Armistice Capital, LLC |
Delaware |
0 |
44796 |
0 |
44796 |
0 |
4.99 % |
14/11/2024 |
Steven Boyd |
United States of America |
0 |
44796 |
0 |
44796 |
0 |
4.99 % |
14/11/2024 |
Millennium Management LLC |
Delaware |
0 |
41390 |
0 |
41390 |
41390 |
4.9 % |
19/09/2024 |
ICS Opportunities II LLC |
Cayman Islands |
0 |
40406 |
0 |
40406 |
40406 |
4.7 % |
19/09/2024 |
Millennium Group Management LLC |
Delaware |
0 |
41390 |
0 |
41390 |
41390 |
4.9 % |
19/09/2024 |
Israel A. Englander |
United States |
0 |
41390 |
0 |
41390 |
41390 |
4.9 % |
19/09/2024 |
Steven Boyd |
United States of America |
0 |
1827615 |
0 |
1827615 |
0 |
9.99 % |
14/02/2024 |
Armistice Capital, LLC |
Delaware |
0 |
1827615 |
0 |
1827615 |
0 |
9.99 % |
14/02/2024 |
BlackRock, Inc. |
Delaware |
2807174 |
0 |
2811074 |
0 |
2811074 |
1.7 % |
08/07/2022 |
BlackRock, Inc. |
Delaware |
10935122 |
0 |
11139459 |
0 |
11139459 |
6.8 % |
04/02/2022 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
03/01/2020 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
03/01/2020 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
03/01/2020 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
03/01/2020 |
Hal Mintz |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
03/01/2020 |
Hal Mintz |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
03/01/2020 |
Sabby Management, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
03/01/2020 |
Sabby Management, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
03/01/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3871219 |
0 |
4631533 |
4631533 |
5.63 % |
08/02/2019 |
Wellington Group Holdings LLP |
Delaware |
0 |
3871219 |
0 |
4631533 |
4631533 |
5.63 % |
08/02/2019 |
Wellington Management Group LLP |
Massachusetts |
0 |
3871219 |
0 |
4631533 |
4631533 |
5.63 % |
08/02/2019 |
Wellington Group Holdings LLP |
Delaware |
0 |
3871219 |
0 |
4631533 |
4631533 |
5.63 % |
08/02/2019 |
Wellington Management Group LLP |
Massachusetts |
0 |
3871219 |
0 |
4631533 |
4631533 |
5.63 % |
08/02/2019 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3871219 |
0 |
4631533 |
4631533 |
5.63 % |
08/02/2019 |
Wellington Management Company LLP |
Delaware |
0 |
3816489 |
0 |
4303452 |
4303452 |
5.23 % |
08/02/2019 |
Wellington Management Company LLP |
Delaware |
0 |
3816489 |
0 |
4303452 |
4303452 |
5.23 % |
08/02/2019 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
3000000 |
0 |
3000000 |
3000000 |
3.25 % |
04/02/2019 |
Sabby Management, LLC |
Delaware USA |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.42 % |
04/02/2019 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
2000000 |
0 |
2000000 |
2000000 |
2.17 % |
04/02/2019 |
Hal Mintz |
USA |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.42 % |
04/02/2019 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
3000000 |
0 |
3000000 |
3000000 |
3.25 % |
04/02/2019 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
2000000 |
0 |
2000000 |
2000000 |
2.17 % |
04/02/2019 |
Sabby Management, LLC |
Delaware USA |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.42 % |
04/02/2019 |
Hal Mintz |
USA |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.42 % |
04/02/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
554565 |
0 |
554565 |
0.728 % |
13/11/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
554565 |
0 |
554565 |
0.728 % |
13/11/2018 |
FMR LLC |
Delaware |
42044 |
0 |
554565 |
0 |
554565 |
0.728 % |
13/11/2018 |
FMR LLC |
Delaware |
42044 |
0 |
554565 |
0 |
554565 |
0.728 % |
13/11/2018 |
Wellington Group Holdings LLP |
Delaware |
0 |
6002838 |
0 |
6777154 |
6777154 |
10.12 % |
10/04/2018 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
6002838 |
0 |
6777154 |
6777154 |
10.12 % |
10/04/2018 |
Wellington Management Company LLP |
Delaware |
0 |
5948108 |
0 |
6452796 |
6452796 |
9.64 % |
10/04/2018 |
Wellington Management Group LLP |
Massachusetts |
0 |
6002838 |
0 |
6777154 |
6777154 |
10.12 % |
10/04/2018 |
Wellington Management Group LLP |
Massachusetts |
0 |
6002838 |
0 |
6777154 |
6777154 |
10.12 % |
10/04/2018 |
Wellington Group Holdings LLP |
Delaware |
0 |
6002838 |
0 |
6777154 |
6777154 |
10.12 % |
10/04/2018 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
6002838 |
0 |
6777154 |
6777154 |
10.12 % |
10/04/2018 |
Wellington Management Company LLP |
Delaware |
0 |
5948108 |
0 |
6452796 |
6452796 |
9.64 % |
10/04/2018 |
BlackRock, Inc. |
Delaware |
3000726 |
0 |
3055373 |
0 |
3055373 |
4.9 % |
08/03/2018 |
Mr. David Kroin |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Mr. David Kroin |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Great Point Partners, LLC |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Great Point Partners, LLC |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Wellington Management Group LLP |
Massachusetts |
0 |
5120913 |
0 |
5866580 |
5866580 |
9.42 % |
08/02/2018 |
Wellington Management Company LLP |
Delaware |
0 |
5066183 |
0 |
5627853 |
5627853 |
9.03 % |
08/02/2018 |
Wellington Group Holdings LLP |
Delaware |
0 |
5120913 |
0 |
5866580 |
5866580 |
9.42 % |
08/02/2018 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5120913 |
0 |
5866580 |
5866580 |
9.42 % |
08/02/2018 |
FMR LLC |
Delaware |
235146 |
0 |
4299597 |
0 |
4299597 |
7.374 % |
10/08/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
4299597 |
0 |
4299597 |
7.374 % |
10/08/2017 |
FMR LLC |
Delaware |
235146 |
0 |
4299597 |
0 |
4299597 |
7.374 % |
10/08/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
4299597 |
0 |
4299597 |
7.374 % |
10/08/2017 |
Mr. David Kroin |
USA |
0 |
3000650 |
0 |
3000650 |
3000650 |
5.73 % |
14/02/2017 |
Great Point Partners, LLC |
USA |
0 |
3000650 |
0 |
3000650 |
3000650 |
5.73 % |
14/02/2017 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
3000650 |
0 |
3000650 |
3000650 |
5.73 % |
14/02/2017 |
Wellington Group Holdings LLP |
Delaware |
0 |
6343302 |
0 |
7326898 |
7326898 |
14 % |
09/02/2017 |
Wellington Management Company LLP |
Delaware |
0 |
6288572 |
0 |
6985572 |
6985572 |
13.35 % |
09/02/2017 |
Wellington Management Group LLP |
Massachusetts |
0 |
6343302 |
0 |
7326898 |
7326898 |
14 % |
09/02/2017 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
6343302 |
0 |
7326898 |
7326898 |
14 % |
09/02/2017 |
BlackRock, Inc. |
Delaware |
3357103 |
0 |
3441091 |
0 |
3441091 |
6.6 % |
26/01/2017 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2931900 |
0 |
2931900 |
2931900 |
5.6 % |
12/12/2016 |
Great Point Partners, LLC |
USA |
0 |
2931900 |
0 |
2931900 |
2931900 |
5.6 % |
12/12/2016 |
Mr. David Kroin |
USA |
0 |
2931900 |
0 |
2931900 |
2931900 |
5.6 % |
12/12/2016 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2931900 |
0 |
2931900 |
2931900 |
5.6 % |
12/12/2016 |
Great Point Partners, LLC |
USA |
0 |
2931900 |
0 |
2931900 |
2931900 |
5.6 % |
12/12/2016 |
Mr. David Kroin |
USA |
0 |
2931900 |
0 |
2931900 |
2931900 |
5.6 % |
12/12/2016 |
Wellington Group Holdings LLP |
Delaware |
0 |
4926970 |
0 |
5716625 |
5716625 |
11.25 % |
10/03/2016 |
Wellington Management Group LLP |
Massachusetts |
0 |
4926970 |
0 |
5716625 |
5716625 |
11.25 % |
10/03/2016 |
Wellington Group Holdings LLP |
Delaware |
0 |
4926970 |
0 |
5716625 |
5716625 |
11.25 % |
10/03/2016 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4926970 |
0 |
5716625 |
5716625 |
11.25 % |
10/03/2016 |
Wellington Management Company LLP |
Delaware |
0 |
4756295 |
0 |
5275466 |
5275466 |
10.39 % |
10/03/2016 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4926970 |
0 |
5716625 |
5716625 |
11.25 % |
10/03/2016 |
Wellington Management Company LLP |
Delaware |
0 |
4756295 |
0 |
5275466 |
5275466 |
10.39 % |
10/03/2016 |
Wellington Management Group LLP |
Massachusetts |
0 |
4926970 |
0 |
5716625 |
5716625 |
11.25 % |
10/03/2016 |
RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
HealthCare Partners VIII, L.P. |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
4.8 % |
29/01/2016 |
HealthCare Partners VIII, LLC |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
4.8 % |
29/01/2016 |
James H. Cavanaugh, Ph.D. |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
4.8 % |
29/01/2016 |
Christopher Mirabelli, Ph.D. |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
4.8 % |
29/01/2016 |
HealthCare Ventures VIII, L.P. |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
4.8 % |
29/01/2016 |
Harold R. Werner |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
4.8 % |
29/01/2016 |
John W. Littlechild |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
4.8 % |
29/01/2016 |
Augustine Lawlor |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
4.8 % |
29/01/2016 |
Wellington Management Company LLP |
Delaware |
0 |
3614094 |
0 |
3835969 |
3835969 |
7.59 % |
13/10/2015 |
Wellington Management Company LLP |
Delaware |
0 |
3614094 |
0 |
3835969 |
3835969 |
7.59 % |
13/10/2015 |
Wellington Management Group LLP |
Massachusetts |
0 |
3871247 |
0 |
4256876 |
4256876 |
8.42 % |
13/10/2015 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3871247 |
0 |
4256876 |
4256876 |
8.42 % |
13/10/2015 |
Wellington Group Holdings LLP |
Delaware |
0 |
3871247 |
0 |
4256876 |
4256876 |
8.42 % |
13/10/2015 |
Wellington Management Group LLP |
Massachusetts |
0 |
3871247 |
0 |
4256876 |
4256876 |
8.42 % |
13/10/2015 |
Wellington Group Holdings LLP |
Delaware |
0 |
3871247 |
0 |
4256876 |
4256876 |
8.42 % |
13/10/2015 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3871247 |
0 |
4256876 |
4256876 |
8.42 % |
13/10/2015 |
Fidelity OTC Portfolio |
Massachusetts |
3354221 |
0 |
0 |
0 |
3354221 |
8.522 % |
10/06/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
4834721 |
0 |
4834721 |
12.284 % |
10/06/2015 |
FMR LLC |
Delaware |
80500 |
0 |
4834721 |
0 |
4834721 |
12.284 % |
10/06/2015 |
Fidelity OTC Portfolio |
Massachusetts |
3354221 |
0 |
0 |
0 |
3354221 |
8.522 % |
10/06/2015 |
Abigail P. Johnson |
United States of America |
0 |
0 |
4834721 |
0 |
4834721 |
12.284 % |
10/06/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
4834721 |
0 |
4834721 |
12.284 % |
10/06/2015 |
FMR LLC |
Delaware |
80500 |
0 |
4834721 |
0 |
4834721 |
12.284 % |
10/06/2015 |
Abigail P. Johnson |
United States of America |
0 |
0 |
4834721 |
0 |
4834721 |
12.284 % |
10/06/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
2974647 |
0 |
|
2974647 |
7.9 % |
17/02/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2398421 |
0 |
2398421 |
2398421 |
6.4 % |
17/02/2015 |
Peter Kolchinsky |
United States |
0 |
2974647 |
0 |
2974647 |
2974647 |
7.9 % |
17/02/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
2974647 |
0 |
|
2974647 |
7.9 % |
17/02/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2398421 |
0 |
2398421 |
2398421 |
6.4 % |
17/02/2015 |
Peter Kolchinsky |
United States |
0 |
2974647 |
0 |
2974647 |
2974647 |
7.9 % |
17/02/2015 |
HealthCare Partners VIII, LLC |
Delaware |
0 |
2446251 |
0 |
2446251 |
2446251 |
6.2 % |
28/01/2015 |
HealthCare Ventures VIII, L.P. |
Delaware |
0 |
2446251 |
0 |
2446251 |
2446251 |
6.2 % |
28/01/2015 |
HealthCare Partners VIII, L.P. |
Delaware |
0 |
2446251 |
0 |
2446251 |
2446251 |
6.2 % |
28/01/2015 |
Augustine Lawlor |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
6.2 % |
28/01/2015 |
John W. Littlechild |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
6.2 % |
28/01/2015 |
Harold R. Werner |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
6.2 % |
28/01/2015 |
Christopher Mirabelli, Ph.D. |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
6.2 % |
28/01/2015 |
James H. Cavanaugh, Ph.D. |
United States |
0 |
2446251 |
0 |
2446251 |
2446251 |
6.2 % |
28/01/2015 |
Camber Capital Management LLC |
Massachusetts |
0 |
2870000 |
0 |
2870000 |
2870000 |
7.63 % |
15/12/2014 |
Stephen DuBois Not applicable |
Stephen DuBois – United States |
0 |
2870000 |
0 |
2870000 |
2870000 |
7.63 % |
15/12/2014 |
Camber Capital Management LLC |
Massachusetts |
0 |
2870000 |
0 |
2870000 |
2870000 |
7.63 % |
15/12/2014 |
Stephen DuBois Not applicable |
Stephen DuBois – United States |
0 |
2870000 |
0 |
2870000 |
2870000 |
7.63 % |
15/12/2014 |
Peter Kolchinsky |
United States |
0 |
2974647 |
0 |
2974647 |
2974647 |
7.9 % |
12/12/2014 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2398421 |
0 |
2398421 |
2398421 |
6.4 % |
12/12/2014 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2398421 |
0 |
2398421 |
2398421 |
6.4 % |
12/12/2014 |
Peter Kolchinsky |
United States |
0 |
2974647 |
0 |
2974647 |
2974647 |
7.9 % |
12/12/2014 |
RA Capital Management, LLC |
Massachusetts |
0 |
2974647 |
0 |
2974647 |
2974647 |
7.9 % |
12/12/2014 |
RA Capital Management, LLC |
Massachusetts |
0 |
2974647 |
0 |
2974647 |
2974647 |
7.9 % |
12/12/2014 |
Wellington Management Company, LLP |
Massachusetts |
0 |
2810961 |
0 |
2980095 |
2980095 |
11.31 % |
10/11/2014 |
Wellington Management Company, LLP |
Massachusetts |
0 |
2810961 |
0 |
2980095 |
2980095 |
11.31 % |
10/11/2014 |