| RTW Investments, LP |
Delaware |
0 |
4169393 |
0 |
0 |
4169393 |
6.1 % |
14/11/2024 |
| Roderick Wong, M.D. |
United States |
0 |
4169393 |
0 |
0 |
4169393 |
6.1 % |
14/11/2024 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
6814226 |
0 |
6814226 |
9.989 % |
12/11/2024 |
| FMR LLC |
Delaware |
6814224 |
0 |
6814226 |
0 |
6814226 |
9.989 % |
12/11/2024 |
| Incyte Corporation |
Delaware |
4004544 |
0 |
4004544 |
0 |
4004544 |
6.9 % |
25/03/2024 |
| Robert Pohly |
Delaware |
0 |
3412410 |
0 |
3412410 |
3412410 |
5.9 % |
14/02/2024 |
| Samlyn, LP |
Delaware |
0 |
3412410 |
0 |
3412410 |
3412410 |
5.9 % |
14/02/2024 |
| Samlyn Capital, LLC |
Delaware |
0 |
3412410 |
0 |
3412410 |
3412410 |
5.9 % |
14/02/2024 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
2521553 |
0 |
0 |
2521553 |
5.5 % |
30/09/2022 |
| Deerfield Partners, L.P. |
Delaware |
0 |
2521553 |
0 |
0 |
2521553 |
5.5 % |
30/09/2022 |
| James E. Flynn |
Delaware |
0 |
2521553 |
0 |
0 |
2521553 |
5.5 % |
30/09/2022 |
| Company, L.P. |
Delaware |
0 |
2521553 |
0 |
0 |
2521553 |
5.5 % |
30/09/2022 |
| Capital LP |
Delaware, USA |
0 |
2242224 |
0 |
0 |
2242224 |
5.1 % |
16/05/2022 |
| Capital Master LP |
Delaware, USA |
0 |
2242224 |
0 |
0 |
2242224 |
5.1 % |
16/05/2022 |
| MVA Investors, LLC |
|
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Aaron I. Davis |
|
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Boxer Capital, LLC |
|
0 |
1900000 |
0 |
1900000 |
1900000 |
4.4 % |
14/02/2022 |
| Boxer Asset Management Inc. |
|
0 |
1900000 |
0 |
1900000 |
1900000 |
4.4 % |
14/02/2022 |
| Joe Lewis |
|
0 |
1900000 |
0 |
1900000 |
1900000 |
4.4 % |
14/02/2022 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
3679300 |
0 |
3679300 |
3679300 |
8.51 % |
14/02/2022 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
3679300 |
0 |
3679300 |
0 |
3679300 |
8.51 % |
14/02/2022 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
3679300 |
0 |
3679300 |
3679300 |
8.51 % |
14/02/2022 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
3679300 |
0 |
3679300 |
3679300 |
8.51 % |
14/02/2022 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
3679300 |
0 |
3679300 |
0 |
3679300 |
8.51 % |
14/02/2022 |
| BVF Inc. |
|
0 |
0 |
0 |
4135071 |
4135071 |
9.6 % |
11/02/2022 |
| Biotechnology Value Fund, L.P. |
|
0 |
0 |
0 |
2203079 |
2203079 |
5.1 % |
11/02/2022 |
| BVF I GP LLC |
|
0 |
0 |
0 |
2203079 |
2203079 |
5.1 % |
11/02/2022 |
| BVF II GP LLC |
|
0 |
0 |
0 |
1605380 |
1605380 |
3.7 % |
11/02/2022 |
| Biotechnology Value Fund II, L.P. |
|
0 |
0 |
0 |
1605380 |
1605380 |
3.7 % |
11/02/2022 |
| Biotechnology Value Trading Fund OS LP |
|
0 |
0 |
0 |
245681 |
245681 |
1 % |
11/02/2022 |
| BVF Partners OS Ltd. |
|
0 |
0 |
0 |
245681 |
245681 |
1 % |
11/02/2022 |
| BVF Partners L.P. |
|
0 |
0 |
0 |
4135071 |
4135071 |
9.6 % |
11/02/2022 |
| Mark N. Lampert |
|
0 |
0 |
0 |
4135071 |
4135071 |
9.6 % |
11/02/2022 |
| BVF GP HOLDINGS LLC |
|
0 |
0 |
0 |
3808459 |
3808459 |
8.8 % |
11/02/2022 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4288694 |
0 |
0 |
4600358 |
12 % |
10/08/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
4200210 |
0 |
0 |
4212299 |
10.98 % |
10/08/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
4288694 |
0 |
0 |
4600358 |
12 % |
10/08/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
4288694 |
0 |
0 |
4600358 |
12 % |
10/08/2021 |
| Oleg Nodelman |
United States |
0 |
0 |
0 |
0 |
0 |
11 % |
12/02/2021 |
| EcoR1 Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
11 % |
12/02/2021 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
11 % |
12/02/2021 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
2936798 |
0 |
2936798 |
2936798 |
10.1 % |
12/02/2021 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
2936798 |
0 |
2936798 |
0 |
2936798 |
10.1 % |
12/02/2021 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
2936798 |
0 |
2936798 |
2936798 |
10.1 % |
12/02/2021 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
2936798 |
0 |
2936798 |
2936798 |
10.1 % |
12/02/2021 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
2936798 |
0 |
2936798 |
0 |
2936798 |
10.1 % |
12/02/2021 |
| Incyte Corporation |
Delaware |
3550000 |
0 |
3550000 |
10 |
3550000 |
9.4 % |
25/01/2021 |
| 1,600,000 |
Delaware |
0 |
1600000 |
0 |
1600000 |
1600000 |
5.5 % |
20/01/2021 |
| 10 |
Delaware |
0 |
20000 |
0 |
20000 |
20000 |
0.1 % |
20/01/2021 |
| 10 |
Delaware |
0 |
20000 |
0 |
20000 |
20000 |
0.1 % |
20/01/2021 |
| 1,600,000 |
Delaware |
0 |
1600000 |
0 |
1600000 |
1600000 |
5.5 % |
20/01/2021 |
| 1,600,000 |
Delaware |
0 |
1600000 |
0 |
1600000 |
1600000 |
5.5 % |
20/01/2021 |
| Incyte Corporation |
|
3200000 |
0 |
3200000 |
11 |
3200000 |
11 % |
28/12/2020 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
2936798 |
0 |
2936798 |
2936798 |
10.11 % |
10/11/2020 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
2936798 |
0 |
2936798 |
0 |
2936798 |
10.11 % |
10/11/2020 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
2936798 |
0 |
2936798 |
2936798 |
10.11 % |
10/11/2020 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
2936798 |
0 |
2936798 |
2936798 |
10.11 % |
10/11/2020 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
2936798 |
0 |
2936798 |
0 |
2936798 |
10.11 % |
10/11/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
2610548 |
0 |
2610548 |
2610548 |
9 % |
03/06/2020 |
| Oleg Nodelman |
Delaware |
0 |
1906861 |
0 |
1906861 |
1906861 |
11 % |
24/04/2020 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
1613921 |
0 |
1613921 |
1613921 |
11 % |
24/04/2020 |
| EcoR1 Capital, LLC |
Delaware |
0 |
1906861 |
0 |
1906861 |
1906861 |
11 % |
24/04/2020 |
| EcoR1 Capital, LLC |
Delaware |
0 |
1718200 |
0 |
1718200 |
1718200 |
11 % |
14/02/2020 |
| Oleg Nodelman |
United States |
0 |
1718200 |
0 |
1718200 |
1718200 |
11 % |
14/02/2020 |
| Medicxi Ventures Management (Jersey) Limited |
Jersey |
1600000 |
0 |
1600000 |
0 |
1600000 |
5.5 % |
14/11/2019 |
| Medicxi Growth I GP Limited |
Jersey |
1600000 |
0 |
1600000 |
0 |
1600000 |
5.5 % |
14/11/2019 |
| Medicxi Growth I LP |
Jersey |
1562872 |
0 |
1562872 |
0 |
1562872 |
5.4 % |
14/11/2019 |
| Co-Invest |
Jersey |
37128 |
0 |
37128 |
0 |
37128 |
0.1 % |
14/11/2019 |
| Aquilo Capital, L.P. |
Delaware |
0 |
1168346 |
0 |
0 |
1168346 |
5.1 % |
03/01/2019 |
| Mr. Marc Schneidman |
Delaware |
0 |
1451650 |
0 |
0 |
1451650 |
6.4 % |
03/01/2019 |
| Aquilo Capital Management, LLC |
Delaware |
0 |
1451650 |
0 |
0 |
1451650 |
6.4 % |
03/01/2019 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
200282 |
200282 |
1 % |
23/02/2018 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
991850 |
991850 |
4.4 % |
23/02/2018 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
2124443 |
2124443 |
9.4 % |
23/02/2018 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
661180 |
661180 |
2.9 % |
23/02/2018 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
200282 |
200282 |
1 % |
23/02/2018 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
2124443 |
2124443 |
9.4 % |
23/02/2018 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
2124443 |
2124443 |
9.4 % |
23/02/2018 |
| ( 13-5315170 |
Delaware |
260942 |
0 |
260942 |
0 |
260942 |
1.34 % |
13/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
1171481 |
0 |
0 |
1181946 |
6.09 % |
08/02/2018 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
1171481 |
0 |
0 |
1181946 |
6.09 % |
08/02/2018 |
| Wellington Management Company LLP |
Massachusetts |
0 |
1171481 |
0 |
0 |
1171481 |
6.04 % |
08/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
1171481 |
0 |
0 |
1181946 |
6.09 % |
08/02/2018 |
| Julian C. Baker |
Delaware |
1160014 |
0 |
1160014 |
0 |
1160014 |
7.2 % |
14/02/2017 |
| Felix J. Baker |
Delaware |
1160014 |
0 |
1160014 |
0 |
1160014 |
7.2 % |
14/02/2017 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
1160014 |
0 |
1160014 |
0 |
1160014 |
7.2 % |
14/02/2017 |
| Baker Bros. Advisors LP |
Delaware |
1160014 |
0 |
1160014 |
0 |
1160014 |
7.2 % |
14/02/2017 |
| Baker Bros. Advisors LP |
Delaware |
1160014 |
0 |
1160014 |
0 |
1160014 |
7.2 % |
14/02/2017 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
1160014 |
0 |
1160014 |
0 |
1160014 |
7.2 % |
14/02/2017 |
| Julian C. Baker |
Delaware |
1160014 |
0 |
1160014 |
0 |
1160014 |
7.2 % |
14/02/2017 |
| Felix J. Baker |
Delaware |
1160014 |
0 |
1160014 |
0 |
1160014 |
7.2 % |
14/02/2017 |
| Aglaia Oncology Seed Fund B.V. |
The Netherlands |
397291 |
0 |
397291 |
0 |
397291 |
2.5 % |
10/02/2017 |
| Aglaia Oncology Fund B.V. |
The Netherlands |
711854 |
397291 |
711854 |
0 |
1109145 |
6.9 % |
10/02/2017 |
| Karl Rothweiler |
The Netherlands |
0 |
1109145 |
0 |
0 |
1109145 |
6.9 % |
10/02/2017 |
| Mark Krul |
The Netherlands |
0 |
1109145 |
0 |
0 |
1109145 |
6.9 % |
10/02/2017 |
| Aglaia BioMedical Ventures B.V. |
The Netherlands |
0 |
1109145 |
0 |
0 |
1109145 |
6.9 % |
10/02/2017 |
| Incyte Corporation |
Delaware |
3200000 |
0 |
3200000 |
0 |
3200000 |
16.6 % |
23/01/2017 |
| EIN: 22-1024240 |
New Jersey |
0 |
1195943 |
0 |
0 |
1195943 |
7.4 % |
18/01/2017 |
| EIN: 22-2007137 |
New Jersey |
0 |
1195943 |
0 |
0 |
1195943 |
7.4 % |
18/01/2017 |
| ( 13-5315170 |
Delaware |
1142548 |
0 |
1142548 |
0 |
1142548 |
11 % |
06/06/2016 |
| Sofinnova Venture Partners IX, L.P. (“SVP IX”) |
Delaware |
1401403 |
0 |
1401403 |
10 |
1401403 |
9.1 % |
27/05/2016 |
| Dr. James I. Healy (“Healy”) |
U.S. Citizen |
0 |
1401403 |
0 |
10 |
1401403 |
9.1 % |
27/05/2016 |
| Dr. Anand Mehra (“Mehra”) |
U.S. Citizen |
1401403 |
1401403 |
1401403 |
10 |
1401403 |
9.1 % |
27/05/2016 |
| Dr. Michael F. Powell (“Powell”) |
U.S. Citizen |
0 |
1401403 |
0 |
10 |
1401403 |
9.1 % |
27/05/2016 |
| Sofinnova Management IX, L.L.C. (“SM IX”) |
Delaware |
1401403 |
0 |
1401403 |
0 |
1401403 |
9.1 % |
27/05/2016 |
