| Point72 Asset Management, L.P. |
Delaware |
0 |
5791505 |
0 |
0 |
5791505 |
7.7 % |
05/04/2024 |
| Steven A. Cohen |
Delaware |
0 |
5932908 |
0 |
0 |
5932908 |
7.9 % |
05/04/2024 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
141403 |
0 |
0 |
141403 |
0.2 % |
05/04/2024 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
5791505 |
0 |
0 |
5791505 |
7.7 % |
05/04/2024 |
| Israel A. Englander |
Delaware |
0 |
3451825 |
0 |
3451825 |
3451825 |
5.7 % |
17/01/2024 |
| Millennium Management LLC |
Delaware |
0 |
3451825 |
0 |
3451825 |
3451825 |
5.7 % |
17/01/2024 |
| Millennium Group Management LLC |
Delaware |
0 |
3451825 |
0 |
3451825 |
3451825 |
5.7 % |
17/01/2024 |
| Integrated Core Strategies (US) LLC |
Delaware |
0 |
3106844 |
0 |
3106844 |
3106844 |
5.1 % |
17/01/2024 |
| Robert Atchinson |
Delaware |
0 |
3549320 |
0 |
0 |
3549320 |
5.86 % |
10/10/2023 |
| Phillip Gross |
Delaware |
0 |
3549320 |
0 |
0 |
3549320 |
5.86 % |
10/10/2023 |
| Adage Capital Management, L.P. |
Delaware |
0 |
3549320 |
0 |
0 |
3549320 |
5.86 % |
10/10/2023 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
3549320 |
0 |
0 |
3549320 |
5.86 % |
10/10/2023 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
3549320 |
0 |
0 |
3549320 |
5.86 % |
10/10/2023 |
| David Rosen |
United States of America |
0 |
3211872 |
0 |
0 |
3211872 |
5.59 % |
10/02/2023 |
| LP |
State of Delaware |
0 |
3211872 |
0 |
0 |
3211872 |
5.59 % |
10/02/2023 |
| Millennium Management LLC |
|
0 |
2422673 |
0 |
2422673 |
2422673 |
5.2 % |
08/07/2022 |
| Israel A. Englander |
|
0 |
2422673 |
0 |
2422673 |
2422673 |
5.2 % |
08/07/2022 |
| Millennium Group Management LLC |
|
0 |
2422673 |
0 |
2422673 |
2422673 |
5.2 % |
08/07/2022 |
| Eventide Asset Management, LLC |
Delaware |
2708975 |
0 |
2708975 |
0 |
2708975 |
5.9 % |
14/02/2022 |
| Averill Master Fund, Ltd. |
|
0 |
2473795 |
0 |
2473795 |
2473795 |
5.4 % |
11/02/2022 |
| Suvretta Capital Management, LLC |
|
0 |
2473795 |
0 |
2473795 |
2473795 |
5.4 % |
11/02/2022 |
| Aaron Cowen |
|
0 |
2473795 |
0 |
2473795 |
2473795 |
5.4 % |
11/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
3558267 |
0 |
3700043 |
0 |
3700043 |
8 % |
02/02/2022 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
2951959 |
2951959 |
6.4 % |
18/01/2022 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
156738 |
156738 |
1 % |
18/01/2022 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
3160416 |
3160416 |
6.8 % |
18/01/2022 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1242996 |
1242996 |
2.7 % |
18/01/2022 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1242996 |
1242996 |
2.7 % |
18/01/2022 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
1708963 |
1708963 |
3.7 % |
18/01/2022 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1708963 |
1708963 |
3.7 % |
18/01/2022 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
156738 |
156738 |
1 % |
18/01/2022 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
3160416 |
3160416 |
6.8 % |
18/01/2022 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
3160416 |
3160416 |
6.8 % |
18/01/2022 |
| Averill Master Fund, Ltd. |
Delaware |
0 |
2408395 |
0 |
2408395 |
2408395 |
5.2 % |
10/12/2021 |
| Aaron Cowen |
Delaware |
0 |
2408395 |
0 |
2408395 |
2408395 |
5.2 % |
10/12/2021 |
| Suvretta Capital Management, LLC |
Delaware |
0 |
2408395 |
0 |
2408395 |
2408395 |
5.2 % |
10/12/2021 |
| BRISTOL-MYERS SQUIBB COMPANY
22-0790350 |
Delaware, U.S.A. |
0 |
1726197 |
0 |
1726197 |
1726197 |
3.8 % |
05/04/2021 |
| CELGENE CORPORATION
22-2711928 |
Delaware, U.S.A. |
0 |
1726197 |
0 |
1726197 |
1726197 |
3.8 % |
05/04/2021 |
| 72-1614961 |
Delaware |
0 |
1144979 |
0 |
0 |
1144979 |
2.5 % |
16/02/2021 |
| 66-0677421 |
Delaware |
0 |
1144979 |
0 |
0 |
1144979 |
2.5 % |
16/02/2021 |
| Ridgeback Capital Management LLC 42-1684320 |
Delaware |
0 |
1144979 |
0 |
0 |
1144979 |
2.5 % |
16/02/2021 |
| Biotechnology Value Fund II, L.P. |
|
0 |
0 |
0 |
719659 |
719659 |
1.6 % |
12/02/2021 |
| BVF II GP LLC |
|
0 |
0 |
0 |
719659 |
719659 |
1.6 % |
12/02/2021 |
| Biotechnology Value Trading Fund OS LP |
|
0 |
0 |
0 |
119184 |
119184 |
1 % |
12/02/2021 |
| BVF GP HOLDINGS LLC |
|
0 |
0 |
0 |
1699111 |
1699111 |
3.8 % |
12/02/2021 |
| Mark N. Lampert |
|
0 |
0 |
0 |
1854162 |
1854162 |
4.1 % |
12/02/2021 |
| BVF Inc. |
|
0 |
0 |
0 |
1854162 |
1854162 |
4.1 % |
12/02/2021 |
| BVF Partners L.P. |
|
0 |
0 |
0 |
1854162 |
1854162 |
4.1 % |
12/02/2021 |
| Biotechnology Value Fund, L.P. |
|
0 |
0 |
0 |
979452 |
979452 |
2.2 % |
12/02/2021 |
| BVF Partners OS Ltd. |
|
0 |
0 |
0 |
119184 |
119184 |
1 % |
12/02/2021 |
| BVF I GP LLC |
|
0 |
0 |
0 |
979452 |
979452 |
2.2 % |
12/02/2021 |
| Eventide Asset Management, LLC |
Delaware |
2370975 |
0 |
2370975 |
0 |
2370975 |
5.3 % |
12/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
2630583 |
0 |
2717929 |
0 |
2717929 |
6.2 % |
02/02/2021 |
| Oleg Nodelman |
Delaware |
0 |
2328492 |
0 |
2328492 |
2328492 |
11 % |
28/08/2020 |
| EcoR1 Capital, LLC |
Delaware |
0 |
2328492 |
0 |
2328492 |
2328492 |
11 % |
28/08/2020 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
1971034 |
0 |
1971034 |
1971034 |
11 % |
28/08/2020 |
| Ridgeback Capital Investments Ltd. 00-0000000 |
Cayman Islands |
0 |
2014687 |
0 |
2014687 |
2014687 |
5.3 % |
24/08/2020 |
| Ridgeback Capital Management LLC 42-1684320 |
Delaware |
0 |
2014687 |
0 |
2014687 |
2014687 |
5.3 % |
24/08/2020 |
| Ridgeback Capital Investments L.P. 00-0000000 |
Cayman Islands |
0 |
2014687 |
0 |
2014687 |
2014687 |
5.3 % |
24/08/2020 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
160472 |
160472 |
1 % |
22/05/2020 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
160472 |
160472 |
1 % |
22/05/2020 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
924337 |
934337 |
2.6 % |
22/05/2020 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
2368392 |
2368392 |
6.6 % |
22/05/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1238203 |
1238203 |
3.5 % |
22/05/2020 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
1238203 |
1238203 |
3.5 % |
22/05/2020 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
924337 |
924337 |
2.6 % |
22/05/2020 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
2368392 |
2368392 |
6.6 % |
22/05/2020 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
2368392 |
2368392 |
6.6 % |
22/05/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
2162540 |
2162540 |
6 % |
22/05/2020 |
| John G. Freund |
|
0 |
1960053 |
0 |
0 |
1960053 |
8.5 % |
12/02/2020 |
| Skyline Venture Partners V, L.P. |
|
0 |
1960053 |
0 |
0 |
1960053 |
8.5 % |
12/02/2020 |
| Yasunori Kaneko |
|
0 |
1960053 |
0 |
0 |
1960053 |
8.5 % |
12/02/2020 |
| Skyline Venture Management V, LLC |
|
0 |
1960053 |
0 |
0 |
1960053 |
8.5 % |
12/02/2020 |
| CELGENE |
Delaware, U.S.A. |
1726197 |
0 |
1726197 |
0 |
1726197 |
7.5 % |
10/02/2020 |
| LV Management Group, LLC |
Delaware |
0 |
1540813 |
0 |
1540813 |
1540813 |
6.7 % |
14/02/2019 |
| Steven E. Hall, Ph.D. |
United States |
0 |
1540813 |
0 |
1540813 |
1540813 |
6.7 % |
14/02/2019 |
| Lilly Ventures Fund I, LLC |
Delaware |
0 |
1540813 |
0 |
1540813 |
1540813 |
6.7 % |
14/02/2019 |
| Armen B. Shanafelt, Ph.D. |
United States |
0 |
1540813 |
0 |
1540813 |
1540813 |
6.7 % |
14/02/2019 |
| S. Edward Torres |
United States |
0 |
1540813 |
0 |
1540813 |
1540813 |
6.7 % |
14/02/2019 |
| Eventide Asset Management, LLC |
Delaware |
1244895 |
0 |
1244895 |
0 |
1244895 |
5.4 % |
13/02/2019 |
| Alta Partners VIII, L.P. |
Delaware |
1944901 |
0 |
1944901 |
0 |
1944901 |
8.5 % |
12/02/2019 |
| Alta Partners Management VIII, LLC |
Delaware |
0 |
1944901 |
0 |
1944901 |
1944901 |
8.5 % |
12/02/2019 |
| Farah Champsi |
Delaware |
0 |
1944901 |
0 |
1944901 |
1944901 |
8.5 % |
12/02/2019 |
| Daniel Janney |
Delaware |
3615 |
1944901 |
3615 |
1944901 |
1948516 |
8.5 % |
12/02/2019 |
| Guy Nohra |
Delaware |
0 |
1944901 |
0 |
1944901 |
1944901 |
8.5 % |
12/02/2019 |
| International Life Sciences Fund III (GP), L.P. |
DELAWARE |
942789 |
0 |
942789 |
0 |
942789 |
4.1 % |
09/10/2018 |
| International Life Sciences Fund III (LP1), L.P. |
DELAWARE |
942789 |
0 |
942789 |
0 |
942789 |
4.1 % |
09/10/2018 |
| L.P. |
DELAWARE |
942789 |
0 |
942789 |
0 |
942789 |
4.1 % |
09/10/2018 |
| SV Life Sciences Fund V, L.P. |
DELAWARE |
881751 |
0 |
881751 |
0 |
881751 |
3.9 % |
09/10/2018 |
| Co-Investment, |
DELAWARE |
942789 |
0 |
942789 |
0 |
942789 |
4.1 % |
09/10/2018 |
| SV Life Sciences Fund V Strategic Partners, L.P. |
DELAWARE |
881751 |
0 |
881751 |
0 |
881751 |
3.9 % |
09/10/2018 |
| SVLSF V, LLC |
DELAWARE |
881751 |
0 |
881751 |
0 |
881751 |
3.9 % |
09/10/2018 |
| ILSF III, LLC |
DELAWARE |
942789 |
0 |
942789 |
0 |
942789 |
4.1 % |
09/10/2018 |
| SV Life Sciences Fund V (GP), L.P. |
DELAWARE |
881751 |
0 |
881751 |
0 |
881751 |
3.9 % |
09/10/2018 |
| Merck & Co., Inc. |
New Jersey |
2723509 |
0 |
2723509 |
0 |
2723509 |
11.9 % |
04/10/2018 |
| Merck Sharp & Dohme Corp. |
New Jersey |
2723509 |
0 |
2723509 |
0 |
2723509 |
11.9 % |
04/10/2018 |
| 2. |
Delaware |
0 |
1748421 |
0 |
1748421 |
10 |
7.7 % |
04/10/2018 |
| 2. |
Delaware |
0 |
1748421 |
0 |
1748421 |
10 |
7.7 % |
04/10/2018 |
| 2. |
Delaware |
0 |
1748421 |
0 |
1748421 |
10 |
7.7 % |
04/10/2018 |
| 2. |
Delaware |
0 |
1748421 |
0 |
1748421 |
10 |
7.7 % |
04/10/2018 |