| 95-1411037 |
Delaware |
1478041 |
0 |
1478041 |
0 |
13 |
5.3 % |
12/11/2024 |
| prospectus supplement filed with the Securities and Exchange Commission (“SEC”) under Rule 424(b)(5) |
Qatar |
1755311 |
0 |
0 |
1755311 |
1755311 |
6.03 % |
12/11/2024 |
| Juan Jose Chacon Quiros |
4. Citizenship or Place of Organization Costa Rica |
1439943 |
0 |
1439943 |
1439943 |
1439943 |
11 % |
09/02/2024 |
| Pura Vida Investments, LLC |
Delaware |
0 |
1319398 |
0 |
1319398 |
1319398 |
5.5 % |
14/02/2022 |
| Efrem Kamen |
Delaware |
0 |
1319398 |
0 |
1319398 |
1319398 |
5.5 % |
14/02/2022 |
| Brown Advisory Incorporated ("BAI") |
Brown Advisory Incorporated is a Maryland Corporation. |
1441994 |
0 |
0 |
0 |
1668969 |
6.95 % |
04/02/2022 |
| Brown Advisory LLC ("BALLC") |
Brown Advisory LLC is a Maryland Limited Liability Corporation. |
1433194 |
0 |
0 |
0 |
1660169 |
6.92 % |
04/02/2022 |
| Brown Investment Advisory & Trust Company ("BIATC") |
Brown Investment Advisory & Trust Company is a Maryland Trust Company. |
8800 |
0 |
0 |
0 |
8800 |
0.04 % |
04/02/2022 |
| Juan Jose Chacon Quiros |
Costa Rica |
1371818 |
0 |
1371818 |
0 |
1371818 |
11 % |
01/02/2022 |
| S |
Delaware |
6250 |
1182446 |
6250 |
1182446 |
1188696 |
5.07 % |
16/02/2021 |
| S |
Delaware |
0 |
1182446 |
0 |
1182446 |
1182446 |
5.04 % |
16/02/2021 |
| Wilmot B. Harkey |
USA |
0 |
2042099 |
0 |
0 |
2042099 |
8.7 % |
16/02/2021 |
| Nantahala Capital Management, LLC |
USA |
0 |
2042099 |
0 |
0 |
2042099 |
8.7 % |
16/02/2021 |
| Daniel Mack |
USA |
28218 |
2042099 |
28218 |
0 |
2070317 |
8.8 % |
16/02/2021 |
| S |
Delaware |
0 |
1195284 |
0 |
1195284 |
1195284 |
5.12 % |
02/10/2020 |
| S |
Delaware |
0 |
1195284 |
0 |
1195284 |
1195284 |
5.12 % |
02/10/2020 |
| Roderick Wong |
United States of America |
0 |
2032446 |
0 |
0 |
2032446 |
9.87 % |
14/02/2020 |
| RTW Master Fund, Ltd. |
Cayman Islands |
0 |
1559017 |
0 |
0 |
1559017 |
7.57 % |
14/02/2020 |
| RTW
Investments, LP |
United States of America |
0 |
2032446 |
0 |
0 |
2032446 |
9.87 % |
14/02/2020 |
| CPH TU, LP |
4. Citizenship or Place of Organization Delaware |
0 |
0 |
0 |
0 |
0 |
11 % |
11/02/2020 |
| Nicholas Lewin |
4. Citizenship or Place of Organization United States of America |
876622 |
0 |
876622 |
876622 |
876622 |
11 % |
11/02/2020 |
| Juan Jose Chacon Quiros |
4. Citizenship or Place of Organization United States of America |
1422504 |
0 |
1422504 |
1422504 |
1422504 |
11 % |
11/02/2020 |
| Jason G. Wild |
United States of America |
0 |
3104485 |
0 |
0 |
3104485 |
15.21 % |
29/05/2019 |
| JW GP, LLC |
Delaware, United States of America |
0 |
2320364 |
0 |
0 |
2302364 |
11.37 % |
29/05/2019 |
| J.W. Opportunities Master Fund, LLC |
Delaware, United States of America |
0 |
784121 |
0 |
21 |
784121 |
3.84 % |
29/05/2019 |
| 1,260,528 |
Delaware |
0 |
1260528 |
0 |
1260528 |
1260528 |
6.2 % |
28/05/2019 |
| 1,260,528 |
Delaware |
0 |
1260528 |
0 |
1260528 |
1260528 |
6.2 % |
28/05/2019 |
| 1,260,528 |
Delaware |
0 |
1260528 |
0 |
1260528 |
1260528 |
6.2 % |
28/05/2019 |
| Perceptive Advisors LLC |
Delaware |
0 |
1344242 |
0 |
1344242 |
1344242 |
6.5 % |
14/02/2019 |
| Joseph Edelman |
Delaware |
0 |
1344242 |
0 |
1344242 |
1344242 |
6.5 % |
14/02/2019 |
| Perceptive Life Sciences Master Fund, Ltd. |
Delaware |
0 |
1344242 |
0 |
1344242 |
1344242 |
6.5 % |
14/02/2019 |
| Juan Jose Chacon Quiros |
4. Citizenship or Place of Organization United States of America |
1393897 |
0 |
1393897 |
1393897 |
1393897 |
11 % |
13/02/2019 |
| Roderick
Wong |
States of America |
0 |
1054091 |
0 |
0 |
1054091 |
5.13 % |
18/01/2019 |
| RTW
Investments, LP |
United States of America |
0 |
1054091 |
0 |
0 |
1054091 |
5.13 % |
18/01/2019 |
