DVAX

Dynavax Technologies Corporation DVAX

Bénéficiaire Individuel

Déclarant Citoyenneté ou lieu d'organisation Pouvoir de vote unique Pouvoir de vote partagé Pouvoir de disposition unique Pouvoir de disposition partagé Montant en propriété effective Pourcentage détenu Date d'achat
Kynam Capital Management, LP Delaware 0 8332687 0 8332687 8332687 6.34 % 14/11/2024
Yue Tang U.S. 0 8332687 0 8332687 8332687 6.34 % 14/11/2024
Kynam Capital Management GP, LLC Delaware 0 8332687 0 8332687 8332687 6.34 % 14/11/2024
BlackRock, Inc. Delaware 20753430 0 20957496 0 20957496 16 % 12/11/2024
BlackRock, Inc. Delaware 0 0 20957496 0 20957496 16 % 18/10/2024
STATE STREET CORPORATION MA 0 7303301 0 7690274 7690274 5.9 % 16/10/2024
J. Christopher Donahue United States 6158200 6158200 6158200 4.7 % 09/09/2024
Ann C. Donahue United States 6158200 6158200 6158200 4.7 % 09/09/2024
Federated Hermes, Inc. Pennsylvania 6158200 6158200 6158200 4.7 % 09/09/2024
Voting Shares Irrevocable Trust Pennsylvania 6158200 6158200 6158200 4.7 % 09/09/2024
Thomas R. Donahue United States 6158200 6158200 6158200 4.7 % 09/09/2024
David Kroin United States 0 7093214 0 7093214 0 5.49 % 14/02/2024
Deep Track Capital, LP Delaware 0 7093214 0 7093214 0 5.49 % 14/02/2024
Deep Track Biotechnology Master Fund, Ltd. Cayman Islands 0 7093214 0 7093214 0 5.49 % 14/02/2024
The Vanguard Group Pennsylvania 0 214270 8947934 327854 9275788 7.18 % 13/02/2024
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 9142924 0 9495785 9495785 7.35 % 25/01/2024
SSGA FUNDS MANAGEMENT, INC. BOSTON, MASSACHUSETTS 0 6773733 0 6797622 6797622 5.26 % 25/01/2024
BlackRock, Inc. Delaware 22945978 0 23396930 0 23396930 18.1 % 19/01/2024
Ann C. Donahue United States 11364666 11364666 11364666 8.79 % 18/01/2024
Voting Shares Irrevocable Trust Pennsylvania 11364666 11364666 11364666 8.79 % 18/01/2024
J. Christopher Donahue United States 11364666 11364666 11364666 8.79 % 18/01/2024
Federated Hermes, Inc. Pennsylvania 11364666 11364666 11364666 8.79 % 18/01/2024
Thomas R. Donahue United States 11364666 11364666 11364666 8.79 % 18/01/2024
David Kroin United States 0 6556180 0 6556180 6556180 5.1 % 19/05/2023
Deep Track Capital, LP Delaware 0 6556180 0 6556180 6556180 5.1 % 19/05/2023
Deep Track Biotechnology Master Fund, Ltd. Cayman Islands 0 6556180 0 6556180 6556180 5.1 % 19/05/2023
Deep Track Capital, LP Delaware 0 6556180 0 6556180 6556180 5.1 % 19/05/2023
David Kroin United States 0 6556180 0 6556180 6556180 5.1 % 19/05/2023
Deep Track Biotechnology Master Fund, Ltd. Cayman Islands 0 6556180 0 6556180 6556180 5.1 % 19/05/2023
The Vanguard Group Pennsylvania 0 202924 8044087 300775 8344862 6.54 % 09/02/2023
Federated Hermes, Inc. Pennsylvania 12640363 12640363 12640363 9.91 % 01/02/2023
Thomas R. Donahue United States 12640363 12640363 12640363 9.91 % 01/02/2023
J. Christopher Donahue United States 12640363 12640363 12640363 9.91 % 01/02/2023
Voting Shares Irrevocable Trust Pennsylvania 12640363 12640363 12640363 9.91 % 01/02/2023
BlackRock, Inc. Delaware 18910430 0 19086463 0 19086463 15 % 26/01/2023
BlackRock, Inc. Delaware 17134117 0 17307722 0 17307722 13.7 % 09/06/2022
Chicago Capital LLC Illinois 5734000 0 5734000 0 5734000 4.7 % 04/03/2022
Chicago Capital LLC Illinois 5734000 0 5734000 0 5734000 4.7 % 04/03/2022
Chicago Capital LLC Washington 133006000 0 133006000 0 5734033 4.3 % 04/03/2022
Chicago Capital LLC Washington 133006000 0 133006000 0 5734033 4.3 % 04/03/2022
Voting Shares Irrevocable Trust 16782838 16782838 16782838 13.92 % 14/02/2022
J. Christopher Donahue 16782838 16782838 16782838 13.92 % 14/02/2022
Rhodora J. Donahue 16782838 16782838 16782838 13.92 % 14/02/2022
Thomas R. Donahue 16782838 16782838 16782838 13.92 % 14/02/2022
(entities only Federated Hermes, Inc. 16782838 16782838 16782838 13.92 % 14/02/2022
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 6025339 0 6245356 6245356 5.21 % 11/02/2022
BlackRock, Inc. Delaware 7659797 0 7868324 0 7868324 6.6 % 01/02/2022
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 4993202 0 5214257 5214257 4.54 % 12/10/2021
Thomas R. Donahue 12521800 12521800 12521800 11.31 % 12/02/2021
J. Christopher Donahue 12521800 12521800 12521800 11.31 % 12/02/2021
(entities only Federated Hermes, Inc. 12521800 12521800 12521800 11.31 % 12/02/2021
Voting Shares Irrevocable Trust 12521800 12521800 12521800 11.31 % 12/02/2021
Rhodora J. Donahue 12521800 12521800 12521800 11.31 % 12/02/2021
STATE STREET CORPORATION NO. OF THE ABOVE PERSON: BOSTON MASSACHUSETTS 0 10487577 0 10887296 10887296 9.88 % 11/02/2021
SSGA FUNDS MANAGEMENT, INC. NO. OF THE ABOVE PERSON: BOSTON MASSACHUSETTS 0 9008830 0 9030119 9030119 8.2 % 11/02/2021
BlackRock, Inc. Delaware 7975325 0 8188156 0 8188156 7.4 % 29/01/2021
SSgA Funds Management, Inc. BOSTON, MASSACHUSETTS 0 9815651 0 9836940 9836940 8.98 % 13/10/2020
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 11175355 0 11603107 11603107 10.6 % 13/10/2020
Chicago Capital, LLC Illinois 4227763 0 4227763 0 4227763 5.04 % 14/02/2020
HealthCor Market Neutral Master Fund, L.P. Cayman Islands 0 0 0 0 0 0 % 14/02/2020
HealthCor Offshore Master Fund, L.P. Cayman Islands 0 0 0 0 0 0 % 14/02/2020
HealthCor Offshore GP, LLC Delaware 0 0 0 0 0 0 % 14/02/2020
HealthCor Group, LLC Delaware 0 0 0 0 0 0 % 14/02/2020
Arthur Cohen United States 0 0 0 0 0 0 % 14/02/2020
Joseph Healey United States 0 0 0 0 0 0 % 14/02/2020
HealthCor Sanatate Offshore Master Fund, L.P. Cayman Islands 0 0 0 0 0 0 % 14/02/2020
HealthCor Offshore II GP, LLC Delaware 0 0 0 0 0 0 % 14/02/2020
HealthCor Market Neutral Master Fund, L.P. Cayman Islands 0 0 0 0 0 0 % 14/02/2020
HealthCor Market Neutral GP, LLC Delaware 0 0 0 0 0 0 % 14/02/2020
HealthCor Management, L.P. Delaware 0 0 0 0 0 0 % 14/02/2020
HealthCor Associates, LLC Delaware 0 0 0 0 0 0 % 14/02/2020
HealthCor Offshore Master Fund, L.P. Cayman Islands 0 0 0 0 0 0 % 14/02/2020
HealthCor Offshore GP, LLC Delaware 0 0 0 0 0 0 % 14/02/2020
HealthCor Group, LLC Delaware 0 0 0 0 0 0 % 14/02/2020
Arthur Cohen United States 0 0 0 0 0 0 % 14/02/2020
Joseph Healey United States 0 0 0 0 0 0 % 14/02/2020
HealthCor Sanatate Offshore Master Fund, L.P. Cayman Islands 0 0 0 0 0 0 % 14/02/2020
HealthCor Offshore II GP, LLC Delaware 0 0 0 0 0 0 % 14/02/2020
HealthCor Market Neutral GP, LLC Delaware 0 0 0 0 0 0 % 14/02/2020
HealthCor Management, L.P. Delaware 0 0 0 0 0 0 % 14/02/2020
HealthCor Associates, LLC Delaware 0 0 0 0 0 0 % 14/02/2020
Richard Mashaal Canada 0 4113889 0 4113889 4113889 4.9 % 07/02/2020
Senvest Management, LLC Delaware 0 4113889 0 4113889 4113889 4.9 % 07/02/2020
Richard Mashaal Canada 0 4113889 0 4113889 4113889 4.9 % 07/02/2020
Senvest Management, LLC Delaware 0 4113889 0 4113889 4113889 4.9 % 07/02/2020
Millennium Group Management LLC 348589 0.4 % 05/02/2020
Millennium Group Management LLC 348589 0.4 % 05/02/2020
Integrated Core Strategies (US) LLC 348589 0.4 % 05/02/2020
Millennium Management LLC 348589 0.4 % 05/02/2020
Millennium Management LLC 348589 0.4 % 05/02/2020
Israel A. Englander 348589 0.4 % 05/02/2020
Israel A. Englander 348589 0.4 % 05/02/2020
Integrated Core Strategies (US) LLC 348589 0.4 % 05/02/2020
BlackRock, Inc. Delaware 5996422 0 6181895 0 6181895 7.4 % 05/02/2020
Charles B. Johnson USA 4 4 4 4 158 0 % 04/02/2020
Franklin Resources, Inc. Delaware 4 4 4 4 158 0 % 04/02/2020
Rupert H. Johnson, Jr. USA 4 4 4 4 158 0 % 04/02/2020
Chicago Capital LLC Washington 4390560 0 4390560 0 4390560 5.2 % 23/08/2019
Chicago Capital LLC Washington 4390560 0 4390560 0 4390560 5.2 % 23/08/2019
Israel A. Englander 3467187 5.3 % 09/07/2019
Integrated Core Strategies (US) LLC 3467187 5.3 % 09/07/2019
Millennium Group Management LLC 3467187 5.3 % 09/07/2019
Israel A. Englander 3467187 5.3 % 09/07/2019
Integrated Core Strategies (US) LLC 3467187 5.3 % 09/07/2019
Millennium Management LLC 3467187 5.3 % 09/07/2019
Millennium Group Management LLC 3467187 5.3 % 09/07/2019
Millennium Management LLC 3467187 5.3 % 09/07/2019
Steven A. Cohen United States 0 24694 0 24694 24694 0.1 % 14/02/2019
Point72 Asset Management, L.P. Delaware 0 0 0 0 0 0 % 14/02/2019
Point72 Capital Advisors, Inc. Delaware 0 0 0 0 0 0 % 14/02/2019
Cubist Systematic Strategies, LLC Delaware 0 24694 0 24694 24694 0.1 % 14/02/2019
HealthCor Offshore II GP, LLC Delaware 0 1160646 0 1160646 1160646 1.9 % 14/02/2019
HealthCor Offshore II GP, LLC Delaware 0 1160646 0 1160646 1160646 1.9 % 14/02/2019
HealthCor Sanatate Offshore Master Fund, L.P. Cayman Islands 0 1160646 0 1160646 1160646 1.9 % 14/02/2019
Joseph Healey United States 0 4613280 0 4613280 4613280 7.4 % 14/02/2019
Arthur Cohen United States 0 4613280 0 4613280 4613280 7.4 % 14/02/2019
HealthCor Group, LLC Delaware 0 2750000 0 2750000 2750000 4.4 % 14/02/2019
HealthCor Offshore GP, LLC Delaware 0 1589354 0 1589354 1589354 2.5 % 14/02/2019
HealthCor Offshore Master Fund, L.P. Cayman Islands 0 1589354 0 1589354 1589354 2.5 % 14/02/2019
HealthCor Associates, LLC Delaware 0 4613280 0 4613280 4613280 7.4 % 14/02/2019
HealthCor Management, L.P. Delaware 0 4613280 0 4613280 4613280 7.4 % 14/02/2019
HealthCor Management, L.P. Delaware 0 4613280 0 4613280 4613280 7.4 % 14/02/2019
HealthCor Associates, LLC Delaware 0 4613280 0 4613280 4613280 7.4 % 14/02/2019
HealthCor Offshore Master Fund, L.P. Cayman Islands 0 1589354 0 1589354 1589354 2.5 % 14/02/2019
HealthCor Offshore GP, LLC Delaware 0 1589354 0 1589354 1589354 2.5 % 14/02/2019
HealthCor Group, LLC Delaware 0 2750000 0 2750000 2750000 4.4 % 14/02/2019
Arthur Cohen United States 0 4613280 0 4613280 4613280 7.4 % 14/02/2019
Joseph Healey United States 0 4613280 0 4613280 4613280 7.4 % 14/02/2019
HealthCor Sanatate Offshore Master Fund, L.P. Cayman Islands 0 1160646 0 1160646 1160646 1.9 % 14/02/2019
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 2794549 0 3018416 3018416 4.8 % 12/02/2019
BlackRock, Inc. Delaware 3996747 0 4128600 0 4128600 6.6 % 04/02/2019
Franklin Resources, Inc. Delaware 4 4 4 4 3199278 5.1 % 25/01/2019
Franklin Advisers, Inc. California 3167578 0 3167578 0 3167578 5.1 % 25/01/2019
Rupert H. Johnson, Jr. USA 4 4 4 4 3199278 5.1 % 25/01/2019
Charles B. Johnson USA 4 4 4 4 3199278 5.1 % 25/01/2019
Richard Mashaal Canada 0 3173112 0 3173112 3173112 5.06 % 08/01/2019
Senvest Management, LLC Delaware 0 3173112 0 3173112 3173112 5.06 % 08/01/2019
Richard Mashaal Canada 0 3173112 0 3173112 3173112 5.06 % 08/01/2019
Senvest Management, LLC Delaware 0 3173112 0 3173112 3173112 5.06 % 08/01/2019
HealthCor Associates, LLC Delaware 0 3450000 0 3450000 3450000 5.5 % 11/10/2018
Arthur Cohen United States 0 3450000 0 3450000 3450000 5.5 % 11/10/2018
HealthCor Group, LLC Delaware 0 1830170 0 1830170 1830170 2.9 % 11/10/2018
HealthCor Offshore GP, LLC Delaware 0 1056604 0 1056604 1056604 1.7 % 11/10/2018
Arthur Cohen United States 0 3450000 0 3450000 3450000 5.5 % 11/10/2018
Joseph Healey United States 0 3450000 0 3450000 3450000 5.5 % 11/10/2018
HealthCor Sanatate Offshore Master Fund, L.P. Cayman Islands 0 773566 0 773566 566660 1.2 % 11/10/2018
HealthCor Management, L.P. Delaware 0 3450000 0 3450000 3450000 5.5 % 11/10/2018
HealthCor Sanatate Offshore Master Fund, L.P. Cayman Islands 0 773566 0 773566 566660 1.2 % 11/10/2018
HealthCor Offshore II GP, LLC Delaware 0 773566 0 773566 773566 1.2 % 11/10/2018
Joseph Healey United States 0 3450000 0 3450000 3450000 5.5 % 11/10/2018
HealthCor Offshore II GP, LLC Delaware 0 773566 0 773566 773566 1.2 % 11/10/2018
HealthCor Offshore Master Fund, L.P. Cayman Islands 0 1056604 0 1056604 1056604 1.7 % 11/10/2018
HealthCor Management, L.P. Delaware 0 3450000 0 3450000 3450000 5.5 % 11/10/2018
HealthCor Associates, LLC Delaware 0 3450000 0 3450000 3450000 5.5 % 11/10/2018
HealthCor Offshore Master Fund, L.P. Cayman Islands 0 1056604 0 1056604 1056604 1.7 % 11/10/2018
HealthCor Offshore GP, LLC Delaware 0 1056604 0 1056604 1056604 1.7 % 11/10/2018
HealthCor Group, LLC Delaware 0 1830170 0 1830170 1830170 2.9 % 11/10/2018
Cubist Systematic Strategies, LLC Delaware 0 3295 0 3295 3295 0.1 % 14/02/2018
Point72 Asset Management, L.P. Delaware 0 3808142 0 3808142 3808142 6.3 % 14/02/2018
Point72 Capital Advisors, Inc. Delaware 0 3808142 0 3808142 3808142 6.3 % 14/02/2018
Steven A. Cohen 3 United States 0 3811437 0 3811437 3811437 6.3 % 14/02/2018
SSGA FUNDS MANAGEMENT, INC. MASSACHUSETTS 0 3497149 0 3497149 3497149 5.77 % 14/02/2018
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 4580203 0 4580203 4580203 7.56 % 14/02/2018
BlackRock, Inc. Delaware 3768756 0 3873883 0 3873883 6.4 % 29/01/2018
Thomas R. Donahue 2711425 2711425 2711425 4.95 % 09/08/2017
(entities only Federated Investors, Inc. 2711425 2711425 2711425 4.95 % 09/08/2017
J. Christopher Donahue 2711425 2711425 2711425 4.95 % 09/08/2017
Rhodora J. Donahue 2711425 2711425 2711425 4.95 % 09/08/2017
Voting Shares Irrevocable Trust 2711425 2711425 2711425 4.95 % 09/08/2017
Steven A. Cohen United States 0 2540293 0 2540293 2540293 5.2 % 06/06/2017
Point72 Asset Management, L.P. Delaware 0 2535200 0 2535200 2535200 5.2 % 06/06/2017
Point72 Capital Advisors, Inc. Delaware 0 2535200 0 2535200 2535200 5.2 % 06/06/2017
Cubist Systematic Strategies, LLC Delaware 0 5093 0 5093 5093 0.1 % 06/06/2017
Steven A. Cohen United States 0 2540293 0 2540293 2540293 5.2 % 06/06/2017
Cubist Systematic Strategies, LLC Delaware 0 5093 0 5093 5093 0.1 % 06/06/2017
Point72 Capital Advisors, Inc. Delaware 0 2535200 0 2535200 2535200 5.2 % 06/06/2017
Point72 Asset Management, L.P. Delaware 0 2535200 0 2535200 2535200 5.2 % 06/06/2017
Senvest Management, LLC Delaware 0 1998930 0 1998930 1998930 4.85 % 01/03/2017
Richard Mashaal Canada 0 1998930 0 1998930 1998930 4.85 % 01/03/2017
Senvest Management, LLC Delaware 0 1998930 0 1998930 1998930 4.85 % 01/03/2017
Richard Mashaal Canada 0 1998930 0 1998930 1998930 4.85 % 01/03/2017
Point72 Capital Advisors, Inc. Delaware 0 0 0 0 0 0 % 14/02/2017
Cubist Systematic Strategies, LLC Delaware 0 7245 0 7245 7245 0.1 % 14/02/2017
Steven A. Cohen United States 0 7245 0 7245 7245 0.1 % 14/02/2017
Point72 Asset Management, L.P. Delaware 0 0 0 0 0 0 % 14/02/2017
Steven A. Cohen United States 0 7245 0 7245 7245 0.1 % 14/02/2017
Point72 Asset Management, L.P. Delaware 0 0 0 0 0 0 % 14/02/2017
Point72 Capital Advisors, Inc. Delaware 0 0 0 0 0 0 % 14/02/2017
Cubist Systematic Strategies, LLC Delaware 0 7245 0 7245 7245 0.1 % 14/02/2017
FMR LLC Delaware 0 0 1263235 0 1263235 3.278 % 14/02/2017
Abigail P. Johnson United States of America 0 0 1263235 0 1263235 3.278 % 14/02/2017
Glenhill Capital Advisors, LLC Delaware 0 415893 0 415893 415893 1.1 % 14/02/2017
Glenhill Capital Management, LLC Delaware 0 388600 0 388600 388600 1 % 14/02/2017
Glenn J. Krevlin United States 388600 27293 415893 0 415893 1.1 % 14/02/2017
Glenhill Advisors, LLC Delaware 388600 27293 415893 0 415893 1.1 % 14/02/2017
Glenhill Advisors, LLC Delaware 388600 27293 415893 0 415893 1.1 % 14/02/2017
Glenn J. Krevlin United States 388600 27293 415893 0 415893 1.1 % 14/02/2017
Glenhill Capital Management, LLC Delaware 0 388600 0 388600 388600 1 % 14/02/2017
Glenhill Capital Advisors, LLC Delaware 0 415893 0 415893 415893 1.1 % 14/02/2017
Morgan Stanley & Co LLC The state of organization is Delaware. 0 0 141678 141678 0.3 % 13/02/2017
Morgan Stanley The state of organization is Delaware. 46185 0 190963 190963 0.4 % 13/02/2017
Samuel D. Isaly United States 0 0 0 0 0 0 % 13/02/2017
OrbiMed Capital LLC Delaware 0 0 0 0 0 0 % 13/02/2017
OrbiMed Advisors LLC Delaware 0 0 0 0 0 0 % 13/02/2017
OrbiMed Capital LLC Delaware 0 0 0 0 0 0 % 13/02/2017
Samuel D. Isaly United States 0 0 0 0 0 0 % 13/02/2017
OrbiMed Advisors LLC Delaware 0 0 0 0 0 0 % 13/02/2017
Morgan Stanley The state of organization is Delaware. 45105 0 2529618 2529618 6.5 % 10/02/2017
Morgan Stanley & Co LLC The state of organization is Delaware. 0 0 2281413 2281413 5.9 % 10/02/2017
BlackRock, Inc. Delaware 2521865 0 2603923 0 2603923 6.8 % 23/01/2017
Cubist Systematic Strategies, LLC Delaware 0 10308 0 10308 10308 0.1 % 06/10/2016
Steven A. Cohen United States 0 2280608 0 2280608 2280608 5.9 % 06/10/2016
Point72 Capital Advisors, Inc. Delaware 0 2140300 0 2140300 2140300 5.6 % 06/10/2016
Steven A. Cohen United States 0 2280608 0 2280608 2280608 5.9 % 06/10/2016
Point72 Asset Management, L.P. Delaware 0 2140300 0 2140300 2140300 5.6 % 06/10/2016
Cubist Systematic Strategies, LLC Delaware 0 10308 0 10308 10308 0.1 % 06/10/2016
EverPoint Asset Management, LLC Delaware 0 130000 0 130000 130000 0.3 % 06/10/2016
Point72 Asset Management, L.P. Delaware 0 2140300 0 2140300 2140300 5.6 % 06/10/2016
Point72 Capital Advisors, Inc. Delaware 0 2140300 0 2140300 2140300 5.6 % 06/10/2016
EverPoint Asset Management, LLC Delaware 0 130000 0 130000 130000 0.3 % 06/10/2016
Glenhill Capital Management, LLC Delaware 0 1547865 0 1547865 1547865 4 % 19/09/2016
Glenn J. Krevlin United States 1547865 560899 2108764 0 2108764 5.5 % 19/09/2016
Glenhill Advisors, LLC Delaware 1547865 560899 2108764 0 2108764 5.5 % 19/09/2016
Glenhill Capital Advisors, LLC Delaware 0 2108764 0 2108764 2108764 5.5 % 19/09/2016
Glenhill Advisors, LLC Delaware 1547865 560899 2108764 0 2108764 5.5 % 19/09/2016
Glenn J. Krevlin United States 1547865 560899 2108764 0 2108764 5.5 % 19/09/2016
Glenhill Capital Management, LLC Delaware 0 1547865 0 1547865 1547865 4 % 19/09/2016
Glenhill Capital Advisors, LLC Delaware 0 2108764 0 2108764 2108764 5.5 % 19/09/2016
RA Capital Healthcare Fund, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
RA Capital Healthcare Fund, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
Peter Kolchinsky United States 0 0 0 0 0 0 % 16/02/2016
RA Capital Management, LLC Massachusetts 0 0 0 0 0 0 % 16/02/2016
Peter Kolchinsky United States 0 0 0 0 0 0 % 16/02/2016
RA Capital Management, LLC Massachusetts 0 0 0 0 0 0 % 16/02/2016
Putnam Investments, LLC. d/b/a/ Putnam Investments Delaware 47012 0 111765 0 111765 0.3 % 16/02/2016
Putnam Investment Management, LLC. Delaware 6260 0 71013 0 71013 0.2 % 16/02/2016
The Putnam Advisory Company, LLC. Delaware 40752 0 40752 0 40752 0.1 % 16/02/2016
OrbiMed Capital LLC Delaware 0 1701400 0 0 1701400 4.43 % 16/02/2016
OrbiMed Advisors LLC Delaware 0 770800 0 770800 770800 2.01 % 16/02/2016
Samuel D. Isaly United States 0 2472200 0 2472200 2472200 6.43 % 16/02/2016
Samuel D. Isaly United States 0 2472200 0 2472200 2472200 6.43 % 16/02/2016
OrbiMed Advisors LLC Delaware 0 770800 0 770800 770800 2.01 % 16/02/2016
OrbiMed Capital LLC Delaware 0 1701400 0 0 1701400 4.43 % 16/02/2016
Paul E. Orlin United States of America 0 1880225 0 1880225 1880225 4.9 % 16/02/2016
Amici Capital, LLC Delaware 0 1880225 0 1880225 1880225 4.9 % 16/02/2016
Abigail P. Johnson United States of America 0 0 2636982 0 2636982 6.862 % 12/02/2016
FMR LLC Delaware 500 0 2636982 0 2636982 6.862 % 12/02/2016
(entities only Federated Investors, Inc. 2977629 2977629 2977629 7.75 % 11/02/2016
John F. Donahue 2977629 2977629 2977629 7.75 % 11/02/2016
Rhodora J. Donahue 2977629 2977629 2977629 7.75 % 11/02/2016
Voting Shares Irrevocable Trust 2977629 2977629 2977629 7.75 % 11/02/2016
J. Christopher Donahue 2977629 2977629 2977629 7.75 % 11/02/2016
Westfield Capital Management Company, LP Massachusetts 0 0 0 0 0 0 % 05/02/2016
Westfield Capital Management Company, LP Massachusetts 0 0 0 0 0 0 % 05/02/2016
BlackRock, Inc. Delaware 2154041 0 2240598 0 2240598 5.8 % 26/01/2016
Rhodora J. Donahue 2974479 2974479 2974479 8.89 % 07/08/2015
John F. Donahue 2974479 2974479 2974479 8.89 % 07/08/2015
Voting Shares Irrevocable Trust 2974479 2974479 2974479 8.89 % 07/08/2015
(entities only Federated Investors, Inc. 2974479 2974479 2974479 8.89 % 07/08/2015
J. Christopher Donahue 2974479 2974479 2974479 8.89 % 07/08/2015
RA Capital Healthcare Fund, L.P. Delaware 0 2082435 0 2082435 2082435 7.9 % 17/02/2015
I.R.S. Identification Nos. of above persons (entities only). Delaware 0 2082435 0 2082435 2082435 7.9 % 17/02/2015
RA Capital Management, LLC Massachusetts 0 2603044 0 2603044 9.9 % 17/02/2015
Peter Kolchinsky United States 0 2603044 0 2603044 2603044 9.9 % 17/02/2015
Paul E. Orlin United States of America 0 2479809 0 2479809 2479809 9.4 % 17/02/2015
Amici Capital, LLC Delaware 0 2479809 0 2479809 2479809 9.4 % 17/02/2015
Putnam Investment Management, LLC. Delaware 1973 0 1321896 0 1321896 5 % 17/02/2015
The Putnam Advisory Company, LLC. Delaware 98288 0 106196 0 106196 0.4 % 17/02/2015
Putnam Investments, LLC. d/b/a/ Putnam Investments Delaware 100261 0 1428092 0 1428092 5.4 % 17/02/2015
HealthCor Associates, LLC Delaware 0 0 0 0 0 0 % 13/02/2015
HealthCor Offshore GP, LLC Delaware 0 0 0 0 0 0 % 13/02/2015
HealthCor Group, LLC Delaware 0 0 0 0 0 0 % 13/02/2015
Arthur Cohen United States 0 0 0 0 0 0 % 13/02/2015
Joseph Healey United States 0 0 0 0 0 0 % 13/02/2015
HealthCor Long Offshore Master Fund, L.P. Cayman Islands 0 0 0 0 0 0 % 13/02/2015
HealthCor Long Master GP, LLC Delaware 0 0 0 0 0 0 % 13/02/2015
HealthCor Management, L.P. Delaware 0 0 0 0 0 0 % 13/02/2015
HealthCor Offshore Master Fund, L.P. Cayman Islands 0 0 0 0 0 0 % 13/02/2015
Westfield Capital Management Company, LP Massachusetts 1021901 0 1696760 0 1696760 6.45 % 09/02/2015
Westfield Capital Management Company, LP Massachusetts 1021901 0 1696760 0 1696760 6.45 % 09/02/2015
BlackRock, Inc. Delaware 1625187 0 1693274 0 1693274 6.4 % 30/01/2015
Amici Capital, LLC Delaware 0 1958408 0 1958408 1958408 7.45 % 21/11/2014
Paul E. Orlin United States of America 0 1958408 0 1958408 1958408 7.45 % 21/11/2014
Steven A. Cohen United States 0 7577533 0 7577533 7577533 2.9 % 14/02/2014
S.A.C. Capital Associates, LLC Anguilla, British West Indies 0 7577533 0 7577533 7577533 2.9 % 14/02/2014
S.A.C. Capital Advisors, Inc. Delaware 0 7577533 0 7577533 7577533 2.9 % 14/02/2014
S.A.C. Capital Advisors, L.P. Delaware 0 7577533 0 7577533 7577533 2.9 % 14/02/2014
Peter Kolchinsky United States 0 25999886 0 25999886 25999886 9.9 % 14/02/2014
RA Capital Healthcare Fund, L.P. Delaware 0 20657853 0 20657853 20657853 7.9 % 14/02/2014
RA Capital Management, LLC Massachusetts 0 25999886 0 25999886 25999886 9.9 % 14/02/2014
Joseph Healey United States 0 14800000 0 14800000 14800000 5.64 % 13/02/2014
HealthCor Long Master GP, LLC Delaware 0 761334 0 761334 761334 0.29 % 13/02/2014
HealthCor Management, L.P. Delaware 0 14800000 0 14800000 14800000 5.64 % 13/02/2014
HealthCor Associates, LLC Delaware 0 14800000 0 14800000 14800000 5.64 % 13/02/2014
HealthCor Offshore Master Fund, L.P. Cayman Islands 0 14038666 0 14038666 14038666 5.35 % 13/02/2014
HealthCor Offshore GP, LLC Delaware 0 14038666 0 14038666 14038666 5.35 % 13/02/2014
HealthCor Group, LLC Delaware 0 14800000 0 14800000 14800000 5.64 % 13/02/2014
Arthur Cohen United States 0 14800000 0 14800000 14800000 5.64 % 13/02/2014
HealthCor Long Offshore Master Fund, L.P. Cayman Islands 0 761334 0 761334 761334 0.29 % 13/02/2014
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 8843407 0 8843407 8843407 3.4 % 05/02/2014
BlackRock, Inc. Delaware 14425414 0 15060852 0 15060852 5.7 % 28/01/2014
RA Capital Management, LLC Massachusetts 0 25993234 0 25993234 25993234 9.9 % 05/11/2013
Peter Kolchinsky United States 0 25993234 0 25993234 25993234 9.9 % 05/11/2013
RA Capital Healthcare Fund, L.P. Delaware 0 20301157 0 20301157 20301157 7.7 % 05/11/2013
FMR LLC Delaware 228513 0 8254424 0 8254424 4.513 % 10/07/2013
Edward C. Johnson 3d United States of America 0 0 8254424 0 8254424 4.513 % 10/07/2013
S.A.C. Capital Advisors, Inc. Delaware 0 9341708 0 9341708 9341708 5.2 % 14/02/2013
Steven A. Cohen United States 0 9341708 0 9341708 9341708 5.2 % 14/02/2013
S.A.C. Capital Associates, LLC Anguilla, British West Indies 0 9339108 0 9339108 9339108 5.2 % 14/02/2013
S.A.C. Capital Advisors, L.P. Delaware 0 9341708 0 9341708 9341708 5.2 % 14/02/2013
FMR LLC Delaware 343300 0 24912228 0 24912228 13.94 % 14/02/2013
Edward C. Johnson 3d United States of America 0 0 24912228 0 24912228 13.94 % 14/02/2013
HealthCor Associates, LLC Delaware 0 17600000 0 17600000 17600000 9.85 % 14/02/2013
HealthCor Offshore Master Fund, L.P. Cayman Islands 0 16750000 0 16750000 16750000 9.37 % 14/02/2013
HealthCor Offshore GP, LLC Delaware 0 16750000 0 16750000 16750000 9.37 % 14/02/2013
HealthCor Hybrid Offshore Master Fund, L.P. Cayman Islands 0 0 0 0 0 0 % 14/02/2013
HealthCor Hybrid Offshore GP, LLC Delaware 0 0 0 0 0 0 % 14/02/2013
HealthCor Group, LLC Delaware 0 17600000 0 17600000 17600000 9.85 % 14/02/2013
Arthur Cohen United States 0 17600000 0 17600000 17600000 9.85 % 14/02/2013
Joseph Healey United States 0 17600000 0 17600000 17600000 9.85 % 14/02/2013
HealthCor Long Offshore Master Fund, L.P. Cayman Islands 0 850000 0 850000 850000 0.48 % 14/02/2013
HealthCor Long Master GP, LLC Delaware 0 850000 0 850000 850000 0.48 % 14/02/2013
HealthCor Management, L.P. Delaware 0 17600000 0 17600000 17600000 9.85 % 14/02/2013
Federated Investors, Inc. Pennsylvania 31942154 31942154 17.54 % 12/02/2013
J. Christopher Donahue United States 31942154 31942154 31942154 17.54 % 12/02/2013
Rhodora J. Donahue United States 31942154 31942154 31942154 17.54 % 12/02/2013
John F. Donahue United States 31942154 31942154 31942154 17.54 % 12/02/2013
Voting Shares Irrevocable Trust Pennsylvania 31942154 31942154 17.54 % 12/02/2013
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 9168898 0 9168898 9168898 5.1 % 11/02/2013
HealthCor Group, LLC Delaware 0 16400000 0 16400000 16400000 9.18 % 21/11/2012
HealthCor Long Offshore Master Fund, L.P. Delaware 0 825000 0 825000 825000 0.46 % 21/11/2012
HealthCor Long Master GP, LLC Delaware 0 825000 0 825000 825000 0.46 % 21/11/2012
HealthCor Offshore Master Fund, L.P. Cayman Islands 0 14872486 0 14872486 14872486 8.32 % 21/11/2012
HealthCor Offshore GP, LLC Delaware 0 14872486 0 14872486 14872486 8.32 % 21/11/2012
HealthCor Hybrid Offshore Master Fund, L.P. Cayman Islands 0 702514 0 702514 702514 0.39 % 21/11/2012
HealthCor Hybrid Offshore GP, LLC Delaware 0 702514 0 702514 702514 0.39 % 21/11/2012
HealthCor Management, L.P. Delaware 0 16400000 0 16400000 16400000 9.18 % 21/11/2012
Arthur Cohen United States 0 16400000 0 16400000 16400000 9.18 % 21/11/2012
Joseph Healey United States 0 16400000 0 16400000 16400000 9.18 % 21/11/2012
HealthCor Associates, LLC Delaware 0 16400000 0 16400000 16400000 9.18 % 21/11/2012
BlackRock, Inc. Delaware 6679126 0 6679126 0 6679126 4.29 % 10/04/2012
S.A.C. Capital Advisors, L.P. Delaware 0 7856130 0 7856130 7856130 5.1 % 05/03/2012
Steven A. Cohen United States 0 7856130 0 7856130 7856130 5.1 % 05/03/2012
S.A.C. Capital Associates, LLC Anguilla, British West Indies 0 7849999 0 7849999 7849999 5.1 % 05/03/2012
S.A.C. Capital Advisors, Inc. Delaware 0 7856130 0 7856130 7856130 5.1 % 05/03/2012
FMR LLC Delaware 32300 0 22981655 0 22981655 15 % 14/02/2012
Edward C. Johnson 3d United States of America 0 0 22981655 0 22981655 15 % 14/02/2012
Great Point Partners, LLC USA 0 47500001 0 47500001 47500001 3.67 % 14/02/2012
Mr. David Kroin USA 0 47500001 0 47500001 47500001 3.67 % 14/02/2012
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP USA 0 47500001 0 47500001 47500001 3.67 % 14/02/2012
BlackRock, Inc. Delaware 10587995 0 10587995 0 10587995 6.91 % 13/02/2012
Vivo Ventures Fund V, L.P. Delaware 0 781490 0 781490 781490 0.6 % 10/02/2012
Vivo Ventures V, LLC Delaware 0 790693 0 790693 790693 0.6 % 10/02/2012
Vivo Ventures VI, LLC Delaware 0 3356373 0 3356373 3356373 2.6 % 10/02/2012
Vivo Ventures VI Affiliates Fund, L.P. Delaware 0 24391 0 24391 24391 0.1 % 10/02/2012
Vivo Ventures V Affiliates Fund, L.P. Delaware 0 9203 0 9203 9203 0.1 % 10/02/2012
Vivo Ventures Fund VI, L.P. Delaware 0 3331982 0 3331982 3331982 2.6 % 10/02/2012
Federated Investors, Inc. Pennsylvania 28727444 28727444 18.77 % 09/02/2012
Rhodora J. Donahue United States 28727444 28727444 28727444 18.77 % 09/02/2012
John F. Donahue United States 28727444 28727444 28727444 18.77 % 09/02/2012
Voting Shares Irrevocable Trust Pennsylvania 28727444 28727444 18.77 % 09/02/2012
J. Christopher Donahue United States 28727444 28727444 28727444 18.77 % 09/02/2012
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP USA 0 92940001 0 92940001 92940001 7.83 % 14/02/2011
Great Point Partners, LLC USA 0 92940001 0 92940001 92940001 7.83 % 14/02/2011
Mr. David Kroin USA 0 92940001 0 92940001 92940001 7.83 % 14/02/2011
Mark N. Lampert United States 0 0 0 0 0 0 % 11/02/2011
Biotechnology Value Fund II, L.P. Delaware 0 0 0 0 0 0 % 11/02/2011
BVF Investments, L.L.C. Delaware 0 0 0 0 0 0 % 11/02/2011
Investment 10, L.L.C. Illinois 0 0 0 0 0 0 % 11/02/2011
BVF Partners L.P. Delaware 0 0 0 0 0 0 % 11/02/2011
BVF Inc. Delaware 0 0 0 0 0 0 % 11/02/2011
Biotechnology Value Fund, L.P. Delaware 0 0 0 0 0 0 % 11/02/2011
J. Christopher Donahue United States 0 24595668 0 24595668 24595668 20.67 % 09/02/2011
Rhodora J. Donahue United States 0 24595668 0 24595668 24595668 20.67 % 09/02/2011
John F. Donahue United States 0 24595668 0 24595668 24595668 20.67 % 09/02/2011
Voting Shares Irrevocable Trust Pennsylvania 24595668 0 24595668 0 24595668 20.67 % 09/02/2011
Federated Investors, Inc. Pennsylvania 24595668 0 24595668 0 24595668 20.67 % 09/02/2011
BlackRock, Inc. Delaware 8579064 0 8579064 0 8579064 7.42 % 04/02/2011
Deerfield Private Design Fund, L.P. Delaware 0 1002873 0 1002873 1002873 0.86 % 03/02/2011
Deerfield Management Company, L.P. Delaware 0 576036 0 576036 576036 0.5 % 03/02/2011
Deerfield Special Situations Fund, L.P. Delaware 0 362294 0 362294 362294 0.31 % 03/02/2011
Deerfield Capital, L.P. Delaware 0 3000965 0 3000965 3000965 2.53 % 03/02/2011
Deerfield Private Design International, L.P. British Virgin Islands 0 1635798 0 1635798 1635798 1.4 % 03/02/2011
Deerfield Special Situations Fund International Limited British Virgin Islands 0 576036 0 576036 576036 0.5 % 03/02/2011
James E. Flynn United States 0 3577001 0 3577001 3577001 3 % 03/02/2011
Edward C. Johnson 3d United States of America 0 0 13744100 0 13744100 11.892 % 10/01/2011
FMR LLC Delaware 30000 0 13744100 0 13744100 11.892 % 10/01/2011
Stephen DuBois Stephen DuBois United States 0 4752056 0 4752056 4752056 4.1 % 08/11/2010
Camber Capital Management LLC Camber Capital Management LLC Massachusetts 0 8211 0 8211 4752056 4.1 % 08/11/2010
Federated Investors, Inc. Pennsylvania 14030089 0 14030089 0 14030089 18.56 % 09/07/2010
Rhodora J. Donahue United States 0 14030089 0 14030089 14030089 18.56 % 09/07/2010
J. Christopher Donahue United States 0 14030089 0 14030089 14030089 18.56 % 09/07/2010
John F. Donahue United States 0 14030089 0 14030089 14030089 18.56 % 09/07/2010
Voting Shares Irrevocable Trust Pennsylvania 14030089 0 14030089 0 14030089 18.56 % 09/07/2010
Rhodora J. Donahue United States 0 11572159 0 11572159 11572159 12.87 % 10/05/2010
John F. Donahue United States 0 11572159 0 11572159 11572159 12.87 % 10/05/2010
J. Christopher Donahue United States 0 11572159 0 11572159 11572159 12.87 % 10/05/2010
Voting Shares Irrevocable Trust Pennsylvania 11572159 0 11572159 0 11572159 12.87 % 10/05/2010
Federated Investors, Inc. Pennsylvania 11572159 0 11572159 0 11572159 12.87 % 10/05/2010
Great Point Partners, LLC USA 0 89130001 0 89130001 89130001 9.99 % 07/05/2010
Mr. David Kroin USA 0 89130001 0 89130001 89130001 9.99 % 07/05/2010
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP USA 0 89130001 0 89130001 89130001 9.99 % 07/05/2010
Vivo Ventures VI Affiliates Fund, L.P. Delaware 0 45594 0 45594 45594 0.1 % 22/04/2010
Vivo Ventures V, LLC Delaware 0 1476765 0 1476765 1476765 1.7 % 22/04/2010
Vivo Ventures V Affiliates Fund, L.P. Delaware 0 17130 0 17130 17130 0.1 % 22/04/2010
Vivo Ventures VI, LLC Delaware 0 6269235 0 6269235 6269235 7.1 % 22/04/2010
Vivo Ventures Fund VI, L.P. Delaware 0 6223641 0 6223641 6223641 7 % 22/04/2010
Vivo Ventures Fund V, L.P. Delaware 0 1459635 0 1459635 1459635 1.7 % 22/04/2010
Investment 10, L.L.C. Illinois 0 282000 0 282000 282000 0 % 12/02/2010
Mark N. Lampert United States 0 4560851 0 4560851 4560851 8.4 % 12/02/2010
BVF Investments, L.L.C. Delaware 0 2564000 0 2564000 2564000 4.7 % 12/02/2010
Biotechnology Value Fund II, L.P. Delaware 0 698000 0 698000 698000 1.3 % 12/02/2010
BVF Inc. Delaware 0 4560851 0 4560851 4560851 8.4 % 12/02/2010
Biotechnology Value Fund, L.P. Delaware 0 1016851 0 1016851 1016851 1.9 % 12/02/2010
BVF Partners L.P. Delaware 0 4560851 0 4560851 4560851 8.4 % 12/02/2010
Jérôme G. Pfund 4033556 10.1 % 13/02/2008
Michael L. Sjöström 4033556 10.1 % 13/02/2008
Sectoral Asset Management Inc. 4033556 10.1 % 13/02/2008

Senat trading

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Senat Divulgation

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