| Dodge & Cox |
CALIFORNIA |
0 |
0 |
0 |
0 |
12252356 |
6.2 % |
14/05/2026 |
| Baker Bros. Advisors LP |
DE |
30865077 |
0 |
30865077 |
0 |
30865077 |
15.4 % |
11/05/2026 |
| Felix J. Baker |
UNITED STATES |
31225572 |
0 |
31225572 |
0 |
31225572 |
15.6 % |
11/05/2026 |
| Baker Bros. Advisors (GP) LLC |
DE |
30865077 |
0 |
30865077 |
0 |
30865077 |
15.4 % |
11/05/2026 |
| FBB Associates |
NY |
33410 |
0 |
33410 |
0 |
33410 |
0.02 % |
11/05/2026 |
| FBB3 LLC |
DE |
31140 |
0 |
31140 |
0 |
31140 |
0.02 % |
11/05/2026 |
| Julian C. Baker |
UNITED STATES |
31223155 |
0 |
31223155 |
0 |
31223155 |
15.6 % |
11/05/2026 |
| FBB2, LLC |
DE |
14755 |
0 |
14755 |
0 |
14755 |
0.01 % |
11/05/2026 |
| Vanguard Capital Management |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
12591630 |
6.32 % |
30/04/2026 |
| The Vanguard Group |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
0 |
0 % |
27/03/2026 |
| FBB3 LLC |
DE |
31140 |
0 |
31140 |
0 |
31140 |
0.02 % |
10/02/2026 |
| FBB2, LLC |
DE |
14755 |
0 |
14755 |
0 |
14755 |
0.01 % |
10/02/2026 |
| Baker Bros. Advisors LP |
DE |
30852922 |
0 |
30852922 |
0 |
30852922 |
15.5 % |
10/02/2026 |
| FBB Associates |
NY |
33410 |
0 |
33410 |
0 |
33410 |
0.02 % |
10/02/2026 |
| Julian C. Baker |
UNITED STATES |
31211000 |
0 |
31211000 |
0 |
31211000 |
15.7 % |
10/02/2026 |
| Felix J. Baker |
UNITED STATES |
31213417 |
0 |
31213417 |
0 |
31213417 |
15.7 % |
10/02/2026 |
| Baker Bros. Advisors (GP) LLC |
DE |
30852922 |
0 |
30852922 |
0 |
30852922 |
15.5 % |
10/02/2026 |
| STATE STREET CORPORATION |
MASSACHUSETTS |
9676796 |
9676796 |
9676796 |
0 |
9677414 |
5 % |
10/11/2025 |
| INCYTE CORP |
DELAWARE |
0 |
0 |
0 |
0 |
4372124 |
9.9 % |
07/11/2025 |
| BlackRock, Inc. |
DELAWARE |
0 |
0 |
0 |
0 |
15242171 |
7.8 % |
17/10/2025 |
| (1) BlackRock, Inc. |
Delaware |
15862613 |
0 |
17077446 |
0 |
17077446 |
8.9 % |
08/11/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
17077446 |
0 |
17077446 |
8.9 % |
21/10/2024 |
| STATE STREET CORPORATION |
MA |
0 |
7423375 |
0 |
0 |
10552047 |
5.5 % |
17/10/2024 |
| Incyte Corporation |
Delaware |
4004544 |
0 |
4004544 |
0 |
4004544 |
6.9 % |
25/03/2024 |
| PAGE 2 OF 4 PAGES |
|
15965436 |
0 |
16657586 |
0 |
16657586 |
7.5 % |
14/02/2022 |
| 52-0556948 |
Maryland |
6931098 |
0 |
18910214 |
0 |
18910214 |
8.5 % |
12/10/2021 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
13015498 |
0 |
0 |
13499976 |
6.16 % |
04/02/2021 |
| Wellington Management Company LLP |
Massachusetts |
0 |
12821926 |
0 |
0 |
12902408 |
5.89 % |
04/02/2021 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
13015498 |
0 |
0 |
13499976 |
6.16 % |
04/02/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
13015498 |
0 |
0 |
13499976 |
6.16 % |
04/02/2021 |
| Incyte Corporation |
|
3550000 |
0 |
3550000 |
11 |
3550000 |
9.4 % |
25/01/2021 |
| Incyte Corporation |
Delaware |
3200000 |
0 |
3200000 |
10 |
3200000 |
11 % |
28/12/2020 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
12947665 |
0 |
0 |
13431834 |
6.24 % |
27/01/2020 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
12947665 |
0 |
0 |
13431834 |
6.24 % |
27/01/2020 |
| Wellington Management Company LLP |
Massachusetts |
0 |
12770594 |
0 |
0 |
12781402 |
5.93 % |
27/01/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
12947665 |
0 |
0 |
13431834 |
6.24 % |
27/01/2020 |
| FBB Associates |
New York |
33410 |
0 |
33410 |
10 |
33410 |
0.02 % |
27/02/2019 |
| Felix J. Baker |
United States |
34521176 |
0 |
34521176 |
10 |
34521176 |
16.1 % |
27/02/2019 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
34411607 |
0 |
34411607 |
10 |
34411607 |
16.1 % |
27/02/2019 |
| Julian C. Baker |
United States |
34518759 |
0 |
34518759 |
10 |
34518759 |
16.1 % |
27/02/2019 |
| Baker Bros. Advisors LP |
Delaware |
34411607 |
0 |
34411607 |
10 |
34411607 |
16.1 % |
27/02/2019 |
| FBB2, LLC |
Delaware |
15110 |
0 |
15110 |
10 |
15110 |
0.01 % |
27/02/2019 |
| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND |
Delaware |
11113220 |
|
0 |
0 |
11113220 |
5.22 % |
31/01/2019 |
| 52-0556948 |
Maryland |
4511237 |
0 |
14812315 |
0 |
14812315 |
7 % |
14/02/2018 |
| FBB2, LLC |
Delaware |
15110 |
0 |
15110 |
0 |
15110 |
0.01 % |
28/04/2017 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
34295011 |
0 |
34295011 |
0 |
34295011 |
16.7 % |
28/04/2017 |
| Julian C. Baker |
United States |
34402163 |
0 |
34402163 |
0 |
34402163 |
16.8 % |
28/04/2017 |
| Felix J. Baker |
United States |
34404580 |
0 |
34404580 |
0 |
34404580 |
16.8 % |
28/04/2017 |
| FBB Associates |
New York |
33410 |
0 |
33410 |
0 |
33410 |
0.02 % |
28/04/2017 |
| Baker Bros. Advisors LP |
Delaware |
34295011 |
0 |
34295011 |
0 |
34295011 |
16.7 % |
28/04/2017 |
| Capital World Investors ** |
Delaware |
16920700 |
0 |
16920700 |
0 |
16920700 |
10 % |
13/02/2015 |
| BARCLAYS GLOBAL INVESTORS, NA. |
Pennsylvania |
136301 |
|
9093655 |
130201 |
5655345 |
4.67 % |
10/02/2015 |
| (1) BlackRock, Inc. |
Delaware |
8164834 |
0 |
8940287 |
0 |
8940287 |
5.3 % |
06/02/2015 |
| Michael L. Sjöström |
Canada |
1125060 |
0 |
1185260 |
0 |
1185260 |
0.7 % |
11/02/2014 |
| Sectoral Asset Management Inc. |
Canada |
1125060 |
0 |
1185260 |
0 |
1185260 |
0.7 % |
11/02/2014 |
| Jérôme G. Pfund |
Canada |
1125060 |
0 |
1185260 |
0 |
1185260 |
0.7 % |
11/02/2014 |
| (1) BlackRock, Inc. |
Delaware |
7591226 |
0 |
8189299 |
0 |
8189299 |
5.1 % |
11/02/2014 |
| Sectoral Asset Management Inc. |
Canada |
3528982 |
0 |
7862619 |
0 |
7862619 |
6 % |
14/02/2013 |
| Michael L. Sjöström |
Canada |
3528982 |
0 |
7862619 |
0 |
7862619 |
6 % |
14/02/2013 |
| Jérôme G. Pfund |
Canada |
3528982 |
0 |
7862619 |
0 |
7862619 |
6 % |
14/02/2013 |
| (1) BlackRock, Inc. |
Delaware |
0 |
6428009 |
6428009 |
0 |
6428009 |
5.06 % |
09/02/2012 |
| American International Group, Inc. |
Pennsylvania |
131569 |
|
6860606 |
131569 |
1000 |
37.45 % |
10/02/2011 |
| Steven A. Cohen |
Delaware |
0 |
6805100 |
0 |
0 |
6805100 |
5.6 % |
10/03/2010 |
| S.A.C. Capital Advisors, Inc. |
Delaware |
0 |
6805100 |
0 |
0 |
6805100 |
5.6 % |
10/03/2010 |
| S.A.C. Capital Associates, LLC |
Delaware |
0 |
6800000 |
0 |
0 |
6800000 |
5.6 % |
10/03/2010 |
| CR Intrinsic Investors, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/03/2010 |
| S.A.C. Capital Advisors, L.P. |
Delaware |
0 |
6805100 |
0 |
0 |
6805100 |
5.6 % |
10/03/2010 |
| FMR LLC |
Delaware |
1261850 |
0 |
6462538 |
0 |
6462538 |
5.452 % |
16/02/2010 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
6462538 |
0 |
6462538 |
5.452 % |
16/02/2010 |
| BlackRock for purposes of Schedule 13G filings. |
Delaware |
6602766 |
0 |
6602766 |
0 |
6602766 |
5.57 % |
29/01/2010 |
| 52-0791372 |
Maryland |
5327400 |
0 |
0 |
0 |
5327400 |
5.4 % |
12/02/2009 |
| 52-0556948 |
MARYLAND |
2898000 |
0 |
14657718 |
0 |
14657718 |
14.9 % |
12/02/2009 |
| Marvin H. Davidson |
United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| Davidson Kempner Healthcare International Ltd. |
Cayman Islands |
0 |
1965752 |
0 |
1965752 |
1965752 |
2.3 % |
28/07/2008 |
| DK Group LLC |
Delaware |
0 |
1280815 |
0 |
1280815 |
1280815 |
1.5 % |
28/07/2008 |
| DK Management Partners LP |
Delaware |
0 |
1965752 |
0 |
1965752 |
1965752 |
2.3 % |
28/07/2008 |
| DK Stillwater GP LLC |
Delaware |
0 |
1965752 |
0 |
1965752 |
1965752 |
2.3 % |
28/07/2008 |
| Stephen M. Dowicz |
United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| Scott E. Davidson |
United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| Robert J. Brivio, Jr. |
United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| Eric P. Epstein |
United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| Anthony A. Yoseloff |
United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| Avram Z. Friedman |
United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| Conor Bastable |
United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| Davidson Kempner International, Ltd. |
British Virgin Islands |
0 |
648880 |
0 |
648880 |
648880 |
0.8 % |
28/07/2008 |
| Davidson Kempner Healthcare Fund LP |
Delaware |
0 |
1280815 |
0 |
1280815 |
1280815 |
1.5 % |
28/07/2008 |
| Davidson Kempner Partners |
New York |
0 |
182504 |
0 |
182504 |
182504 |
0.2 % |
28/07/2008 |
| Davidson Kempner Institutional Partners, L.P. |
Delaware |
0 |
361647 |
0 |
361647 |
361647 |
0.4 % |
28/07/2008 |
| M. H. Davidson & Co. |
New York |
0 |
22228 |
0 |
22228 |
22228 |
0 % |
28/07/2008 |
| MHD Management Co. |
New York |
0 |
182504 |
0 |
182504 |
182504 |
0.2 % |
28/07/2008 |
| Davidson Kempner Advisers Inc. |
New York |
0 |
361647 |
0 |
361647 |
361647 |
0.4 % |
28/07/2008 |
| Davidson Kempner International Advisors, L.L.C. |
Delaware |
0 |
648880 |
0 |
648880 |
648880 |
0.8 % |
28/07/2008 |
| Thomas L. Kempner, Jr. |
United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| Michael J. Leffell |
United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| Timothy I. Levart |
United Kingdom & United States |
0 |
4461826 |
0 |
4461826 |
4461826 |
5.3 % |
28/07/2008 |
| LLC 42-1684320 |
Delaware |
0 |
5102899 |
0 |
0 |
5102899 |
6 % |
20/03/2008 |
| 00-0000000 |
Cayman Islands |
0 |
5102899 |
0 |
0 |
5102899 |
6 % |
20/03/2008 |
| 00-0000000 |
Cayman Islands |
0 |
5102899 |
0 |
0 |
5102899 |
6 % |
20/03/2008 |
| 52-0556948 |
MARYLAND |
868100 |
0 |
8640318 |
0 |
8640318 |
10.2 % |
10/01/2007 |
| 52-0556948 |
MARYLAND |
989100 |
0 |
4480860 |
0 |
4480860 |
5.3 % |
14/02/2006 |
| Arnold H. Snider |
United States |
0 |
6000000 |
0 |
6000000 |
6000000 |
7.27 % |
08/02/2005 |
| Deerfield International Limited |
British Virgin Islands |
0 |
3102000 |
0 |
3102000 |
3102000 |
3.76 % |
08/02/2005 |
| Deerfield Management Company, L.P. |
New York |
0 |
3102000 |
0 |
3102000 |
3102000 |
3.76 % |
08/02/2005 |
| Deerfield Capital, L.P. |
Delaware |
0 |
2898000 |
0 |
2898000 |
2898000 |
3.51 % |
08/02/2005 |
| Deerfield Partners, L.P. |
Delaware |
0 |
2898000 |
0 |
2898000 |
2898000 |
3.51 % |
08/02/2005 |
| Deerfield International Limited |
British Virgin Islands |
0 |
2111134 |
0 |
2111134 |
2111134 |
2.93 % |
26/09/2003 |
| Arnold H. Snider |
United States |
0 |
4398200 |
0 |
4398200 |
4398200 |
6.1 % |
26/09/2003 |
| Deerfield Management Company |
New York |
0 |
2111134 |
0 |
2111134 |
2111134 |
2.93 % |
26/09/2003 |
| Deerfield Capital, L.P. |
Delaware |
0 |
2287066 |
0 |
2287066 |
2287066 |
3.17 % |
26/09/2003 |
| Deerfield Partners, L.P. |
Delaware |
0 |
2287066 |
0 |
2287066 |
2287066 |
3.17 % |
26/09/2003 |
| BARCLAYS CAPITAL SECURITIES LIMITED |
England. |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2003 |
| BARCLAYS PRIVATE BANK AND TRUST LIMITED (Sussie) |
U.S.A. |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2003 |
| BARCLAYS BANK TRUST COMPANY LIMITED |
England |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2003 |
| BARCLAYS PRIVATE BANK AND TRUST (JERSEY) LIMITED |
England |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2003 |
| BARCLAYS CAPITAL INVESTMENTS |
England. |
65 |
0 |
65 |
0 |
65 |
0 % |
13/02/2003 |
| BARCLAYS BANK PLC |
England |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2003 |
| BARCLAYS GLOBAL INVESTORS, LTD |
England |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2003 |
| BARCLAYS GLOBAL FUND ADVISORS |
U.S.A. |
1811969 |
0 |
1811969 |
0 |
1811969 |
2.59 % |
13/02/2003 |
| 943112180 |
U.S.A. |
2260715 |
0 |
2260715 |
0 |
2260715 |
3.23 % |
13/02/2003 |
| BARCLAYS PRIVATE BANK & TRUST (ISLE OF MAN) LIMITED |
England. |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2003 |
| BARCLAYS LIFE ASSURANCE COMPANY LIMITED |
England |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2003 |
| BARCLAYS TRUST AND BANKING COMPANY (JAPAN) LIMITED |
Japan |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2003 |
| EIN #84-0765359 |
Colorado |
3524295 |
0 |
3524295 |
0 |
3524295 |
11.6 % |
10/03/2000 |
| Thomas H. Bailey |
USA |
3524295 |
0 |
3524295 |
0 |
3524295 |
11.6 % |
10/03/2000 |
| 94-3136539 |
Delaware |
779323 |
0 |
779323 |
0 |
779323 |
9.9 % |
03/04/1998 |
| Nos. of Above Persons |
Delaware |
100000 |
0 |
0 |
0 |
100000 |
11 % |
10/02/1997 |
| Nos. of Above Persons |
Bermuda |
62877 |
0 |
0 |
0 |
62877 |
11 % |
10/02/1997 |
| ###-##-#### |
U.S. Citizen |
6005 |
0 |
0 |
418892 |
424897 |
11 % |
10/02/1997 |
| Nos. of Above Persons |
U.S. Citizen |
0 |
0 |
0 |
410000 |
410000 |
11 % |
10/02/1997 |
| Nos. of Above Persons |
Delaware |
100 |
0 |
0 |
0 |
100 |
11 % |
10/02/1997 |
| Nos. of Above Persons |
Delaware |
247123 |
0 |
0 |
0 |
247123 |
11 % |
10/02/1997 |
| INVESCO PLC |
England |
0 |
755000 |
0 |
755000 |
755000 |
11.8 % |
07/06/1994 |
| INVESCO North American Holdings, Inc. |
State of Delaware |
0 |
755000 |
0 |
755000 |
755000 |
11.8 % |
07/06/1994 |
| INVESCO Funds Group, Inc. |
State of Delaware |
0 |
755000 |
0 |
755000 |
755000 |
11.8 % |
07/06/1994 |
| INVESCO, Inc. |
State of Delaware |
0 |
755000 |
0 |
755000 |
755000 |
11.8 % |
07/06/1994 |
| INVESCO North American Group, Ltd. |
England |
0 |
755000 |
0 |
755000 |
755000 |
11.8 % |
07/06/1994 |