| The Vanguard Group - 23-1945930 |
|
0 |
8780 |
3030136 |
25917 |
3056053 |
3.99 % |
09/02/2022 |
| Vanguard Index Funds - Vanguard Total Stock Market Index Fund - 23-2671505 |
|
2082157 |
0 |
0 |
0 |
2082157 |
2.72 % |
09/02/2022 |
| Vanguard Index Funds - Vanguard Total Stock Market Index Fund - 23-2671505 |
Pennsylvania |
2082157 |
0 |
0 |
0 |
2082157 |
2.72 % |
09/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
8780 |
3030136 |
25917 |
3056053 |
3.99 % |
09/02/2022 |
| Polaris Venture Partners III, L.P. |
|
0 |
1142961 |
0 |
1142961 |
1142961 |
2.4 % |
12/02/2021 |
| Jonathan A. Flint |
|
0 |
1659325 |
0 |
1659325 |
1659325 |
3.5 % |
12/02/2021 |
| Polaris Venture Management Co. III, L.L.C. |
|
0 |
1189873 |
0 |
1189873 |
1189873 |
2.5 % |
12/02/2021 |
| Polaris Venture Partners Founders’ Fund III, L.P. |
|
0 |
17760 |
0 |
17760 |
17760 |
0 % |
12/02/2021 |
| Polaris Venture Partners Entrepreneurs’ Fund III, L.P. |
|
0 |
29152 |
0 |
29152 |
29152 |
0.1 % |
12/02/2021 |
| Terrance G. McGuire |
|
0 |
1659325 |
0 |
1659325 |
1659325 |
3.5 % |
12/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
0 |
2993275 |
0 |
2993275 |
7.88 % |
10/02/2021 |
| Hudson Bay Capital Management LP |
United States |
0 |
382500 |
0 |
0 |
382500 |
0.92 % |
09/02/2021 |
| Sander Gerber |
United States |
0 |
382500 |
0 |
0 |
382500 |
0.92 % |
09/02/2021 |
| VANGUARD INDEX FUNDS - VANGUARD TOTAL STOCK MARKET INDEX FUND - 23-2671505 |
Delaware |
0 |
0 |
0 |
0 |
2700357 |
7.11 % |
08/02/2021 |
| Polaris Venture Management Co. III, L.L.C. |
Delaware |
0 |
1189873 |
0 |
1189873 |
1189873 |
4.9 % |
12/02/2020 |
| Jonathan A. Flint |
Delaware |
0 |
1659325 |
0 |
1659325 |
1659325 |
6.8 % |
12/02/2020 |
| Polaris Venture Partners Founders’ Fund III, L.P. |
Delaware |
0 |
17760 |
0 |
17760 |
17760 |
0.1 % |
12/02/2020 |
| Polaris Venture Partners Entrepreneurs’ Fund III, L.P. |
Delaware |
0 |
29152 |
0 |
29152 |
29152 |
0.1 % |
12/02/2020 |
| Terrance G. McGuire |
Delaware |
0 |
1659325 |
0 |
1659325 |
1659325 |
6.8 % |
12/02/2020 |
| Polaris Venture Partners III, L.P. |
Delaware |
0 |
1142961 |
0 |
1142961 |
1142961 |
4.7 % |
12/02/2020 |
| Heights Capital Management, Inc. |
Delaware |
0 |
599901 |
0 |
599901 |
599901 |
4.9 % |
14/02/2019 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
599901 |
0 |
599901 |
599901 |
4.9 % |
14/02/2019 |
| Hudson Bay Capital Management LP |
United States |
0 |
682500 |
0 |
0 |
682500 |
5.64 % |
01/02/2019 |
| Sander Gerber |
United States |
0 |
682500 |
0 |
0 |
682500 |
5.64 % |
01/02/2019 |
| Empery Asset Management, LP |
Delaware |
0 |
700000 |
0 |
0 |
700000 |
4.99 % |
15/01/2019 |
| Martin D. Hoe |
Delaware |
0 |
700000 |
0 |
0 |
700000 |
4.99 % |
15/01/2019 |
| Ryan M. Lane |
Delaware |
0 |
700000 |
0 |
0 |
700000 |
4.99 % |
15/01/2019 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
975000 |
0 |
975000 |
975000 |
8.8 % |
22/02/2018 |
| Heights Capital Management, Inc. |
Delaware |
0 |
975000 |
0 |
975000 |
975000 |
8.8 % |
22/02/2018 |
| Ryan M. Lane |
Delaware |
0 |
700000 |
0 |
0 |
700000 |
9.05 % |
21/02/2018 |
| Martin D. Hoe |
Delaware |
0 |
700000 |
0 |
0 |
700000 |
9.05 % |
21/02/2018 |
| Empery Asset Management, LP |
Delaware |
0 |
700000 |
0 |
0 |
700000 |
9.05 % |
21/02/2018 |
| Venrock Partners Management V, LLC |
Delaware |
0 |
301498 |
0 |
0 |
301498 |
4.99 % |
13/02/2018 |
| Venrock Entrepreneurs Fund V, L.P. |
Delaware |
0 |
301498 |
0 |
0 |
301498 |
4.99 % |
13/02/2018 |
| Venrock Associates V, L.P. |
Delaware |
0 |
301498 |
0 |
0 |
301498 |
4.99 % |
13/02/2018 |
| VEF Management V, LLC |
Delaware |
0 |
301498 |
0 |
0 |
301498 |
4.99 % |
13/02/2018 |
| Venrock Partners V, L.P. |
Delaware |
0 |
301498 |
0 |
0 |
301498 |
4.99 % |
13/02/2018 |
| Venrock Management V, LLC |
Delaware |
0 |
301498 |
0 |
0 |
301498 |
4.99 % |
13/02/2018 |
| CVF, LLC |
Delaware |
260137 |
0 |
260137 |
0 |
260137 |
4.3 % |
09/02/2018 |
| Steven E. Hall, Ph.D. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Armen B. Shanafelt, Ph.D. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Lilly Ventures Fund I, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| LV Management Group, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| S. Edward Torres |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| CVF, LLC |
Delaware |
2601387 |
0 |
2601387 |
0 |
2601387 |
9.48 % |
10/02/2017 |
| FMR LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/09/2016 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/09/2016 |
| CVF, LLC |
Delaware |
2599920 |
0 |
2599920 |
0 |
2599920 |
9.51 % |
11/02/2016 |
| CVF, LLC |
Delaware |
2259244 |
0 |
2259244 |
0 |
2259244 |
11.2 % |
17/02/2015 |
| 15.9%3 |
Delaware |
0 |
30340392 |
0 |
30340392 |
30340392 |
15.9 % |
25/04/2014 |
| 15.9%3 |
Delaware |
0 |
30340392 |
0 |
30340392 |
30340392 |
15.9 % |
25/04/2014 |
| 15.9%3 |
Delaware |
0 |
30340392 |
0 |
30340392 |
30340392 |
15.9 % |
25/04/2014 |
| 15.9%3 |
Delaware |
0 |
30340392 |
0 |
30340392 |
30340392 |
15.9 % |
25/04/2014 |
| 15.9%3 |
Delaware |
0 |
30340392 |
0 |
30340392 |
30340392 |
15.9 % |
25/04/2014 |
| 15.9%3 |
Delaware |
0 |
30340392 |
0 |
30340392 |
30340392 |
15.9 % |
25/04/2014 |
| Page 6 of 20 Pages |
Delaware |
0 |
951999 |
0 |
951999 |
951999 |
5 % |
18/04/2014 |
| Page 5 of 20 Pages |
Delaware |
0 |
951999 |
0 |
951999 |
951999 |
5 % |
18/04/2014 |
| Page 3 of 20 Pages |
Delaware |
0 |
36105 |
0 |
36105 |
36105 |
0.2 % |
18/04/2014 |
| Page 9 of 20 Pages |
Delaware |
0 |
951999 |
0 |
951999 |
951999 |
5 % |
18/04/2014 |
| Page 8 of 20 Pages |
Delaware |
0 |
951999 |
0 |
951999 |
951999 |
5 % |
18/04/2014 |
| Page 2 of 20 Pages |
Delaware |
0 |
861041 |
0 |
861041 |
861041 |
4.5 % |
18/04/2014 |
| Page 4 of 20 Pages |
Delaware |
0 |
54853 |
0 |
54853 |
54853 |
0.3 % |
18/04/2014 |
| Page 10 of 20 Pages |
Delaware |
0 |
951999 |
0 |
951999 |
951999 |
5 % |
18/04/2014 |
| Page 7 of 20 Pages |
Delaware |
0 |
951999 |
0 |
951999 |
951999 |
5 % |
18/04/2014 |