| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
188746 |
19680656 |
458038 |
20138694 |
8.88 % |
10/02/2022 |
| 26-0385758 |
Delaware |
6790302 |
0 |
6798963 |
0 |
6798963 |
3.08 % |
10/02/2021 |
| 13-3127734 |
Delaware |
6790302 |
0 |
6798963 |
0 |
6798963 |
3.08 % |
10/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
207479 |
19546237 |
374021 |
19920258 |
9.03 % |
10/02/2021 |
| FMR LLC |
Delaware |
1402683 |
0 |
13253442 |
0 |
13253442 |
6.004 % |
08/02/2021 |
| 13-3127734 |
Delaware |
10100675 |
0 |
10100675 |
0 |
10100675 |
5.39 % |
12/02/2020 |
| 26-0385758 |
Delaware |
10100675 |
0 |
10100675 |
0 |
10100675 |
5.39 % |
12/02/2020 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
98143 |
39781 |
16975647 |
113767 |
17089414 |
9.12 % |
12/02/2020 |
| Jeremy Mindich |
Delaware |
0 |
2527456 |
0 |
2527456 |
2527456 |
1.4 % |
10/01/2020 |
| Matthew Sirovich |
Delaware |
0 |
2527456 |
0 |
2527456 |
2527456 |
1.4 % |
10/01/2020 |
| Scopia Management, Inc. |
Delaware |
0 |
2527456 |
0 |
2527456 |
2527456 |
1.4 % |
10/01/2020 |
| Scopia Capital Management LP |
Delaware |
0 |
2527456 |
0 |
2527456 |
2527456 |
1.4 % |
10/01/2020 |
| Scopia Management, Inc. |
Delaware |
0 |
10725642 |
0 |
10725642 |
10725642 |
6.4 % |
14/02/2019 |
| Jeremy Mindich |
Delaware |
0 |
10725642 |
0 |
10725642 |
10725642 |
6.4 % |
14/02/2019 |
| Scopia Capital Management LP |
Delaware |
0 |
10725642 |
0 |
10725642 |
10725642 |
6.4 % |
14/02/2019 |
| Matthew Sirovich |
Delaware |
0 |
10725642 |
0 |
10725642 |
10725642 |
6.4 % |
14/02/2019 |
| William Blair Investment Management, LLC |
Delaware |
6081140 |
0 |
6686332 |
0 |
6686332 |
4 % |
13/02/2019 |
| Scopia Management, Inc. |
Delaware |
0 |
16370364 |
0 |
16370364 |
16370364 |
9.9 % |
14/02/2018 |
| Scopia Capital Management LP |
Delaware |
0 |
16370364 |
0 |
16370364 |
16370364 |
9.9 % |
14/02/2018 |
| Matthew Sirovich |
Delaware |
0 |
16370364 |
0 |
16370364 |
16370364 |
9.9 % |
14/02/2018 |
| Jeremy Mindich |
Delaware |
0 |
16370364 |
0 |
16370364 |
16370364 |
9.9 % |
14/02/2018 |
| Mark Kingdon |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Kingdon Capital Management, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
1264347 |
0 |
0 |
1264347 |
0.77 % |
14/02/2018 |
| James E. Flynn |
United States |
0 |
6341894 |
0 |
0 |
6341894 |
3.87 % |
14/02/2018 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
1140203 |
0 |
0 |
1140203 |
0.7 % |
14/02/2018 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
995008 |
0 |
0 |
995008 |
0.61 % |
14/02/2018 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
6341894 |
0 |
0 |
6341894 |
3.87 % |
14/02/2018 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
6341894 |
0 |
0 |
6341894 |
3.87 % |
14/02/2018 |
| Situations Fund, L.P. |
Delaware |
0 |
624965 |
0 |
0 |
624965 |
0.38 % |
14/02/2018 |
| L.P. |
Delaware |
0 |
2317371 |
0 |
0 |
2317371 |
1.41 % |
14/02/2018 |
| William Blair Investment Management, LLC |
Delaware |
7885632 |
0 |
8791589 |
0 |
8791589 |
5.36 % |
13/02/2018 |
| Mark Kingdon |
Delaware |
0 |
12748199 |
0 |
12748199 |
12748199 |
7.83 % |
14/02/2017 |
| Kingdon Capital Management, L.L.C. |
Delaware |
0 |
12748199 |
0 |
12748199 |
12748199 |
7.83 % |
14/02/2017 |
| Lone Pine Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Stephen F. Mandel, Jr. |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
8956988 |
0 |
0 |
8956988 |
5.55 % |
14/02/2017 |
| Deerfield Partners, L.P. |
Delaware |
0 |
2701852 |
0 |
0 |
2701852 |
1.68 % |
14/02/2017 |
| Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
3458560 |
0 |
0 |
3458560 |
2.14 % |
14/02/2017 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
661365 |
0 |
0 |
661365 |
0.41 % |
14/02/2017 |
| James E. Flynn |
United States |
0 |
8956988 |
0 |
0 |
8956988 |
5.55 % |
14/02/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
8956988 |
0 |
0 |
8956988 |
5.55 % |
14/02/2017 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
995008 |
0 |
0 |
995008 |
0.62 % |
14/02/2017 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
1140203 |
0 |
0 |
1140203 |
0.71 % |
14/02/2017 |
| Broadfin Capital, LLC |
United States America |
0 |
6759819 |
0 |
6759819 |
6759819 |
4.19 % |
10/02/2017 |
| Kevin Kotler |
United States America |
0 |
6759819 |
0 |
6759819 |
6759819 |
4.19 % |
10/02/2017 |
| Broadfin Healthcare Master Fund, Ltd. |
United States America |
0 |
6759819 |
0 |
6759819 |
6759819 |
4.19 % |
10/02/2017 |
| FMR LLC |
Delaware |
281066 |
0 |
13604036 |
0 |
13604036 |
8.411 % |
11/10/2016 |
| Stephen F. Mandel, Jr. |
United States of America |
0 |
15600988 |
0 |
0 |
15600988 |
9.8 % |
16/02/2016 |
| Lone Pine Capital LLC |
Delaware |
0 |
15600988 |
0 |
0 |
15600988 |
9.8 % |
16/02/2016 |
| Kingdon Capital Management, L.L.C. |
Delaware |
0 |
4776229 |
0 |
4776229 |
4776229 |
2.98 % |
16/02/2016 |
| Mark Kingdon |
Delaware |
0 |
4776229 |
0 |
4776229 |
4776229 |
2.98 % |
16/02/2016 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
11684801 |
0 |
11684801 |
11684801 |
7.34 % |
16/02/2016 |
| Stephen F. Mandel, Jr. |
United States of America |
0 |
8353668 |
0 |
0 |
8353668 |
5.4 % |
27/07/2015 |
| Lone Pine Capital LLC |
Delaware |
0 |
8353668 |
0 |
0 |
8353668 |
5.4 % |
27/07/2015 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
17590380 |
0 |
17590380 |
11.387 % |
11/05/2015 |
| Select Biotechnology Portfolio |
Delaware |
8784102 |
0 |
0 |
0 |
8784102 |
5.686 % |
11/05/2015 |
| FMR LLC |
Delaware |
572040 |
0 |
17590380 |
0 |
17590380 |
11.387 % |
11/05/2015 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
17590380 |
0 |
17590380 |
11.387 % |
11/05/2015 |
| Kingdon Capital Management, L.L.C. |
Delaware |
0 |
6374616 |
0 |
6374616 |
6374616 |
5.36 % |
17/02/2015 |
| Mark Kingdon |
Delaware |
0 |
6374616 |
0 |
6374616 |
6374616 |
5.36 % |
17/02/2015 |
| Deerfield Partners, L.P. |
Delaware |
0 |
3564640 |
0 |
0 |
3564640 |
3 % |
17/02/2015 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
11699047 |
0 |
0 |
11699047 |
9.84 % |
17/02/2015 |
| Deerfield International Master Fund, L.P. |
Delaware |
0 |
4434270 |
0 |
0 |
4434270 |
3.73 % |
17/02/2015 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
11699047 |
0 |
0 |
11699047 |
9.84 % |
17/02/2015 |
| Deerfield Private Design International II, L.P. |
Delaware |
0 |
1030509 |
0 |
0 |
1030509 |
0.87 % |
17/02/2015 |
| James E. Flynn |
Delaware |
0 |
11699047 |
0 |
0 |
11699047 |
9.84 % |
17/02/2015 |
| Deerfield Special Situations International Master Fund, L.P. |
Delaware |
0 |
793890 |
0 |
0 |
793890 |
0.67 % |
17/02/2015 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
899157 |
0 |
0 |
899157 |
0.76 % |
17/02/2015 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
976581 |
0 |
0 |
976581 |
0.82 % |
17/02/2015 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
8917975 |
0 |
8917975 |
8917975 |
7.5 % |
17/02/2015 |
| Broadfin Capital, LLC |
Delaware |
0 |
8917975 |
0 |
8917975 |
8917975 |
7.5 % |
17/02/2015 |
| Kevin Kotler |
Delaware |
0 |
8917975 |
0 |
8917975 |
8917975 |
7.5 % |
17/02/2015 |
| CD-Venture GmbH |
Germany |
2250000 |
0 |
2250000 |
0 |
2250000 |
1.9 % |
17/02/2015 |
| Christoph F. Boehringer |
Germany |
1000000 |
2250000 |
1000000 |
2250000 |
3250000 |
2.7 % |
17/02/2015 |
| 2 |
United States |
0 |
4497065 |
0 |
4497065 |
4497065 |
3.8 % |
12/02/2015 |
| 2 |
United States |
0 |
4497065 |
0 |
4497065 |
4497065 |
3.8 % |
12/02/2015 |
| 2 |
United States |
0 |
4497065 |
0 |
4497065 |
4497065 |
3.8 % |
12/02/2015 |
| 13G |
Delaware |
0 |
3386898 |
0 |
3386898 |
3386898 |
11 % |
12/02/2015 |
| 13G |
United States |
0 |
3386898 |
0 |
3386898 |
3386898 |
11 % |
12/02/2015 |
| 13G |
Delaware |
0 |
3386898 |
0 |
3386898 |
3386898 |
11 % |
12/02/2015 |
| 13G |
Delaware |
0 |
3386898 |
0 |
3386898 |
3386898 |
11 % |
12/02/2015 |
| 13G |
Germany |
0 |
3386898 |
0 |
3386898 |
3386898 |
11 % |
12/02/2015 |
| 13G |
Delaware |
0 |
3386898 |
0 |
3386898 |
3386898 |
11 % |
12/02/2015 |
| 13G |
France |
0 |
3386898 |
0 |
3386898 |
3386898 |
11 % |
12/02/2015 |
| 2 |
Cayman Islands |
0 |
4145409 |
0 |
4145409 |
4145409 |
5.5 % |
07/08/2014 |
| 2 |
Cayman Islands |
0 |
4145409 |
0 |
4145409 |
4145409 |
5.5 % |
07/08/2014 |
| 2 |
Cayman Islands |
0 |
3969962 |
0 |
3969962 |
3969962 |
5.3 % |
07/08/2014 |
| 2 |
Cayman Islands |
0 |
4145409 |
0 |
4145409 |
4145409 |
5.5 % |
07/08/2014 |
| Quaker BioVentures Capital II, LLC |
Delaware |
0 |
3547457 |
0 |
0 |
3547457 |
4.78 % |
07/08/2014 |
| Quaker BioVentures II, L.P. |
Delaware |
0 |
3547457 |
0 |
0 |
3547457 |
4.78 % |
07/08/2014 |
| Quaker BioVentures Capital II, L.P. |
Delaware |
0 |
3547457 |
0 |
0 |
3547457 |
4.78 % |
07/08/2014 |
| Samuel J. Pullara III |
California, USA |
10389 |
3296728 |
10389 |
0 |
3307117 |
5 % |
01/05/2014 |
| James N. White |
California, USA |
76727 |
3296728 |
76727 |
0 |
3373455 |
5.1 % |
01/05/2014 |
| William H. Younger, Jr. |
California, USA |
320144 |
3296728 |
320144 |
0 |
3616872 |
5.4 % |
01/05/2014 |
| G. Leonard Baker, Jr. |
California, USA |
270913 |
3296728 |
270913 |
0 |
3567641 |
5.4 % |
01/05/2014 |
| Andrew T. Sheehan |
California, USA |
8010 |
3296728 |
8010 |
0 |
3304738 |
5 % |
01/05/2014 |
| Stefan A. Dyckerhoff |
California, USA |
10389 |
3296728 |
10389 |
0 |
3307117 |
5 % |
01/05/2014 |
| David L. Anderson |
California, USA |
181419 |
3296728 |
181419 |
0 |
3478147 |
5.2 % |
01/05/2014 |
| Jeffrey W. Bird |
California, USA |
230092 |
3296728 |
230092 |
0 |
3526820 |
5.3 % |
01/05/2014 |
| David E. Sweet |
California, USA |
35658 |
3296728 |
35658 |
0 |
3332386 |
5 % |
01/05/2014 |
| James C. Gaither |
California, USA |
56922 |
3296728 |
56922 |
0 |
3353650 |
5.1 % |
01/05/2014 |
| Tench Coxe |
California, USA |
588898 |
3296728 |
588898 |
0 |
3885626 |
5.9 % |
01/05/2014 |
| Sutter Hill Ventures, a California Limited Partnership |
California, USA |
3296728 |
0 |
3296728 |
0 |
3296728 |
5 % |
01/05/2014 |
| Michael L. Speiser |
California, USA |
5471 |
3296728 |
5471 |
0 |
3302199 |
5 % |
01/05/2014 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
4638888 |
0 |
4638888 |
4638888 |
7.04 % |
14/02/2014 |
| Christoph F. Boehringer |
Germany |
1800000 |
2357575 |
1800000 |
2357575 |
4157575 |
6.3 % |
14/02/2014 |
| CD-Venture GmbH |
Germany |
2357575 |
0 |
2357575 |
0 |
2357575 |
3.6 % |
14/02/2014 |
| 13G |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
13/02/2014 |
| Atlas Venture Associates VI, Inc. |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
5.91 % |
13/02/2014 |
| Jean-Francois Formela |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
5.91 % |
13/02/2014 |
| Kristen Laguerre |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
5.91 % |
13/02/2014 |
| Atlas Venture Associates VI, L.P. |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
5.91 % |
13/02/2014 |
| Jeffrey Fagnan |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
5.91 % |
13/02/2014 |
| 13G |
Germany |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
13/02/2014 |
| 13G |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
13/02/2014 |
| Deerfield Partners, L.P. |
Delaware |
0 |
1379235 |
0 |
0 |
1379235 |
2.09 % |
20/12/2013 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
4407150 |
0 |
0 |
4407150 |
6.69 % |
20/12/2013 |
| Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
1762528 |
0 |
0 |
1762528 |
2.68 % |
20/12/2013 |
| James E. Flynn |
United States |
0 |
4407150 |
0 |
0 |
4407150 |
6.69 % |
20/12/2013 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
4407150 |
0 |
0 |
4407150 |
6.69 % |
20/12/2013 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
694698 |
0 |
0 |
694698 |
1.05 % |
20/12/2013 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
570689 |
0 |
0 |
570689 |
0.87 % |
20/12/2013 |
| Broadfin Capital, LLC |
Delaware |
0 |
3880000 |
0 |
3880000 |
3880000 |
5.89 % |
27/11/2013 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
3880000 |
0 |
3880000 |
3880000 |
5.89 % |
27/11/2013 |
| Kevin Kotler |
Delaware |
0 |
3880000 |
0 |
3880000 |
3880000 |
5.89 % |
27/11/2013 |
| 2 |
Delaware |
0 |
0 |
0 |
0 |
10 |
12 % |
14/02/2013 |
| Quaker BioVentures II, L.P. |
Delaware |
0 |
4206378 |
0 |
4206378 |
4206378 |
6.8 % |
14/02/2013 |
| TANG CAPITAL MANAGEMENT, LLC |
DELAWARE |
0 |
2828720 |
0 |
2828720 |
2828720 |
4.4 % |
14/02/2013 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
2828720 |
0 |
2828720 |
2828720 |
4.4 % |
14/02/2013 |
| KEVIN C. TANG |
UNITED STATES |
0 |
2828720 |
0 |
2828720 |
2828720 |
4.4 % |
14/02/2013 |
| 13G |
United States |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
11/02/2013 |
| 13G |
United States |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
11/02/2013 |
| 13G |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
11/02/2013 |
| 13G |
Germany |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
11/02/2013 |
| 13G |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
11/02/2013 |
| 13G |
France |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
11/02/2013 |
| 13G |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
11/02/2013 |
| 13G |
Delaware |
0 |
3895404 |
0 |
3895404 |
3895404 |
11 % |
11/02/2013 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
8895482 |
0 |
8895482 |
14.986 % |
10/10/2012 |
| FMR LLC |
Delaware |
383835 |
0 |
8895482 |
0 |
8895482 |
14.986 % |
10/10/2012 |
| CD-Venture GmbH |
Germany |
2357575 |
0 |
2357575 |
0 |
2357575 |
3.9 % |
05/10/2012 |
| Christoph F. Boehringer |
Germany |
1600000 |
2357575 |
1600000 |
2357575 |
3957575 |
6.6 % |
05/10/2012 |
| Farallon Capital (AM) Investors, L.P. |
Delaware |
0 |
6500 |
0 |
0 |
6500 |
0 % |
27/09/2012 |
| Thomas F. Steyer |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| Thomas G. Roberts, Jr. |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| Andrew J. M. Spokes |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| Farallon Capital Institutional Partners II, L.P. |
Delaware |
0 |
9800 |
0 |
0 |
9800 |
0 % |
27/09/2012 |
| Mark C. Wehrly |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| John R. Warren |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| Richard B. Fried |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| Daniel J. Hirsch |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| Monica R. Landry |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| FHP Pharma, L.L.C. |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
3.3 % |
27/09/2012 |
| Farallon Capital Partners, L.P. |
Delaware |
0 |
160400 |
0 |
0 |
160400 |
0.3 % |
27/09/2012 |
| Farallon Capital Institutional Partners, L.P. |
Delaware |
0 |
181500 |
0 |
0 |
181500 |
0.3 % |
27/09/2012 |
| Michael G. Linn |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| Stephen L. Millham |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| Rajiv A. Patel |
Delaware |
0 |
2531087 |
0 |
0 |
2531087 |
4.5 % |
27/09/2012 |
| Farallon Capital Management, L.L.C. |
Delaware |
0 |
1892871 |
0 |
0 |
1892871 |
3.3 % |
27/09/2012 |
| Farallon Partners, L.L.C. |
Delaware |
0 |
638216 |
0 |
0 |
638216 |
1.1 % |
27/09/2012 |
| Farallon Capital Offshore Investors II, L.P. |
Delaware |
0 |
263716 |
0 |
0 |
263716 |
0.5 % |
27/09/2012 |
| Farallon Capital Institutional Partners III, L.P. |
Delaware |
0 |
16300 |
0 |
0 |
16300 |
0 % |
27/09/2012 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
5657440 |
0 |
5657440 |
5657440 |
9.9 % |
21/09/2012 |
| Rajiv A. Patel |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Farallon Capital Management, L.L.C. |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| FHP Pharma, L.L.C. |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| John R. Warren |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Thomas F. Steyer |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Andrew J. M. Spokes |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Richard B. Fried |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Thomas G. Roberts, Jr. |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Stephen L. Millham |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Michael G. Linn |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Mark C. Wehrly |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Monica R. Landry |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Daniel J. Hirsch |
Delaware |
0 |
1883071 |
0 |
0 |
1883071 |
5.4 % |
17/09/2012 |
| Michael R. Murphy |
United States of America |
0 |
2550868 |
0 |
10 |
2550868 |
7.5 % |
13/08/2012 |
| Discovery Equity Partners, L.P. |
Illinois |
0 |
2211885 |
0 |
10 |
2211885 |
6.5 % |
13/08/2012 |
| Discovery Group I, LLC |
Delaware |
0 |
2550868 |
0 |
10 |
2550868 |
7.5 % |
13/08/2012 |
| Daniel J. Donoghue |
United States of America |
0 |
2550868 |
0 |
10 |
2550868 |
7.5 % |
13/08/2012 |
| FMR LLC |
Delaware |
145636 |
0 |
2595483 |
0 |
2595483 |
7.701 % |
10/08/2012 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
2595483 |
0 |
2595483 |
7.701 % |
10/08/2012 |
| CAPITAL, L.L.C. |
Delaware |
44197 |
0 |
44 |
0 |
44197 |
0.13 % |
05/07/2012 |
| FMR LLC |
Delaware |
157629 |
0 |
5077882 |
0 |
5077882 |
14.828 % |
12/03/2012 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
5077882 |
0 |
5077882 |
14.828 % |
12/03/2012 |
| Quaker BioVentures II, L.P. |
Delaware |
0 |
3998044 |
0 |
0 |
3998044 |
11.5 % |
09/03/2012 |
| Quaker BioVentures Capital II, L.P. |
Delaware |
0 |
3998044 |
0 |
0 |
3998044 |
11.5 % |
09/03/2012 |
| Quaker BioVentures Capital II, LLC |
Delaware |
0 |
3998044 |
0 |
0 |
3998044 |
11.5 % |
09/03/2012 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1650201 |
0 |
1650201 |
8.45 % |
14/02/2012 |
| FMR LLC |
Delaware |
201 |
0 |
1650201 |
0 |
1650201 |
8.45 % |
14/02/2012 |
| 04-3519872 |
Delaware |
1320000 |
0 |
1485000 |
0 |
1485000 |
7.6 % |
10/02/2012 |
| 13G |
Delaware |
0 |
2859851 |
0 |
2859851 |
2859851 |
11 % |
10/02/2012 |
| 13G |
Delaware |
0 |
2859851 |
0 |
2859851 |
2859851 |
11 % |
10/02/2012 |
| 13G |
Delaware |
0 |
2859851 |
0 |
2859851 |
2859851 |
11 % |
10/02/2012 |
| 13G |
France |
0 |
2859851 |
0 |
2859851 |
2859851 |
11 % |
10/02/2012 |
| 13G |
Delaware |
0 |
2859851 |
0 |
2859851 |
2859851 |
11 % |
10/02/2012 |
| 13G |
Germany |
0 |
2859851 |
0 |
2859851 |
2859851 |
11 % |
10/02/2012 |
| FIRSTMARK CAPITAL, L.L.C. |
Delaware |
1049048 |
0 |
1049048 |
0 |
1049048 |
5.4 % |
18/01/2012 |