| Onroerend Goed Beheer- en Beleggingsmaatschappij A. van Herk B.V. |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Van Herk Private Equity Investments B.V. |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Adrianus van Herk |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Van Herk Investments B.V. |
The Netherlands |
4280865 |
0 |
4280865 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Onroerend Goed Beheer- en Beleggingsmaatschappij A. van Herk B.V. |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| A. van Herk Holding B.V. |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Van Herk Management Services B.V. |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Stichting Administratiekantoor Abchrys |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Van Herk Private Equity Investments B.V. |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Van Herk Management Services B.V. |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Stichting Administratiekantoor Penulata |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Van Herk Investments THI B.V. |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Adrianus van Herk |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Stichting Administratiekantoor Abchrys |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| A. van Herk Holding B.V. |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Stichting Administratiekantoor Penulata |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Van Herk Investments THI B.V. |
The Netherlands |
0 |
4280865 |
0 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| Van Herk Investments B.V. |
The Netherlands |
4280865 |
0 |
4280865 |
0 |
4280865 |
5.3 % |
14/09/2023 |
| FMR LLC |
|
0 |
0 |
4462438 |
0 |
4462438 |
6.271 % |
09/02/2022 |
| FMR LLC |
Delaware |
0 |
0 |
4462438 |
0 |
4462438 |
6.271 % |
09/02/2022 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
4462438 |
0 |
4462438 |
6.271 % |
09/02/2022 |
| Abigail P. Johnson |
|
0 |
0 |
4462438 |
0 |
4462438 |
6.271 % |
09/02/2022 |
| GOLDMAN SACHS & CO. LLC |
Delaware |
0 |
3973650 |
0 |
3973650 |
3973650 |
5.6 % |
07/02/2022 |
| THE GOLDMAN SACHS GROUP, INC. |
Delaware |
0 |
3973650 |
0 |
3973650 |
3973650 |
5.6 % |
07/02/2022 |
| Inspirational Visions BV |
The Netherlands |
35411 |
0 |
35411 |
0 |
35411 |
0.1 % |
04/02/2022 |
| Privium Fund Management B.V. |
The Netherlands |
4765659 |
0 |
4765659 |
0 |
4765659 |
6.7 % |
04/02/2022 |
| Patrick Johan Hendrik Krol |
The Netherlands |
4827372 |
0 |
4827372 |
0 |
4827372 |
6.8 % |
04/02/2022 |
| Stichting Aescap Life Sciences |
The Netherlands |
4765659 |
0 |
4765659 |
0 |
4765659 |
6.7 % |
04/02/2022 |
| 35-0470950 |
Indiana |
3989976 |
0 |
3989976 |
0 |
3989976 |
5.6 % |
10/09/2021 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
4910738 |
0 |
0 |
5320031 |
10.78 % |
08/11/2019 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
4910738 |
0 |
0 |
5320031 |
10.78 % |
08/11/2019 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
4910738 |
0 |
0 |
5320031 |
10.78 % |
08/11/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
4910738 |
0 |
0 |
5320031 |
10.78 % |
08/11/2019 |
| Wellington Management Company LLP |
Massachusetts |
0 |
4910738 |
0 |
0 |
5080969 |
10.29 % |
08/11/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
4910738 |
0 |
0 |
5320031 |
10.78 % |
08/11/2019 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
4910738 |
0 |
0 |
5320031 |
10.78 % |
08/11/2019 |
| Wellington Management Company LLP |
Massachusetts |
0 |
4910738 |
0 |
0 |
5080969 |
10.29 % |
08/11/2019 |
| Roderick Wong |
Delaware |
0 |
3569613 |
0 |
3569613 |
3569613 |
9.22 % |
22/02/2019 |
| Roderick Wong |
Delaware |
0 |
3569613 |
0 |
3569613 |
3569613 |
9.22 % |
22/02/2019 |
| RTW Master Fund, Ltd. |
Delaware |
0 |
2567205 |
0 |
2567205 |
2567205 |
6.63 % |
22/02/2019 |
| RTW Master Fund, Ltd. |
Delaware |
0 |
2567205 |
0 |
2567205 |
2567205 |
6.63 % |
22/02/2019 |
| RTW
Investments, LP |
Delaware |
0 |
3569613 |
0 |
3569613 |
3569613 |
9.22 % |
22/02/2019 |
| RTW
Investments, LP |
Delaware |
0 |
3569613 |
0 |
3569613 |
3569613 |
9.22 % |
22/02/2019 |
| UBS Group AG directly and on behalf of certain subsidiaries |
Switzerland |
0 |
2079315 |
0 |
2079315 |
2079315 |
5.39 % |
15/02/2019 |
| GOLDMAN SACHS & CO. LLC |
Delaware |
0 |
3409200 |
0 |
3409200 |
3409200 |
8.8 % |
07/02/2019 |
| THE GOLDMAN SACHS GROUP, INC. |
Delaware |
0 |
3409200 |
0 |
3409200 |
3409200 |
8.8 % |
07/02/2019 |
| Identification #52-2069785 (formerly 13-2631108) |
Delaware |
2995305 |
0 |
0 |
2995305 |
2995305 |
11 % |
01/02/2019 |
| Roderick
Wong |
Delaware |
0 |
1903158 |
0 |
1903158 |
1903158 |
5.05 % |
17/09/2018 |
| Roderick
Wong |
Delaware |
0 |
1903158 |
0 |
1903158 |
1903158 |
5.05 % |
17/09/2018 |
| RTW
Investments, LP |
Delaware |
0 |
1903158 |
0 |
1903158 |
1903158 |
5.05 % |
17/09/2018 |
| RTW
Investments, LP |
Delaware |
0 |
1903158 |
0 |
1903158 |
1903158 |
5.05 % |
17/09/2018 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
1876245 |
0 |
0 |
1876245 |
5.88 % |
25/05/2018 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1876245 |
0 |
0 |
1876245 |
5.88 % |
25/05/2018 |
| Phillip Gross |
Delaware |
0 |
1876245 |
0 |
0 |
1876245 |
5.88 % |
25/05/2018 |
| Robert Atchinson |
Delaware |
0 |
1876245 |
0 |
0 |
1876245 |
5.88 % |
25/05/2018 |
| Robert Atchinson |
Delaware |
0 |
1876245 |
0 |
0 |
1876245 |
5.88 % |
25/05/2018 |
| Phillip Gross |
Delaware |
0 |
1876245 |
0 |
0 |
1876245 |
5.88 % |
25/05/2018 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1876245 |
0 |
0 |
1876245 |
5.88 % |
25/05/2018 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1876245 |
0 |
0 |
1876245 |
5.88 % |
25/05/2018 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
1876245 |
0 |
0 |
1876245 |
5.88 % |
25/05/2018 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1876245 |
0 |
0 |
1876245 |
5.88 % |
25/05/2018 |
| Inspirational Visions BV |
The Netherlands |
1801200 |
0 |
1801200 |
0 |
1801200 |
5.6 % |
12/04/2018 |
| Aescap Medical Investment BV |
The Netherlands |
1786800 |
0 |
1786800 |
0 |
1786800 |
5.6 % |
12/04/2018 |
| Redmile Group, LLC |
DELAWARE |
0 |
1558392 |
0 |
1558392 |
1558392 |
4.89 % |
14/02/2018 |
| Mr. Pascal Minne |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Invus Public Equities, L.P. |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Invus Public Equities, L.P. |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Invus Public Equities Advisors, LLC |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Westend S.A. |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Stichting Administratiekantoor Westend |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Stichting Administratiekantoor Westend |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Invus Public Equities Advisors, LLC |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Artal International S.C.A. |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Artal International Management S.A. |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Artal Group S.A. |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Westend S.A. |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Artal Group S.A. |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Artal International Management S.A. |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Artal International S.C.A. |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Mr. Pascal Minne |
Bermuda |
1900000 |
0 |
1900000 |
0 |
1900000 |
5.96 % |
09/02/2018 |
| Identification #52-2069785 (formerly 13-2631108) |
Delaware |
2635552 |
0 |
0 |
2635552 |
2635552 |
11 % |
06/02/2018 |
| Identification #52-2069785 (formerly 13-2631108) |
Delaware |
2635552 |
0 |
0 |
2635552 |
2635552 |
11 % |
06/02/2018 |
| 2 |
The Netherlands |
2646285 |
0 |
2646285 |
0 |
2646285 |
10.5 % |
11/10/2017 |
| Invus Public Equities, L.P. |
Bermuda |
1500000 |
0 |
1500000 |
0 |
1500000 |
6 % |
06/07/2017 |
| Artal International Management S.A. |
Bermuda |
1500000 |
0 |
1500000 |
0 |
1500000 |
6 % |
06/07/2017 |
| Artal Group S.A. |
Bermuda |
1500000 |
0 |
1500000 |
0 |
1500000 |
6 % |
06/07/2017 |
| Westend S.A. |
Bermuda |
1500000 |
0 |
1500000 |
0 |
1500000 |
6 % |
06/07/2017 |
| Stichting Administratiekantoor Westend |
Bermuda |
1500000 |
0 |
1500000 |
0 |
1500000 |
6 % |
06/07/2017 |
| Mr. Pascal Minne |
Bermuda |
1500000 |
0 |
1500000 |
0 |
1500000 |
6 % |
06/07/2017 |
| Invus Public Equities, L.P. |
Bermuda |
1500000 |
0 |
1500000 |
0 |
1500000 |
6 % |
06/07/2017 |
| Invus Public Equities Advisors, LLC |
Bermuda |
1500000 |
0 |
1500000 |
0 |
1500000 |
6 % |
06/07/2017 |
| Artal International S.C.A. |
Bermuda |
1500000 |
0 |
1500000 |
0 |
1500000 |
6 % |
06/07/2017 |
| Redmile Group, LLC |
DELAWARE |
0 |
1578174 |
0 |
0 |
1578174 |
6.76 % |
14/02/2017 |
| JEREMY C. GREEN |
UNITED
STATES |
0 |
1578174 |
0 |
0 |
1578174 |
6.76 % |
14/02/2017 |
| Identification #52-2069785 (formerly 13-2631108) |
Delaware |
0 |
0 |
0 |
0 |
2674844 |
11 % |
08/04/2016 |
| Identification #52-2069785 (formerly 13-2631108) |
Delaware |
0 |
0 |
0 |
0 |
2674844 |
11 % |
08/04/2016 |
| NAME OF REPORTING |
Delaware |
0 |
833600 |
0 |
833600 |
995800 |
4.48 % |
17/02/2015 |
| NAME OF REPORTING |
Delaware |
0 |
833600 |
0 |
833600 |
1829400 |
8.24 % |
17/02/2015 |
| NAME OF REPORTING |
Delaware |
0 |
833600 |
0 |
833600 |
995800 |
4.48 % |
17/02/2015 |
| NAME OF REPORTING |
Delaware |
0 |
833600 |
0 |
833600 |
1829400 |
8.24 % |
17/02/2015 |
| NAME OF REPORTING |
Delaware |
0 |
833600 |
0 |
833600 |
833600 |
3.75 % |
17/02/2015 |
| NAME OF REPORTING |
Delaware |
0 |
833600 |
0 |
833600 |
833600 |
3.75 % |
17/02/2015 |
| Sofinnova Partners SAS (“SP SAS”) |
France |
2874324 |
2874324 |
2874324 |
2874324 |
2874324 |
12.3 % |
17/02/2015 |
| Monique Saulnier (“Saulnier”) |
French Citizen |
0 |
2874324 |
0 |
2874324 |
2874324 |
12.3 % |
17/02/2015 |
| Denis Lucquin (“Lucquin”) |
French Citizen |
0 |
2874324 |
0 |
2874324 |
2874324 |
12.3 % |
17/02/2015 |
| Sofinnova Capital VII FCPR (“SC VII”) |
France |
2874324 |
2874324 |
2874324 |
2874324 |
2874324 |
12.3 % |
17/02/2015 |
| Antoine Papiernik (“Papiernik”) |
French Citizen |
0 |
2874324 |
0 |
2874324 |
2874324 |
12.3 % |
17/02/2015 |
| Rafaèle Tordjman (“Tordjman”) |
French Citizen |
0 |
2874324 |
0 |
2874324 |
2874324 |
12.3 % |
17/02/2015 |
| Select Biotechnology Portfolio |
Massachusetts |
1510385 |
0 |
0 |
0 |
1510385 |
6.799 % |
13/02/2015 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1759801 |
0 |
1759801 |
7.922 % |
13/02/2015 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1759801 |
0 |
1759801 |
7.922 % |
13/02/2015 |
| FMR LLC |
Delaware |
0 |
0 |
1759801 |
0 |
1759801 |
7.922 % |
13/02/2015 |