| (1) BlackRock, Inc. |
Delaware |
5026073 |
0 |
5105370 |
0 |
5105370 |
6.5 % |
03/02/2023 |
| (1) BlackRock, Inc. |
Delaware |
2735392 |
0 |
2789007 |
0 |
2789007 |
5 % |
09/03/2022 |
| Abingworth LLP |
England |
0 |
4183716 |
0 |
0 |
4183716 |
7.9 % |
14/02/2022 |
| Abingworth Bioventures VI, LP |
England |
0 |
4183716 |
0 |
0 |
4183716 |
7.9 % |
14/02/2022 |
| Roche Holding Ltd |
Switzerland |
0 |
0 |
0 |
0 |
2334113 |
4.4 % |
14/02/2022 |
| Roche Finance Ltd |
Switzerland |
0 |
0 |
0 |
0 |
2334113 |
4.4 % |
14/02/2022 |
| EIN #00-0000000 |
Jersey, Channel Islands |
0 |
4246664 |
0 |
4246664 |
4246664 |
8 % |
10/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
0 |
0 |
0 |
3134286 |
5.94 % |
10/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
2733722 |
0 |
2777047 |
0 |
2777047 |
5.3 % |
04/02/2022 |
| TPG GP A, LLC |
Delaware |
0 |
4149544 |
0 |
0 |
4149544 |
7.9 % |
18/01/2022 |
| Jon Winkelried |
Delaware |
0 |
4149544 |
0 |
0 |
4149544 |
7.9 % |
18/01/2022 |
| James G. Coulter |
Delaware |
0 |
4149544 |
0 |
0 |
4149544 |
7.9 % |
18/01/2022 |
| David Bonderman |
Delaware |
0 |
4149544 |
0 |
0 |
4149544 |
7.9 % |
18/01/2022 |
| VI, LP |
England |
0 |
4168718 |
0 |
0 |
4168718 |
8.2 % |
16/02/2021 |
| Abingworth LLP |
England |
0 |
4168718 |
0 |
0 |
4168718 |
8.2 % |
16/02/2021 |
| Roche Holding Ltd |
Switzerland |
0 |
2587754 |
0 |
2587754 |
2587754 |
5.1 % |
16/02/2021 |
| Roche Finance Ltd |
Switzerland |
0 |
2587754 |
0 |
2587754 |
2587754 |
5.1 % |
16/02/2021 |
| Juliet Tammenoms Bakker |
|
2430 |
3106350 |
2430 |
3106350 |
3108780 |
6.1 % |
12/02/2021 |
| Longitude Venture Partners II, L.P. |
|
0 |
3106350 |
0 |
3106350 |
3106350 |
6.1 % |
12/02/2021 |
| Longitude Capital Partners II, LLC |
|
0 |
3106350 |
0 |
3106350 |
3106350 |
6.1 % |
12/02/2021 |
| Patrick G. Enright |
|
2430 |
3106350 |
2430 |
3106350 |
3108780 |
6.1 % |
12/02/2021 |
| Bonderman |
Delaware |
0 |
4729278 |
0 |
0 |
4729278 |
9.3 % |
12/02/2021 |
| G. Coulter |
Delaware |
0 |
4729278 |
0 |
0 |
4729278 |
9.3 % |
12/02/2021 |
| Group Holdings (SBS) Advisors, Inc. |
Delaware |
0 |
4729278 |
0 |
0 |
4729278 |
9.3 % |
12/02/2021 |
| EIN #00-0000000 |
Jersey, Channel Islands |
0 |
4196778 |
0 |
4196778 |
4196778 |
8.2 % |
12/02/2021 |
| FMR LLC |
Delaware |
1338391 |
0 |
5670048 |
0 |
5670048 |
11.177 % |
10/08/2020 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
5670048 |
0 |
5670048 |
11.177 % |
10/08/2020 |
| RA Capital Management, L.P. |
Delaware |
0 |
5489181 |
0 |
0 |
5489181 |
10.8 % |
10/07/2020 |
| Peter Kolchinsky |
Delaware |
0 |
5489181 |
0 |
0 |
5489181 |
10.8 % |
10/07/2020 |
| Rajeev Shah |
Delaware |
0 |
5489181 |
0 |
0 |
5489181 |
10.8 % |
10/07/2020 |
| Bonderman |
Delaware |
0 |
5156553 |
0 |
0 |
5156553 |
10.2 % |
26/06/2020 |
| G. Coulter |
Delaware |
0 |
5156553 |
0 |
0 |
5156553 |
10.2 % |
26/06/2020 |
| Group Holdings (SBS) Advisors, Inc. |
Delaware |
0 |
5156553 |
0 |
0 |
5156553 |
10.2 % |
26/06/2020 |