| (1) BlackRock, Inc. |
Delaware |
3689708 |
0 |
0 |
0 |
3827223 |
7.8 % |
08/11/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
0 |
0 |
3827223 |
7.8 % |
22/10/2024 |
| Frazier Life Sciences Public Fund, L.P. |
Delaware |
0 |
1295100 |
0 |
1295100 |
1295100 |
2.7 % |
29/03/2024 |
| FHMLSP, L.L.C. |
Delaware |
0 |
1295100 |
0 |
1295100 |
1295100 |
2.7 % |
29/03/2024 |
| Patrick J. Heron |
Delaware |
0 |
2631713 |
0 |
2631713 |
2631713 |
5.4 % |
29/03/2024 |
| Albert Cha |
Delaware |
0 |
1934155 |
0 |
1934155 |
1934155 |
4 % |
29/03/2024 |
| FHMLSP, L.P. |
Delaware |
0 |
1295100 |
0 |
1295100 |
1295100 |
2.7 % |
29/03/2024 |
| Frazier Life Sciences Public Overage Fund, L.P. |
Delaware |
0 |
639055 |
0 |
639055 |
639055 |
1.3 % |
29/03/2024 |
| FHMLS XI, L.L.C. |
Delaware |
0 |
453381 |
0 |
453381 |
453381 |
0.9 % |
29/03/2024 |
| James Brush |
Delaware |
0 |
1934155 |
0 |
1934155 |
1934155 |
4 % |
29/03/2024 |
| FHMLSP Overage, L.L.C. |
Delaware |
0 |
639055 |
0 |
639055 |
639055 |
1.3 % |
29/03/2024 |
| FHMLS X, L.L.C. |
Delaware |
0 |
244177 |
0 |
244177 |
244177 |
0.5 % |
29/03/2024 |
| FHMLSP Overage, L.P. |
Delaware |
0 |
639055 |
0 |
639055 |
639055 |
1.3 % |
29/03/2024 |
| Frazier Life Sciences X, L.P. |
Delaware |
0 |
244177 |
0 |
244177 |
244177 |
0.5 % |
29/03/2024 |
| Frazier Life Sciences XI, L.P. |
Delaware |
0 |
453381 |
0 |
453381 |
453381 |
0.9 % |
29/03/2024 |
| James N. Topper |
Delaware |
0 |
2631713 |
0 |
2631713 |
2631713 |
5.4 % |
29/03/2024 |
| Daniel Estes |
Delaware |
0 |
453381 |
0 |
453381 |
453381 |
0.9 % |
29/03/2024 |
| FHMLS XI, L.P. |
Delaware |
0 |
453381 |
0 |
453381 |
453381 |
0.9 % |
29/03/2024 |
| FHMLS X, L.P. |
Delaware |
0 |
244177 |
0 |
244177 |
244177 |
0.5 % |
29/03/2024 |
| Acorn Capital Advisors GP, LLC |
Delaware |
0 |
1150774 |
0 |
0 |
1150774 |
2.4 % |
01/09/2023 |
| Acorn Bioventures 2 L.P. |
Delaware |
0 |
1589161 |
0 |
0 |
1589161 |
3.3 % |
01/09/2023 |
| Acorn Capital Advisors GP 2, LLC |
Delaware |
0 |
1589161 |
0 |
0 |
1589161 |
3.3 % |
01/09/2023 |
| Acorn Bioventures, L.P. |
Delaware |
0 |
1150774 |
0 |
0 |
1150774 |
2.4 % |
01/09/2023 |
| Anders Hove |
United States of America |
0 |
2739935 |
0 |
0 |
2739935 |
5.8 % |
01/09/2023 |
| (1) BlackRock, Inc. |
Delaware |
1786656 |
0 |
1903137 |
0 |
1903137 |
4.2 % |
08/07/2022 |
| James E. Flynn |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Deerfield Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
57212 |
3608532 |
71655 |
3680187 |
9 % |
10/02/2022 |
| STATE STREET CORPORATION |
|
0 |
539502 |
0 |
578090 |
578090 |
1.41 % |
10/02/2022 |
| THE GOLDMAN SACHS GROUP, INC. |
Delaware |
0 |
0 |
13 |
2097647 |
2097647 |
5.1 % |
08/02/2022 |
| GOLDMAN SACHS & CO. LLC |
Delaware |
0 |
0 |
13 |
2097647 |
2097647 |
5.1 % |
08/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
3098519 |
0 |
3204237 |
0 |
3204237 |
7.8 % |
02/02/2022 |
| Israel A. Englander |
United States |
0 |
2237699 |
0 |
2237699 |
2237699 |
5.5 % |
14/01/2022 |
| Millennium Group Management LLC |
United States |
0 |
2237699 |
0 |
2237699 |
2237699 |
5.5 % |
14/01/2022 |
| Millennium Management LLC |
United States |
0 |
2237699 |
0 |
2237699 |
2237699 |
5.5 % |
14/01/2022 |
| Integrated Core Strategies (US) LLC |
|
0 |
1762308 |
0 |
1762308 |
1762308 |
4.3 % |
19/11/2021 |
| Israel A. Englander |
|
0 |
2004338 |
0 |
2004338 |
2004338 |
4.9 % |
19/11/2021 |
| Millennium Group Management LLC |
|
0 |
2004338 |
0 |
2004338 |
2004338 |
4.9 % |
19/11/2021 |
| Millennium Management LLC |
|
0 |
2004338 |
0 |
2004338 |
2004338 |
4.9 % |
19/11/2021 |
| ICS Opportunities, Ltd. |
|
0 |
18848 |
0 |
18848 |
18848 |
0 % |
19/11/2021 |
| Integrated Assets II LLC |
|
0 |
218968 |
0 |
218968 |
218968 |
0.5 % |
19/11/2021 |
| Integrated Assets, Ltd. |
|
0 |
4214 |
0 |
4214 |
4214 |
0 % |
19/11/2021 |
| Millennium International Management LP |
|
0 |
242030 |
0 |
242030 |
242030 |
0.6 % |
19/11/2021 |
| 13-3017981 |
New York |
890396 |
0 |
890396 |
0 |
890396 |
2.18 % |
10/11/2021 |
| Alger Group Holdings, LLC |
New York |
3416003 |
0 |
3416003 |
0 |
3416003 |
8.59 % |
16/02/2021 |
| Alger Associates, Inc. 13-3017981 |
New York |
3416003 |
0 |
3416003 |
0 |
3416003 |
8.59 % |
16/02/2021 |
| Oleg Nodelman |
Delaware |
0 |
0 |
0 |
0 |
0 |
11 % |
12/02/2021 |
| EcoR1 Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
11 % |
12/02/2021 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
11 % |
12/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
70804 |
3303707 |
92982 |
3396689 |
8.54 % |
10/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
2894586 |
0 |
2996015 |
0 |
2996015 |
7.5 % |
29/01/2021 |
| Company, L.P. |
Delaware |
0 |
2278153 |
0 |
0 |
2278153 |
5.74 % |
10/08/2020 |
| Deerfield Partners, L.P. |
Delaware |
0 |
2278153 |
0 |
0 |
2278153 |
5.74 % |
10/08/2020 |
| James E. Flynn |
United States |
0 |
2278153 |
0 |
0 |
2278153 |
5.74 % |
10/08/2020 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
2278153 |
0 |
0 |
2278153 |
5.74 % |
10/08/2020 |
| EcoR1 Capital, LLC |
United States |
0 |
0 |
0 |
2536156 |
2536156 |
11 % |
26/03/2020 |
| Oleg Nodelman |
United States |
0 |
0 |
0 |
2536156 |
2536156 |
11 % |
26/03/2020 |
| EcoR1 Capital Fund Qualified, L.P. |
United States |
0 |
0 |
0 |
2146384 |
2146384 |
11 % |
26/03/2020 |
| OrbiMed Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| OrbiMed Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
2779738 |
0 |
2891336 |
0 |
2891336 |
7.4 % |
05/02/2020 |
| Mr. David Kroin |
USA |
0 |
1096626 |
0 |
1096626 |
1096626 |
2.8 % |
14/05/2019 |
| Great
Point Partners, LLC |
USA |
0 |
1096626 |
0 |
1096626 |
1096626 |
2.8 % |
14/05/2019 |
| Dr.
Jeffrey R. Jay, M.D. |
USA |
0 |
1096626 |
0 |
1096626 |
1096626 |
2.8 % |
14/05/2019 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
1970000 |
0 |
1970000 |
1970000 |
5.1 % |
14/05/2019 |
| Great Point Partners, LLC |
USA |
0 |
1970000 |
0 |
1970000 |
1970000 |
5.1 % |
14/05/2019 |
| Mr. David Kroin |
USA |
0 |
1970000 |
0 |
1970000 |
1970000 |
5.1 % |
14/05/2019 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2019 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2019 |
| Phillip Gross |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2019 |
| Robert Atchinson |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2019 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2019 |
| 52-0556948 |
Maryland |
293243 |
0 |
1976517 |
0 |
1976517 |
5.2 % |
14/02/2018 |
| (1)Names of reporting persons. BlackRock, Inc. |
Delaware |
2323335 |
0 |
2385036 |
0 |
2385036 |
6.4 % |
01/02/2018 |
| BARCLAYS GLOBAL INVESTORS, NA. |
Jersey, Channel Islands |
0 |
4355643 |
0 |
4355643 |
667255 |
2.89 % |
10/01/2018 |
| STEIN ROE & FARNHAM INCORPORATED |
Delaware |
2212105 |
0 |
2212105 |
0 |
468400 |
5.43 % |
13/02/2017 |
| Grantham, Mayo, Van Otterloo & Co. LLC 04-2691242 |
Boston Massachusetts USA |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2017 |
| Wellington Management Group LLP |
Delaware |
0 |
2089140 |
0 |
0 |
2368538 |
6.43 % |
09/02/2017 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2089140 |
0 |
0 |
2368538 |
6.43 % |
09/02/2017 |
| Wellington Management Company LLP |
Delaware |
0 |
2024332 |
0 |
0 |
2255442 |
6.13 % |
09/02/2017 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2089140 |
0 |
0 |
2368538 |
6.43 % |
09/02/2017 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
1946098 |
0 |
1946098 |
1946098 |
5.29 % |
08/02/2017 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
1658520 |
0 |
0 |
1658520 |
5.1 % |
12/02/2016 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
6457 |
0 |
0 |
6457 |
4 % |
12/02/2016 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
1658520 |
0 |
0 |
1658520 |
5.1 % |
12/02/2016 |
| Steven A. Cohen |
United States |
0 |
1664977 |
0 |
0 |
1664977 |
5.1 % |
12/02/2016 |
| Grantham, Mayo, Van Otterloo & Co. LLC 04-2691242 |
Boston, Massachusetts USA |
2899776 |
0 |
2899776 |
0 |
2899776 |
8.9401 % |
12/02/2016 |
| NAME OF REPORTING |
Delaware |
0 |
890600 |
0 |
890600 |
890600 |
2.75 % |
11/02/2016 |
| NAME OF REPORTING |
Delaware |
0 |
890600 |
0 |
890600 |
2238825 |
6.9 % |
11/02/2016 |
| NAME OF REPORTING |
Delaware |
0 |
890600 |
0 |
890600 |
1348225 |
4.16 % |
11/02/2016 |
| Vanguard Group - 23-1945930 |
Pennsylvania |
30032 |
|
1495383 |
27732 |
1523115 |
5.05 % |
10/02/2015 |
| Lord, Abbett & Co. LLC |
Delaware |
1315012 |
0 |
1376059 |
0 |
1376059 |
4.57 % |
10/04/2014 |
| Lord, Abbett & Co. LLC |
Delaware |
1429858 |
0 |
1493477 |
0 |
1493477 |
5.21 % |
14/02/2014 |
| Harris Financial Corp |
MARYLAND |
0 |
0 |
0 |
0 |
15755346 |
6.181 % |
10/01/2014 |
| Brookside Capital Partners Fund, L.P. |
Delaware |
1041703 |
0 |
1041703 |
0 |
1041703 |
3.63 % |
26/07/2013 |
| Brookside Capital Trading Fund, L.P. |
Delaware |
300000 |
0 |
300000 |
0 |
300000 |
1.05 % |
26/07/2013 |
| Brookside Capital Partners Fund, L.P. |
Delaware |
1666667 |
0 |
1666667 |
0 |
1666667 |
8.317 % |
26/07/2013 |
| Foresite Capital II-AA, LLC (“FC II-AA”) |
Delaware |
100000 |
100000 |
100000 |
100000 |
100000 |
0.4 % |
25/10/2012 |
| James Tananbaum (“Tananbaum”) |
United States |
1519999 |
1519999 |
1519999 |
1519999 |
1519999 |
5.5 % |
25/10/2012 |
| Foresite Capital II-A, LLC (“FC II-A”) |
Delaware |
1386666 |
1386666 |
1386666 |
1386666 |
1386666 |
5 % |
25/10/2012 |
| Foresite Capital II-A Management, LLC (“FCM II-A”) |
Delaware |
1386666 |
1386666 |
1386666 |
1386666 |
1386666 |
5 % |
25/10/2012 |
| Phillip Gross |
United States |
0 |
3200000 |
0 |
0 |
3200000 |
15.97 % |
31/01/2012 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
3200000 |
0 |
0 |
3200000 |
15.97 % |
31/01/2012 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
3200000 |
0 |
0 |
3200000 |
15.97 % |
31/01/2012 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
3200000 |
0 |
0 |
3200000 |
15.97 % |
31/01/2012 |
| Robert Atchinson |
United States |
0 |
3200000 |
0 |
0 |
3200000 |
15.97 % |
31/01/2012 |
| FMR LLC |
Delaware |
0 |
0 |
3333334 |
0 |
3333334 |
16.361 % |
10/11/2011 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
3333334 |
0 |
3333334 |
16.361 % |
10/11/2011 |