FMR LLC |
Delaware |
19388579 |
0 |
19388579 |
0 |
19388579 |
14.999 % |
09/02/2024 |
Abigail P. Johnson |
United States of America |
0 |
0 |
19388579 |
0 |
19388579 |
14.999 % |
09/02/2024 |
Ann C. Donahue |
United States |
|
5175805 |
|
5175805 |
5175805 |
4.04 % |
07/11/2023 |
Federated Hermes, Inc. |
Pennsylvania |
5175805 |
|
5175805 |
|
5175805 |
4.04 % |
07/11/2023 |
J. Christopher Donahue |
United States |
|
5175805 |
|
5175805 |
5175805 |
4.04 % |
07/11/2023 |
Voting Shares Irrevocable Trust |
Pennsylvania |
5175805 |
|
5175805 |
|
5175805 |
4.04 % |
07/11/2023 |
Thomas R. Donahue |
United States |
|
5175805 |
|
5175805 |
5175805 |
4.04 % |
07/11/2023 |
Voting Shares Irrevocable Trust |
Pennsylvania |
11500520 |
0 |
11500520 |
0 |
11500520 |
9 % |
10/05/2023 |
Federated Hermes, Inc. |
Pennsylvania |
11500520 |
0 |
11500520 |
0 |
11500520 |
9 % |
10/05/2023 |
J. Christopher Donahue |
United States |
0 |
11500520 |
0 |
11500520 |
11500520 |
9 % |
10/05/2023 |
Thomas R. Donahue |
United States |
0 |
11500520 |
0 |
11500520 |
11500520 |
9 % |
10/05/2023 |
Ann C. Donahue |
United States |
0 |
11500520 |
0 |
11500520 |
11500520 |
9 % |
10/05/2023 |
BlackRock, Inc. |
Delaware |
6233587 |
0 |
6458974 |
0 |
6458974 |
5.2 % |
03/02/2023 |
Thomas R. Donahue |
|
|
17982256 |
|
17982256 |
17982256 |
14.5 % |
11/07/2022 |
(entities only Federated Hermes, Inc. |
|
17982256 |
|
17982256 |
|
17982256 |
14.5 % |
11/07/2022 |
Voting Shares Irrevocable Trust |
|
17982256 |
|
17982256 |
|
17982256 |
14.5 % |
11/07/2022 |
Rhodora J. Donahue |
|
|
17982256 |
|
17982256 |
17982256 |
14.5 % |
11/07/2022 |
J. Christopher Donahue |
|
|
17982256 |
|
17982256 |
17982256 |
14.5 % |
11/07/2022 |
Rajeev Shah |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
Peter Kolchinsky |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
Thomas R. Donahue |
|
|
6914136 |
|
6914136 |
6914136 |
7.53 % |
14/02/2022 |
J. Christopher Donahue |
|
|
6914136 |
|
6914136 |
6914136 |
7.53 % |
14/02/2022 |
(entities only Federated Hermes, Inc. |
|
6914136 |
|
6914136 |
|
6914136 |
7.53 % |
14/02/2022 |
Voting Shares Irrevocable Trust |
|
6914136 |
|
6914136 |
|
6914136 |
7.53 % |
14/02/2022 |
Rhodora J. Donahue |
|
|
6914136 |
|
6914136 |
6914136 |
7.53 % |
14/02/2022 |
Nikko Asset Management Americas, Inc. |
USA |
0 |
0 |
0 |
785519 |
785519 |
0.86 % |
14/02/2022 |
Nikko Asset Management Americas, Inc. |
USA |
0 |
0 |
0 |
785519 |
785519 |
0.86 % |
14/02/2022 |
The Vanguard Group |
Pennsylvania For |
0 |
128864 |
4498050 |
178215 |
4676265 |
5.09 % |
10/02/2022 |
Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
785519 |
0 |
785519 |
785519 |
0.85 % |
04/02/2022 |
Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
785519 |
0 |
785519 |
785519 |
0.85 % |
04/02/2022 |
Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
785519 |
0 |
785519 |
785519 |
0.85 % |
04/02/2022 |
Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
785519 |
0 |
785519 |
785519 |
0.85 % |
04/02/2022 |
BlackRock, Inc. |
Delaware |
5666496 |
0 |
5862691 |
0 |
5862691 |
6.4 % |
03/02/2022 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
4668473 |
0 |
4785589 |
4785589 |
5.21 % |
10/01/2022 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
9886217 |
0 |
10003391 |
10003391 |
10.91 % |
12/10/2021 |
SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
8790623 |
0 |
8803523 |
8803523 |
9.6 % |
12/10/2021 |
Rajeev Shah |
United States of America |
0 |
4702206 |
0 |
4702206 |
4702206 |
5.1 % |
05/05/2021 |
RA Capital Management, L.P. |
Delaware |
0 |
4702206 |
0 |
4702206 |
4702206 |
5.1 % |
05/05/2021 |
Peter Kolchinsky |
United States of America |
0 |
4702206 |
0 |
4702206 |
4702206 |
5.1 % |
05/05/2021 |
Rajeev Shah |
United States of America |
0 |
4702206 |
0 |
4702206 |
4702206 |
5.1 % |
05/05/2021 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
4702206 |
0 |
4702206 |
4702206 |
5.1 % |
05/05/2021 |
RA Capital Management, L.P. |
Delaware |
0 |
4702206 |
0 |
4702206 |
4702206 |
5.1 % |
05/05/2021 |
Peter Kolchinsky |
United States of America |
0 |
4702206 |
0 |
4702206 |
4702206 |
5.1 % |
05/05/2021 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
4702206 |
0 |
4702206 |
4702206 |
5.1 % |
05/05/2021 |
ARK Investment Management LLC |
Delaware United States |
12097738 |
1158078 |
13741254 |
0 |
13741254 |
15.06 % |
16/02/2021 |
Nikko Asset Management Americas, Inc. |
USA |
0 |
4848596 |
|
5823603 |
5823603 |
6.38 % |
11/02/2021 |
Nikko Asset Management Americas, Inc. |
USA |
0 |
4848596 |
|
5823603 |
5823603 |
6.38 % |
11/02/2021 |
Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
5823603 |
0 |
5823603 |
5823603 |
6.38 % |
05/02/2021 |
Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
5823603 |
0 |
5823603 |
5823603 |
6.38 % |
05/02/2021 |
Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
5823603 |
0 |
5823603 |
5823603 |
6.38 % |
05/02/2021 |
Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
5823603 |
0 |
5823603 |
5823603 |
6.38 % |
05/02/2021 |
BlackRock, Inc. |
Delaware |
6116397 |
0 |
6273836 |
0 |
6273836 |
6.9 % |
01/02/2021 |
ARK Investment Management LLC |
Delaware, United States |
10864479 |
936296 |
12293033 |
0 |
12293033 |
13.77 % |
09/10/2020 |
ARK Investment Management LLC |
Delaware, United States |
10864479 |
936296 |
12293033 |
0 |
12293033 |
13.77 % |
09/10/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
10800500 |
0 |
10800500 |
12.095 % |
10/09/2020 |
FMR LLC |
Delaware |
4119074 |
0 |
10800500 |
0 |
10800500 |
12.095 % |
10/09/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
10800500 |
0 |
10800500 |
12.095 % |
10/09/2020 |
FMR LLC |
Delaware |
4119074 |
0 |
10800500 |
0 |
10800500 |
12.095 % |
10/09/2020 |
Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
5624990 |
0 |
5624990 |
5624990 |
6.3 % |
09/09/2020 |
Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
5624990 |
0 |
5624990 |
5624990 |
6.3 % |
09/09/2020 |
Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
5624990 |
0 |
5624990 |
5624990 |
6.3 % |
09/09/2020 |
Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
5624990 |
0 |
5624990 |
5624990 |
6.3 % |
09/09/2020 |
Nikko Asset Management Americas, Inc. |
USA |
0 |
4428873 |
|
5624990 |
5624990 |
6.3 % |
08/09/2020 |
Nikko Asset Management Americas, Inc. |
USA |
0 |
4428873 |
|
5624990 |
5624990 |
6.3 % |
08/09/2020 |
ARK Investment Management LLC |
Delaware, United States |
5983163 |
445694 |
7273840 |
0 |
7273840 |
10.39 % |
14/02/2020 |
Nikko Asset Management Americas, Inc. |
USA |
0 |
5434478 |
0 |
8273223 |
8273223 |
11.82 % |
12/02/2020 |
Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
8273223 |
0 |
8273223 |
8273223 |
11.82 % |
12/02/2020 |
Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
8273223 |
0 |
8273223 |
8273223 |
11.82 % |
12/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6499118 |
0 |
6499118 |
9.282 % |
07/02/2020 |
FMR LLC |
Delaware |
2079689 |
0 |
6499118 |
0 |
6499118 |
9.282 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6935146 |
0 |
6935146 |
9.919 % |
12/11/2019 |
FMR LLC |
Delaware |
2070479 |
0 |
6935146 |
0 |
6935146 |
9.919 % |
12/11/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6935146 |
0 |
6935146 |
9.919 % |
12/11/2019 |
FMR LLC |
Delaware |
2070479 |
0 |
6935146 |
0 |
6935146 |
9.919 % |
12/11/2019 |
Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
7098097 |
0 |
7098097 |
7098097 |
10.15 % |
09/09/2019 |
Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
7098097 |
0 |
7098097 |
7098097 |
10.15 % |
09/09/2019 |
Nikko Asset Management Americas, Inc. |
USA |
0 |
4245980 |
|
7098097 |
7098097 |
10.15 % |
06/09/2019 |
Nikko Asset Management Americas, Inc. |
USA |
0 |
4245980 |
|
7098097 |
7098097 |
10.15 % |
06/09/2019 |
BlackRock, Inc. |
Delaware |
2168453 |
0 |
2256858 |
0 |
2256858 |
5.5 % |
07/02/2019 |
FMR LLC |
Delaware |
709025 |
0 |
6053363 |
0 |
6053363 |
15 % |
14/02/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6053363 |
0 |
6053363 |
15 % |
14/02/2017 |
FMR LLC |
Delaware |
709025 |
0 |
6053363 |
0 |
6053363 |
15 % |
14/02/2017 |
Select Biotechnology Portfolio |
Massachusetts |
2320475 |
0 |
0 |
0 |
2320475 |
5.75 % |
14/02/2017 |
Select Biotechnology Portfolio |
Massachusetts |
2320475 |
0 |
0 |
0 |
2320475 |
5.75 % |
14/02/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6053363 |
0 |
6053363 |
15 % |
14/02/2017 |
Flagship Ventures General Partner LLC |
Delaware United States America |
0 |
599297 |
0 |
599297 |
599297 |
1.53 % |
16/02/2016 |
Flagship Ventures Fund IVRx, L.P. |
Delaware United States America |
0 |
2205603 |
0 |
2205603 |
2205603 |
5.65 % |
16/02/2016 |
Flagship Ventures Fund IV, L.P. |
Delaware United States America |
0 |
11877976 |
0 |
11877976 |
11877976 |
30.41 % |
16/02/2016 |
Flagship VentureLabs IV, LLC |
Delaware United States America |
0 |
3055556 |
0 |
3055556 |
3055556 |
7.82 % |
16/02/2016 |
Flagship Ventures Fund IV General Partner LLC |
Delaware United States America |
0 |
14083579 |
0 |
14083579 |
14083579 |
36.06 % |
16/02/2016 |
Noubar B. Afeyan, Ph.D. |
United States America |
0 |
14682876 |
0 |
14682876 |
14682876 |
37.59 % |
16/02/2016 |
Edwin M. Kania, Jr. |
United States |
0 |
14682876 |
0 |
14682876 |
14682876 |
37.59 % |
16/02/2016 |
Flagship Ventures Fund 2007, L.P. |
Delaware United States America |
0 |
599297 |
0 |
599297 |
599297 |
1.53 % |
16/02/2016 |
FMR LLC |
Delaware |
895182 |
0 |
5858365 |
0 |
5858365 |
14.999 % |
12/02/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
5858365 |
0 |
5858365 |
14.999 % |
12/02/2016 |
Select Biotechnology Portfolio |
Massachusetts |
2320475 |
0 |
0 |
0 |
2320475 |
5.941 % |
12/02/2016 |
Select Biotechnology Portfolio |
Massachusetts |
2320475 |
0 |
0 |
0 |
2320475 |
5.941 % |
12/02/2016 |
FMR LLC |
Delaware |
895182 |
0 |
5858365 |
0 |
5858365 |
14.999 % |
12/02/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
5858365 |
0 |
5858365 |
14.999 % |
12/02/2016 |
Nestlé Health Science US Holdings, Inc. |
Delaware |
0 |
6888888 |
0 |
6888888 |
6888888 |
17.7 % |
06/07/2015 |
Nestlé S.A. |
Switzerland |
0 |
6888888 |
0 |
6888888 |
6888888 |
17.7 % |
06/07/2015 |
NIMCO US, Inc. |
Delaware |
0 |
6888888 |
0 |
6888888 |
6888888 |
17.7 % |
06/07/2015 |