| (1) BlackRock, Inc. |
Delaware |
1856062 |
0 |
1886016 |
0 |
1886016 |
7.3 % |
08/11/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
1886016 |
0 |
1886016 |
7.3 % |
22/10/2024 |
| Deep Track Capital, LP |
Delaware |
0 |
2593822 |
0 |
0 |
2593822 |
9.99 % |
26/04/2024 |
| David Kroin |
United States |
0 |
2593822 |
0 |
0 |
2593822 |
9.99 % |
26/04/2024 |
| Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
2593822 |
0 |
0 |
2593822 |
9.99 % |
26/04/2024 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
19380848 |
0 |
19423348 |
19423348 |
8.76 % |
11/04/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
22831657 |
0 |
23267928 |
23267928 |
10.49 % |
11/04/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
12865359 |
0 |
13300430 |
13300430 |
6.32 % |
11/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
17604149 |
0 |
18244914 |
0 |
18244914 |
8.7 % |
01/02/2022 |
| Nikko Asset Management Americas, Inc. |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| Wasatch Advisors, Inc. 87-0319391 |
|
3939018 |
0 |
3939018 |
0 |
3939018 |
2.3 % |
11/02/2021 |
| STATE STREET CORPORATION |
BOSTON MASSACHUSETTS |
0 |
8234462 |
0 |
8894555 |
8894555 |
5.25 % |
10/02/2021 |
| Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2021 |
| Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2021 |
| Nikko Asset Management Americas, Inc. |
USA |
0 |
0 |
0 |
5047608 |
5047608 |
5.05 % |
12/02/2020 |
| Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
5047608 |
0 |
5047608 |
5047608 |
5.05 % |
12/02/2020 |
| Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
5047608 |
0 |
5047608 |
5047608 |
5.05 % |
12/02/2020 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
184043 |
0 |
4868351 |
184043 |
5052394 |
5.05 % |
11/02/2020 |
| Wasatch Advisors, Inc. 87-0319391 |
|
7482827 |
0 |
7482827 |
0 |
7482827 |
7.5 % |
10/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
7530151 |
0 |
7634600 |
0 |
7634600 |
7.6 % |
05/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
7091675 |
0 |
7251925 |
0 |
7251925 |
7.6 % |
04/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
6488283 |
0 |
6627505 |
0 |
6627505 |
7.3 % |
25/01/2018 |
| (1) BlackRock, Inc. |
Delaware |
5186763 |
0 |
5336496 |
0 |
5336496 |
7.2 % |
25/01/2017 |
| Capital Ventures International |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2016 |
| Heights Capital Management, Inc. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2016 |
| (1) BlackRock, Inc. |
Delaware |
4775844 |
0 |
4940893 |
0 |
4940893 |
6.9 % |
26/01/2016 |
| Capital Ventures International |
Cayman Islands |
0 |
4250000 |
0 |
4250000 |
4250000 |
6.1 % |
08/05/2015 |
| Heights Capital Management, Inc. |
Delaware |
0 |
4250000 |
0 |
4250000 |
4250000 |
6.1 % |
08/05/2015 |
| (1) BlackRock, Inc. |
Delaware |
3462839 |
0 |
3590287 |
0 |
3590287 |
5.9 % |
02/02/2015 |
| Capital Ventures International |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2014 |
| Heights Capital Management, Inc. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2014 |
| Capital Ventures International |
Cayman Islands |
0 |
9090908 |
0 |
9090908 |
9090908 |
5.1 % |
15/03/2013 |
| Heights Capital Management, Inc. |
Delaware |
0 |
9090908 |
0 |
9090908 |
9090908 |
5.1 % |
15/03/2013 |
| The Vanguard Group |
00 |
2 |
7 |
|
21130400 |
4323409 |
5.77 % |
10/02/2011 |
| Dr. J. Joseph Kim |
United States |
11631232 |
0 |
15081232 |
10 |
15081232 |
16.9 % |
10/06/2009 |
| the Stockholders listed therein. |
Delaware |
8000000 |
0 |
0 |
10 |
8000000 |
9.3 % |
10/06/2009 |
| Conus Partners, Inc. |
New York |
0 |
2323273 |
0 |
2323273 |
2323273 |
5.86 % |
26/03/2007 |
| Andrew Zacks |
United States of America |
0 |
2323273 |
0 |
2323273 |
2323273 |
5.86 % |
26/03/2007 |
| Conus Partners, Inc. |
New York |
0 |
1136592 |
0 |
1136592 |
1136592 |
3.2 % |
14/02/2007 |
| Andrew Zacks |
United States of America |
0 |
1136592 |
0 |
1136592 |
1136592 |
3.2 % |
14/02/2007 |
| Zesiger Capital Group LLC |
New York, New York |
0 |
0 |
0 |
0 |
2247600 |
6.2 % |
13/02/2007 |
| SDS Management, LLC |
Delaware |
0 |
1792295 |
0 |
1792295 |
1792295 |
4.89 % |
22/11/2006 |
| Mr. Steven Derby |
United States |
0 |
1792295 |
0 |
1792295 |
1792295 |
4.89 % |
22/11/2006 |
| SDS Capital Group SPC, Ltd. |
Cayman Islands |
1792295 |
0 |
1792295 |
0 |
1792295 |
4.89 % |
22/11/2006 |
| Zesiger Capital Group LLC |
New York, New York |
0 |
0 |
0 |
0 |
1944000 |
6.5 % |
10/01/2006 |
| Merck & Co., Inc. |
: |
0 |
0 |
0 |
0 |
1687500 |
5.64 % |
09/01/2006 |
| Andrew Zacks |
United States of America |
0 |
1546028 |
0 |
1546028 |
1546028 |
5.25 % |
05/01/2006 |
| Conus Partners, Inc. |
New York Corporation |
0 |
1546028 |
0 |
1546028 |
1546028 |
5.25 % |
05/01/2006 |
| 22-2007137 |
New Jersey |
0 |
2242611 |
0 |
2242611 |
2242611 |
4.5 % |
04/02/2003 |
| 22-1024240 |
New Jersey |
0 |
2242611 |
0 |
2242611 |
2242611 |
4.5 % |
04/02/2003 |
| Conus Partners Inc. |
New York Corporation |
0 |
2453200 |
0 |
2453200 |
2453200 |
6.11 % |
04/06/2002 |
| Andrew Zacks |
United States |
0 |
2453200 |
0 |
2453200 |
2453200 |
6.11 % |
04/06/2002 |
| 22-1024240 |
New Jersey |
0 |
0 |
0 |
2242611 |
2242611 |
8.2 % |
21/03/2001 |
| 22-2007137 |
New Jersey |
0 |
0 |
0 |
2242611 |
2242611 |
8.2 % |
21/03/2001 |