| Blue Owl Capital Holdings LP |
Delaware |
1493252 |
0 |
1493252 |
0 |
1493252 |
5.74 % |
14/02/2024 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
1471771 |
0 |
0 |
1471771 |
5.7 % |
02/01/2024 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
1471771 |
0 |
0 |
1471771 |
5.7 % |
02/01/2024 |
| Steven A. Cohen |
Delaware |
0 |
1471771 |
0 |
0 |
1471771 |
5.7 % |
02/01/2024 |
| Samsara BioCapital, L.P. |
Delaware |
0 |
1588564 |
0 |
10 |
1588564 |
7.4 % |
20/10/2023 |
| Srinivas Akkaraju |
United States |
16982 |
1588564 |
16982 |
10 |
1605546 |
7.5 % |
20/10/2023 |
| Samsara BioCapital GP, LLC |
Delaware |
0 |
1588564 |
0 |
10 |
1588564 |
7.4 % |
20/10/2023 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1253828 |
0 |
0 |
1253828 |
6.04 % |
25/01/2023 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1253828 |
0 |
0 |
1253828 |
6.04 % |
25/01/2023 |
| Robert Atchinson |
United States |
0 |
1253828 |
0 |
0 |
1253828 |
6.04 % |
25/01/2023 |
| Phillip Gross |
United States |
0 |
1253828 |
0 |
0 |
1253828 |
6.04 % |
25/01/2023 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
1253828 |
0 |
0 |
1253828 |
6.04 % |
25/01/2023 |
| Avidity Private Master Fund I LP |
Delaware |
0 |
1169610 |
0 |
1169610 |
1169610 |
5.6 % |
20/09/2022 |
| Avidity Partners Management LP |
Delaware |
0 |
2120000 |
0 |
2120000 |
2120000 |
9.9 % |
20/09/2022 |
| Avidity Partners Management (GP) LLC |
Delaware |
0 |
2120000 |
0 |
2120000 |
2120000 |
9.9 % |
20/09/2022 |
| Avidity Capital Partners Fund (GP) LP |
Delaware |
0 |
2120000 |
0 |
2120000 |
2120000 |
9.9 % |
20/09/2022 |
| Michael Gregory |
Delaware |
0 |
2120000 |
0 |
2120000 |
2120000 |
9.9 % |
20/09/2022 |
| Avidity Capital Partners (GP) LLC |
Delaware |
0 |
2120000 |
0 |
2120000 |
2120000 |
9.9 % |
20/09/2022 |
| David Witzke |
Delaware |
0 |
2120000 |
0 |
2120000 |
2120000 |
9.9 % |
20/09/2022 |
| Deep Track Capital, LP |
Delaware |
0 |
699281 |
0 |
0 |
699281 |
9.99 % |
19/09/2022 |
| David Kroin |
United States |
0 |
699281 |
0 |
0 |
699281 |
9.99 % |
19/09/2022 |
| Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
699281 |
0 |
0 |
699281 |
9.99 % |
19/09/2022 |
| Tyme Technologies, Inc. |
|
0 |
17460552 |
0 |
11 |
17460552 |
28 % |
13/07/2022 |
| Syros Pharmaceuticals, Inc. |
|
0 |
17819723 |
0 |
17819723 |
17819723 |
9.9 % |
13/07/2022 |
| (1) BlackRock, Inc. |
Delaware |
1523266 |
0 |
1524309 |
0 |
1524309 |
2.4 % |
08/07/2022 |
| Nikko Asset Management Americas, Inc. |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Invus Public Equities Advisors, LLC |
|
3500000 |
0 |
3500000 |
0 |
3500000 |
5.6 % |
11/02/2022 |
| Artal International S.C.A. |
|
3500000 |
0 |
3500000 |
0 |
3500000 |
5.6 % |
11/02/2022 |
| Artal International Management S.A. |
|
3500000 |
0 |
3500000 |
0 |
3500000 |
5.6 % |
11/02/2022 |
| Artal Group S.A. |
|
3500000 |
0 |
3500000 |
0 |
3500000 |
5.6 % |
11/02/2022 |
| Westend S.A. |
|
3500000 |
0 |
3500000 |
0 |
3500000 |
5.6 % |
11/02/2022 |
| Stichting Administratiekantoor Westend |
|
3500000 |
0 |
3500000 |
0 |
3500000 |
5.6 % |
11/02/2022 |
| Mr. Amaury Wittouck |
|
3500000 |
0 |
3500000 |
0 |
3500000 |
5.6 % |
11/02/2022 |
| Invus Public Equities, L.P. |
|
3500000 |
0 |
3500000 |
0 |
3500000 |
5.6 % |
11/02/2022 |
| Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
0 |
0 |
0 |
0 |
0 % |
04/02/2022 |
| Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
0 |
0 |
0 |
0 |
0 % |
04/02/2022 |
| ARK
Investment Management LLC |
Delaware, United States |
7848713 |
186593 |
8589598 |
0 |
8589598 |
13.94 % |
10/03/2021 |
| Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
4381992 |
0 |
0 |
4381992 |
9.57 % |
05/02/2021 |
| Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
4381992 |
0 |
0 |
4381992 |
9.57 % |
05/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
3305388 |
0 |
3325560 |
0 |
3325560 |
7.3 % |
01/02/2021 |
| Ally Bridge MedAlpha Management GP, LLC |
Cayman Islands |
0 |
3033125 |
0 |
3033125 |
3033125 |
5.4 % |
18/12/2020 |
| Fan Yu |
Cayman Islands |
0 |
3033125 |
0 |
3033125 |
3033125 |
5.4 % |
18/12/2020 |
| ABG Management Ltd. |
Cayman Islands |
0 |
3033125 |
0 |
3033125 |
3033125 |
5.4 % |
18/12/2020 |
| Ally Bridge Group (NY) LLC |
Cayman Islands |
0 |
3033125 |
0 |
3033125 |
3033125 |
5.4 % |
18/12/2020 |
| Ally Bridge MedAlpha Management L.P. |
Cayman Islands |
0 |
3033125 |
0 |
3033125 |
3033125 |
5.4 % |
18/12/2020 |
| Ally Bridge MedAlpha Master Fund L.P. |
Cayman Islands |
0 |
3033125 |
0 |
3033125 |
3033125 |
5.4 % |
18/12/2020 |
| Bain Capital Life Sciences Fund II, L.P. |
Cayman Islands |
0 |
5785036 |
0 |
5785036 |
10 |
9.99 % |
14/12/2020 |
| Nikko Asset Management Americas, Inc. |
USA |
0 |
3133118 |
0 |
4974662 |
4974662 |
11.72 % |
12/02/2020 |
| Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
4974662 |
0 |
4974662 |
4974662 |
11.72 % |
12/02/2020 |
| (“SMTH”) |
Japan |
0 |
4974662 |
0 |
4974662 |
4974662 |
11.72 % |
12/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
2827572 |
0 |
2863412 |
0 |
2863412 |
6.7 % |
07/02/2020 |
| Sumitomo Mitsui Trust Holdings, Inc. (“SMTH”) |
Japan |
0 |
4305724 |
0 |
0 |
4305724 |
10.15 % |
09/09/2019 |
| Nikko Asset Management Co., Ltd. (“NAM”) |
Japan |
0 |
4305724 |
0 |
0 |
4305724 |
10.15 % |
09/09/2019 |
| Nikko Asset Management Americas, Inc. |
USA |
0 |
2460653 |
0 |
4305724 |
4305724 |
10.15 % |
06/09/2019 |
| Company, L.P. |
Delaware |
0 |
2033559 |
0 |
0 |
2033559 |
4.76 % |
09/04/2019 |
| James E. Flynn |
United States |
0 |
2033559 |
0 |
0 |
2033559 |
4.76 % |
09/04/2019 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
1651252 |
0 |
0 |
1651252 |
3.88 % |
09/04/2019 |
| Fund, L.P. |
Delaware |
0 |
382307 |
0 |
0 |
382307 |
0.9 % |
09/04/2019 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
382307 |
0 |
0 |
382307 |
0.9 % |
09/04/2019 |
| Mgmt III, L.P. |
Delaware |
0 |
1651252 |
0 |
0 |
1651252 |
3.88 % |
09/04/2019 |
| (1) BlackRock, Inc. |
Delaware |
1948884 |
0 |
1986130 |
0 |
1986130 |
5.9 % |
07/02/2019 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
1268945 |
0 |
0 |
1268945 |
5.43 % |
14/02/2017 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
543833 |
0 |
0 |
543833 |
2.33 % |
14/02/2017 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
1268945 |
0 |
0 |
1268945 |
5.43 % |
14/02/2017 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1812778 |
0 |
0 |
1812778 |
7.75 % |
14/02/2017 |
| James E. Flynn |
United States |
0 |
1812778 |
0 |
0 |
1812778 |
7.75 % |
14/02/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
543833 |
0 |
0 |
543833 |
2.33 % |
14/02/2017 |
| FMR LLC |
Delaware |
436300 |
0 |
3027285 |
0 |
3027285 |
13.3 % |
11/07/2016 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
628566 |
0 |
0 |
628566 |
2.69 % |
06/07/2016 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
1466654 |
0 |
0 |
1466654 |
6.28 % |
06/07/2016 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
1466654 |
0 |
0 |
1466654 |
6.28 % |
06/07/2016 |
| James E. Flynn |
United States |
0 |
2095220 |
0 |
0 |
2095220 |
8.97 % |
06/07/2016 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
628566 |
0 |
0 |
628566 |
2.69 % |
06/07/2016 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
2095220 |
0 |
0 |
2095220 |
8.97 % |
06/07/2016 |