| Conestoga Capital Advisors LLC |
Delaware |
2346776 |
0 |
2479475 |
0 |
2479475 |
5.25 % |
19/01/2023 |
| The Brown Capital Management Small Company Fund |
|
3137553 |
0 |
3137553 |
0 |
3137553 |
6.7 % |
14/02/2022 |
| Brown Capital Management, LLC |
|
3690369 |
0 |
5789989 |
0 |
5789989 |
12.37 % |
14/02/2022 |
| 13-3017981 |
New York |
3203362 |
0 |
3203362 |
0 |
3203362 |
6.8 % |
14/02/2022 |
| STATE STREET CORPORATION |
|
0 |
0 |
0 |
0 |
2809660 |
6 % |
10/02/2022 |
| Brown Capital Management, LLC |
|
2421125 |
0 |
4022775 |
0 |
4022775 |
8.86 % |
12/02/2021 |
| Deerfield Partners, L.P. |
|
0 |
64946 |
0 |
0 |
64946 |
0.14 % |
12/02/2021 |
| Deerfield Mgmt, L.P. |
|
0 |
64946 |
0 |
0 |
64946 |
0.14 % |
12/02/2021 |
| Company, L.P. |
|
0 |
64946 |
0 |
0 |
64946 |
0.14 % |
12/02/2021 |
| James E. Flynn |
|
0 |
64946 |
0 |
0 |
64946 |
0.14 % |
12/02/2021 |
| Roderick
Wong |
Delaware |
0 |
4517570 |
0 |
4517570 |
4517570 |
9.94 % |
12/02/2021 |
| RTW
Master Fund, Ltd. |
Delaware |
0 |
3172630 |
0 |
3172630 |
3172630 |
6.98 % |
12/02/2021 |
| RTW
Investments, LP |
Delaware |
0 |
4517570 |
0 |
4517570 |
4517570 |
9.94 % |
12/02/2021 |
| Brown Capital Management, LLC |
State of Maryland |
2294696 |
0 |
3751168 |
0 |
3751168 |
8.34 % |
10/06/2020 |
| BRONCO (BARCLAYS CAYMAN) LIMITED |
Delaware |
2697147 |
0 |
2697147 |
0 |
0 |
0 % |
14/02/2020 |
| Consonance Capman GP LLC |
Delaware, USA |
0 |
1556137 |
0 |
0 |
1556137 |
3.48 % |
14/02/2020 |
| Consonance Capital Management LP |
Delaware, USA |
0 |
1446668 |
0 |
0 |
1446668 |
3.24 % |
14/02/2020 |
| Consonance Capital Opportunity Fund Management LP |
Delaware, USA |
0 |
109469 |
0 |
0 |
109469 |
0.24 % |
14/02/2020 |
| Mitchell Blutt |
Delaware, USA |
0 |
1556137 |
0 |
0 |
1556137 |
3.48 % |
14/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
2885459 |
0 |
2966530 |
0 |
2966530 |
6.8 % |
07/02/2019 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
2626000 |
0 |
0 |
2626000 |
6.15 % |
19/10/2018 |
| Deerfield Partners, L.P. |
Delaware |
0 |
2626000 |
0 |
0 |
2626000 |
6.15 % |
19/10/2018 |
| James E. Flynn |
Delaware |
0 |
2626000 |
0 |
0 |
2626000 |
6.15 % |
19/10/2018 |
| Company, L.P. |
Delaware |
0 |
2626000 |
0 |
0 |
2626000 |
6.15 % |
19/10/2018 |
| S |
Delaware, United States of America |
0 |
1758914 |
0 |
0 |
1758914 |
5.04 % |
18/01/2018 |
| S |
Delaware, United States of America |
0 |
1758914 |
0 |
0 |
1758914 |
5.04 % |
18/01/2018 |
| Strategos Fund, L.P. |
United States |
0 |
1698960 |
0 |
1698960 |
1698960 |
5.18 % |
28/08/2017 |
| Archon Capital Management LLC |
United States |
0 |
2481324 |
0 |
2481324 |
2481324 |
7.56 % |
28/08/2017 |
| Constantinos Christofilis |
United States |
0 |
2481324 |
0 |
2481324 |
2481324 |
7.56 % |
28/08/2017 |
| Jon M. Plexico |
California |
1883800 |
0 |
1883800 |
0 |
1883800 |
5.9 % |
14/02/2017 |
| Timothy P. Lynch |
California |
1883800 |
0 |
1883800 |
0 |
1883800 |
5.9 % |
14/02/2017 |
| Stonepine Capital Management, LLC |
California |
1883800 |
0 |
1883800 |
0 |
1883800 |
5.9 % |
14/02/2017 |
| Stonepine Capital, L.P. |
California |
1883800 |
0 |
1883800 |
0 |
1883800 |
5.9 % |
14/02/2017 |
| KENNETH B. DART |
CAYMAN ISLANDS |
0 |
1881381 |
0 |
1881381 |
1881381 |
5.5 % |
18/01/2017 |
| EASTERN CAPITAL LIMITED |
CAYMAN ISLANDS |
0 |
1881381 |
0 |
1881381 |
1881381 |
5.5 % |
18/01/2017 |
| PORTFOLIO SERVICES LTD. |
CAYMAN ISLANDS |
0 |
1881381 |
0 |
1881381 |
1881381 |
5.5 % |
18/01/2017 |
| 2 |
Cayman Islands |
0 |
1422475 |
0 |
1422475 |
1422475 |
6 % |
12/12/2014 |
| 2 |
Cayman Islands |
0 |
1422475 |
0 |
1422475 |
1422475 |
6 % |
12/12/2014 |
| 2 |
Cayman Islands |
0 |
1422475 |
0 |
1422475 |
1422475 |
6 % |
12/12/2014 |
| 2 |
Cayman Islands |
0 |
1422475 |
0 |
1422475 |
1422475 |
6 % |
12/12/2014 |
| (1) BlackRock, Inc. |
Delaware |
562398 |
0 |
562398 |
0 |
562398 |
2.6 % |
08/10/2014 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2170000 |
0 |
2170000 |
2170000 |
9.99 % |
22/09/2014 |
| Mr. David Kroin |
USA |
0 |
2170000 |
0 |
2170000 |
2170000 |
9.99 % |
22/09/2014 |
| Great Point Partners, LLC |
USA |
0 |
2170000 |
0 |
2170000 |
2170000 |
9.99 % |
22/09/2014 |
| Jon M. Plexico |
California |
1700000 |
0 |
1700000 |
0 |
1700000 |
7.1 % |
22/09/2014 |
| Stonepine Capital Management, LLC |
California |
1700000 |
0 |
1700000 |
0 |
1700000 |
7.1 % |
22/09/2014 |
| Stonepine Capital, L.P. |
California |
1700000 |
0 |
1700000 |
0 |
1700000 |
7.1 % |
22/09/2014 |
| Timothy P. Lynch |
California |
1700000 |
0 |
1700000 |
0 |
1700000 |
7.1 % |
22/09/2014 |
| (1) BlackRock, Inc. |
Delaware |
230728 |
0 |
230728 |
0 |
230728 |
5.3 % |
28/01/2014 |
| EASTERN CAPITAL LIMITED |
CAYMAN ISLANDS |
0 |
15749769 |
0 |
0 |
15749769 |
19.2 % |
23/08/2013 |
| KENNETH B. DART |
CAYMAN ISLANDS |
0 |
15749769 |
0 |
0 |
15749769 |
19.2 % |
23/08/2013 |
| PORTFOLIO SERVICES LTD. |
CAYMAN ISLANDS |
0 |
15749769 |
0 |
0 |
15749769 |
19.2 % |
23/08/2013 |
| Capital Ventures International |
Cayman Islands |
0 |
3333333 |
0 |
3333333 |
3333333 |
8.6 % |
20/12/2010 |
| Heights Capital Management, Inc. |
Delaware |
0 |
3333333 |
0 |
3333333 |
3333333 |
8.6 % |
20/12/2010 |
| RGC International Investors, LDC |
Cayman Islands |
0 |
2614386 |
0 |
2614386 |
2614386 |
5.2 % |
15/01/2003 |
| RGC General Partner Corp. |
Delaware |
0 |
2614386 |
0 |
2614386 |
2614386 |
5.2 % |
15/01/2003 |
| Rose Glen Capital Management, L.P. |
Delaware |
0 |
2614386 |
0 |
2614386 |
2614386 |
5.2 % |
15/01/2003 |
| ( |
United States |
0 |
0 |
0 |
0 |
0 |
11 % |
22/05/2000 |
| ( |
United States |
0 |
0 |
0 |
0 |
401500 |
11 % |
18/05/2000 |
| Rose Glen Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
3114151 |
3114151 |
11 % |
09/03/2000 |
| RGC General Partner Corp. |
Delaware |
0 |
0 |
0 |
3114151 |
3114151 |
11 % |
09/03/2000 |
| RGC International Investors, LDC |
Cayman Islands |
0 |
0 |
0 |
3114151 |
3114151 |
11 % |
09/03/2000 |
| ( |
United States |
0 |
0 |
0 |
0 |
1500000 |
11 % |
20/08/1999 |
| 13-5315170 |
Delaware |
864546 |
0 |
864546 |
0 |
864546 |
6.4 % |
28/05/1998 |
| The Kaufmann Fund, Inc. TIN # 13-2605091 |
United States |
0 |
0 |
2550000 |
0 |
2550000 |
11 % |
18/12/1997 |