| FHMLS X, L.P. |
Delaware |
0 |
125513 |
0 |
125513 |
125513 |
0.2 % |
20/11/2024 |
| Frazier Life Sciences X, L.P. |
Delaware |
0 |
125513 |
0 |
125513 |
125513 |
0.2 % |
20/11/2024 |
| FHMLSP Overage, L.P. |
Delaware |
0 |
925809 |
0 |
925809 |
925809 |
1.5 % |
20/11/2024 |
| Frazier Life Sciences Public Fund, L.P. |
Delaware |
0 |
1549193 |
0 |
1549193 |
1549193 |
2.5 % |
20/11/2024 |
| Patrick J. Heron |
Delaware |
0 |
3175665 |
0 |
3175665 |
3175665 |
5.1 % |
20/11/2024 |
| James N. Topper |
Delaware |
0 |
3175665 |
0 |
3175665 |
3175665 |
5.1 % |
20/11/2024 |
| FHMLS X, L.L.C. |
Delaware |
0 |
125513 |
0 |
125513 |
125513 |
0.2 % |
20/11/2024 |
| FHMLSP, L.L.C. |
Delaware |
0 |
1549193 |
0 |
1549193 |
1549193 |
2.5 % |
20/11/2024 |
| Frazier Life Sciences Public Overage Fund, L.P. |
Delaware |
0 |
925809 |
0 |
925809 |
925809 |
1.5 % |
20/11/2024 |
| Frazier Life Sciences XI, L.P. |
Delaware |
0 |
575150 |
0 |
575150 |
575150 |
0.9 % |
20/11/2024 |
| FHMLSP Overage, L.L.C. |
Delaware |
0 |
925809 |
0 |
925809 |
925809 |
1.5 % |
20/11/2024 |
| FHMLS XI, L.L.C. |
Delaware |
0 |
575150 |
0 |
575150 |
575150 |
0.9 % |
20/11/2024 |
| FHMLSP, L.P. |
Delaware |
0 |
1549193 |
0 |
1549193 |
1549193 |
2.5 % |
20/11/2024 |
| Daniel Estes |
Delaware |
0 |
575150 |
0 |
575150 |
575150 |
0.9 % |
20/11/2024 |
| FHMLS XI, L.P. |
Delaware |
0 |
575150 |
0 |
575150 |
575150 |
0.9 % |
20/11/2024 |
| James Brush |
Delaware |
0 |
2475002 |
0 |
2475002 |
2475002 |
3.9 % |
20/11/2024 |
| Albert Cha |
Delaware |
0 |
2475002 |
0 |
2475002 |
2475002 |
3.9 % |
20/11/2024 |
| Israel A. Englander |
Delaware |
0 |
3209974 |
0 |
3209974 |
3209974 |
5.1 % |
04/06/2024 |
| Millennium Management LLC |
Delaware |
0 |
3209974 |
0 |
3209974 |
3209974 |
5.1 % |
04/06/2024 |
| Millennium Group Management LLC |
Delaware |
0 |
3209974 |
0 |
3209974 |
3209974 |
5.1 % |
04/06/2024 |
| Israel A. Englander |
Delaware |
0 |
2704716 |
0 |
2704716 |
2704716 |
4.3 % |
21/05/2024 |
| Millennium Group Management LLC |
Delaware |
0 |
2704716 |
0 |
2704716 |
2704716 |
4.3 % |
21/05/2024 |
| Millennium Management LLC |
Delaware |
0 |
2704716 |
0 |
2704716 |
2704716 |
4.3 % |
21/05/2024 |
| 85-4328500 |
Maryland |
1963905 |
0 |
5639994 |
0 |
5639994 |
9.1 % |
14/02/2024 |
| RA Capital Management, L.P. |
Delaware |
0 |
3764871 |
0 |
3764871 |
3764871 |
6.1 % |
30/10/2023 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
3764871 |
0 |
3764871 |
3764871 |
6.1 % |
30/10/2023 |
| Peter Kolchinsky |
United States of America |
0 |
3764871 |
0 |
3764871 |
3764871 |
6.1 % |
30/10/2023 |
| Rajeev Shah |
United States of America |
0 |
3764871 |
0 |
3764871 |
3764871 |
6.1 % |
30/10/2023 |
| Steven Boyd |
United States of America |
0 |
6092000 |
0 |
0 |
6092000 |
9.91 % |
14/02/2023 |
| Armistice Capital, LLC |
Delaware |
0 |
6092000 |
0 |
0 |
6092000 |
9.91 % |
14/02/2023 |
| Israel A. Englander |
|
0 |
3187639 |
0 |
3187639 |
3187639 |
5.2 % |
02/09/2022 |
| Millennium Group Management LLC |
|
0 |
3187639 |
0 |
3187639 |
3187639 |
5.2 % |
02/09/2022 |
| Millennium Management LLC |
|
0 |
3187639 |
0 |
3187639 |
3187639 |
5.2 % |
02/09/2022 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
15/08/2022 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
15/08/2022 |
| Rajeev Shah |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/08/2022 |
| Peter Kolchinsky |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/08/2022 |
| Roderick Wong |
United States |
0 |
3975554 |
0 |
0 |
3975554 |
6.5 % |
14/02/2022 |
| RTW Investments, LP |
Delaware |
0 |
3975554 |
0 |
0 |
3975554 |
6.5 % |
14/02/2022 |
| 2. |
|
0 |
7275564 |
0 |
7275564 |
7275564 |
11.9 % |
11/02/2022 |
| 10. |
|
0 |
7275564 |
0 |
7275564 |
7275564 |
11.9 % |
11/02/2022 |
| Wasatch Advisors, Inc. 87-0319391 |
|
4108701 |
0 |
4108701 |
0 |
4108701 |
6.7 % |
11/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
105962 |
3798266 |
147912 |
3946178 |
6.44 % |
10/02/2022 |
| THE GOLDMAN SACHS GROUP, INC. |
Delaware |
0 |
3300519 |
0 |
3300534 |
3300534 |
5.4 % |
04/02/2022 |
| GOLDMAN SACHS & CO. LLC |
Delaware |
0 |
3300519 |
0 |
3300534 |
3300534 |
5.4 % |
04/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
5054932 |
0 |
5194833 |
0 |
5194833 |
8.5 % |
02/02/2022 |
| Peter Kolchinsky |
United States of America |
0 |
4375217 |
0 |
4375217 |
4375217 |
7.8 % |
16/02/2021 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
4363794 |
0 |
4363794 |
4363794 |
7.8 % |
16/02/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
4375217 |
0 |
4375217 |
4375217 |
7.8 % |
16/02/2021 |
| Rajeev Shah |
United States of America |
0 |
4375217 |
0 |
4375217 |
4375217 |
7.8 % |
16/02/2021 |
| Point72 Capital Advisors, Inc. |
Citizenship or place of organization Delaware |
0 |
1460133 |
0 |
1460133 |
1460133 |
4 % |
16/02/2021 |
| Steven A. Cohen |
Citizenship or place of organization United States |
0 |
1475558 |
0 |
1475558 |
1475558 |
4 % |
16/02/2021 |
| Cubist Systematic Strategies, LLC |
Citizenship or place of organization Delaware |
0 |
15425 |
0 |
15425 |
15425 |
4 % |
16/02/2021 |
| Point72 Asset Management, L.P. |
Citizenship or place of organization Delaware |
0 |
1460133 |
0 |
1460133 |
1460133 |
4 % |
16/02/2021 |
| BB Biotech AG |
Switzerland |
0 |
4815564 |
0 |
4815564 |
4815564 |
8.6 % |
12/02/2021 |
| Biotech Target N.V. |
Switzerland |
0 |
4815564 |
0 |
4815564 |
4815564 |
8.6 % |
12/02/2021 |
| Wasatch Advisors, Inc. 87-0319391 |
|
0 |
3672416 |
3672416 |
0 |
3672416 |
6.5 % |
11/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
5000151 |
0 |
5104831 |
0 |
5104831 |
9.1 % |
29/01/2021 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
2679903 |
0 |
2679903 |
2679903 |
4 % |
21/08/2020 |
| 52-0556948 |
Maryland |
3003 |
0 |
3003 |
0 |
3003 |
0 % |
14/02/2020 |
| 98-0557567 |
Bermuda |
4144773 |
0 |
4498822 |
0 |
4498822 |
9.2 % |
13/02/2020 |
| 52-0556948 |
Maryland |
328284 |
0 |
2250287 |
0 |
2250287 |
5.3 % |
14/02/2019 |
| Vanguard Group - 23-1945930 |
Pennsylvania |
81087 |
3400 |
2470240 |
80887 |
2551127 |
6.03 % |
11/02/2019 |
| EIN: 22-2007137 |
New Jersey |
0 |
1923077 |
0 |
0 |
1923077 |
4.6 % |
22/01/2019 |
| EIN: 22-1024240 |
New Jersey |
0 |
1923077 |
0 |
0 |
1923077 |
4.6 % |
22/01/2019 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
4446841 |
0 |
0 |
4446841 |
10.53 % |
18/01/2019 |
| 10 |
Delaware |
0 |
2200000 |
0 |
2200000 |
2200000 |
6 % |
14/02/2018 |
| 10 |
Delaware |
0 |
787260 |
0 |
787260 |
787260 |
2.1 % |
14/02/2018 |
| 10 |
Delaware |
0 |
2200000 |
0 |
2200000 |
2200000 |
6 % |
14/02/2018 |
| 10. |
Switzerland |
0 |
2600412 |
0 |
2600412 |
2600412 |
7.1 % |
14/02/2018 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
3933906 |
0 |
0 |
3933906 |
10.68 % |
06/02/2018 |
| 10 |
Delaware |
0 |
2200000 |
0 |
2200000 |
2200000 |
6 % |
06/11/2017 |
| 10 |
Delaware |
0 |
323223 |
0 |
323223 |
323223 |
0.9 % |
06/11/2017 |
| 10 |
Delaware |
0 |
2523223 |
0 |
2523223 |
2523223 |
6.9 % |
06/11/2017 |
| 10 |
Delaware |
0 |
2200000 |
0 |
2200000 |
2200000 |
6 % |
06/11/2017 |
| 1,987,000 |
Delaware |
0 |
1987000 |
0 |
1987000 |
1987000 |
5.5 % |
12/06/2017 |
| 1,987,000 |
Delaware |
0 |
1987000 |
0 |
1987000 |
1987000 |
5.5 % |
12/06/2017 |
| 1,987,000 |
Delaware |
0 |
1987000 |
0 |
1987000 |
1987000 |
5.5 % |
12/06/2017 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
2888944 |
0 |
0 |
2888944 |
8.42 % |
04/02/2016 |
| (1) BlackRock, Inc. |
Delaware |
2029782 |
0 |
2087529 |
0 |
2087529 |
6.1 % |
28/01/2016 |
| Select Biotechnology Portfolio |
Massachusetts |
2523785 |
0 |
0 |
0 |
2523785 |
9.08 % |
13/02/2015 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3212042 |
0 |
3212042 |
11.556 % |
13/02/2015 |
| FMR LLC |
Delaware |
200 |
0 |
3212042 |
0 |
3212042 |
11.556 % |
13/02/2015 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
3212042 |
0 |
3212042 |
11.556 % |
13/02/2015 |
| Alta BioPharma Partners III GmbH & Co. Beteiligungs KG |
Germany |
104877 |
0 |
104877 |
104877 |
104877 |
0.4 % |
12/02/2015 |
| Alta Embarcadero BioPharma Partners III, LLC |
California |
38484 |
0 |
38484 |
38484 |
38484 |
0.1 % |
12/02/2015 |
| Farah Champsi |
United States |
0 |
1704996 |
0 |
1704996 |
1704996 |
6.1 % |
12/02/2015 |
| Alta BioPharma Partners III, L.P. |
Delaware |
1561635 |
0 |
1561635 |
1561635 |
1561635 |
5.6 % |
12/02/2015 |
| Alta BioPharma Management III, LLC |
Delaware |
0 |
1666512 |
0 |
1666512 |
1666512 |
6 % |
12/02/2015 |
| Edward Penhoet |
United States |
0 |
1704996 |
0 |
1704996 |
1704996 |
6.1 % |
12/02/2015 |
| EIN: 22-1024240 |
New Jersey |
0 |
1923077 |
0 |
1923077 |
1923077 |
6.5 % |
05/02/2015 |
| 10. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2015 |
| 10. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2015 |
| 10. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2015 |
| 10. |
Delaware |
615 |
0 |
615 |
0 |
615 |
0 % |
05/02/2015 |
| 1,021 |
Delaware |
1021 |
0 |
1021 |
0 |
1021 |
0 % |
05/02/2015 |
| 10. |
Delaware |
2042 |
0 |
2042 |
0 |
2042 |
0 % |
05/02/2015 |
| 10. |
Delaware |
2247 |
0 |
2247 |
0 |
2247 |
0 % |
05/02/2015 |
| 10. |
Delaware |
5359 |
0 |
5359 |
0 |
5359 |
0 % |
05/02/2015 |
| 10. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2015 |
| 10. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2015 |
| 1,964 |
Delaware |
1964 |
0 |
1964 |
0 |
1964 |
0 % |
05/02/2015 |
| 10. |
Delaware |
2436 |
0 |
2436 |
0 |
2436 |
0 % |
05/02/2015 |
| 0.1% |
Delaware |
14836 |
0 |
14836 |
0 |
14836 |
0.1 % |
05/02/2015 |
| 10. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2015 |
| 10. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2015 |
| 10. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2015 |
| 10. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2015 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
5523 |
0 |
0 |
5523 |
4 % |
09/04/2014 |
| EverPoint Asset Management, LLC |
Delaware |
0 |
50000 |
0 |
0 |
50000 |
0.2 % |
09/04/2014 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
1761907 |
0 |
0 |
1761907 |
6.4 % |
09/04/2014 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
1761907 |
0 |
0 |
1761907 |
6.4 % |
09/04/2014 |
| Steven A. Cohen |
United States |
0 |
1817430 |
0 |
0 |
1817430 |
6.6 % |
09/04/2014 |
| Edward Penhoet |
United States |
0 |
2013509 |
0 |
2013509 |
2013509 |
8.05 % |
14/02/2014 |
| Alta BioPharma Partners III, L.P. |
Delaware |
1844208 |
0 |
1844208 |
0 |
1844208 |
7.37 % |
14/02/2014 |
| Alta Embarcadero BioPharma Partners III, LLC |
California |
45447 |
0 |
45447 |
0 |
45447 |
0.18 % |
14/02/2014 |
| Farah Champsi |
United States |
0 |
2013509 |
0 |
2013509 |
2013509 |
8.05 % |
14/02/2014 |
| Edward Hurwitz |
United States |
0 |
2013509 |
0 |
2013509 |
2013509 |
8.05 % |
14/02/2014 |
| Alta BioPharma Partners III GmbH & Co. Beteiligungs KG |
Germany |
123854 |
0 |
123854 |
0 |
123854 |
0.5 % |
14/02/2014 |
| Alta BioPharma Management III, LLC |
Delaware |
0 |
1968062 |
0 |
1968062 |
1968062 |
7.87 % |
14/02/2014 |
| David Bonderman |
Delaware |
0 |
2208762 |
0 |
0 |
2208762 |
8.8 % |
13/02/2014 |
| James G. Coulter |
Delaware |
0 |
2208762 |
0 |
0 |
2208762 |
8.8 % |
13/02/2014 |
| TPG Group Holdings (SBS) Advisors, Inc. |
Delaware |
0 |
2208762 |
0 |
0 |
2208762 |
8.8 % |
13/02/2014 |
| George R. Hecht |
Montreal Quebec Canada |
1313315 |
0 |
1313315 |
0 |
5140013 |
5.8 % |
13/02/2014 |
| Alpha Capital Anstalt |
Delaware |
25568 |
0 |
25568 |
0 |
694444 |
8.11 % |
12/02/2014 |