La Jolla Pharmaceutical Company LJPC
Trading inactive
| Déclarant | Citoyenneté ou lieu d'organisation | Pouvoir de vote unique | Pouvoir de vote partagé | Pouvoir de disposition unique | Pouvoir de disposition partagé | Montant en propriété effective | Pourcentage détenu | Date d'achat |
|---|---|---|---|---|---|---|---|---|
| Roderick Wong | United States | 0 | 2590932 | 0 | 2590932 | 2590932 | 9.3 % | 14/02/2022 |
| RTW Investments, LP | Delaware | 0 | 2590932 | 0 | 2590932 | 2590932 | 9.3 % | 14/02/2022 |
| BlackRock, Inc. | Delaware | 384479 | 0 | 384695 | 0 | 384695 | 1.4 % | 12/07/2021 |
| BlackRock, Inc. | Delaware | 1458800 | 0 | 1477499 | 0 | 1477499 | 5.4 % | 29/01/2021 |
| Broadfin Capital, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 04/01/2021 |
| Kevin Kotler | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 04/01/2021 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 04/01/2021 |
| Broadfin Capital, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 04/01/2021 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 04/01/2021 |
| Kevin Kotler | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 04/01/2021 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Joseph Edelman | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Perceptive Advisors LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Kevin Kotler | United States of America | 0 | 2688068 | 0 | 2688068 | 2688068 | 9.9 % | 13/02/2020 |
| Kevin Kotler | United States of America | 0 | 2688068 | 0 | 2688068 | 2688068 | 9.9 % | 13/02/2020 |
| Broadfin Capital, LLC | Delaware | 0 | 2688068 | 0 | 2688068 | 2688068 | 9.9 % | 13/02/2020 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 2688068 | 0 | 2688068 | 2688068 | 9.9 % | 13/02/2020 |
| Broadfin Capital, LLC | Delaware | 0 | 2688068 | 0 | 2688068 | 2688068 | 9.9 % | 13/02/2020 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 2688068 | 0 | 2688068 | 2688068 | 9.9 % | 13/02/2020 |
| Jérôme G. Pfund | Swiss | 0 | 0 % | 13/02/2020 | ||||
| Michael L. Sjöström | Swiss | 0 | 0 % | 13/02/2020 | ||||
| Michael L. Sjöström | Swiss | 0 | 0 % | 13/02/2020 | ||||
| Jérôme G. Pfund | Swiss | 0 | 0 % | 13/02/2020 | ||||
| Sectoral Asset Management Inc. | Canada | 0 | 0 % | 13/02/2020 | ||||
| Sectoral Asset Management Inc. | Canada | 0 | 0 % | 13/02/2020 | ||||
| FMR LLC | Delaware | 0 | 0 | 1255018 | 0 | 1255018 | 4.621 % | 07/02/2020 |
| FMR LLC | Delaware | 0 | 0 | 1255018 | 0 | 1255018 | 4.621 % | 07/02/2020 |
| Abigail P. Johnson | United States of America | 0 | 0 | 1255018 | 0 | 1255018 | 4.621 % | 07/02/2020 |
| Abigail P. Johnson | United States of America | 0 | 0 | 1255018 | 0 | 1255018 | 4.621 % | 07/02/2020 |
| Jennison Associates LLC S.S. or | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 07/02/2020 |
| BlackRock, Inc. | Delaware | 1549190 | 0 | 1574336 | 0 | 1574336 | 5.8 % | 05/02/2020 |
| FMR LLC | Delaware | 0 | 0 | 1864851 | 0 | 1864851 | 6.866 % | 10/12/2019 |
| Abigail P. Johnson | United States of America | 0 | 0 | 1864851 | 0 | 1864851 | 6.866 % | 10/12/2019 |
| FMR LLC | Delaware | 0 | 0 | 1864851 | 0 | 1864851 | 6.866 % | 10/12/2019 |
| Abigail P. Johnson | United States of America | 0 | 0 | 1864851 | 0 | 1864851 | 6.866 % | 10/12/2019 |
| Roderick Wong | United States of America | 0 | 2274369 | 0 | 2274369 | 2274369 | 8.39 % | 14/06/2019 |
| RTW Master Fund, Ltd. | Cayman Islands | 0 | 1742166 | 0 | 1742166 | 1742166 | 6.43 % | 14/06/2019 |
| Roderick Wong | United States of America | 0 | 2274369 | 0 | 2274369 | 2274369 | 8.39 % | 14/06/2019 |
| RTW Master Fund, Ltd. | Cayman Islands | 0 | 1742166 | 0 | 1742166 | 1742166 | 6.43 % | 14/06/2019 |
| RTW Investments, LP | Delaware | 0 | 2274369 | 0 | 2274369 | 2274369 | 8.39 % | 14/06/2019 |
| RTW Investments, LP | Delaware | 0 | 2274369 | 0 | 2274369 | 2274369 | 8.39 % | 14/06/2019 |
| Scopia Capital Management LP | Delaware | 0 | 480000 | 0 | 480000 | 480000 | 1.8 % | 10/04/2019 |
| Matthew Sirovich | United States | 0 | 480000 | 0 | 480000 | 480000 | 1.8 % | 10/04/2019 |
| Scopia Management, Inc. | New York | 0 | 480000 | 0 | 480000 | 480000 | 1.8 % | 10/04/2019 |
| Jeremy Mindich | United States | 0 | 480000 | 0 | 480000 | 480000 | 1.8 % | 10/04/2019 |
| Scopia Capital Management LP | Delaware | 0 | 480000 | 0 | 480000 | 480000 | 1.8 % | 10/04/2019 |
| Jeremy Mindich | United States | 0 | 480000 | 0 | 480000 | 480000 | 1.8 % | 10/04/2019 |
| Matthew Sirovich | United States | 0 | 480000 | 0 | 480000 | 480000 | 1.8 % | 10/04/2019 |
| Scopia Management, Inc. | New York | 0 | 480000 | 0 | 480000 | 480000 | 1.8 % | 10/04/2019 |
| Jeremy Mindich | United States | 0 | 2387336 | 0 | 2387336 | 2387336 | 9.1 % | 14/02/2019 |
| Scopia Capital Management LP | Delaware | 0 | 2387336 | 0 | 2387336 | 2387336 | 9.1 % | 14/02/2019 |
| Scopia Management, Inc. | New York | 0 | 2387336 | 0 | 2387336 | 2387336 | 9.1 % | 14/02/2019 |
| Matthew Sirovich | United States | 0 | 2387336 | 0 | 2387336 | 2387336 | 9.1 % | 14/02/2019 |
| Michael L. Sjöström | Swiss | 1759171 | 6.7 % | 13/02/2019 | ||||
| Jérôme G. Pfund | Swiss | 1759171 | 6.7 % | 13/02/2019 | ||||
| Sectoral Asset Management Inc. | Canada | 1759171 | 6.7 % | 13/02/2019 | ||||
| Jérôme G. Pfund | Swiss | 1759171 | 6.7 % | 13/02/2019 | ||||
| Michael L. Sjöström | Swiss | 1759171 | 6.7 % | 13/02/2019 | ||||
| Sectoral Asset Management Inc. | Canada | 1759171 | 6.7 % | 13/02/2019 | ||||
| BlackRock, Inc. | Delaware | 1460293 | 0 | 1498561 | 0 | 1498561 | 5.7 % | 07/02/2019 |
| Jennison Associates LLC S.S. or | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 07/02/2019 |
| Jennison Associates LLC S.S. or I.R.S. Identification No. of Above Person: IRS Identification (formerly | Delaware | 3268744 | 0 | 0 | 3268744 | 3268744 | 12.5 % | 01/02/2019 |
| Perceptive Advisors LLC | Delaware | 0 | 2253376 | 0 | 2253376 | 2253376 | 8.6 % | 11/01/2019 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 2253376 | 0 | 2253376 | 2253376 | 8.6 % | 11/01/2019 |
| Joseph Edelman | United States of America | 0 | 2253376 | 0 | 2253376 | 2253376 | 8.6 % | 11/01/2019 |
| BlackRock, Inc. | Delaware | 1140264 | 0 | 1165133 | 0 | 1165133 | 4.6 % | 06/04/2018 |
| Consonance Capital Opportunity Fund Management LP | Delaware USA | 0 | 44626 | 0 | 44626 | 44626 | 0.2 % | 14/02/2018 |
| Consonance Capital Management LP | Delaware, USA | 0 | 2034685 | 0 | 2034685 | 2034685 | 9.19 % | 14/02/2018 |
| Mitchell Blutt | USA | 0 | 2079311 | 0 | 2079311 | 2079311 | 9.39 % | 14/02/2018 |
| Consonance Capman GP LLC | Delaware, USA | 0 | 2079311 | 0 | 2079311 | 2079311 | 9.39 % | 14/02/2018 |
| FMR LLC | Delaware | 18100 | 0 | 3321786 | 0 | 3321786 | 14.999 % | 13/02/2018 |
| FMR LLC | Delaware | 18100 | 0 | 3321786 | 0 | 3321786 | 14.999 % | 13/02/2018 |
| Select Biotechnology Portfolio | Massachusetts | 1189798 | 0 | 0 | 0 | 1189798 | 5.372 % | 13/02/2018 |
| Select Biotechnology Portfolio | Massachusetts | 1189798 | 0 | 0 | 0 | 1189798 | 5.372 % | 13/02/2018 |
| Abigail P. Johnson | United States of America | 0 | 0 | 3321786 | 0 | 3321786 | 14.999 % | 13/02/2018 |
| Abigail P. Johnson | United States of America | 0 | 0 | 3321786 | 0 | 3321786 | 14.999 % | 13/02/2018 |
| Rupert H. Johnson, Jr. | USA | 4 | 4 | 4 | 4 | 0 | 0 % | 07/02/2018 |
| Franklin Resources, Inc. | Delaware | 4 | 4 | 4 | 4 | 0 | 0 % | 07/02/2018 |
| Charles B. Johnson | USA | 4 | 4 | 4 | 4 | 0 | 0 % | 07/02/2018 |
| Janus Capital Management LLC EIN #753019302 | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 06/02/2018 |
| Janus Capital Management LLC EIN #753019302 | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 06/02/2018 |
| Jennison Associates LLC S.S. or | Delaware | 2220482 | 0 | 0 | 2220482 | 2220482 | 10 % | 05/02/2018 |
| BlackRock, Inc. | Delaware | 1152390 | 0 | 1177575 | 0 | 1177575 | 5.3 % | 01/02/2018 |
| Kevin Kotler | United States of America | 0 | 1029866 | 0 | 1029866 | 1029866 | 4.65 % | 11/01/2018 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1029866 | 0 | 1029866 | 1029866 | 4.65 % | 11/01/2018 |
| Broadfin Capital, LLC | Delaware | 0 | 1029866 | 0 | 1029866 | 1029866 | 4.65 % | 11/01/2018 |
| Broadfin Capital, LLC | Delaware | 0 | 1029866 | 0 | 1029866 | 1029866 | 4.65 % | 11/01/2018 |
| Kevin Kotler | United States of America | 0 | 1029866 | 0 | 1029866 | 1029866 | 4.65 % | 11/01/2018 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1029866 | 0 | 1029866 | 1029866 | 4.65 % | 11/01/2018 |
| Broadfin Capital, LLC | Delaware | 0 | 1108239 | 0 | 1108239 | 1108239 | 5 % | 11/01/2018 |
| Broadfin Capital, LLC | Delaware | 0 | 1108239 | 0 | 1108239 | 1108239 | 5 % | 11/01/2018 |
| Kevin Kotler | United States of America | 0 | 1108239 | 0 | 1108239 | 1108239 | 5 % | 11/01/2018 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1108239 | 0 | 1108239 | 1108239 | 5 % | 11/01/2018 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1108239 | 0 | 1108239 | 1108239 | 5 % | 11/01/2018 |
| Kevin Kotler | United States of America | 0 | 1108239 | 0 | 1108239 | 1108239 | 5 % | 11/01/2018 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 3388611 | 0 | 3388611 | 3388611 | 15.3 % | 18/12/2017 |
| Perceptive Advisors LLC | Delaware | 0 | 3388611 | 0 | 3388611 | 3388611 | 15.3 % | 18/12/2017 |
| Joseph Edelman | United States of America | 0 | 3388611 | 0 | 3388611 | 3388611 | 15.3 % | 18/12/2017 |
| RTW Master Fund, Ltd. | Cayman Islands | 0 | 1320890 | 0 | 1320890 | 1320890 | 7.2 % | 15/02/2017 |
| Roderick Wong | United States of America | 0 | 1320890 | 0 | 1320890 | 1320890 | 7.2 % | 15/02/2017 |
| RTW Master Fund, Ltd. | Cayman Islands | 0 | 1320890 | 0 | 1320890 | 1320890 | 7.2 % | 15/02/2017 |
| RTW Investments, LP | Delaware | 0 | 1349066 | 0 | 1349066 | 1349066 | 7.4 % | 15/02/2017 |
| RTW Investments, LP | Delaware | 0 | 1349066 | 0 | 1349066 | 1349066 | 7.4 % | 15/02/2017 |
| Roderick Wong | United States of America | 0 | 1320890 | 0 | 1320890 | 1320890 | 7.2 % | 15/02/2017 |
| Visium Asset Management, LP | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Visium Asset Management, LP | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| JG Asset, LLC | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Jacob Gottlieb | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Jacob Gottlieb | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| JG Asset, LLC | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Perceptive Advisors LLC | Delaware, United States of America | 0 | 1319274 | 0 | 1319274 | 1319274 | 7.22 % | 14/02/2017 |
| Joseph Edelman | United States of America | 0 | 1319274 | 0 | 1319274 | 1319274 | 7.22 % | 14/02/2017 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 1250012 | 0 | 1250012 | 1250012 | 6.84 % | 14/02/2017 |
| Kevin Kotler | United States America | 0 | 1510316 | 0 | 1510316 | 1510316 | 8.27 % | 10/02/2017 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1510316 | 0 | 1510316 | 1510316 | 8.27 % | 10/02/2017 |
| Broadfin Capital, LLC | Delaware | 0 | 1510316 | 0 | 1510316 | 1510316 | 8.27 % | 10/02/2017 |
| Baker Bros. Advisors | Delaware | 795191 | 0 | 795191 | 0 | 795191 | 4.2 % | 16/02/2016 |
| Baker Bros. Advisors LP | Delaware | 795191 | 0 | 795191 | 0 | 795191 | 4.2 % | 16/02/2016 |
| Felix J. Baker | United States | 795191 | 0 | 795191 | 0 | 795191 | 4.2 % | 16/02/2016 |
| Julian C. Baker | United States | 795191 | 0 | 795191 | 0 | 795191 | 4.2 % | 16/02/2016 |
| Felix J. Baker | United States | 795191 | 0 | 795191 | 0 | 795191 | 4.2 % | 16/02/2016 |
| Julian C. Baker | United States | 795191 | 0 | 795191 | 0 | 795191 | 4.2 % | 16/02/2016 |
| Baker Bros. Advisors | Delaware | 795191 | 0 | 795191 | 0 | 795191 | 4.2 % | 16/02/2016 |
| Baker Bros. Advisors LP | Delaware | 795191 | 0 | 795191 | 0 | 795191 | 4.2 % | 16/02/2016 |
| Broadfin Capital, LLC | Delaware | 0 | 1165373 | 0 | 1165373 | 1165373 | 6.4 % | 12/02/2016 |
| Kevin Kotler | United States of America | 0 | 1165373 | 0 | 1165373 | 1165373 | 6.4 % | 12/02/2016 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1165373 | 0 | 1165373 | 1165373 | 6.4 % | 12/02/2016 |
| JG Asset, LLC | United States | 0 | 1182013 | 0 | 1182013 | 1182013 | 6.5 % | 08/02/2016 |
| Visium Asset Management, LP | United States | 0 | 1182013 | 0 | 1182013 | 1182013 | 6.5 % | 08/02/2016 |
| Jacob Gottlieb | United States | 0 | 1182013 | 0 | 1182013 | 1182013 | 6.5 % | 08/02/2016 |
| Visium Balanced Master Fund, Ltd. | Cayman Islands | 0 | 1182013 | 0 | 1182013 | 1182013 | 6.5 % | 08/02/2016 |
| Baker Bros. Advisors LP | Delaware | 1220423 | 0 | 1220423 | 0 | 1220423 | 7.6 % | 17/02/2015 |
| Baker Bros. Advisors LP | Delaware | 1220423 | 0 | 1220423 | 0 | 1220423 | 7.6 % | 17/02/2015 |
| Baker Bros. Advisors | Delaware | 1220423 | 0 | 1220423 | 0 | 1220423 | 7.6 % | 17/02/2015 |
| Felix J. Baker | United States | 1220423 | 0 | 1220423 | 0 | 1220423 | 7.6 % | 17/02/2015 |
| Julian C. Baker | United States | 1220423 | 0 | 1220423 | 0 | 1220423 | 7.6 % | 17/02/2015 |
| Julian C. Baker | United States | 1220423 | 0 | 1220423 | 0 | 1220423 | 7.6 % | 17/02/2015 |
| Felix J. Baker | United States | 1220423 | 0 | 1220423 | 0 | 1220423 | 7.6 % | 17/02/2015 |
| Baker Bros. Advisors | Delaware | 1220423 | 0 | 1220423 | 0 | 1220423 | 7.6 % | 17/02/2015 |
| Broadfin Capital, LLC | Delaware | 0 | 1121370 | 0 | 1121370 | 1121370 | 7.4 % | 17/02/2015 |
| Kevin Kotler | United States of America | 0 | 1121370 | 0 | 1121370 | 1121370 | 7.4 % | 17/02/2015 |
| Kevin Kotler | United States of America | 0 | 1121370 | 0 | 1121370 | 1121370 | 7.4 % | 17/02/2015 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1121370 | 0 | 1121370 | 1121370 | 7.4 % | 17/02/2015 |
| Broadfin Capital, LLC | Delaware | 0 | 1121370 | 0 | 1121370 | 1121370 | 7.4 % | 17/02/2015 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 1121370 | 0 | 1121370 | 1121370 | 7.4 % | 17/02/2015 |
| RTW Master Fund, Ltd. | Cayman Islands | 0 | 1327261 | 0 | 1327261 | 1327261 | 8.6 % | 17/02/2015 |
| Roderick Wong | United States of America | 0 | 1327261 | 0 | 1327261 | 1327261 | 8.6 % | 17/02/2015 |
| RTW Investments, LLC | Delaware | 0 | 1327261 | 0 | 1327261 | 1327261 | 8.6 % | 17/02/2015 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 1850470 | 0 | 1850470 | 12.153 % | 10/02/2015 |
| FMR LLC | Delaware | 0 | 0 | 1850470 | 0 | 1850470 | 12.153 % | 10/02/2015 |
| Abigail P. Johnson | United States of America | 0 | 0 | 1850470 | 0 | 1850470 | 12.153 % | 10/02/2015 |
| Select Biotechnology Portfolio | Massachusetts | 950397 | 0 | 0 | 0 | 950397 | 6.241 % | 10/02/2015 |
| KEVIN C. TANG | UNITED STATES | 42840 | 1699067 | 42840 | 1699067 | 1741067 | 11.4 % | 29/07/2014 |
| TANG CAPITAL MANAGEMENT, LLC | DELAWARE | 0 | 1699067 | 0 | 1699067 | 1699067 | 11.2 % | 29/07/2014 |
| TANG CAPITAL PARTNERS, LP | DELAWARE | 0 | 1699067 | 0 | 1699067 | 1699067 | 11.2 % | 29/07/2014 |
| KEVIN C. TANG | UNITED STATES | 42840 | 1699067 | 42840 | 1699067 | 1741067 | 11.4 % | 29/07/2014 |
| TANG CAPITAL MANAGEMENT, LLC | DELAWARE | 0 | 1699067 | 0 | 1699067 | 1699067 | 11.2 % | 29/07/2014 |
| TANG CAPITAL PARTNERS, LP | DELAWARE | 0 | 1699067 | 0 | 1699067 | 1699067 | 11.2 % | 29/07/2014 |
| Broadfin Capital, LLC | Delaware | 0 | 389921 | 0 | 389921 | 389921 | 5.37 % | 16/04/2014 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 389921 | 0 | 389921 | 389921 | 5.37 % | 16/04/2014 |
| Kevin Kotler | United States of America | 0 | 389921 | 0 | 389921 | 389921 | 5.37 % | 16/04/2014 |
| Broadfin Capital, LLC | Delaware | 0 | 389921 | 0 | 389921 | 389921 | 5.37 % | 16/04/2014 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 389921 | 0 | 389921 | 389921 | 5.37 % | 16/04/2014 |
| Kevin Kotler | United States of America | 0 | 389921 | 0 | 389921 | 389921 | 5.37 % | 16/04/2014 |
| Rupert H. Johnson, Jr. | USA | 4 | 4 | 4 | 4 | 920400 | 12.7 % | 10/04/2014 |
| Charles B. Johnson | USA | 4 | 4 | 4 | 4 | 920400 | 12.7 % | 10/04/2014 |
| Franklin Resources, Inc. | Delaware | 4 | 4 | 4 | 4 | 920400 | 12.7 % | 10/04/2014 |
| Franklin Advisers, Inc. | California | 920400 | 0 | 920400 | 0 | 920400 | 12.7 % | 10/04/2014 |
| TANG CAPITAL MANAGEMENT, LLC | DELAWARE | 0 | 459442 | 0 | 459442 | 459442 | 9.8 % | 16/01/2014 |
| KEVIN C. TANG | UNITED STATES | 0 | 468214 | 0 | 468214 | 468214 | 9.9 % | 16/01/2014 |
| TANG CAPITAL MANAGEMENT, LLC | DELAWARE | 0 | 459442 | 0 | 459442 | 459442 | 9.8 % | 16/01/2014 |
| TANG CAPITAL PARTNERS, LP | DELAWARE | 0 | 459442 | 0 | 459442 | 459442 | 9.8 % | 16/01/2014 |
| KEVIN C. TANG | UNITED STATES | 0 | 468214 | 0 | 468214 | 468214 | 9.9 % | 16/01/2014 |
| TANG CAPITAL PARTNERS, LP | DELAWARE | 0 | 459442 | 0 | 459442 | 459442 | 9.8 % | 16/01/2014 |
| RTW Master Fund, Ltd. | Cayman Islands | 0 | 1489878 | 0 | 1489878 | 1489878 | 9.99 % | 14/02/2013 |
| Roderick Wong | United States of America | 0 | 1489878 | 0 | 1489878 | 1489878 | 9.99 % | 14/02/2013 |
| RTW Investments, LLC | Delaware | 0 | 1489878 | 0 | 1489878 | 1489878 | 9.99 % | 14/02/2013 |
| RTW Investments, LLC | Delaware | 0 | 8791667 | 0 | 8791667 | 8791667 | 9.99 % | 16/02/2012 |
| Roderick Wong | United States of America | 0 | 8791667 | 0 | 8791667 | 8791667 | 9.99 % | 16/02/2012 |
| RTW Master Fund, Ltd. | Cayman Islands | 0 | 8791667 | 0 | 8791667 | 8791667 | 9.99 % | 16/02/2012 |
| Kevin C. Tang | United States | 0 | 9468361 | 0 | 9468361 | 9468361 | 9.9 % | 03/06/2010 |
| Tang Capital Management, LLC | Delaware | 0 | 8837137 | 0 | 8837137 | 8837137 | 9.3 % | 03/06/2010 |
| Tang Capital Partners, LP | Delaware | 0 | 8837137 | 0 | 8837137 | 8837137 | 9.3 % | 03/06/2010 |
| RTW Investments, LLC | Delaware | 0 | 9468361 | 0 | 9468361 | 9468361 | 9.99 % | 03/06/2010 |
| Roderick Wong | United States of America | 0 | 9468361 | 0 | 9468361 | 9468361 | 9.99 % | 03/06/2010 |
| RTW Master Fund, Ltd. | Cayman Islands | 0 | 9468361 | 0 | 9468361 | 9468361 | 9.99 % | 03/06/2010 |
| Joseph Lewis | United Kingdom | 0 | 8277434 | 0 | 8277434 | 8277434 | 8.741 % | 03/06/2010 |
| Boxer Capital, LLC | Delaware | 0 | 8277434 | 0 | 8277434 | 8277434 | 8.741 % | 03/06/2010 |
| Boxer Asset Management Inc. | Bahamas | 0 | 8277434 | 0 | 8277434 | 8277434 | 8.741 % | 03/06/2010 |
| MVA Investors, LLC | Delaware | 0 | 1190927 | 0 | 1190927 | 1190927 | 1.258 % | 03/06/2010 |
| Alejandro Gonzalez | Mexico | 6768669 | 0 | 6768669 | 0 | 6768669 | 17.1 % | 17/01/2008 |