| (1) BlackRock, Inc. |
Delaware |
4249129 |
0 |
4319918 |
0 |
4319918 |
6.1 % |
29/01/2024 |
| Madison Avenue GP, LLC |
Cayman Islands |
0 |
3609054 |
0 |
3609054 |
3609054 |
5.1 % |
31/07/2023 |
| Madison Avenue International LP |
Cayman Islands |
0 |
3609054 |
0 |
3609054 |
3609054 |
5.1 % |
31/07/2023 |
| Eli Samaha |
Cayman Islands |
0 |
3609054 |
0 |
3609054 |
3609054 |
5.1 % |
31/07/2023 |
| Caraway Jackson Investments LLC |
Cayman Islands |
0 |
3609054 |
0 |
3609054 |
3609054 |
5.1 % |
31/07/2023 |
| Madison Avenue Partners, LP |
Cayman Islands |
0 |
3609054 |
0 |
3609054 |
3609054 |
5.1 % |
31/07/2023 |
| EMAI Management, LLC |
Cayman Islands |
0 |
3609054 |
0 |
3609054 |
3609054 |
5.1 % |
31/07/2023 |
| Rubric Capital Management LP |
State of Delaware |
0 |
6828065 |
0 |
0 |
6828065 |
9.69 % |
10/02/2023 |
| David Rosen |
United States of America |
0 |
6828065 |
0 |
0 |
6828065 |
9.69 % |
10/02/2023 |
| During |
States of America |
3103932 |
0 |
3103932 |
0 |
3103932 |
4.5 % |
14/02/2022 |
| M. Levin |
States of America |
6554770 |
0 |
6554770 |
0 |
6554770 |
9.4 % |
14/02/2022 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
5531793 |
0 |
5531793 |
5531793 |
11 % |
14/02/2022 |
| EcoR1 Capital, LLC |
Delaware |
0 |
6082200 |
0 |
6082200 |
6082200 |
11 % |
14/02/2022 |
| Oleg Nodelman |
United States |
0 |
6082200 |
0 |
6082200 |
6082200 |
11 % |
14/02/2022 |
| Stonepine Capital Management, LLC |
California |
4006185 |
0 |
4006185 |
0 |
4006185 |
11 % |
11/02/2022 |
| Timothy P. Lynch |
U.S.A. |
4006185 |
0 |
4006185 |
0 |
4006185 |
11 % |
11/02/2022 |
| Jon M. Plexico |
U.S.A. |
4006185 |
0 |
4006185 |
0 |
4006185 |
11 % |
11/02/2022 |
| Stonepine Capital, L.P. |
Delaware |
4006185 |
0 |
4006185 |
0 |
4006185 |
11 % |
11/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
7825 |
0 |
19641 |
3442618 |
5.06 % |
10/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
1202730 |
0 |
1202730 |
0 |
1202730 |
1.8 % |
12/07/2021 |
| Stonepine Capital Management, LLC |
California |
3500000 |
0 |
3500000 |
0 |
3500000 |
11 % |
29/04/2021 |
| Timothy P. Lynch |
U.S.A. |
3500000 |
0 |
3500000 |
0 |
3500000 |
11 % |
29/04/2021 |
| Stonepine Capital, L.P. |
Delaware |
3500000 |
0 |
3500000 |
0 |
3500000 |
11 % |
29/04/2021 |
| Jon M. Plexico |
U.S.A. |
3500000 |
0 |
3500000 |
0 |
3500000 |
11 % |
29/04/2021 |
| EcoR1 Capital, LLC |
Delaware |
0 |
6082200 |
0 |
6082200 |
6082200 |
11 % |
09/03/2021 |
| Oleg Nodelman |
Delaware |
0 |
6082200 |
0 |
6082200 |
6082200 |
11 % |
09/03/2021 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
5108438 |
0 |
5108438 |
5108438 |
11 % |
09/03/2021 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2021 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2021 |
| Mitchell Blutt |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2021 |
| Consonance Capital Management LP |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2021 |
| Jeremy M. Levin |
United States of America |
6092270 |
0 |
6092270 |
0 |
6092270 |
9.6 % |
16/02/2021 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
1193518 |
0 |
0 |
1193518 |
2.04 % |
16/02/2021 |
| Consonance Capital Management LP |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
6058505 |
0 |
0 |
6058505 |
9.99 % |
16/02/2021 |
| Mitchell Blutt |
USA |
0 |
6058505 |
0 |
0 |
6058505 |
9.99 % |
16/02/2021 |
| Biotechnology Value Trading Fund OS LP |
|
0 |
0 |
0 |
292021 |
292021 |
1 % |
12/02/2021 |
| BVF Inc. |
|
0 |
0 |
0 |
4522051 |
4522051 |
6.9 % |
12/02/2021 |
| Mark N. Lampert |
|
0 |
0 |
0 |
4522051 |
4522051 |
6.9 % |
12/02/2021 |
| BVF II GP LLC |
|
0 |
0 |
0 |
1741127 |
1741127 |
2.7 % |
12/02/2021 |
| BVF I GP LLC |
|
0 |
0 |
0 |
2405294 |
2405294 |
3.7 % |
12/02/2021 |
| BVF GP HOLDINGS LLC |
|
0 |
0 |
0 |
4146421 |
4146421 |
6.3 % |
12/02/2021 |
| Biotechnology Value Fund, L.P. |
|
0 |
0 |
0 |
2405294 |
2405294 |
3.7 % |
12/02/2021 |
| BVF Partners OS Ltd. |
|
0 |
0 |
0 |
292021 |
292021 |
1 % |
12/02/2021 |
| Biotechnology Value Fund II, L.P. |
|
0 |
0 |
0 |
1741127 |
1741127 |
2.7 % |
12/02/2021 |
| BVF Partners L.P. |
|
0 |
0 |
0 |
4522051 |
4522051 |
6.9 % |
12/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
3392180 |
0 |
3411733 |
0 |
3411733 |
5.4 % |
02/02/2021 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
2888888 |
0 |
0 |
2888888 |
6.04 % |
14/02/2020 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
1183384 |
0 |
0 |
1183384 |
2.47 % |
14/02/2020 |
| Consonance Capital Management LP |
Delaware USA |
0 |
1705504 |
0 |
0 |
1705504 |
3.57 % |
14/02/2020 |
| Mitchell Blutt |
USA |
0 |
2888888 |
0 |
0 |
2888888 |
6.04 % |
14/02/2020 |
| 11.7% (2) |
|
5722933 |
0 |
5722933 |
0 |
5722933 |
11.7 % |
14/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
637483 |
0 |
655442 |
0 |
655442 |
1.8 % |
08/03/2019 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
2119747 |
2119747 |
5.6 % |
04/03/2019 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1260167 |
1260167 |
3.4 % |
04/03/2019 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
3772000 |
3772000 |
9.99 % |
04/03/2019 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
3772000 |
3772000 |
9.99 % |
04/03/2019 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
219574 |
219574 |
1 % |
04/03/2019 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
219574 |
219574 |
1 % |
04/03/2019 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
3772000 |
3772000 |
9.99 % |
04/03/2019 |
| M. Levin |
States of America |
5801028 |
0 |
5801028 |
0 |
5801028 |
22.9 % |
14/02/2019 |
| During |
States of America |
4824103 |
0 |
4824103 |
0 |
4824103 |
19.2 % |
14/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
1401324 |
0 |
1414696 |
0 |
1414696 |
5.7 % |
07/02/2019 |
| Armistice Capital, LLC |
Delaware |
0 |
1600000 |
0 |
1600000 |
1600000 |
6.5 % |
10/12/2018 |
| Armistice Capital Master Fund Ltd. |
Delaware |
0 |
1600000 |
0 |
1600000 |
1600000 |
6.5 % |
10/12/2018 |
| Steven Boyd |
Delaware |
0 |
1600000 |
0 |
1600000 |
1600000 |
6.5 % |
10/12/2018 |
| Takeda Pharmaceutical Company Limited |
Japan |
1781996 |
0 |
1781996 |
0 |
1781996 |
7.2 % |
16/04/2018 |
| FMR LLC |
Delaware |
14062 |
0 |
1473873 |
0 |
1473873 |
5.99 % |
13/02/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1473873 |
0 |
1473873 |
5.99 % |
13/02/2018 |