Capital Research Global Investors |
Delaware |
7763349 |
0 |
7772404 |
0 |
7772404 |
11.1 % |
12/11/2024 |
Abigail P. Johnson |
United States of America |
0 |
0 |
8068635 |
0 |
8068635 |
11.482 % |
07/10/2024 |
FMR LLC |
Delaware |
7947020 |
0 |
8068635 |
0 |
8068635 |
11.482 % |
07/10/2024 |
The Vanguard Group |
Pennsylvania |
0 |
92673 |
7731162 |
298446 |
8029608 |
11.5 % |
13/02/2024 |
Capital World Investors |
Delaware |
2286144 |
0 |
2312283 |
0 |
2312283 |
3.3 % |
09/02/2024 |
Capital World Investors |
Delaware |
2286144 |
0 |
2312283 |
0 |
2312283 |
3.3 % |
09/02/2024 |
Capital Research Global Investors |
Delaware |
9469592 |
0 |
9476623 |
0 |
9476623 |
13.6 % |
09/02/2024 |
Capital Research Global Investors |
Delaware |
9469592 |
0 |
9476623 |
0 |
9476623 |
13.6 % |
09/02/2024 |
Abigail P. Johnson |
United States of America |
0 |
0 |
5903449 |
0 |
5903449 |
8.45 % |
09/02/2024 |
FMR LLC |
Delaware |
5786398 |
0 |
5903449 |
0 |
5903449 |
8.45 % |
09/02/2024 |
Wellington Management Group LLP |
Massachusetts |
0 |
3173101 |
0 |
3401606 |
3401606 |
4.87 % |
08/02/2024 |
Wellington Group Holdings LLP |
Delaware |
0 |
3173101 |
0 |
3401606 |
3401606 |
4.87 % |
08/02/2024 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3173101 |
0 |
3401606 |
3401606 |
4.87 % |
08/02/2024 |
BlackRock, Inc. |
Delaware |
5637641 |
0 |
6102546 |
0 |
6102546 |
8.7 % |
25/01/2024 |
FMR LLC |
Delaware |
6588475 |
0 |
6629593 |
0 |
6629593 |
9.488 % |
13/10/2023 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6629593 |
0 |
6629593 |
9.488 % |
13/10/2023 |
FMR LLC |
Delaware |
6588475 |
0 |
6629593 |
0 |
6629593 |
9.488 % |
13/10/2023 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6629593 |
0 |
6629593 |
9.488 % |
13/10/2023 |
FMR LLC |
Delaware |
6588475 |
0 |
6629593 |
0 |
6629593 |
9.488 % |
10/10/2023 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6629593 |
0 |
6629593 |
9.488 % |
10/10/2023 |
FMR LLC |
Delaware |
6588475 |
0 |
6629593 |
0 |
6629593 |
9.488 % |
10/10/2023 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6629593 |
0 |
6629593 |
9.488 % |
10/10/2023 |
The Vanguard Group |
Pennsylvania |
0 |
104666 |
7608206 |
295198 |
7903404 |
11.36 % |
10/04/2023 |
The Vanguard Group |
Pennsylvania |
0 |
104666 |
7608206 |
295198 |
7903404 |
11.36 % |
10/04/2023 |
Capital Research Global Investors |
Delaware |
6144590 |
0 |
6151361 |
0 |
6151361 |
8.9 % |
13/02/2023 |
Capital World Investors |
Delaware |
4064384 |
0 |
4097334 |
0 |
4097334 |
5.9 % |
13/02/2023 |
The Vanguard Group |
Pennsylvania For |
0 |
56141 |
6374995 |
153260 |
6528255 |
9.4 % |
09/02/2023 |
Wellington Management Company LLP |
Delaware |
0 |
5044683 |
0 |
5467625 |
5467625 |
7.87 % |
06/02/2023 |
Wellington Group Holdings LLP |
Delaware |
0 |
5179296 |
0 |
5702028 |
5702028 |
8.21 % |
06/02/2023 |
Wellington Management Group LLP |
Massachusetts |
0 |
5179296 |
0 |
5702028 |
5702028 |
8.21 % |
06/02/2023 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5179296 |
0 |
5702028 |
5702028 |
8.21 % |
06/02/2023 |
BlackRock, Inc. |
Delaware |
4840806 |
0 |
5244355 |
0 |
5244355 |
7.6 % |
31/01/2023 |
Capital World Investors |
Delaware |
6732615 |
0 |
6762544 |
0 |
6762544 |
9.8 % |
11/02/2022 |
Capital World Investors |
Delaware |
6732615 |
0 |
6762544 |
0 |
6762544 |
9.8 % |
11/02/2022 |
Capital Research Global Investors |
Delaware |
7804722 |
0 |
7811512 |
0 |
7811512 |
11.3 % |
11/02/2022 |
Capital Research Global Investors |
Delaware |
7804722 |
0 |
7811512 |
0 |
7811512 |
11.3 % |
11/02/2022 |
The Vanguard Group |
Pennsylvania For |
0 |
65291 |
5997320 |
147689 |
6145009 |
8.91 % |
10/02/2022 |
BlackRock, Inc. |
Delaware |
4227466 |
0 |
4655627 |
0 |
4655627 |
6.8 % |
02/02/2022 |
Capital Research Global Investors |
Delaware |
5641586 |
0 |
5644340 |
0 |
5644340 |
8.6 % |
16/02/2021 |
Capital Research Global Investors |
Delaware |
5641586 |
0 |
5644340 |
0 |
5644340 |
8.6 % |
16/02/2021 |
Capital World Investors |
Delaware |
7030789 |
0 |
7055579 |
0 |
7055579 |
10.7 % |
16/02/2021 |
Capital World Investors |
Delaware |
7030789 |
0 |
7055579 |
0 |
7055579 |
10.7 % |
16/02/2021 |
The Vanguard Group |
Pennsylvania |
0 |
68700 |
5723656 |
158158 |
5881814 |
8.92 % |
10/02/2021 |
The Vanguard Group |
Pennsylvania |
0 |
68700 |
5723656 |
158158 |
5881814 |
8.92 % |
10/02/2021 |
Abigail P. Johnson |
United States of America |
0 |
0 |
9902460 |
0 |
9902460 |
14.999 % |
08/02/2021 |
FMR LLC |
Delaware |
2160329 |
0 |
9902460 |
0 |
9902460 |
14.999 % |
08/02/2021 |
BlackRock, Inc. |
Delaware |
3727050 |
0 |
4140223 |
0 |
4140223 |
6.3 % |
05/02/2021 |
Capital World Investors |
Delaware |
6587597 |
0 |
6611263 |
0 |
6611263 |
10.1 % |
09/10/2020 |
Capital World Investors |
Delaware |
6587597 |
0 |
6611263 |
0 |
6611263 |
10.1 % |
09/10/2020 |
Capital Research Global Investors |
Delaware |
6684091 |
0 |
6684091 |
0 |
6684091 |
10.8 % |
14/02/2020 |
Capital World Investors |
Delaware |
3979198 |
0 |
4014292 |
0 |
4014292 |
6.4 % |
13/02/2020 |
The Vanguard Group |
Pennsylvania |
47590 |
17088 |
5519344 |
58692 |
5578036 |
9.02 % |
12/02/2020 |
BlackRock, Inc. |
Delaware |
3233778 |
0 |
3556339 |
0 |
3556339 |
5.8 % |
10/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
9285577 |
0 |
9285577 |
14.999 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
9285577 |
0 |
9285577 |
14.999 % |
07/02/2020 |
FMR LLC |
Delaware |
1814805 |
0 |
9285577 |
0 |
9285577 |
14.999 % |
07/02/2020 |
FMR LLC |
Delaware |
1814805 |
0 |
9285577 |
0 |
9285577 |
14.999 % |
07/02/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2245529 |
0 |
2535015 |
2535015 |
4.1 % |
28/01/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
2245529 |
0 |
2535015 |
2535015 |
4.1 % |
28/01/2020 |
Wellington Group Holdings LLP |
Delaware |
0 |
2245529 |
0 |
2535015 |
2535015 |
4.1 % |
28/01/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
2245529 |
0 |
2535015 |
2535015 |
4.1 % |
28/01/2020 |
Wellington Group Holdings LLP |
Delaware |
0 |
2245529 |
0 |
2535015 |
2535015 |
4.1 % |
28/01/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2245529 |
0 |
2535015 |
2535015 |
4.1 % |
28/01/2020 |
PRIMECAP Management Company |
|
|
|
|
|
2953216 |
4.78 % |
06/12/2019 |
Wellington Management Company LLP |
Delaware |
0 |
3690738 |
0 |
5015690 |
5015690 |
8.31 % |
10/10/2019 |
Wellington Management Company LLP |
Delaware |
0 |
3690738 |
0 |
5015690 |
5015690 |
8.31 % |
10/10/2019 |
Wellington Management Group LLP |
Massachusetts |
0 |
3712131 |
0 |
5159195 |
5159195 |
8.55 % |
10/10/2019 |
Wellington Group Holdings LLP |
Delaware |
0 |
3712131 |
0 |
5159195 |
5159195 |
8.55 % |
10/10/2019 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3712131 |
0 |
5159195 |
5159195 |
8.55 % |
10/10/2019 |
Wellington Management Group LLP |
Massachusetts |
0 |
3712131 |
0 |
5159195 |
5159195 |
8.55 % |
10/10/2019 |
Wellington Group Holdings LLP |
Delaware |
0 |
3712131 |
0 |
5159195 |
5159195 |
8.55 % |
10/10/2019 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3712131 |
0 |
5159195 |
5159195 |
8.55 % |
10/10/2019 |
SMALLCAP World Fund, Inc. |
Maryland |
0 |
0 |
0 |
0 |
3757400 |
6.3 % |
13/02/2019 |
Capital Research Global Investors |
Delaware |
4290819 |
0 |
4290819 |
0 |
4290819 |
7.2 % |
13/02/2019 |
Capital Research Global Investors |
Delaware |
4290819 |
0 |
4290819 |
0 |
4290819 |
7.2 % |
13/02/2019 |
The Vanguard Group |
Pennsylvania |
32068 |
8844 |
5153709 |
35443 |
5189152 |
8.78 % |
12/02/2019 |
Wellington Management Group LLP |
Massachusetts |
0 |
5381936 |
0 |
8192155 |
8192155 |
13.87 % |
12/02/2019 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5381936 |
0 |
8192155 |
8192155 |
13.87 % |
12/02/2019 |
Wellington Management Company LLP |
Delaware |
0 |
5325267 |
0 |
7892694 |
7892694 |
13.36 % |
12/02/2019 |
Wellington Group Holdings LLP |
Delaware |
0 |
5381936 |
0 |
8192155 |
8192155 |
13.87 % |
12/02/2019 |
PRIMECAP Management Company |
|
|
|
|
|
4876258 |
8.25 % |
08/02/2019 |
BlackRock, Inc. |
Delaware |
2500111 |
0 |
2735990 |
0 |
2735990 |
4.7 % |
10/07/2018 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4299825 |
0 |
5938012 |
5938012 |
10.11 % |
10/05/2018 |
Wellington Management Company LLP |
Delaware |
0 |
4272137 |
0 |
5787386 |
5787386 |
9.86 % |
10/05/2018 |
Wellington Group Holdings LLP |
Delaware |
0 |
4299825 |
0 |
5938012 |
5938012 |
10.11 % |
10/05/2018 |
Wellington Management Group LLP |
Massachusetts |
0 |
4299825 |
0 |
5938012 |
5938012 |
10.11 % |
10/05/2018 |
Wellington Management Company LLP |
Delaware |
0 |
4272137 |
0 |
5787386 |
5787386 |
9.86 % |
10/05/2018 |
Wellington Management Group LLP |
Massachusetts |
0 |
4299825 |
0 |
5938012 |
5938012 |
10.11 % |
10/05/2018 |
Wellington Group Holdings LLP |
Delaware |
0 |
4299825 |
0 |
5938012 |
5938012 |
10.11 % |
10/05/2018 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4299825 |
0 |
5938012 |
5938012 |
10.11 % |
10/05/2018 |
PRIMECAP Management Company |
|
|
|
|
|
4953672 |
8.51 % |
27/02/2018 |
PRIMECAP Management Company |
|
|
|
|
|
4953672 |
8.51 % |
27/02/2018 |
Capital Research Global Investors |
Delaware |
5693900 |
0 |
5693900 |
0 |
5693900 |
9.7 % |
13/02/2018 |
The Vanguard Group |
Pennsylvania |
112797 |
8844 |
4710961 |
117185 |
4828146 |
8.29 % |
09/02/2018 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3194270 |
0 |
4777627 |
4777627 |
8.21 % |
08/02/2018 |
Wellington Management Company LLP |
Delaware |
0 |
3145836 |
0 |
4611328 |
4611328 |
7.92 % |
08/02/2018 |
Wellington Group Holdings LLP |
Delaware |
0 |
3194270 |
0 |
4777627 |
4777627 |
8.21 % |
08/02/2018 |
Wellington Management Group LLP |
Massachusetts |
0 |
3194270 |
0 |
4777627 |
4777627 |
8.21 % |
08/02/2018 |
BlackRock, Inc. |
Delaware |
3758839 |
0 |
3881915 |
0 |
3881915 |
6.7 % |
08/02/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
8613906 |
0 |
8613906 |
14.999 % |
14/02/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
8613906 |
0 |
8613906 |
14.999 % |
14/02/2017 |
FMR LLC |
Delaware |
974642 |
0 |
8613906 |
0 |
8613906 |
14.999 % |
14/02/2017 |
FMR LLC |
Delaware |
974642 |
0 |
8613906 |
0 |
8613906 |
14.999 % |
14/02/2017 |
Capital Research Global Investors |
Delaware |
5411633 |
0 |
5411633 |
0 |
5411633 |
9.4 % |
13/02/2017 |
The Vanguard Group |
Pennsylvania |
114245 |
8144 |
4252849 |
119533 |
4372382 |
7.61 % |
10/02/2017 |
PRIMECAP Management Company |
|
|
|
|
|
5179272 |
9.02 % |
09/02/2017 |
Wellington Management Company LLP |
Delaware |
0 |
4129361 |
0 |
5917477 |
5917477 |
10.3 % |
09/02/2017 |
Wellington Management Group LLP |
Massachusetts |
0 |
4131768 |
0 |
6084784 |
6084784 |
10.6 % |
09/02/2017 |
Wellington Group Holdings LLP |
Delaware |
0 |
4131768 |
0 |
6084784 |
6084784 |
10.6 % |
09/02/2017 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4131768 |
0 |
6084784 |
6084784 |
10.6 % |
09/02/2017 |
BlackRock, Inc. |
Delaware |
4234167 |
0 |
4385632 |
0 |
4385632 |
7.6 % |
25/01/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6025967 |
0 |
6025967 |
10.542 % |
11/07/2016 |
FMR LLC |
Delaware |
589100 |
0 |
6025967 |
0 |
6025967 |
10.542 % |
11/07/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6025967 |
0 |
6025967 |
10.542 % |
11/07/2016 |
FMR LLC |
Delaware |
589100 |
0 |
6025967 |
0 |
6025967 |
10.542 % |
11/07/2016 |
PRIMECAP Management Company |
|
|
|
|
|
5195669 |
9.13 % |
12/02/2016 |
PRIMECAP Management Company |
|
|
|
|
|
5195669 |
9.13 % |
12/02/2016 |
Wellington Management Company LLP |
Delaware |
0 |
4259347 |
0 |
5957337 |
5957337 |
10.46 % |
11/02/2016 |
Wellington Management Group LLP |
Massachusetts |
0 |
4271890 |
0 |
6131041 |
6131041 |
10.77 % |
11/02/2016 |
Wellington Group Holdings LLP |
Delaware |
0 |
4271890 |
0 |
6131041 |
6131041 |
10.77 % |
11/02/2016 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4271890 |
0 |
6131041 |
6131041 |
10.77 % |
11/02/2016 |
The Vanguard Group |
Pennsylvania |
124737 |
5000 |
3821105 |
126237 |
3947342 |
6.93 % |
10/02/2016 |
BlackRock, Inc. |
Delaware |
3739828 |
0 |
3872341 |
0 |
3872341 |
6.8 % |
26/01/2016 |
Capital Research Global Investors |
Delaware |
6009433 |
0 |
6009433 |
0 |
6009433 |
10.6 % |
08/01/2016 |
Capital Research Global Investors |
Delaware |
6009433 |
0 |
6009433 |
0 |
6009433 |
10.6 % |
08/01/2016 |
Wellington Group Holdings LLP |
Delaware |
0 |
5038426 |
0 |
7023038 |
7023038 |
12.44 % |
10/04/2015 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5038426 |
0 |
7023038 |
7023038 |
12.44 % |
10/04/2015 |
Wellington Management Company LLP |
Delaware |
0 |
5011026 |
0 |
6866527 |
6866527 |
12.16 % |
10/04/2015 |
Wellington Management Company LLP |
Delaware |
0 |
5011026 |
0 |
6866527 |
6866527 |
12.16 % |
10/04/2015 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5038426 |
0 |
7023038 |
7023038 |
12.44 % |
10/04/2015 |
Wellington Group Holdings LLP |
Delaware |
0 |
5038426 |
0 |
7023038 |
7023038 |
12.44 % |
10/04/2015 |
Wellington Management Group LLP |
Massachusetts |
0 |
5038426 |
0 |
7023038 |
7023038 |
12.44 % |
10/04/2015 |
Wellington Management Group LLP |
Massachusetts |
0 |
5038426 |
0 |
7023038 |
7023038 |
12.44 % |
10/04/2015 |
PRIMECAP Management Company |
|
|
|
|
|
2831635 |
5.02 % |
07/04/2015 |
OrbiMed Advisors LLC |
Delaware |
0 |
948800 |
0 |
948800 |
948800 |
1.69 % |
17/02/2015 |
Samuel D. Isaly |
United States |
0 |
1997000 |
0 |
1997000 |
1997000 |
3.56 % |
17/02/2015 |
OrbiMed Capital LLC |
Delaware |
0 |
1048200 |
0 |
0 |
1048200 |
1.87 % |
17/02/2015 |
Capital Research Global Investors |
Delaware |
2452733 |
0 |
2452733 |
0 |
2452733 |
4.4 % |
13/02/2015 |
Capital Research Global Investors |
Delaware |
2452733 |
0 |
2452733 |
0 |
2452733 |
4.4 % |
13/02/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
5066103 |
0 |
5066103 |
9.033 % |
13/02/2015 |
FMR LLC |
Delaware |
642103 |
0 |
5066103 |
0 |
5066103 |
9.033 % |
13/02/2015 |
Fidelity Growth Company Fund |
Massachusetts |
3377500 |
0 |
0 |
0 |
3377500 |
6.022 % |
13/02/2015 |
Abigail P. Johnson |
United States of America |
0 |
0 |
5066103 |
0 |
5066103 |
9.033 % |
13/02/2015 |
Wellington Management Group LLP |
Massachusetts |
0 |
2899126 |
0 |
4146103 |
4146103 |
7.39 % |
12/02/2015 |
The Vanguard Group |
Pennsylvania |
74080 |
|
3374526 |
69780 |
3444306 |
6.14 % |
10/02/2015 |
BlackRock, Inc. |
Delaware |
3238611 |
0 |
3358285 |
0 |
3358285 |
6 % |
30/01/2015 |
Wellington Management Company, LLP |
Massachusetts |
0 |
1692404 |
0 |
2794377 |
2794377 |
5.12 % |
14/02/2014 |
Wellington Management Company, LLP |
Massachusetts |
0 |
1692404 |
0 |
2794377 |
2794377 |
5.12 % |
14/02/2014 |
FRONTIER CAPITAL MANAGEMENT CO., LLC. |
DELAWARE |
1217560 |
|
1969124 |
|
1969124 |
3.61 % |
13/02/2014 |
OrbiMed Capital LLC |
Delaware |
0 |
1590000 |
0 |
0 |
1590000 |
2.92 % |
13/02/2014 |
OrbiMed Advisors LLC |
Delaware |
0 |
1298500 |
0 |
1298500 |
1298500 |
2.38 % |
13/02/2014 |
Samuel D. Isaly |
United States |
0 |
2888500 |
0 |
2888500 |
2888500 |
5.3 % |
13/02/2014 |
Capital Research Global Investors |
Delaware |
3238966 |
0 |
3238966 |
0 |
3238966 |
5.9 % |
12/02/2014 |
Capital Research Global Investors |
Delaware |
3238966 |
0 |
3238966 |
0 |
3238966 |
5.9 % |
12/02/2014 |
The Vanguard Group |
Pennsylvania |
75589 |
|
3123296 |
71289 |
3194585 |
5.85 % |
11/02/2014 |
BlackRock, Inc. |
Delaware |
2958814 |
0 |
3132229 |
0 |
3132229 |
5.7 % |
10/02/2014 |
Jennison Associates LLC S.S. or I.R.S. Identification No. of Above Person: IRS Identification (formerly |
Delaware |
548680 |
0 |
0 |
548680 |
548680 |
1 % |
07/02/2014 |
Federated Investors, Inc. |
Pennsylvania |
1851933 |
|
1851933 |
|
1851933 |
3.51 % |
08/03/2013 |
Rhodora J. Donahue |
United States |
|
1851933 |
|
1851933 |
1851933 |
3.51 % |
08/03/2013 |
John F. Donahue |
United States |
|
1851933 |
|
1851933 |
1851933 |
3.51 % |
08/03/2013 |
J. Christopher Donahue |
United States |
|
1851933 |
|
1851933 |
1851933 |
3.51 % |
08/03/2013 |
Voting Shares Irrevocable Trust |
Pennsylvania |
1851933 |
|
1851933 |
|
1851933 |
3.51 % |
08/03/2013 |
FMR LLC |
Delaware |
600 |
0 |
7219300 |
0 |
7219300 |
14.989 % |
14/02/2013 |
FMR LLC |
Delaware |
600 |
0 |
7219300 |
0 |
7219300 |
14.989 % |
14/02/2013 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
7219300 |
0 |
7219300 |
14.989 % |
14/02/2013 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
7219300 |
0 |
7219300 |
14.989 % |
14/02/2013 |
IRS IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
DELAWARE |
1859837 |
|
3042621 |
|
3042621 |
5.827 % |
14/02/2013 |
S Wellington Management Company, LLP |
Massachusetts |
0 |
1685887 |
0 |
3137762 |
3137762 |
6.01 % |
14/02/2013 |
The Vanguard Group |
Pennsylvania |
68068 |
|
2574299 |
66068 |
2640367 |
5.48 % |
13/02/2013 |
Jennison Associates LLC S.S. or I.R.S. Identification No. of Above Person: IRS Identification (formerly |
Delaware |
2650408 |
0 |
0 |
2650408 |
2650408 |
5.5 % |
11/02/2013 |
BlackRock, Inc. |
Delaware |
2665200 |
0 |
2665200 |
0 |
2665200 |
5.53 % |
08/02/2013 |
Fred Alger Management, Alger Associates, Incorporated |
New York, New York |
2326153 |
0 |
2326153 |
0 |
2326153 |
4.89 % |
12/03/2012 |
Fred Alger Management, Alger Associates, Incorporated |
New York, New York |
2326153 |
0 |
2326153 |
0 |
2326153 |
4.89 % |
12/03/2012 |
BlackRock, Inc. |
Delaware |
2458394 |
0 |
2458394 |
0 |
2458394 |
5.19 % |
09/02/2012 |
Fred Alger Management, Alger Associates, Incorporated |
New York, New York |
2405306 |
0 |
2405306 |
0 |
2405306 |
5.08 % |
10/01/2012 |
Fred Alger Management, Alger Associates, Incorporated |
New York, New York |
2405306 |
0 |
2405306 |
0 |
2405306 |
5.08 % |
10/01/2012 |
FMR LLC |
Delaware |
400 |
0 |
5665800 |
0 |
5665800 |
11.981 % |
11/10/2011 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
5665800 |
0 |
5665800 |
11.981 % |
11/10/2011 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
5665800 |
0 |
5665800 |
11.981 % |
11/10/2011 |
FMR LLC |
Delaware |
400 |
0 |
5665800 |
0 |
5665800 |
11.981 % |
11/10/2011 |
IRS IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
DELAWARE |
2219544 |
|
3381078 |
|
3381078 |
7.832 % |
14/02/2011 |
Versant Ventures I, LLC |
Delaware, United States of America |
0 |
1970943 |
0 |
1970943 |
1970943 |
4.91 % |
14/02/2011 |
Versant Affiliates Fund L.P. |
Delaware, United States of America |
82778 |
0 |
82778 |
0 |
82778 |
0.2 % |
14/02/2011 |
ROSS A. JAFFE, M.D. |
United States of America |
19810 |
1970943 |
19810 |
1970943 |
1990753 |
4.96 % |
14/02/2011 |
SAMUEL D. COLELLA |
United States of America |
0 |
1970943 |
0 |
1970943 |
1970943 |
4.91 % |
14/02/2011 |
BRIAN G. ATWOOD |
United States of America |
0 |
1970943 |
0 |
1970943 |
1970943 |
4.91 % |
14/02/2011 |
BARBARA N. LUBASH |
United States of America |
0 |
1970943 |
0 |
1970943 |
1970943 |
4.91 % |
14/02/2011 |
DONALD B. MILDER |
United States of America |
0 |
1970943 |
0 |
1970943 |
1970943 |
4.91 % |
14/02/2011 |
WILLIAM J. LINK, Ph.D. |
United States of America |
0 |
1970943 |
0 |
1970943 |
1970943 |
4.91 % |
14/02/2011 |
REBECCA B. ROBERTSON |
United States of America |
0 |
1970943 |
0 |
1970943 |
1970943 |
4.91 % |
14/02/2011 |
Versant Venture Capital I, L.P. |
Delaware, United States of America |
1813273 |
0 |
1813273 |
0 |
1813273 |
4.52 % |
14/02/2011 |
Versant Side Fund I, L.P. |
Delaware, United States of America |
35475 |
0 |
35475 |
0 |
35475 |
0.08 % |
14/02/2011 |
Fred Alger Management, Inc. Alger Associates, Incorporated |
New York New York |
2681289 |
0 |
2681289 |
0 |
2681289 |
6.21 % |
14/02/2011 |
OrbiMed Advisors LLC |
Delaware |
0 |
1458803 |
0 |
1458803 |
1458803 |
3.38 % |
11/02/2011 |
OrbiMed Capital GP II LLC |
Delaware |
0 |
1329020 |
0 |
1329020 |
1329020 |
3.08 % |
11/02/2011 |
Samuel D. Isaly |
United States |
0 |
1458803 |
0 |
1458803 |
1458803 |
3.38 % |
11/02/2011 |
James E. Flynn |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield Private Design International, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield Private Design Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield International Limited |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield Management Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield Capital, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield International Limited |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield Private Design Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield Capital, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
James E. Flynn |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield Private Design International, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Deerfield Management Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2011 |
Gilder, Gagnon, Howe & Co. LLC |
New York |
50304 |
0 |
50304 |
1942204 |
1992508 |
4.8 % |
10/12/2010 |
Gilder, Gagnon, Howe & Co. LLC |
New York |
62963 |
0 |
62963 |
2639971 |
2702934 |
7.3 % |
16/02/2010 |
FMR LLC |
Delaware |
0 |
0 |
3131400 |
0 |
3131400 |
8.512 % |
16/02/2010 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
3131400 |
0 |
3131400 |
8.512 % |
16/02/2010 |
FMR LLC |
Delaware |
0 |
0 |
3131400 |
0 |
3131400 |
8.512 % |
16/02/2010 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
3131400 |
0 |
3131400 |
8.512 % |
16/02/2010 |
OrbiMed Capital II LLC |
Delaware |
0 |
1689020 |
0 |
1689020 |
1689020 |
4.65 % |
12/02/2010 |
OrbiMed Advisors LLC |
Delaware |
0 |
129783 |
0 |
129783 |
129783 |
0.36 % |
12/02/2010 |
Samuel D. Isaly |
United States |
0 |
1818803 |
0 |
1818803 |
1818803 |
5.01 % |
12/02/2010 |
Fred Alger Management, Alger Associates, Incorporated |
New York, New York |
3435241 |
0 |
3435241 |
0 |
3435241 |
9.34 % |
28/01/2010 |
Fred Alger Management, Alger Associates, Incorporated |
New York, New York |
3435241 |
0 |
3435241 |
0 |
3435241 |
9.34 % |
28/01/2010 |