Macquarie Management Holdings Inc |
State of Delaware |
987248 |
0 |
987248 |
0 |
987248 |
5.66 % |
14/02/2024 |
Macquarie Group Limited |
Sydney, New South Wales Australia |
0 |
0 |
0 |
0 |
987248 |
5.66 % |
14/02/2024 |
Macquarie Investment Management Business Trust |
State of Delaware |
987248 |
0 |
987248 |
0 |
987248 |
5.66 % |
14/02/2024 |
The Vanguard Group |
Pennsylvania |
0 |
14350 |
1845956 |
30558 |
1876514 |
10.76 % |
13/02/2024 |
William Blair Investment Management, LLC |
Delaware |
102833 |
0 |
141128 |
0 |
141128 |
0.8 % |
09/02/2023 |
The Vanguard Group |
Pennsylvania For |
0 |
13209 |
1814734 |
28381 |
1843115 |
10.91 % |
09/02/2023 |
Cardinal Capital Management, LLC |
United States |
139485 |
0 |
162608 |
0 |
162608 |
1 % |
11/02/2022 |
The Vanguard Group |
Pennsylvania |
0 |
14972 |
1687085 |
29650 |
1716735 |
10.27 % |
10/02/2022 |
William Blair Investment Management, LLC |
Delaware |
1239224 |
0 |
1400341 |
0 |
1400341 |
8.4 % |
09/02/2022 |
The Vanguard Group |
Pennsylvania |
0 |
16409 |
1691696 |
30595 |
1722291 |
10.33 % |
12/10/2021 |
William Blair Investment Management, LLC |
Delaware |
1141732 |
0 |
1279548 |
0 |
1279548 |
7.7 % |
07/05/2021 |
Cardinal Capital Management, LLC |
United States |
859641 |
0 |
1088265 |
0 |
1088265 |
6.8 % |
16/02/2021 |
William Blair Investment Management, LLC |
Delaware |
1823923 |
0 |
2041045 |
0 |
2041045 |
12.7 % |
11/02/2021 |
Renaissance Technologies LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
The Vanguard Group |
Pennsylvania |
0 |
34881 |
1411488 |
47437 |
1458925 |
9.07 % |
10/02/2021 |
William Blair Investment Management, LLC |
Delaware |
1720269 |
0 |
1895374 |
0 |
1895374 |
11.8 % |
08/10/2020 |
Cardinal Capital Management, LLC |
United States |
690728 |
0 |
919994 |
0 |
919994 |
5.2 % |
14/02/2020 |
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
1021189 |
0 |
1021189 |
0 |
1021189 |
5.81 % |
13/02/2020 |
Renaissance Technologies LLC |
Delaware |
1021189 |
0 |
1021189 |
0 |
1021189 |
5.81 % |
13/02/2020 |
William Blair Investment Management, LLC |
Delaware |
1300700 |
0 |
1416850 |
0 |
1416850 |
8.1 % |
10/02/2020 |
William Blair Investment Management, LLC |
Delaware |
916990 |
0 |
979261 |
0 |
979261 |
4.6 % |
13/02/2019 |
Renaissance Technologies LLC |
Delaware |
1291039 |
0 |
1397922 |
82897 |
1480819 |
6.97 % |
12/02/2019 |
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
1291039 |
0 |
1397922 |
82897 |
1480819 |
6.97 % |
12/02/2019 |
The Vanguard Group |
Pennsylvania |
43521 |
2773 |
1885746 |
44104 |
1929850 |
9.07 % |
12/02/2019 |
William Blair Investment Management, LLC |
Delaware |
1145138 |
0 |
1235629 |
0 |
1235629 |
5.85 % |
13/02/2018 |
The Vanguard Group |
Pennsylvania |
39896 |
2547 |
1806971 |
40843 |
1847814 |
8.75 % |
09/02/2018 |
David M. Knott |
|
|
|
|
|
1100656 |
5.3 % |
13/02/2017 |
Dorset Management Corporation |
|
|
|
|
|
996257 |
4.8 % |
13/02/2017 |
The Vanguard Group |
Pennsylvania |
37920 |
2547 |
1573958 |
39467 |
1613425 |
7.71 % |
10/02/2017 |
Victory Capital Management Inc. as successor to RS Investment Management Co. LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
02/11/2016 |
Cardinal Capital Management, LLC |
United States |
446988 |
0 |
852131 |
0 |
852131 |
4.3 % |
12/02/2016 |
RS Investment Management Co. LLC |
Delaware |
1075903 |
0 |
1089730 |
0 |
1089730 |
5.47 % |
11/02/2016 |
The Vanguard Group |
Pennsylvania |
39030 |
1200 |
1309323 |
39130 |
1348453 |
6.76 % |
10/02/2016 |
BLAIR WILLIAM & CO/IL |
222 W. Adams, Chicago, IL 60606' |
1052861 |
0 |
1165039 |
0 |
1165039 |
5.82 % |
02/07/2015 |
RS Investment Management Co. LLC |
Delaware |
1094263 |
0 |
1430650 |
0 |
1430650 |
7.14 % |
12/02/2015 |
Cardinal Capital Management, LLC |
United States |
479300 |
0 |
985795 |
0 |
985795 |
5 % |
12/02/2015 |
The Vanguard Group |
Pennsylvania |
27436 |
|
971318 |
25936 |
997254 |
5.07 % |
10/02/2015 |
BVF Investments, L.L.C. |
Delaware |
0 |
1040859 |
0 |
1040859 |
1040859 |
5 % |
21/08/2014 |
Investment 10, L.L.C. |
Illinois |
0 |
47663 |
0 |
47663 |
47663 |
0 % |
21/08/2014 |
MSI BVF SPV, LLC |
Delaware |
0 |
61252 |
0 |
61252 |
61252 |
0 % |
21/08/2014 |
BVF Partners L.P. |
Delaware |
0 |
1408599 |
0 |
1408599 |
1408599 |
6.8 % |
21/08/2014 |
BVF Inc. |
Delaware |
0 |
1408599 |
0 |
1408599 |
1408599 |
6.8 % |
21/08/2014 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
88372 |
0 |
88372 |
88372 |
0 % |
21/08/2014 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
170453 |
0 |
170453 |
170453 |
0 % |
21/08/2014 |
Mark N. Lampert |
United States |
0 |
1408599 |
0 |
1408599 |
1408599 |
6.8 % |
21/08/2014 |
RS Investment Management Co. LLC |
Delaware |
1212801 |
|
1315098 |
|
1315098 |
6.44 % |
13/02/2014 |
The Vanguard Group |
Pennsylvania |
28287 |
|
653230 |
26787 |
680017 |
3.33 % |
12/02/2014 |
BLAIR WILLIAM & CO/IL |
W Adams Chicago IL |
1216383 |
0 |
1216383 |
0 |
1216383 |
5.96 % |
06/02/2014 |
BVF Inc. |
Delaware |
0 |
2626160 |
0 |
2626160 |
2626160 |
12.9 % |
06/12/2013 |
BVF Partners L.P. |
Delaware |
0 |
2626160 |
0 |
2626160 |
2626160 |
12.9 % |
06/12/2013 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
190967 |
0 |
190967 |
190967 |
0 % |
06/12/2013 |
BVF Investments, L.L.C. |
Delaware |
0 |
2008834 |
0 |
2008834 |
2008834 |
9.8 % |
06/12/2013 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
324836 |
0 |
324836 |
324836 |
1.6 % |
06/12/2013 |
Investment 10, L.L.C. |
Illinois |
0 |
101523 |
0 |
101523 |
101523 |
0 % |
06/12/2013 |
Mark N. Lampert |
United States |
0 |
2626160 |
0 |
2626160 |
2626160 |
12.9 % |
06/12/2013 |
Wellington Management Company, LLP |
Massachusetts |
0 |
1151086 |
0 |
1160086 |
1160086 |
5.81 % |
14/02/2013 |
Park West Asset Management LLC |
Delaware |
1016386 |
0 |
1016386 |
0 |
1016386 |
5.1 % |
14/02/2013 |
Peter S. Park |
United States of America |
1016386 |
0 |
1016386 |
0 |
1016386 |
5.1 % |
14/02/2013 |
The Vanguard Group |
Pennsylvania |
26602 |
|
1037623 |
24902 |
1062525 |
5.32 % |
13/02/2013 |
Peter S. Park |
United States of America |
1016378 |
0 |
1016378 |
0 |
1016378 |
5.1 % |
26/12/2012 |
Park West Asset Management LLC |
Delaware |
1016378 |
0 |
1016378 |
0 |
1016378 |
5.1 % |
26/12/2012 |
THE VANGUARD GROUP, INC. |
Pennsylvania |
26102 |
|
948946 |
26102 |
975048 |
4.96 % |
09/02/2012 |
Wellington Management Company, LLP |
Massachusetts |
0 |
1177542 |
0 |
1267025 |
1267025 |
6.44 % |
12/12/2011 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
725036 |
0 |
725036 |
725036 |
3.7 % |
23/11/2011 |
BVF Partners L.P. |
Delaware |
0 |
3476044 |
0 |
3476044 |
3476044 |
17.7 % |
23/11/2011 |
BVF Inc. |
Delaware |
0 |
3476044 |
0 |
3476044 |
3476044 |
17.7 % |
23/11/2011 |
Investment 10, L.L.C. |
Illinois |
0 |
238531 |
0 |
238531 |
238531 |
1.2 % |
23/11/2011 |
BVF Investments, L.L.C. |
Delaware |
0 |
2068326 |
0 |
2068326 |
2068326 |
10.5 % |
23/11/2011 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
444151 |
0 |
444151 |
444151 |
2.3 % |
23/11/2011 |
Mark N. Lampert |
United States |
0 |
3476044 |
0 |
3476044 |
3476044 |
17.7 % |
23/11/2011 |
BVF Inc. |
Delaware |
0 |
2110482 |
0 |
2110482 |
2110482 |
10.7 % |
29/06/2011 |
Mark N. Lampert |
United States |
0 |
2110482 |
0 |
2110482 |
2110482 |
10.7 % |
29/06/2011 |
BVF Partners L.P. |
Delaware |
0 |
2110482 |
0 |
2110482 |
2110482 |
10.7 % |
29/06/2011 |
Investment 10, L.L.C. |
Illinois |
0 |
137447 |
0 |
137447 |
137447 |
0 % |
29/06/2011 |
BVF Investments, L.L.C. |
Delaware |
0 |
1198636 |
0 |
1198636 |
1198636 |
6.1 % |
29/06/2011 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
311563 |
0 |
311563 |
311563 |
1.6 % |
29/06/2011 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
462836 |
0 |
462836 |
462836 |
2.4 % |
29/06/2011 |
Wellington Management Company, LLP |
Massachusetts |
0 |
2180136 |
0 |
2259498 |
2259498 |
11.52 % |
14/02/2011 |
THE VANGUARD GROUP, INC. |
Pennsylvania |
33402 |
|
1085192 |
33402 |
1118594 |
5.7 % |
10/02/2011 |