
James E. Flynn United States 0 20887051 0 20887051 20887051 9.98 % 07/02/2012
LANSDOWNE UK EQUITY FUND LIMITED CAYMAN ISLANDS 0 3636176 0 3636176 3636176 5.03 % 14/11/2011
LANSDOWNE PARTNERS LIMITED PARTNERSHIP ENGLAND 0 4322680 0 4322680 4322680 5.98 % 14/11/2011
Wellington Management Company, LLP Massachusetts 0 2277140 0 2813846 2813846 3.89 % 10/06/2011
Wellington Management Company, LLP Massachusetts 0 5174082 0 6050093 6050093 9.13 % 14/02/2011
CREDIT SUISSE AG/N/A Switzerland 0 848853 0 848853 848853 1.29 % 14/02/2011
QVT Financial GP LLC . Delaware 0 5253909 0 5253909 5253909 7.76 % 11/02/2011
QVT Financial LP . Delaware 0 5253909 0 5253909 5253909 7.76 % 11/02/2011
QVT Associates GP LLC . Delaware 0 5253909 0 5253909 5253909 7.76 % 11/02/2011
QVT Fund LP . Cayman Islands 0 4741253 0 4741253 4741253 7.02 % 11/02/2011
KENNETH B. DART CAYMAN ISLANDS 0 5103410 0 5103410 5103410 7.75 % 28/01/2011
EASTERN CAPITAL LIMITED CAYMAN ISLANDS 0 5103410 0 5103410 5103410 7.75 % 28/01/2011
Fargo and Company Delaware 36895 0 45213 0 45213 0.07 % 10/01/2011
Fargo and Company Delaware 3361685 0 73162 0 3361685 5.52 % 10/03/2010
S Credit Suisse AG Switzerland 0 1378878 0 5428643 5428643 8.91 % 23/02/2010
CREDIT SUISSE AG/ Switzerland 0 1339442 0 5389207 5389207 7.66 % 16/02/2010
QVT Fund LP Cayman Islands 0 3825248 0 3825248 3825248 6.11 % 16/02/2010
QVT Associates GP LLC Delaware 0 4239337 0 4239337 6.75 % 16/02/2010
QVT Financial GP LLC Delaware 0 4239337 0 4239337 4239337 6.75 % 16/02/2010
QVT Financial LP Delaware 0 4239337 0 4239337 4239337 6.75 % 16/02/2010
S Wellington Management Company, LLP Massachusetts 0 5713363 0 6595461 6595461 10.75 % 12/02/2010
Fargo and Company Delaware 3361685 0 73162 0 3361685 0 % 29/01/2010
Vulcan Ventures Incorporated 2314700 8.1 % 12/05/2005
Paul G. Allen 2314700 8.1 % 12/05/2005

Senat trading

Bureau Date de la transaction Date de réception Type Montant Commentaire

Senat Divulgation

Représentant Date de la transaction Date de divulgation Type Montant District
Lisa McClain 2025-06-17 2025-08-13 Sale (Full) $1,001 - $15,000 MI09
Lisa McClain 2025-06-11 2025-08-13 Purchase $1,001 - $15,000 MI09