PRIMECAP Management Company |
177 E. Colorado Blvd., 11th Floor, Pasadena, CA 91105 |
7216911 |
0 |
7216911 |
0 |
7216911 |
11.81 % |
12/11/2024 |
Rajeev Shah |
United States |
0 |
5330412 |
0 |
5330412 |
5330412 |
9.03 % |
14/02/2024 |
Peter Kolchinsky |
United States |
0 |
5330412 |
0 |
5330412 |
5330412 |
9.02 % |
14/02/2024 |
RA Capital Management, L.P. |
Delaware |
0 |
5330412 |
0 |
5330412 |
5330412 |
9.01 % |
14/02/2024 |
RA Capital Healthcare Fund, L.P. |
United States |
0 |
5330412 |
0 |
5330412 |
5330412 |
9.04 % |
14/02/2024 |
Baker Bros. Advisors LP |
Delaware |
6398365 |
0 |
6398365 |
0 |
6398365 |
10.8 % |
14/02/2024 |
Felix J. Baker |
United States |
6398365 |
0 |
6398365 |
0 |
6398365 |
10.8 % |
14/02/2024 |
Baker Bros. Advisors |
Delaware |
6398365 |
0 |
6398365 |
0 |
6398365 |
10.8 % |
14/02/2024 |
Julian C. Baker |
United States |
6398365 |
0 |
6398365 |
0 |
6398365 |
10.8 % |
14/02/2024 |
The Vanguard Group |
Pennsylvania |
0 |
93382 |
3089760 |
137178 |
3226938 |
5.46 % |
13/02/2024 |
Joseph Edelman |
United States of America |
0 |
3260013 |
0 |
3260013 |
3260013 |
5.5 % |
12/02/2024 |
Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
3260013 |
0 |
3260013 |
3260013 |
5.5 % |
12/02/2024 |
Perceptive Advisors LLC |
Delaware |
0 |
3260013 |
0 |
3260013 |
3260013 |
5.5 % |
12/02/2024 |
BlackRock, Inc. |
Delaware |
6292938 |
0 |
6351750 |
0 |
6351750 |
10.7 % |
24/01/2024 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
2070099 |
0 |
2206018 |
2206018 |
3.73 % |
23/01/2024 |
BlackRock, Inc. |
Delaware |
6214182 |
0 |
6265005 |
0 |
6265005 |
11 % |
07/07/2023 |
THE GOLDMAN SACHS GROUP, INC. |
Delaware |
0 |
5201142 |
0 |
5201260 |
5201260 |
9.2 % |
07/02/2023 |
GOLDMAN SACHS & CO. LLC |
New York |
0 |
5201142 |
0 |
5201260 |
5201260 |
9.2 % |
07/02/2023 |
BlackRock, Inc. |
Delaware |
3683867 |
0 |
3723714 |
0 |
3723714 |
6.6 % |
03/02/2023 |
Felix J. Baker |
United States |
6062702 |
0 |
6062702 |
0 |
6062702 |
10.9 % |
07/10/2022 |
Baker Bros. Advisors (GP) LLC |
Delaware |
6062702 |
0 |
6062702 |
0 |
6062702 |
10.9 % |
07/10/2022 |
Felix J. Baker |
United States |
6062702 |
0 |
6062702 |
0 |
6062702 |
10.9 % |
07/10/2022 |
Julian C. Baker |
United States |
6062702 |
0 |
6062702 |
0 |
6062702 |
10.9 % |
07/10/2022 |
Baker Bros. Advisors LP |
Delaware |
6062702 |
0 |
6062702 |
0 |
6062702 |
10.9 % |
07/10/2022 |
Baker Bros. Advisors (GP) LLC |
Delaware |
6062702 |
0 |
6062702 |
0 |
6062702 |
10.9 % |
07/10/2022 |
Julian C. Baker |
United States |
6062702 |
0 |
6062702 |
0 |
6062702 |
10.9 % |
07/10/2022 |
Baker Bros. Advisors LP |
Delaware |
6062702 |
0 |
6062702 |
0 |
6062702 |
10.9 % |
07/10/2022 |
BlackRock, Inc. |
Delaware |
1156750 |
0 |
1177575 |
0 |
1177575 |
2.3 % |
08/07/2022 |
(entities only Federated Hermes, Inc. |
|
5065113 |
|
5065113 |
|
5065113 |
10.06 % |
11/04/2022 |
J. Christopher Donahue |
|
|
5065113 |
|
5065113 |
5065113 |
10.06 % |
11/04/2022 |
Voting Shares Irrevocable Trust |
|
5065113 |
|
5065113 |
|
5065113 |
10.06 % |
11/04/2022 |
Thomas R. Donahue |
|
|
5065113 |
|
5065113 |
5065113 |
10.06 % |
11/04/2022 |
Rhodora J. Donahue |
|
|
5065113 |
|
5065113 |
5065113 |
10.06 % |
11/04/2022 |
Baker Bros. Advisors LLC |
Delaware |
3863239 |
0 |
3863239 |
0 |
3863239 |
7.7 % |
14/02/2022 |
Baker Bros. Advisors LP |
Delaware |
3863239 |
0 |
3863239 |
0 |
3863239 |
7.7 % |
14/02/2022 |
Julian C. Baker |
United States |
3863239 |
0 |
3863239 |
0 |
3863239 |
7.7 % |
14/02/2022 |
Felix J. Baker |
United States |
3863239 |
0 |
3863239 |
0 |
3863239 |
7.7 % |
14/02/2022 |
RA Capital Management, L.P. |
Delaware |
0 |
4871067 |
0 |
4871067 |
4871067 |
9.7 % |
14/02/2022 |
Rajeev Shah |
United States |
0 |
4871067 |
0 |
4871067 |
4871067 |
9.7 % |
14/02/2022 |
RA Capital Healthcare Fund, L.P. |
United States |
0 |
4871067 |
0 |
4871067 |
4871067 |
9.7 % |
14/02/2022 |
Peter Kolchinsky |
United States |
0 |
4871067 |
0 |
4871067 |
4871067 |
9.7 % |
14/02/2022 |
J. Christopher Donahue |
|
|
2803335 |
|
2803335 |
2803335 |
5.58 % |
14/02/2022 |
(entities only Federated Hermes, Inc. |
|
2803335 |
|
2803335 |
|
2803335 |
5.58 % |
14/02/2022 |
Voting Shares Irrevocable Trust |
|
2803335 |
|
2803335 |
|
2803335 |
5.58 % |
14/02/2022 |
Thomas R. Donahue |
|
|
2803335 |
|
2803335 |
2803335 |
5.58 % |
14/02/2022 |
Rhodora J. Donahue |
|
|
2803335 |
|
2803335 |
2803335 |
5.58 % |
14/02/2022 |
BlackRock, Inc. |
Delaware |
3248859 |
0 |
3328061 |
0 |
3328061 |
6.6 % |
03/02/2022 |
(entities only Federated Hermes, Inc. |
|
1775704 |
|
1775704 |
|
1775704 |
3.53 % |
10/12/2021 |
J. Christopher Donahue |
|
|
1775704 |
|
1775704 |
1775704 |
3.53 % |
10/12/2021 |
Voting Shares Irrevocable Trust |
|
1775704 |
|
1775704 |
|
1775704 |
3.53 % |
10/12/2021 |
Thomas R. Donahue |
|
|
1775704 |
|
1775704 |
1775704 |
3.53 % |
10/12/2021 |
Rhodora J. Donahue |
|
|
1775704 |
|
1775704 |
1775704 |
3.53 % |
10/12/2021 |
PRIMECAP Management Company |
177 E. Colorado Blvd., 11th Floor, Pasadena, CA 91105 |
5570691 |
0 |
5570691 |
0 |
5570691 |
11.14 % |
08/03/2021 |
PRIMECAP Management Company |
177 E. Colorado Blvd., 11th Floor, Pasadena, CA 91105 |
5570691 |
0 |
5570691 |
0 |
5570691 |
11.14 % |
08/03/2021 |
Baker Bros. Advisors LLC |
Delaware |
2314873 |
0 |
2314873 |
0 |
2314873 |
5.2 % |
16/02/2021 |
Julian C. Baker |
United States |
2314873 |
0 |
2314873 |
0 |
2314873 |
5.2 % |
16/02/2021 |
Baker Bros. Advisors LP |
Delaware |
2314873 |
0 |
2314873 |
0 |
2314873 |
5.2 % |
16/02/2021 |
Felix J. Baker |
United States |
2314873 |
0 |
2314873 |
0 |
2314873 |
5.2 % |
16/02/2021 |
RA Capital Management, L.P. |
Delaware |
0 |
4179067 |
0 |
4179067 |
4179067 |
9.5 % |
16/02/2021 |
RA Capital Healthcare Fund, L.P. |
United States |
0 |
3739239 |
0 |
3739239 |
3739239 |
8.5 % |
16/02/2021 |
Rajeev Shah |
United States |
0 |
4179067 |
0 |
4179067 |
4179067 |
9.5 % |
16/02/2021 |
Peter Kolchinsky |
United States |
0 |
4179067 |
0 |
4179067 |
4179067 |
9.5 % |
16/02/2021 |
Rhodora J. Donahue |
|
|
2617600 |
|
2617600 |
2617600 |
5.92 % |
12/02/2021 |
Voting Shares Irrevocable Trust |
|
2617600 |
|
2617600 |
|
2617600 |
5.92 % |
12/02/2021 |
J. Christopher Donahue |
|
|
2617600 |
|
2617600 |
2617600 |
5.92 % |
12/02/2021 |
(entities only Federated Hermes, Inc. |
|
2617600 |
|
2617600 |
|
2617600 |
5.92 % |
12/02/2021 |
Thomas R. Donahue |
|
|
2617600 |
|
2617600 |
2617600 |
5.92 % |
12/02/2021 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
291005 |
0 |
291005 |
291005 |
0.66 % |
12/02/2021 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
2430198 |
0 |
2430198 |
2430198 |
5.5 % |
12/02/2021 |
Deerfield Management Company, L.P. |
Delaware |
0 |
2721203 |
0 |
2721203 |
2721203 |
6.16 % |
12/02/2021 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
291005 |
0 |
291005 |
291005 |
0.66 % |
12/02/2021 |
Deerfield Partners, L.P. |
Delaware |
0 |
2430198 |
0 |
2430198 |
2430198 |
5.5 % |
12/02/2021 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
291005 |
0 |
291005 |
291005 |
0.66 % |
12/02/2021 |
James E. Flynn |
United States |
0 |
2721203 |
0 |
2721203 |
2721203 |
6.16 % |
12/02/2021 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
2430198 |
0 |
2430198 |
2430198 |
5.5 % |
12/02/2021 |
Deerfield Management Company, L.P. |
Delaware |
0 |
2721203 |
0 |
2721203 |
2721203 |
6.16 % |
12/02/2021 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
291005 |
0 |
291005 |
291005 |
0.66 % |
12/02/2021 |
Deerfield Partners, L.P. |
Delaware |
0 |
2430198 |
0 |
2430198 |
2430198 |
5.5 % |
12/02/2021 |
James E. Flynn |
United States |
0 |
2721203 |
0 |
2721203 |
2721203 |
6.16 % |
12/02/2021 |
Wellington Management Group LLP |
Massachusetts |
0 |
1925212 |
0 |
2101227 |
2101227 |
4.75 % |
04/02/2021 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
1925212 |
0 |
2101227 |
2101227 |
4.75 % |
04/02/2021 |
Wellington Group Holdings LLP |
Delaware |
0 |
1925212 |
0 |
2101227 |
2101227 |
4.75 % |
04/02/2021 |
BlackRock, Inc. |
Delaware |
2700024 |
0 |
2731106 |
0 |
2731106 |
6.2 % |
01/02/2021 |
Janus Henderson Group plc EIN |
Jersey, Channel Islands |
0 |
4415469 |
0 |
4415469 |
4415469 |
10 % |
11/05/2020 |
PRIMECAP Management Company |
|
|
|
|
|
3542591 |
8.04 % |
24/04/2020 |
S Deerfield Partners, L.P. |
Delaware |
0 |
3998286 |
0 |
3998286 |
3998286 |
9.1 % |
13/02/2020 |
S Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
291005 |
0 |
291005 |
291005 |
0.66 % |
13/02/2020 |
S James E. Flynn |
United States |
0 |
4289291 |
0 |
4289291 |
4289291 |
9.76 % |
13/02/2020 |
S Deerfield Mgmt, L.P. |
Delaware |
0 |
3998286 |
0 |
3998286 |
3998286 |
9.1 % |
13/02/2020 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
4289291 |
0 |
4289291 |
4289291 |
9.76 % |
13/02/2020 |
S Deerfield Mgmt III, L.P. |
Delaware |
0 |
291005 |
0 |
291005 |
291005 |
0.66 % |
13/02/2020 |
TRV GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2020 |
Robert I. Tepper |
United States |
210247 |
0 |
210247 |
0 |
210247 |
0.5 % |
05/02/2020 |
Kevin Starr |
United States |
323526 |
0 |
323526 |
0 |
323526 |
0.7 % |
05/02/2020 |
Third Rock Ventures GP, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2020 |
Third Rock Ventures, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
05/02/2020 |
Mark Levin |
United States |
223527 |
0 |
223527 |
0 |
223527 |
0.5 % |
05/02/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
3082138 |
0 |
3320751 |
3320751 |
7.56 % |
28/01/2020 |
Wellington Group Holdings LLP |
Delaware |
0 |
3082138 |
0 |
3320751 |
3320751 |
7.56 % |
28/01/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3082138 |
0 |
3320751 |
3320751 |
7.56 % |
28/01/2020 |
Wellington Management Company LLP |
Delaware |
0 |
3026983 |
0 |
3186449 |
3186449 |
7.25 % |
28/01/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
3082138 |
0 |
3320751 |
3320751 |
7.56 % |
28/01/2020 |
Wellington Group Holdings LLP |
Delaware |
0 |
3082138 |
0 |
3320751 |
3320751 |
7.56 % |
28/01/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3082138 |
0 |
3320751 |
3320751 |
7.56 % |
28/01/2020 |
Wellington Management Company LLP |
Delaware |
0 |
3026983 |
0 |
3186449 |
3186449 |
7.25 % |
28/01/2020 |
RA Capital Management, LLC |
Massachusetts |
0 |
5422312 |
0 |
5422312 |
5422312 |
12.7 % |
18/10/2019 |
Peter Kolchinsky |
United States |
0 |
5422312 |
0 |
5422312 |
5422312 |
12.7 % |
18/10/2019 |
RA Capital Management, LLC |
Massachusetts |
0 |
5422312 |
0 |
5422312 |
5422312 |
12.7 % |
18/10/2019 |
Peter Kolchinsky |
United States |
0 |
5422312 |
0 |
5422312 |
5422312 |
12.7 % |
18/10/2019 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
291005 |
0 |
291005 |
291005 |
0.84 % |
19/08/2019 |
Deerfield Partners, L.P. |
Delaware |
0 |
1458000 |
0 |
1458000 |
1458000 |
4.22 % |
19/08/2019 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
291005 |
0 |
291005 |
291005 |
0.84 % |
19/08/2019 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1749005 |
0 |
1749005 |
1749005 |
5.07 % |
19/08/2019 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
1458000 |
0 |
1458000 |
1458000 |
4.22 % |
19/08/2019 |
James E. Flynn |
United States |
0 |
1749005 |
0 |
1749005 |
1749005 |
5.07 % |
19/08/2019 |
Deerfield Partners, L.P. |
Delaware |
0 |
1458000 |
0 |
1458000 |
1458000 |
4.22 % |
19/08/2019 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
291005 |
0 |
291005 |
291005 |
0.84 % |
19/08/2019 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1749005 |
0 |
1749005 |
1749005 |
5.07 % |
19/08/2019 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
1458000 |
0 |
1458000 |
1458000 |
4.22 % |
19/08/2019 |
James E. Flynn |
United States |
0 |
1749005 |
0 |
1749005 |
1749005 |
5.07 % |
19/08/2019 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
291005 |
0 |
291005 |
291005 |
0.84 % |
19/08/2019 |
Peter Kolchinsky |
United States |
0 |
1950332 |
0 |
1950332 |
1950332 |
5.7 % |
14/02/2019 |
RA Capital Management, LLC |
Massachusetts |
0 |
1950332 |
0 |
1950332 |
1950332 |
5.7 % |
14/02/2019 |
Baker Bros. Advisors LP |
Delaware |
2708200 |
0 |
2708200 |
0 |
2708200 |
7.9 % |
13/02/2019 |
Baker Bros. Advisors LLC |
Delaware |
2708200 |
0 |
2708200 |
0 |
2708200 |
7.9 % |
13/02/2019 |
Felix J. Baker |
United States |
2708200 |
0 |
2708200 |
0 |
2708200 |
7.9 % |
13/02/2019 |
Julian C. Baker |
United States |
2708200 |
0 |
2708200 |
0 |
2708200 |
7.9 % |
13/02/2019 |
Julian C. Baker |
United States |
2049020 |
0 |
2049020 |
0 |
2049020 |
7.5 % |
13/02/2018 |
Baker Bros. Advisors LP |
Delaware |
2049020 |
0 |
2049020 |
0 |
2049020 |
7.5 % |
13/02/2018 |
Baker Bros. Advisors LLC |
Delaware |
2049020 |
0 |
2049020 |
0 |
2049020 |
7.5 % |
13/02/2018 |
Felix J. Baker |
United States |
2049020 |
0 |
2049020 |
0 |
2049020 |
7.5 % |
13/02/2018 |
Mark Levin |
United States |
0 |
3981437 |
0 |
3981437 |
0 |
14.6 % |
13/02/2018 |
Third Rock Ventures GP, L.P. |
Delaware |
0 |
3981437 |
0 |
3981437 |
3981437 |
14.6 % |
13/02/2018 |
Third Rock Ventures, L.P. |
Delaware |
0 |
3981437 |
0 |
3981437 |
3981437 |
14.6 % |
13/02/2018 |
TRV GP, LLC |
Delaware |
0 |
3981437 |
0 |
3981437 |
3981437 |
14.6 % |
13/02/2018 |
Robert I. Tepper |
United States |
0 |
3981437 |
0 |
3981437 |
0 |
14.6 % |
13/02/2018 |
Kevin Starr |
United States |
0 |
3981437 |
0 |
3981437 |
0 |
14.6 % |
13/02/2018 |
PFIZER INC. |
Delaware |
1427639 |
7 |
1427639 |
0 |
1427639 |
5.4 % |
18/10/2017 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
468505 |
0 |
468505 |
468505 |
1.8 % |
10/10/2017 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
468505 |
0 |
468505 |
468505 |
1.8 % |
10/10/2017 |
James E. Flynn |
United States |
0 |
937010 |
0 |
937010 |
937010 |
3.59 % |
10/10/2017 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
468505 |
0 |
468505 |
468505 |
1.8 % |
10/10/2017 |
Deerfield Management Company, L.P. |
Delaware |
0 |
937010 |
0 |
937010 |
937010 |
3.59 % |
10/10/2017 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
468505 |
0 |
468505 |
468505 |
1.8 % |
10/10/2017 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
468505 |
0 |
468505 |
468505 |
1.8 % |
10/10/2017 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
468505 |
0 |
468505 |
468505 |
1.8 % |
10/10/2017 |
Deerfield Management Company, L.P. |
Delaware |
0 |
937010 |
0 |
937010 |
937010 |
3.59 % |
10/10/2017 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
468505 |
0 |
468505 |
468505 |
1.8 % |
10/10/2017 |
James E. Flynn |
United States |
0 |
937010 |
0 |
937010 |
937010 |
3.59 % |
10/10/2017 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
468505 |
0 |
468505 |
468505 |
1.8 % |
10/10/2017 |