aTyr Pharma, Inc. LIFE
Trading inactive
| Déclarant | Citoyenneté ou lieu d'organisation | Pouvoir de vote unique | Pouvoir de vote partagé | Pouvoir de disposition unique | Pouvoir de disposition partagé | Montant en propriété effective | Pourcentage détenu | Date d'achat |
|---|---|---|---|---|---|---|---|---|
| Logos Global Management LP | Delaware | 0 | 1750000 | 0 | 1750000 | 1750000 | 2.1 % | 14/11/2024 |
| Logos Global Management GP LLC | Delaware | 0 | 1750000 | 0 | 1750000 | 1750000 | 2.1 % | 14/11/2024 |
| Logos GP LLC | Delaware | 0 | 1750000 | 0 | 1750000 | 1750000 | 2.1 % | 14/11/2024 |
| Logos Global Master Fund LP | Cayman Islands | 0 | 1750000 | 0 | 1750000 | 1750000 | 2.1 % | 14/11/2024 |
| Arsani William | United States | 0 | 1750000 | 0 | 1750000 | 1750000 | 2.1 % | 14/11/2024 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 5039846 | 0 | 5039846 | 5039846 | 6.2 % | 15/10/2024 |
| Point72 Asset Management, L.P. | Delaware | 0 | 5039846 | 0 | 5039846 | 5039846 | 6.2 % | 15/10/2024 |
| Steven A. Cohen | United States | 0 | 5039846 | 0 | 5039846 | 5039846 | 6.2 % | 15/10/2024 |
| Thomas R. Donahue | United States | 14666600 | 14666600 | 14666600 | 19.35 % | 07/10/2024 | ||
| J. Christopher Donahue | United States | 14666600 | 14666600 | 14666600 | 19.35 % | 07/10/2024 | ||
| Federated Hermes, Inc. | Pennsylvania | 14666600 | 14666600 | 14666600 | 19.35 % | 07/10/2024 | ||
| Voting Shares Irrevocable Trust | Pennsylvania | 14666600 | 14666600 | 14666600 | 19.35 % | 07/10/2024 | ||
| Ann C. Donahue | United States | 14666600 | 14666600 | 14666600 | 19.35 % | 07/10/2024 | ||
| Laurence W. Lytton | USA | 585013 | 0 | 585013 | 0 | 585013 | 1 % | 14/02/2024 |
| Laurence W. Lytton | USA | 585013 | 0 | 585013 | 0 | 585013 | 1 % | 14/02/2024 |
| Stonepine Capital Management, LLC | California | 0 | 482258 | 0 | 482258 | 482258 | 0.8 % | 13/02/2024 |
| Stonepine Capital, L.P. | Delaware | 0 | 482258 | 0 | 482258 | 482258 | 0.8 % | 13/02/2024 |
| FMR LLC | Delaware | 8784009 | 0 | 8784009 | 0 | 8784009 | 14.999 % | 09/02/2024 |
| Abigail P. Johnson | United States of America | 0 | 0 | 8784009 | 0 | 8784009 | 14.999 % | 09/02/2024 |
| Federated Hermes, Inc. | Pennsylvania | 10169600 | 10169600 | 10169600 | 17.37 % | 18/01/2024 | ||
| Thomas R. Donahue | United States | 10169600 | 10169600 | 10169600 | 17.37 % | 18/01/2024 | ||
| Ann C. Donahue | United States | 10169600 | 10169600 | 10169600 | 17.37 % | 18/01/2024 | ||
| J. Christopher Donahue | United States | 10169600 | 10169600 | 10169600 | 17.37 % | 18/01/2024 | ||
| Voting Shares Irrevocable Trust | Pennsylvania | 10169600 | 10169600 | 10169600 | 17.37 % | 18/01/2024 | ||
| Logos Global Management LP | Delaware | 0 | 5800000 | 0 | 5800000 | 5800000 | 9.9 % | 02/01/2024 |
| Logos GP LLC | Delaware | 0 | 5800000 | 0 | 5800000 | 5800000 | 9.9 % | 02/01/2024 |
| Logos Global Master Fund LP | Cayman Islands | 0 | 5800000 | 0 | 5800000 | 5800000 | 9.9 % | 02/01/2024 |
| Arsani William | United States | 0 | 5800000 | 0 | 5800000 | 5800000 | 9.9 % | 02/01/2024 |
| Logos Global Management GP LLC | Delaware | 0 | 5800000 | 0 | 5800000 | 5800000 | 9.9 % | 02/01/2024 |
| Logos Global Management GP LLC | Delaware | 0 | 5800000 | 0 | 5800000 | 5800000 | 9.9 % | 02/01/2024 |
| Logos Global Management LP | Delaware | 0 | 5800000 | 0 | 5800000 | 5800000 | 9.9 % | 02/01/2024 |
| Arsani William | United States | 0 | 5800000 | 0 | 5800000 | 5800000 | 9.9 % | 02/01/2024 |
| Logos Global Master Fund LP | Cayman Islands | 0 | 5800000 | 0 | 5800000 | 5800000 | 9.9 % | 02/01/2024 |
| Logos GP LLC | Delaware | 0 | 5800000 | 0 | 5800000 | 5800000 | 9.9 % | 02/01/2024 |
| Timothy P. Lynch | U.S.A. | 0 | 4743162 | 0 | 4743162 | 4743162 | 4.4 % | 28/04/2023 |
| Jon M. Plexico | U.S.A. | 0 | 4743162 | 0 | 4743162 | 4743162 | 4.4 % | 28/04/2023 |
| Stonepine Capital Management, LLC | California | 0 | 4743162 | 0 | 4743162 | 4743162 | 4.4 % | 28/04/2023 |
| Stonepine Capital, L.P. | Delaware | 0 | 4743162 | 0 | 4743162 | 4743162 | 4.4 % | 28/04/2023 |
| Stonepine Capital, L.P. | Delaware | 0 | 4743162 | 0 | 4743162 | 4743162 | 4.4 % | 28/04/2023 |
| Stonepine Capital Management, LLC | California | 0 | 4743162 | 0 | 4743162 | 4743162 | 4.4 % | 28/04/2023 |
| Timothy P. Lynch | U.S.A. | 0 | 4743162 | 0 | 4743162 | 4743162 | 4.4 % | 28/04/2023 |
| Jon M. Plexico | U.S.A. | 0 | 4743162 | 0 | 4743162 | 4743162 | 4.4 % | 28/04/2023 |
| Laurence W. Lytton | USA | 4435168 | 5020 | 4435168 | 5020 | 4440188 | 8.7 % | 22/02/2023 |
| Laurence W. Lytton | USA | 4435168 | 5020 | 4435168 | 5020 | 4440188 | 8.7 % | 22/02/2023 |
| Stonepine Capital Management, LLC | California | 0 | 4569433 | 0 | 4569433 | 4569433 | 8.9 % | 17/02/2023 |
| Stonepine Capital, L.P. | Delaware | 0 | 4569433 | 0 | 4569433 | 4569433 | 8.9 % | 17/02/2023 |
| Stonepine Capital Management, LLC | California | 0 | 4569433 | 0 | 4569433 | 4569433 | 8.9 % | 17/02/2023 |
| Stonepine Capital, L.P. | Delaware | 0 | 4569433 | 0 | 4569433 | 4569433 | 8.9 % | 17/02/2023 |
| J. Christopher Donahue | United States | 5231600 | 5231600 | 5231600 | 18.03 % | 01/02/2023 | ||
| Voting Shares Irrevocable Trust | Pennsylvania | 5231600 | 5231600 | 5231600 | 18.03 % | 01/02/2023 | ||
| Thomas R. Donahue | United States | 5231600 | 5231600 | 5231600 | 18.03 % | 01/02/2023 | ||
| Federated Hermes, Inc. | Pennsylvania | 5231600 | 5231600 | 5231600 | 18.03 % | 01/02/2023 | ||
| Ikarian Capital, LLC | Delaware | 0 | 35048 | 0 | 35048 | 35048 | 0.1 % | 14/02/2022 |
| Neil Shahrestani | United States | 0 | 35048 | 0 | 35048 | 35048 | 0.1 % | 14/02/2022 |
| Chart Westcott | United States | 0 | 35048 | 0 | 35048 | 35048 | 0.1 % | 14/02/2022 |
| VHCP Management II, LLC | Delaware | 0 | 15650002 | 0 | 15650002 | 15650002 | 5.6 % | 14/02/2022 |
| Koh, Bong | United States | 0 | 15650002 | 0 | 15650002 | 15650002 | 5.6 % | 14/02/2022 |
| Shah, Nimish | United States | 0 | 15650002 | 0 | 15650002 | 15650002 | 5.6 % | 14/02/2022 |
| VHCP Management EG, LLC | Delaware | 0 | 15650002 | 0 | 15650002 | 15650002 | 5.6 % | 14/02/2022 |
| VHCP Management III, LLC | Delaware | 0 | 15650002 | 0 | 15650002 | 15650002 | 5.6 % | 14/02/2022 |
| Venrock Healthcare Capital Partners EG, L.P. | Delaware | 0 | 15650002 | 0 | 15650002 | 15650002 | 5.6 % | 14/02/2022 |
| VHCP CoInvestment Holdings III, LLC | Delaware | 0 | 15650002 | 0 | 15650002 | 15650002 | 5.6 % | 14/02/2022 |
| Venrock Healthcare Capital Partners III, L.P. | Delaware | 0 | 15650002 | 0 | 15650002 | 15650002 | 5.6 % | 14/02/2022 |
| VHCP CoInvestment Holdings II, LLC | Delaware | 0 | 15650002 | 0 | 15650002 | 15650002 | 5.6 % | 14/02/2022 |
| Venrock Healthcare Capital Partners II, L.P. | Delaware | 0 | 15650002 | 0 | 15650002 | 15650002 | 5.6 % | 14/02/2022 |
| TANG CAPITAL MANAGEMENT, LLC | DELAWARE | 0 | 1113453 | 0 | 1113453 | 1113453 | 4 % | 14/02/2022 |
| KEVIN TANG | UNITED STATES | 0 | 1113453 | 0 | 1113453 | 1113453 | 4 % | 14/02/2022 |
| TANG CAPITAL PARTNERS, LP | DELAWARE | 0 | 1113453 | 0 | 1113453 | 1113453 | 4 % | 14/02/2022 |
| Alyeska Investment Group, L.P. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2022 |
| Alyeska Fund GP, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2022 |
| Anand Parekh | United States America | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2022 |
| Voting Shares Irrevocable Trust | 5222250 | 5222250 | 5222250 | 18.79 % | 14/02/2022 | |||
| Thomas R. Donahue | 5222250 | 5222250 | 5222250 | 18.79 % | 14/02/2022 | |||
| Rhodora J. Donahue | 5222250 | 5222250 | 5222250 | 18.79 % | 14/02/2022 | |||
| J. Christopher Donahue | 5222250 | 5222250 | 5222250 | 18.79 % | 14/02/2022 | |||
| (entities only Federated Hermes, Inc. | 5222250 | 5222250 | 5222250 | 18.79 % | 14/02/2022 | |||
| Thomas R. Donahue | 5222250 | 5222250 | 5222250 | 19.86 % | 08/10/2021 | |||
| (entities only Federated Hermes, Inc. | 5222250 | 5222250 | 5222250 | 19.86 % | 08/10/2021 | |||
| Rhodora J. Donahue | 5222250 | 5222250 | 5222250 | 19.86 % | 08/10/2021 | |||
| J. Christopher Donahue | 5222250 | 5222250 | 5222250 | 19.86 % | 08/10/2021 | |||
| Voting Shares Irrevocable Trust | 5222250 | 5222250 | 5222250 | 19.86 % | 08/10/2021 | |||
| VHCP Holdings II, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Venrock Healthcare Capital Partners II, L.P. | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| VHCP Holdings II, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Venrock Healthcare Capital Partners III, L.P. 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| VHCP Holdings III, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Venrock Healthcare Capital Partners EG, L.P. 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| VHCP Management II, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| VHCP Management III, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| VHCP Management EG, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Shah, Nimish 2. Check the Appropriate Box if a Member of a Group | United States | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Venrock Healthcare Capital Partners II, L.P. | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Venrock Healthcare Capital Partners III, L.P. 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| VHCP Holdings III, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Venrock Healthcare Capital Partners EG, L.P. 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| VHCP Management II, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| VHCP Management III, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| VHCP Management EG, LLC 2. Check the Appropriate Box if a Member of a Group | Delaware | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Shah, Nimish 2. Check the Appropriate Box if a Member of a Group | United States | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Koh, Bong 2. Check the Appropriate Box if a Member of a Group | United States | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Koh, Bong 2. Check the Appropriate Box if a Member of a Group | United States | 0 | 18150002 | 0 | 18150002 | 18150002 | 6.7 % | 27/09/2021 |
| Chart Westcott | United States | 0 | 888580 | 0 | 888580 | 888580 | 5.3 % | 17/09/2021 |
| Ikarian Healthcare Fund GP, L.P. | Delaware | 0 | 717106 | 0 | 717106 | 717106 | 4.2 % | 17/09/2021 |
| Ikarian Healthcare Master Fund, L.P. | Cayman Islands | 0 | 717106 | 0 | 717106 | 717106 | 4.2 % | 17/09/2021 |
| Ikarian Healthcare Fund GP, L.P. | Delaware | 0 | 717106 | 0 | 717106 | 717106 | 4.2 % | 17/09/2021 |
| Chart Westcott | United States | 0 | 888580 | 0 | 888580 | 888580 | 5.3 % | 17/09/2021 |
| Ikarian Capital, LLC | Delaware | 0 | 888580 | 0 | 888580 | 888580 | 5.3 % | 17/09/2021 |
| Neil Shahrestani | United States of America | 0 | 888580 | 0 | 888580 | 888580 | 5.3 % | 17/09/2021 |
| Ikarian Healthcare Master Fund, L.P. | Cayman Islands | 0 | 717106 | 0 | 717106 | 717106 | 4.2 % | 17/09/2021 |
| Ikarian Capital, LLC | Delaware | 0 | 888580 | 0 | 888580 | 888580 | 5.3 % | 17/09/2021 |
| Neil Shahrestani | United States of America | 0 | 888580 | 0 | 888580 | 888580 | 5.3 % | 17/09/2021 |
| TANG CAPITAL PARTNERS, LP | DELAWARE | 0 | 1063453 | 0 | 1063453 | 1063453 | 6.3 % | 17/09/2021 |
| KEVIN TANG | UNITED STATES | 0 | 1063453 | 0 | 1063453 | 1063453 | 6.3 % | 17/09/2021 |
| TANG CAPITAL MANAGEMENT, LLC | DELAWARE | 0 | 1063453 | 0 | 1063453 | 1063453 | 6.3 % | 17/09/2021 |
| KEVIN TANG | UNITED STATES | 0 | 1063453 | 0 | 1063453 | 1063453 | 6.3 % | 17/09/2021 |
| TANG CAPITAL MANAGEMENT, LLC | DELAWARE | 0 | 1063453 | 0 | 1063453 | 1063453 | 6.3 % | 17/09/2021 |
| TANG CAPITAL PARTNERS, LP | DELAWARE | 0 | 1063453 | 0 | 1063453 | 1063453 | 6.3 % | 17/09/2021 |
| Abigail P. Johnson | United States of America | 0 | 0 | 1675880 | 0 | 1675880 | 10.432 % | 12/07/2021 |
| FMR LLC | Delaware | 560207 | 0 | 1675880 | 0 | 1675880 | 10.432 % | 12/07/2021 |
| FMR LLC | Delaware | 560207 | 0 | 1675880 | 0 | 1675880 | 10.432 % | 12/07/2021 |
| Abigail P. Johnson | United States of America | 0 | 0 | 1675880 | 0 | 1675880 | 10.432 % | 12/07/2021 |
| FMR LLC | Delaware | 492027 | 0 | 1584684 | 0 | 1584684 | 9.897 % | 12/04/2021 |
| FMR LLC | Delaware | 492027 | 0 | 1584684 | 0 | 1584684 | 9.897 % | 12/04/2021 |
| Abigail P. Johnson | United States of America | 0 | 0 | 1584684 | 0 | 1584684 | 9.897 % | 12/04/2021 |
| Abigail P. Johnson | United States of America | 0 | 0 | 1584684 | 0 | 1584684 | 9.897 % | 12/04/2021 |
| Voting Shares Irrevocable Trust | 1615000 | 1615000 | 1615000 | 10.09 % | 09/04/2021 | |||
| Thomas R. Donahue | 1615000 | 1615000 | 1615000 | 10.09 % | 09/04/2021 | |||
| (entities only Federated Hermes, Inc. | 1615000 | 1615000 | 1615000 | 10.09 % | 09/04/2021 | |||
| J. Christopher Donahue | 1615000 | 1615000 | 1615000 | 10.09 % | 09/04/2021 | |||
| Rhodora J. Donahue | 1615000 | 1615000 | 1615000 | 10.09 % | 09/04/2021 | |||
| Erik J. Brown | United States | 0 | 1312537 | 0 | 1312537 | 1312537 | 9.15 % | 17/02/2021 |
| Christos Komissopoulos | United States | 0 | 1312537 | 0 | 1312537 | 1312537 | 9.15 % | 17/02/2021 |
| William F. Blank, III | United States | 0 | 1312537 | 0 | 1312537 | 1312537 | 9.15 % | 17/02/2021 |
| Aspire Capital Fund, LLC | Illinois | 0 | 1312537 | 0 | 1312537 | 1312537 | 9.15 % | 17/02/2021 |
| SGM Holdings Corp. | Illinois | 0 | 1312537 | 0 | 1312537 | 1312537 | 9.15 % | 17/02/2021 |
| Aspire Capital Partners, LLC | Illinois | 0 | 1312537 | 0 | 1312537 | 1312537 | 9.15 % | 17/02/2021 |
| Red Cedar Capital Corp. | Illinois | 0 | 1312537 | 0 | 1312537 | 1312537 | 9.15 % | 17/02/2021 |
| Chrisko Investors, Inc. | Illinois | 0 | 1312537 | 0 | 1312537 | 1312537 | 9.15 % | 17/02/2021 |
| WML Ventures Corp. | Illinois | 0 | 1312537 | 0 | 1312537 | 1312537 | 9.15 % | 17/02/2021 |
| Steven G. Martin | United States | 0 | 1312537 | 0 | 1312537 | 1312537 | 9.15 % | 17/02/2021 |
| Alyeska Investment Group, L.P. | Delaware | 0 | 842554 | 0 | 842554 | 0 | 8.3 % | 16/02/2021 |
| Alyeska Fund GP, LLC | Delaware | 0 | 842554 | 0 | 842554 | 0 | 8.3 % | 16/02/2021 |
| Alyeska Investment Group, L.P. | Delaware | 0 | 842554 | 0 | 842554 | 0 | 8.3 % | 16/02/2021 |
| Anand Parekh | United States of America | 0 | 842554 | 0 | 842554 | 0 | 8.3 % | 16/02/2021 |
| Alyeska Fund GP, LLC | Delaware | 0 | 842554 | 0 | 842554 | 0 | 8.3 % | 16/02/2021 |
| Anand Parekh | United States of America | 0 | 842554 | 0 | 842554 | 0 | 8.3 % | 16/02/2021 |
| I.R.S. Identification Nos. of above persons (entities only) | 1615000 | 1615000 | 1615000 | 15.86 % | 12/02/2021 | |||
| I.R.S. Identification Nos. of above persons (entities only | 1615000 | 1615000 | 1615000 | 15.86 % | 12/02/2021 | |||
| I.R.S. Identification Nos. of above persons (entities only). | 1615000 | 1615000 | 1615000 | 15.86 % | 12/02/2021 | |||
| RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION | Delaware | 268718 | 0 | 319130 | 0 | 319130 | 3.13 % | 10/02/2021 |
| Renaissance Technologies LLC | Delaware | 268718 | 0 | 319130 | 0 | 319130 | 3.13 % | 10/02/2021 |
| RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION | Delaware | 268718 | 0 | 319130 | 0 | 319130 | 3.13 % | 10/02/2021 |
| Renaissance Technologies LLC | Delaware | 268718 | 0 | 319130 | 0 | 319130 | 3.13 % | 10/02/2021 |
| (Voluntary) DP VIII Associates, L.P. | 664 | 0 | 664 | 0 | 664 | 0.1 % | 21/01/2021 | |
| (Voluntary) Domain Associates, LLC | 450 | 0 | 450 | 0 | 450 | 0.1 % | 21/01/2021 | |
| (Voluntary) Domain Partners VIII, L.P. | 89425 | 0 | 89425 | 0 | 89425 | 0.9 % | 21/01/2021 | |
| EIN | Delaware, United States of America | 475000 | 0 | 475000 | 475000 | 5.8 % | 18/02/2020 | |
| EIN | Delaware, United States of America | 475000 | 0 | 475000 | 475000 | 5.8 % | 18/02/2020 | |
| RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION | Delaware | 199920 | 0 | 199920 | 0 | 199920 | 5.14 % | 12/02/2020 |
| Renaissance Technologies LLC | Delaware | 199920 | 0 | 199920 | 0 | 199920 | 5.14 % | 12/02/2020 |
| Renaissance Technologies LLC | Delaware | 199920 | 0 | 199920 | 0 | 199920 | 5.14 % | 12/02/2020 |
| RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION | Delaware | 199920 | 0 | 199920 | 0 | 199920 | 5.14 % | 12/02/2020 |
| Select Biotechnology Portfolio | Massachusetts | 262046 | 0 | 0 | 0 | 262046 | 6.736 % | 07/02/2020 |
| Abigail P. Johnson | United States of America | 0 | 0 | 491449 | 0 | 491449 | 12.633 % | 07/02/2020 |
| FMR LLC | Delaware | 50786 | 0 | 491449 | 0 | 491449 | 12.633 % | 07/02/2020 |
| Select Biotechnology Portfolio | Massachusetts | 262046 | 0 | 0 | 0 | 262046 | 6.736 % | 07/02/2020 |
| Abigail P. Johnson | United States of America | 0 | 0 | 491449 | 0 | 491449 | 12.633 % | 07/02/2020 |
| FMR LLC | Delaware | 50786 | 0 | 491449 | 0 | 491449 | 12.633 % | 07/02/2020 |
| Alta Partners Management VIII, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/01/2020 |
| Guy Nohra | U.S.A. | 0 | 0 | 0 | 0 | 0 | 0 % | 14/01/2020 |
| Daniel Janney | U.S.A. | 0 | 0 | 0 | 0 | 0 | 0 % | 14/01/2020 |
| Farah Champsi | U.S.A. | 0 | 0 | 0 | 0 | 0 | 0 % | 14/01/2020 |
| Alta Partners VIII, L.P. (a) | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/01/2020 |
| Abigail P. Johnson | United States of America | 0 | 0 | 6880252 | 0 | 6880252 | 14.999 % | 10/07/2019 |
| FMR LLC | Delaware | 674627 | 0 | 6880252 | 0 | 6880252 | 14.999 % | 10/07/2019 |
| Select Biotechnology Portfolio | Massachusetts | 3668640 | 0 | 0 | 0 | 3668640 | 7.998 % | 10/07/2019 |
| FMR LLC | Delaware | 657401 | 0 | 4181938 | 0 | 4181938 | 9.117 % | 10/06/2019 |
| Abigail P. Johnson | United States of America | 0 | 0 | 4181938 | 0 | 4181938 | 9.117 % | 10/06/2019 |
| Redmile Group, LLC | Delaware | 0 | 707547 | 0 | 707547 | 707547 | 2.3 % | 14/02/2019 |
| Jeremy C. Green | United Kingdom | 0 | 707547 | 0 | 707547 | 707547 | 2.3 % | 14/02/2019 |
| FMR LLC | Delaware | 635749 | 0 | 4328450 | 0 | 4328450 | 14.416 % | 13/02/2019 |
| Fidelity Growth Company Fund | Massachusetts | 2176927 | 0 | 0 | 0 | 2176927 | 7.25 % | 13/02/2019 |
| Abigail P. Johnson | United States of America | 0 | 0 | 4328450 | 0 | 4328450 | 14.416 % | 13/02/2019 |
| Alta Partners VIII, L.P. | Delaware | 1590920 | 0 | 1590920 | 0 | 1590920 | 5.3 % | 12/02/2019 |
| Alta Partners Management VIII, LLC | Delaware | 0 | 1590920 | 0 | 1590920 | 1590920 | 5.3 % | 12/02/2019 |
| Farah Champsi | USA | 0 | 1590920 | 0 | 1590920 | 1590920 | 5.3 % | 12/02/2019 |
| Guy Nohra | USA | 0 | 1590920 | 0 | 1590920 | 1590920 | 5.3 % | 12/02/2019 |
| Daniel Janney | USA | 0 | 1590920 | 0 | 1590920 | 1590920 | 5.3 % | 12/02/2019 |
| Viking Global Investors LP | Delaware | 0 | 3006300 | 0 | 3006300 | 3006300 | 9.5 % | 10/01/2019 |
| Viking Global Opportunities GP LLC | Delaware | 0 | 3006300 | 0 | 3006300 | 3006300 | 9.5 % | 10/01/2019 |
| Viking Global Opportunities Illiquid Investments LP | Cayman Islands | 0 | 3006300 | 0 | 3006300 | 3006300 | 9.5 % | 10/01/2019 |
| Viking Global Opportunities Portfolio GP LLC | Delaware | 0 | 3006300 | 0 | 3006300 | 3006300 | 9.5 % | 10/01/2019 |
| Rose S. Shabet | United States | 0 | 3006300 | 0 | 3006300 | 3006300 | 9.5 % | 10/01/2019 |
| David C. Ott | United States | 0 | 3006300 | 0 | 3006300 | 3006300 | 9.5 % | 10/01/2019 |
| O. Andreas Halvorsen | Norway | 0 | 3006300 | 0 | 3006300 | 3006300 | 9.5 % | 10/01/2019 |
| Oleg Nodelman | United States | 0 | 707547 | 0 | 707547 | 707547 | 2.3 % | 22/05/2018 |
| EcoR1 Capital Fund Qualified, L.P. | Delaware | 0 | 579572 | 0 | 579572 | 579572 | 1.9 % | 22/05/2018 |
| EcoR1 Capital, LLC | Delaware | 0 | 707547 | 0 | 707547 | 707547 | 2.3 % | 22/05/2018 |
| Redmile Group, LLC | DELAWARE | 0 | 2594339 | 0 | 2594339 | 2594339 | 8.52 % | 08/03/2018 |
| JEREMY C. GREEN | UNITED KINGDOM | 0 | 2594339 | 0 | 2594339 | 2594339 | 8.52 % | 08/03/2018 |
| Oleg Nodelman | United States | 0 | 0 | 0 | 0 | 9 | 15.2 % | 14/02/2018 |
| EcoR1 Capital Fund Qualified, L.P. | Delaware | 0 | 0 | 0 | 0 | 9 | 12.5 % | 14/02/2018 |
| EcoR1 Capital, LLC | Delaware | 0 | 0 | 0 | 0 | 9 | 15.2 % | 14/02/2018 |
| Fidelity Growth Company Fund | Massachusetts | 2242318 | 0 | 0 | 0 | 2242318 | 7.535 % | 13/02/2018 |
| FMR LLC | Delaware | 560702 | 0 | 4463752 | 0 | 4463752 | 14.999 % | 13/02/2018 |
| Abigail P. Johnson | United States of America | 0 | 0 | 4463752 | 0 | 4463752 | 14.999 % | 13/02/2018 |
| Alta Partners Management VIII, LLC | Delaware | 0 | 1777875 | 0 | 1777875 | 1777875 | 6 % | 06/02/2018 |
| Farah Champsi | U.S.A. | 0 | 1777875 | 0 | 1777875 | 1777875 | 6 % | 06/02/2018 |
| Guy Nohra | U.S.A. | 0 | 1777875 | 0 | 1777875 | 1777875 | 6 % | 06/02/2018 |
| Alta Partners VIII, L.P. | Delaware | 1777875 | 0 | 1777875 | 0 | 1777875 | 6 % | 06/02/2018 |
| Daniel Janney | U.S.A. | 0 | 1777875 | 0 | 1777875 | 1777875 | 6 % | 06/02/2018 |
| Viking Global Opportunities GP LLC _____________________________________________________________________________ | Delaware | 2932229 | 0 | 2932229 | 2932229 | 9.5 % | 08/09/2017 | |
| Viking Global Investors LP _____________________________________________________________________________ | Delaware | 2932229 | 0 | 2932229 | 2932229 | 9.5 % | 08/09/2017 | |
| Rose S. Shabet _____________________________________________________________________________ | United States | 2932229 | 0 | 2932229 | 2932229 | 9.5 % | 08/09/2017 | |
| David C. Ott _____________________________________________________________________________ | United States | 2932229 | 0 | 2932229 | 2932229 | 9.5 % | 08/09/2017 | |
| O. Andreas Halvorsen _____________________________________________________________________________ | Norway | 2932229 | 0 | 2932229 | 2932229 | 9.5 % | 08/09/2017 | |
| Viking Global Opportunities Illiquid Investments LP _____________________________________________________________________________ | Cayman Islands | 2932229 | 0 | 2932229 | 2932229 | 9.5 % | 08/09/2017 | |
| Viking Global Opportunities Portfolio GP LLC _____________________________________________________________________________ | Delaware | 2932229 | 0 | 2932229 | 2932229 | 9.5 % | 08/09/2017 | |
| EcoR1 Capital Fund Qualified, L.P. | Delaware | 0 | 3767786 | 0 | 3767786 | 3767786 | 12.5 % | 07/09/2017 |
| EcoR1 Capital, LLC | Delaware | 0 | 4642396 | 0 | 4642396 | 4642396 | 15.3 % | 07/09/2017 |
| Oleg Nodelman | United States | 0 | 4642396 | 0 | 4642396 | 4642396 | 15.3 % | 07/09/2017 |
| Oleg Nodelman | United States | 0 | 1961335 | 0 | 1961335 | 1961335 | 8.3 % | 30/01/2017 |
| EcoR1 Capital, LLC | Delaware | 0 | 1961335 | 0 | 1961335 | 1961335 | 8.3 % | 30/01/2017 |
| EcoR1 Capital Fund Qualified, L.P. | Delaware | 0 | 1475934 | 0 | 1475934 | 1475934 | 6.2 % | 30/01/2017 |
| Victory Capital Management Inc. as successor to RS Investment Management Co. LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 02/11/2016 |
| Farah Champsi | U.S.A. | 0 | 1778064 | 0 | 1778064 | 1778064 | 7.5 % | 12/02/2016 |
| Alta Partners Management VIII, LLC | Delaware | 0 | 1778064 | 0 | 1778064 | 1778064 | 7.5 % | 12/02/2016 |
| Daniel Janney | U.S.A. | 0 | 1778064 | 0 | 1778064 | 1778064 | 7.5 % | 12/02/2016 |
| Guy Nohra | U.S.A. | 0 | 1778064 | 0 | 1778064 | 1778064 | 7.5 % | 12/02/2016 |
| Alta Partners VIII, L.P. | Delaware | 1778064 | 0 | 1778064 | 0 | 1778064 | 7.5 % | 12/02/2016 |
| Brandon H. Hull | United States Citizen | 0 | 1758158 | 0 | 1758158 | 1758158 | 7.4 % | 04/02/2016 |
| John J. Park | United States Citizen | 0 | 1758158 | 0 | 1758158 | 1758158 | 7.4 % | 04/02/2016 |
| CHP II, L.P. | Delaware | 0 | 1758158 | 0 | 1758158 | 1758158 | 7.4 % | 04/02/2016 |
| CHP II Management LLC | Delaware | 0 | 1758158 | 0 | 1758158 | 1758158 | 7.4 % | 04/02/2016 |
| John K. Clarke | United States Citizen | 104878 | 1758158 | 104878 | 1758158 | 1863036 | 7.9 % | 04/02/2016 |
| (Voluntary) DP VIII Associates, L.P. | Delaware | 13414 | 0 | 13414 | 0 | 13414 | 0.1 % | 19/01/2016 |
| (Voluntary) Domain Partners VIII, L.P. | Delaware | 1807820 | 0 | 1807820 | 0 | 1807820 | 7.6 % | 19/01/2016 |
| (Voluntary) Domain Associates, LLC | Delaware | 6286 | 0 | 6286 | 0 | 6286 | 0.1 % | 19/01/2016 |
| Deerfield Special Situations Fund, L.P. | Delaware | 0 | 255764 | 0 | 255764 | 255764 | 1.1 % | 13/05/2015 |
| Deerfield Mgmt III, L.P. | Delaware | 0 | 255764 | 0 | 255764 | 255764 | 1.1 % | 13/05/2015 |
| James E. Flynn | United States | 0 | 511528 | 0 | 511528 | 511528 | 2.19 % | 13/05/2015 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 255764 | 0 | 255764 | 255764 | 1.1 % | 13/05/2015 |
| Deerfield Management Company, L.P. | Delaware | 0 | 511528 | 0 | 511528 | 511528 | 2.19 % | 13/05/2015 |
| Deerfield Private Design Fund III, L.P. | Delaware | 0 | 255764 | 0 | 255764 | 255764 | 1.1 % | 13/05/2015 |