| Nantahala
Capital Management, LLC |
MA |
0 |
2910849 |
0 |
0 |
2910849 |
5.1 % |
14/02/2024 |
| Wilmot
B. Harkey |
MA |
0 |
2910849 |
0 |
0 |
2910849 |
5.1 % |
14/02/2024 |
| Daniel
Mack |
MA |
0 |
2910849 |
0 |
0 |
2910849 |
5.1 % |
14/02/2024 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
0 |
0 |
0 |
2943512 |
5.15 % |
13/02/2024 |
| (1) BlackRock, Inc. |
Delaware |
3274535 |
0 |
3339377 |
0 |
3339377 |
5.8 % |
29/01/2024 |
| Edelman |
Delaware |
0 |
3086604 |
0 |
3086604 |
3086604 |
5.4 % |
27/11/2023 |
| Advisors LLC |
Delaware |
0 |
3086604 |
0 |
3086604 |
3086604 |
5.4 % |
27/11/2023 |
| Sciences Master Fund, Ltd. |
Delaware |
0 |
3086604 |
0 |
3086604 |
3086604 |
5.4 % |
27/11/2023 |
| Stonepine Capital Management, LLC |
California |
0 |
4187447 |
0 |
4187447 |
9 |
7.4 % |
16/06/2023 |
| Tang Capital Management, LLC |
DELAWARE |
0 |
3038732 |
0 |
3038732 |
3038732 |
5.4 % |
21/02/2023 |
| Millennium Management LLC |
|
0 |
3328597 |
0 |
3328597 |
3328597 |
5.9 % |
15/02/2023 |
| Israel A. Englander |
|
0 |
3328597 |
0 |
3328597 |
3328597 |
5.9 % |
15/02/2023 |
| Millennium Group Management LLC |
|
0 |
3328597 |
0 |
3328597 |
3328597 |
5.9 % |
15/02/2023 |
| Company, L.P. |
Delaware |
0 |
3030299 |
0 |
0 |
3030299 |
5.41 % |
06/06/2022 |
| Deerfield Partners, L.P. |
Delaware |
0 |
3030299 |
0 |
0 |
3030299 |
5.41 % |
06/06/2022 |
| James E. Flynn |
United States |
0 |
3030299 |
0 |
0 |
3030299 |
5.41 % |
06/06/2022 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
3030299 |
0 |
0 |
3030299 |
5.41 % |
06/06/2022 |
| First Manhattan Co. |
New York |
3334916 |
0 |
3334916 |
0 |
3334916 |
6 % |
14/02/2022 |
| Daewoong Pharmaceutical Co., Ltd. |
Republic of Korea |
3136869 |
0 |
3136869 |
0 |
3136869 |
7.2 % |
01/04/2021 |
| Inc. |
NUMBER OF |
6762652 |
0 |
6762652 |
0 |
6762652 |
16.7 % |
01/03/2021 |
| (1) BlackRock, Inc. |
Delaware |
1608712 |
0 |
1652603 |
0 |
1652603 |
4.9 % |
09/03/2020 |
| (1) BlackRock, Inc. |
Delaware |
1643030 |
0 |
1689075 |
0 |
1689075 |
6.2 % |
07/02/2020 |
| Alphaeon 1 LLC |
Delaware |
8662346 |
0 |
8662346 |
10 |
8662346 |
25.9 % |
17/01/2020 |
| TIMOTHY J. MCDONALD |
DELAWARE |
0 |
1925000 |
0 |
1925000 |
425515 |
7.04 % |
18/11/2019 |
| Wellington Management Company LLP |
Massachusetts |
0 |
1395706 |
0 |
0 |
1439732 |
5.28 % |
12/02/2019 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
1416141 |
0 |
0 |
1523292 |
5.58 % |
12/02/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
1416141 |
0 |
0 |
1523292 |
5.58 % |
12/02/2019 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
1416141 |
0 |
0 |
1523292 |
5.58 % |
12/02/2019 |