| Vanguard Portfolio Management |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
2166241 |
6.04 % |
28/04/2026 |
| Vanguard Capital Management |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
1881214 |
5.25 % |
28/04/2026 |
| The Vanguard Group |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
0 |
0 % |
26/03/2026 |
| T. Rowe Price Associates, Inc. |
MARYLAND |
0 |
0 |
0 |
0 |
4041675 |
11.3 % |
08/01/2026 |
| FMR LLC |
DELAWARE |
0 |
0 |
0 |
0 |
2327329 |
6.5 % |
05/11/2025 |
| BlackRock, Inc. |
DELAWARE |
0 |
0 |
0 |
0 |
4368960 |
12.2 % |
29/04/2025 |
| FMR LLC |
United States of America |
1891846 |
0 |
1893983 |
0 |
1893983 |
5.213 % |
09/02/2024 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1893983 |
0 |
1893983 |
5.213 % |
09/02/2024 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
64460 |
4046047 |
97066 |
4143113 |
11.19 % |
10/02/2022 |
| Wasatch Advisors, Inc. 87-0319391 |
|
2703553 |
0 |
2703553 |
0 |
2703553 |
7.3 % |
09/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
84003 |
3853843 |
113265 |
3967108 |
10.74 % |
10/02/2021 |
| Wasatch Advisors, Inc. 87-0319391 |
|
2238148 |
0 |
2238148 |
0 |
2238148 |
6.1 % |
10/02/2020 |
| FMR LLC |
Delaware |
158698 |
0 |
2740360 |
0 |
2740360 |
7.439 % |
13/02/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2740360 |
0 |
2740360 |
7.439 % |
13/02/2019 |
| Third Rock Ventures II, L.P. |
Pennsylvania |
71769 |
2400 |
2025338 |
71075 |
12475187 |
41 % |
09/02/2018 |
| (. |
Delaware |
1995449 |
0 |
2099027 |
0 |
2099027 |
5.7 % |
09/02/2017 |
| 1,572,879 (See Item 4(a) below) |
United States |
1270838 |
0 |
0 |
0 |
1572879 |
4.3 % |
02/02/2016 |
| 52-2343049 |
New York |
4910019 |
0 |
4910019 |
0 |
4910019 |
13.9 % |
30/01/2015 |
| 90-0421097 |
Cayman Islands |
0 |
0 |
0 |
3107063 |
3107063 |
8.8 % |
30/01/2015 |
| None |
Cayman Islands |
0 |
3107063 |
0 |
3107063 |
3107063 |
8.8 % |
30/01/2015 |
| 98-0446509 |
Cayman Islands |
36501 |
3107063 |
36501 |
3107063 |
3143564 |
8.9 % |
30/01/2015 |
| Not Applicable |
Cayman Islands |
36501 |
3107063 |
36501 |
3107063 |
3143564 |
8.9 % |
30/01/2015 |
| David T. Mitchell |
United States |
2223822 |
0 |
2223822 |
0 |
2975863 |
8.6 % |
06/02/2013 |
| None |
WITH: |
0 |
9157063 |
0 |
9157063 |
9157063 |
26.6 % |
14/02/2012 |
| 98-0446509 |
WITH: |
36501 |
9157063 |
36501 |
9157063 |
9193564 |
26.7 % |
14/02/2012 |
| Not Applicable |
WITH: |
42311 |
9157063 |
42311 |
9157063 |
9199374 |
26.7 % |
14/02/2012 |
| 90-0421097 |
WITH: |
0 |
9157063 |
0 |
9157063 |
9157063 |
26.6 % |
14/02/2012 |
| 04-2683227 |
Massachusetts |
0 |
2222594 |
0 |
0 |
2658824 |
7.73 % |
14/02/2012 |
| 52-2343049 |
New York |
1975240 |
0 |
1975240 |
0 |
1975240 |
5.74 % |
24/01/2012 |
| FMR LLC |
Delaware |
1750 |
0 |
4227491 |
0 |
4227491 |
12.475 % |
08/04/2011 |