| Oleg Nodelman |
Delaware |
0 |
6719304 |
0 |
6719304 |
6719304 |
11 % |
14/11/2024 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
6322288 |
0 |
6322288 |
6322288 |
11 % |
14/11/2024 |
| EcoR1 Capital, LLC |
Delaware |
0 |
6719304 |
0 |
6719304 |
6719304 |
11 % |
14/11/2024 |
| Highbridge Capital Management, LLC |
State of Delaware |
0 |
1454400 |
0 |
0 |
1454400 |
6.6 % |
25/10/2024 |
| Highbridge Capital Management, LLC |
State of Delaware |
0 |
1454400 |
0 |
0 |
1454400 |
6.6 % |
25/10/2024 |
| 85-4328500 |
Maryland |
1285270 |
0 |
4835142 |
0 |
1351367 |
2.2 % |
14/02/2024 |
| Xencor, Inc. |
Delaware |
1885533 |
0 |
1885533 |
0 |
1885533 |
10.5 % |
15/02/2023 |
| 85-4328500 |
Maryland |
1202134 |
0 |
3735070 |
0 |
3735070 |
6.2 % |
14/02/2023 |
| J. Tesi |
States |
2155403 |
0 |
2155403 |
0 |
2155403 |
11.6 % |
21/04/2022 |
| 52-0556948 |
Maryland |
1347705 |
0 |
5908683 |
0 |
5908683 |
10.1 % |
14/02/2022 |
| Altium Growth Fund, LP |
|
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Altium Growth GP, LLC |
|
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Altium Capital Management, LP |
Delaware, United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Altium Growth GP, LLC |
Delaware, United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Altium Capital Management, LP |
|
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| PRIMECAP Management Company |
|
4987822 |
0 |
4987822 |
0 |
4987822 |
8.53 % |
10/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
107852 |
6162211 |
162565 |
6324776 |
10.81 % |
10/02/2022 |
| Altium Capital Management, LP |
Delaware, United States of America |
0 |
909091 |
0 |
0 |
909091 |
5.1 % |
19/07/2021 |
| Altium Capital Management, LP |
Delaware, United States of America |
0 |
909091 |
0 |
0 |
909091 |
5.1 % |
19/07/2021 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
909091 |
0 |
0 |
909091 |
5.1 % |
19/07/2021 |
| Altium Growth GP, LLC |
Delaware, United States of America |
0 |
909091 |
0 |
0 |
909091 |
5.1 % |
19/07/2021 |
| Altium Growth GP, LLC |
Delaware, United States of America |
0 |
909091 |
0 |
0 |
909091 |
5.1 % |
19/07/2021 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
909091 |
0 |
0 |
909091 |
5.1 % |
19/07/2021 |
| 52-0556948 |
Maryland |
1207175 |
0 |
5863909 |
0 |
5863909 |
10 % |
12/07/2021 |
| 52-0556948 |
Maryland |
1123294 |
0 |
5690356 |
0 |
5690356 |
9.9 % |
16/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
123748 |
5828954 |
171327 |
6000281 |
10.44 % |
10/02/2021 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
3849838 |
0 |
0 |
3849838 |
11 % |
17/06/2020 |
| Oleg Nodelman |
Delaware |
0 |
4547072 |
0 |
4547072 |
4547072 |
11 % |
17/06/2020 |
| EcoR1 Capital, LLC |
Delaware |
0 |
4547072 |
0 |
4547072 |
4547072 |
11 % |
17/06/2020 |
| David J. Moss |
United States |
1656750 |
0 |
1656750 |
0 |
1656750 |
14.82 % |
14/02/2020 |
| Xencor, Inc. |
Delaware |
0 |
1654000 |
1654000 |
0 |
1654000 |
15.3 % |
14/02/2020 |
| Linda F. Powers |
Delaware |
700000 |
0 |
700000 |
0 |
700000 |
7.19 % |
04/03/2019 |
| Toucan Capital Fund III, LP |
Delaware |
700000 |
0 |
700000 |
0 |
700000 |
7.19 % |
04/03/2019 |
| Mark Lowdell |
United States |
1753323 |
0 |
1753323 |
0 |
1753323 |
17.55 % |
11/02/2019 |
| Raymond J. Tesi |
United States |
1815833 |
0 |
1815833 |
0 |
1815833 |
18.08 % |
11/02/2019 |
| David J. Moss |
United States |
1505415 |
0 |
1505415 |
0 |
1505415 |
14.99 % |
11/02/2019 |
| 52-0556948 |
Maryland |
674389 |
0 |
5093271 |
0 |
5093271 |
10.8 % |
14/02/2018 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
2020000 |
0 |
0 |
2020000 |
4.35 % |
14/02/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
2020000 |
0 |
0 |
2020000 |
4.35 % |
14/02/2017 |
| Deerfield Partners, L.P. |
Delaware |
0 |
888122 |
0 |
0 |
888122 |
1.91 % |
14/02/2017 |
| Deerfield International Master Fund, L.P. |
Delaware |
0 |
1131878 |
0 |
0 |
1131878 |
2.44 % |
14/02/2017 |
| James E. Flynn |
Delaware |
0 |
2020000 |
0 |
0 |
2020000 |
4.35 % |
14/02/2017 |
| 52-0556948 |
Maryland |
0 |
0 |
0 |
0 |
2561446 |
5.6 % |
07/02/2017 |
| James E. Flynn |
Delaware |
0 |
3092966 |
0 |
0 |
3092966 |
7.64 % |
16/02/2016 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
3092966 |
0 |
0 |
3092966 |
7.64 % |
16/02/2016 |
| Deerfield International Master Fund, L.P. |
Delaware |
0 |
1732063 |
0 |
0 |
1732063 |
4.28 % |
16/02/2016 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
3092966 |
0 |
0 |
3092966 |
7.64 % |
16/02/2016 |
| Deerfield Partners, L.P. |
Delaware |
0 |
1360903 |
0 |
0 |
1360903 |
3.36 % |
16/02/2016 |
| FMR LLC |
Delaware |
5100 |
0 |
4693014 |
0 |
4693014 |
11.628 % |
10/07/2015 |
| RA Capital Management, LLC |
Massachusetts |
0 |
3156844 |
0 |
0 |
3156844 |
7.8 % |
14/05/2015 |
| Peter Kolchinsky |
Massachusetts |
0 |
3156844 |
0 |
0 |
3156844 |
7.8 % |
14/05/2015 |
| RA Capital Healthcare Fund, L.P. |
Massachusetts |
0 |
2507575 |
0 |
0 |
2507575 |
6.2 % |
14/05/2015 |
| Adage Capital Partners, L.P. |
United States |
0 |
1600000 |
0 |
0 |
1600000 |
5.09 % |
05/02/2015 |
| Robert Atchinson |
United States |
0 |
1600000 |
0 |
0 |
1600000 |
5.09 % |
05/02/2015 |
| Adage Capital Partners GP, L.L.C. |
United States |
0 |
1600000 |
0 |
0 |
1600000 |
5.09 % |
05/02/2015 |
| Adage Capital Advisors, L.L.C. |
United States |
0 |
1600000 |
0 |
0 |
1600000 |
5.09 % |
05/02/2015 |
| Phillip Gross |
United States |
0 |
1600000 |
0 |
0 |
1600000 |
5.09 % |
05/02/2015 |
| John Stafford, Jr. |
United States |
1642741 |
0 |
1642741 |
0 |
1642741 |
5.2 % |
16/12/2013 |
| RA Capital Management, LLC |
United States |
0 |
2725000 |
0 |
2725000 |
2725000 |
8.7 % |
10/12/2013 |
| Peter Kolchinsky |
United States |
0 |
2725000 |
0 |
2725000 |
2725000 |
8.7 % |
10/12/2013 |
| RA Capital Healthcare Fund, L.P. |
United States |
0 |
2180000 |
0 |
2180000 |
2180000 |
7 % |
10/12/2013 |
