| Bradley L. Radoff |
USA |
0 |
0 |
629211 |
0 |
629211 |
5.4 % |
18/04/2024 |
| Funicular Funds, LP |
|
0 |
0 |
240 |
0 |
3312219 |
36 % |
16/02/2024 |
| Steven Boyd |
Delaware |
0 |
1285542 |
0 |
0 |
1285542 |
9.99 % |
14/02/2024 |
| Armistice Capital, LLC |
Delaware |
0 |
1285542 |
0 |
0 |
1285542 |
9.99 % |
14/02/2024 |
| OrbiMed Advisors LLC |
Delaware |
0 |
401998 |
0 |
10 |
401998 |
4.7 % |
04/10/2023 |
| OrbiMed Capital GP VI LLC |
Delaware |
0 |
290885 |
0 |
10 |
290885 |
3.4 % |
04/10/2023 |
| OrbiMed Genesis GP LLC |
Delaware |
0 |
111113 |
0 |
10 |
111113 |
1.3 % |
04/10/2023 |
| RA Capital Management, L.P. |
United States of America |
0 |
6666666 |
0 |
0 |
6666666 |
9.9 % |
01/10/2021 |
| Rajeev Shah |
United States of America |
0 |
6666666 |
0 |
0 |
6666666 |
9.9 % |
01/10/2021 |
| RA Capital Healthcare Fund, L.P. |
United States of America |
0 |
6666666 |
0 |
0 |
6666666 |
9.9 % |
01/10/2021 |
| Peter Kolchinsky |
United States of America |
0 |
6666666 |
0 |
0 |
6666666 |
9.9 % |
01/10/2021 |
| FMR LLC |
Delaware |
1625976 |
0 |
7448676 |
0 |
7448676 |
15.459 % |
10/05/2021 |
| Marc Schneidman |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| Aquilo Capital Management, LLC |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| Ginkgo Bioworks, Inc. |
Delaware |
8888888 |
0 |
8888888 |
0 |
8888888 |
19.99 % |
21/06/2019 |
| Mr. Marc Schneidman |
United States |
0 |
1334179 |
0 |
0 |
1334179 |
5.2 % |
14/02/2019 |
| Aquilo Capital Management, LLC |
California |
0 |
1334179 |
0 |
0 |
1334179 |
5.2 % |
14/02/2019 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
3301964 |
0 |
0 |
3563296 |
14 % |
10/05/2018 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
3301964 |
0 |
0 |
3563296 |
14 % |
10/05/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3301964 |
0 |
0 |
3563296 |
14 % |
10/05/2018 |
| Wellington Management Company LLP |
Massachusetts |
0 |
3301964 |
0 |
0 |
3436984 |
13.5 % |
10/05/2018 |
| Hawkes Bay Master Investors (Cayman) L.P. |
Cayman Islands |
0 |
1350075 |
0 |
0 |
1350075 |
5.3 % |
16/04/2018 |
| ( 13-5315170 |
Delaware |
356797 |
0 |
356797 |
0 |
356797 |
1.67 % |
13/02/2018 |
| OrbiMed Advisors LLC |
Delaware |
0 |
1314996 |
0 |
10 |
1314996 |
8.08 % |
07/09/2017 |
| Samuel D. Isaly |
United States |
0 |
1314996 |
0 |
10 |
1314996 |
8.08 % |
07/09/2017 |
| OrbiMed Capital GP VI LLC |
Delaware |
0 |
1314996 |
0 |
10 |
1314996 |
8.08 % |
07/09/2017 |
| James E. Flynn |
United States |
0 |
850143 |
0 |
0 |
850143 |
5.22 % |
05/09/2017 |
| Company, L.P. |
Delaware |
0 |
850143 |
0 |
0 |
850143 |
5.22 % |
05/09/2017 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
850143 |
0 |
0 |
850143 |
5.22 % |
05/09/2017 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
850143 |
0 |
0 |
850143 |
5.22 % |
05/09/2017 |
| Select Biotechnology Portfolio |
Massachusetts |
1146800 |
0 |
0 |
0 |
1146800 |
5.505 % |
12/02/2016 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1428500 |
0 |
1428500 |
6.857 % |
12/02/2016 |
| FMR LLC |
Delaware |
0 |
0 |
1428500 |
0 |
1428500 |
6.857 % |
12/02/2016 |
| PORTFOLIO SERVICES LTD. |
CAYMAN ISLANDS |
0 |
1118741 |
0 |
1118741 |
1118741 |
5.4 % |
15/10/2015 |
| KENNETH B. DART |
CAYMAN ISLANDS |
0 |
1118741 |
0 |
1118741 |
1118741 |
5.4 % |
15/10/2015 |
| EASTERN CAPITAL LIMITED |
CAYMAN ISLANDS |
0 |
1118741 |
0 |
1118741 |
1118741 |
5.4 % |
15/10/2015 |
| ( 13-5315170 |
Delaware |
2489364 |
0 |
2489364 |
0 |
2489364 |
11 % |
14/10/2015 |
| NEA Partners 14, L.P. |
Cayman Islands |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| NEA 14 GP, LTD |
Cayman Islands |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| Peter J. Barris |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| Forest Baskett |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| Patrick J. Kerins |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| Scott D. Sandell |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| Peter W. Sonsini |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| Krishna S. Kolluri |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| Anthony A. Florence, Jr. |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| David M. Mott |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| New Enterprise Associates 14, L.P. |
Cayman Islands |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| Harry R. Weller |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| M. James Barrett |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| Ravi Viswanathan |
United States citizen |
0 |
2971517 |
0 |
10 |
2971517 |
14.8 % |
14/10/2015 |
| Dr. James I. Healy (“Healy”) |
U.S. Citizen |
0 |
2974811 |
0 |
10 |
2974811 |
14.17 % |
08/10/2015 |
| Sofinnova Venture Partners VIII, L.P. (“SVP VIII”) |
Delaware |
2974811 |
0 |
2974811 |
10 |
2974811 |
14.17 % |
08/10/2015 |
| Sofinnova Management VIII, L.L.C. (“SM VIII”) |
Delaware |
2974811 |
0 |
2974811 |
0 |
2974811 |
14.17 % |
08/10/2015 |
| Dr. Srinivas Akkaraju (“Akkaraju”) |
U.S. Citizen |
0 |
2974811 |
0 |
10 |
2974811 |
14.17 % |
08/10/2015 |
| Dr. Michael F. Powell (“Powell”) |
U.S. Citizen |
0 |
2974811 |
1999 |
10 |
2976810 |
14.18 % |
08/10/2015 |
| Dr. Anand Mehra (“Mehra”) |
U.S. Citizen |
0 |
2974811 |
0 |
10 |
2974811 |
14.17 % |
08/10/2015 |
| Cancer Prevention and Research Institute of Texas |
Texas |
2395010 |
0 |
2395010 |
0 |
2395010 |
11.9 % |
08/10/2015 |
