VNDA

Vanda Pharmaceuticals Inc. VNDA

Bénéficiaire Individuel

Déclarant Citoyenneté ou lieu d'organisation Pouvoir de vote unique Pouvoir de vote partagé Pouvoir de disposition unique Pouvoir de disposition partagé Montant en propriété effective Pourcentage détenu Date d'achat
The Vanguard Group Pennsylvania 0 81141 3351487 104600 3456087 6.01 % 13/02/2024
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 3681125 0 3681125 0 3681125 0 % 13/02/2024
Renaissance Technologies LLC Delaware 3681125 0 3681125 0 3681125 0 % 13/02/2024
Dimensional Fund Advisors LP Delaware 1902832 0 1967985 0 1967985 3.4 % 09/02/2024
BlackRock, Inc. Delaware 7508481 0 8346367 0 8346367 14.5 % 23/01/2024
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 1156728 0 1228096 1228096 2.13 % 22/01/2024
BlackRock, Inc. Delaware 6390434 0 6759117 0 6759117 11.8 % 06/10/2023
Patrick Lee, MD USA 0 1087064 0 1087064 1087064 1.42 % 14/02/2023
PAI LLC California 0 1087064 0 1087064 0 1.42 % 14/02/2023
Anthony Joonkyoo Yun, MD USA 0 1087064 0 1087064 1087064 1.42 % 14/02/2023
Palo Alto Investors LP California 0 1087064 0 1087064 1087064 1.42 % 14/02/2023
Anthony Joonkyoo Yun, MD USA 0 1087064 0 1087064 1087064 1.42 % 14/02/2023
Palo Alto Investors LP California 0 1087064 0 1087064 1087064 1.42 % 14/02/2023
PAI LLC California 0 1087064 0 1087064 0 1.42 % 14/02/2023
Patrick Lee, MD USA 0 1087064 0 1087064 1087064 1.42 % 14/02/2023
Renaissance Technologies LLC Delaware 2889425 0 2889425 0 2889425 5.09 % 13/02/2023
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 2889425 0 2889425 0 2889425 5.09 % 13/02/2023
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 3607728 0 3727798 3727798 6.59 % 07/02/2023
BlackRock, Inc. Delaware 10168918 0 10326614 0 10326614 18.2 % 24/01/2023
Armistice Capital, LLC Delaware 0 0 0 0 0 0 % 14/02/2022
Steven Boyd United States America 0 0 0 0 0 0 % 14/02/2022
Patrick Lee, MD USA 0 2834244 0 2834244 2834244 5.09 % 14/02/2022
PAI LLC California 0 2834244 0 2834244 2834244 5.09 % 14/02/2022
Palo Alto Investors LP California 0 2834244 0 2834244 2834244 5.09 % 14/02/2022
Anthony Joonkyoo Yun, MD USA 0 2834244 0 2834244 2834244 5.09 % 14/02/2022
Anthony Joonkyoo Yun, MD USA 0 2834244 0 2834244 2834244 5.09 % 14/02/2022
Palo Alto Investors LP California 0 2834244 0 2834244 2834244 5.09 % 14/02/2022
PAI LLC California 0 2834244 0 2834244 2834244 5.09 % 14/02/2022
Patrick Lee, MD USA 0 2834244 0 2834244 2834244 5.09 % 14/02/2022
Macquarie Group Limited Sydney New South Wales Australia 0 0 0 0 2913471 5.23 % 14/02/2022
Macquarie Investment Management Group Limited Sydney New South Wales Australia 1600 0 1600 0 1600 0 % 14/02/2022
Macquarie Investment Management Business Trust Delaware 2880821 0 2880821 0 2911871 5.23 % 14/02/2022
Macquarie Management Holdings Inc Delaware 2880821 0 2880821 0 2911871 5.23 % 14/02/2022
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 3212214 0 3212214 0 3212214 5.77 % 11/02/2022
Renaissance Technologies LLC Delaware 3212214 0 3212214 0 3212214 5.77 % 11/02/2022
Renaissance Technologies LLC Delaware 3212214 0 3212214 0 3212214 5.77 % 11/02/2022
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 3212214 0 3212214 0 3212214 5.77 % 11/02/2022
The Vanguard Group Pennsylvania For 0 43498 3789010 87674 3876684 6.96 % 10/02/2022
BlackRock, Inc. Delaware 9656224 0 9825375 0 9825375 17.6 % 27/01/2022
BlackRock, Inc. Delaware 9686546 0 9825375 0 9825375 17.6 % 26/01/2022
Steven Boyd United States America 0 5399277 0 5399277 5399277 9.8 % 16/02/2021
Armistice Capital, LLC Delaware 0 5399277 0 5399277 5399277 9.8 % 16/02/2021
Steven Boyd United States of America 0 5399277 0 5399277 5399277 9.8 % 16/02/2021
Armistice Capital, LLC Delaware 0 5399277 0 5399277 5399277 9.8 % 16/02/2021
Anthony Joonkyoo Yun, MD USA 0 4230548 0 4230548 4230548 7.74 % 16/02/2021
Patrick Lee, MD USA 0 4230548 0 4230548 4230548 7.74 % 16/02/2021
PAI LLC California 0 4230548 0 4230548 4230548 7.74 % 16/02/2021
Palo Alto Investors LP California 0 4230548 0 4230548 4230548 7.74 % 16/02/2021
PAI LLC California 0 4230548 0 4230548 4230548 7.74 % 16/02/2021
Patrick Lee, MD USA 0 4230548 0 4230548 4230548 7.74 % 16/02/2021
Palo Alto Investors LP California 0 4230548 0 4230548 4230548 7.74 % 16/02/2021
Anthony Joonkyoo Yun, MD USA 0 4230548 0 4230548 4230548 7.74 % 16/02/2021
Renaissance Technologies LLC Delaware 3980007 0 3990403 0 3990403 7.3 % 11/02/2021
Renaissance Technologies LLC Delaware 3980007 0 3990403 0 3990403 7.3 % 11/02/2021
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 3980007 0 3990403 0 3990403 7.3 % 11/02/2021
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 3980007 0 3990403 0 3990403 7.3 % 11/02/2021
The Vanguard Group Pennsylvania For 0 53837 3864211 94869 3959080 7.24 % 10/02/2021
BlackRock, Inc. Delaware 9676664 0 9814597 0 9814597 17.9 % 25/01/2021
Mitchell Blutt USA 0 0 0 0 0 0 % 14/02/2020
Consonance Capital Management LP Delaware USA 0 0 0 0 0 0 % 14/02/2020
Consonance Capital Opportunity Fund Management LP Delaware USA 0 0 0 0 0 0 % 14/02/2020
Consonance Capman GP LLC Delaware USA 0 0 0 0 0 0 % 14/02/2020
OR Palo Alto Investors LP California 0 4525476 0 4525476 4525476 8.48 % 14/02/2020
OR Anthony Joonkyoo Yun, MD USA 0 4525476 0 4525476 4525476 8.48 % 14/02/2020
OR PAI LLC California 0 4525476 0 4525476 4525476 8.48 % 14/02/2020
OR Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 2907631 0 2907631 2907631 5.45 % 14/02/2020
OR Patrick Lee, MD USA 0 4525476 0 4525476 4525476 8.48 % 14/02/2020
Armistice Capital Master Fund Ltd. Cayman Islands 0 2828000 0 2828000 2828000 5.3 % 14/02/2020
Armistice Capital, LLC Delaware 0 2976000 0 2976000 2976000 5.6 % 14/02/2020
Armistice Capital Master Fund Ltd. Cayman Islands 0 2828000 0 2828000 2828000 5.3 % 14/02/2020
Steven Boyd United States of America 0 2976000 0 2976000 2976000 5.6 % 14/02/2020
Armistice Capital, LLC Delaware 0 2976000 0 2976000 2976000 5.6 % 14/02/2020
Steven Boyd United States America 0 2976000 0 2976000 2976000 5.6 % 14/02/2020
Macquarie Investment Management Holdings Inc Delaware 3084296 0 3084296 0 3093067 5.8 % 13/02/2020
Macquarie Group Limited Sydney New South Wales Australia 0 0 0 0 3097822 5.81 % 13/02/2020
Macquarie Bank Limited Sydney New South Wales Australia 0 0 0 0 3097822 5.81 % 13/02/2020
Macquarie Investment Management Holdings Inc Delaware 3084296 0 3084296 0 3093067 5.8 % 13/02/2020
Macquarie Investment Management Business Trust Delaware 3084296 0 3084296 0 3093067 5.8 % 13/02/2020
Macquarie Funds Management Austria Kapitalanlage AG Vienna Austria 4755 0 4755 0 4755 0.01 % 13/02/2020
Macquarie Bank Limited Sydney New South Wales Australia 0 0 0 0 3097822 5.81 % 13/02/2020
Macquarie Group Limited Sydney New South Wales Australia 0 0 0 0 3097822 5.81 % 13/02/2020
Macquarie Funds Management Austria Kapitalanlage AG Vienna Austria 4755 0 4755 0 4755 0.01 % 13/02/2020
Macquarie Investment Management Business Trust Delaware 3084296 0 3084296 0 3093067 5.8 % 13/02/2020
Renaissance Technologies LLC Delaware 3453112 0 3453112 0 3453112 6.47 % 12/02/2020
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 3453112 0 3453112 0 3453112 6.47 % 12/02/2020
Renaissance Technologies LLC Delaware 3453112 0 3453112 0 3453112 6.47 % 12/02/2020
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 3453112 0 3453112 0 3453112 6.47 % 12/02/2020
The Vanguard Group Pennsylvania 111217 3600 4353679 107104 4460783 8.36 % 12/02/2020
BlackRock, Inc. Delaware 9237768 0 9385881 0 9385881 17.6 % 04/02/2020
Armistice Capital, LLC Delaware 0 3268000 0 3268000 3268000 6.2 % 24/06/2019
Armistice Capital Master Fund Ltd. Cayman Islands 0 3268000 0 3268000 3268000 6.2 % 24/06/2019
Steven Boyd United States of America 0 3268000 0 3268000 3268000 6.2 % 24/06/2019
Steven Boyd United States of America 0 3268000 0 3268000 3268000 6.2 % 24/06/2019
Armistice Capital Master Fund Ltd. Cayman Islands 0 3268000 0 3268000 3268000 6.2 % 24/06/2019
Armistice Capital, LLC Delaware 0 3268000 0 3268000 3268000 6.2 % 24/06/2019
Anthony Joonkyoo Yun, MD U.S.A. 0 4345571 0 4345571 4345571 8.29 % 19/02/2019
Palo Alto Investors LP California 0 4345571 0 4345571 4345571 8.29 % 19/02/2019
Patrick Lee, MD U.S.A. 0 4345571 0 4345571 4345571 8.29 % 19/02/2019
Anthony Joonkyoo Yun, MD U.S.A. 0 4345571 0 4345571 4345571 8.29 % 19/02/2019
Palo Alto Investors LP California 0 4345571 0 4345571 4345571 8.29 % 19/02/2019
PAI LLC California 0 4345571 0 4345571 4345571 8.29 % 19/02/2019
Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 2733722 0 2733722 2733722 5.21 % 19/02/2019
PAI LLC California 0 4345571 0 4345571 4345571 8.29 % 19/02/2019
Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 2733722 0 2733722 2733722 5.21 % 19/02/2019
Patrick Lee, MD U.S.A. 0 4345571 0 4345571 4345571 8.29 % 19/02/2019
Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 0 0 0 9 4.85 % 14/02/2019
PAI LLC California 0 0 0 0 9 7.92 % 14/02/2019
Patrick Lee, MD USA 0 0 0 0 9 7.92 % 14/02/2019
Anthony Joonkyoo Yun, MD USA 0 0 0 0 9 7.92 % 14/02/2019
Palo Alto Investors LP California 0 0 0 0 9 7.92 % 14/02/2019
Armistice Capital Master Fund Ltd. Cayman Islands 0 0 0 0 0 0 % 14/02/2019
Steven Boyd United States America 0 0 0 0 0 0 % 14/02/2019
Armistice Capital, LLC Delaware 0 0 0 0 0 0 % 14/02/2019
Macquarie Investment Management Business Trust Delaware 2450776 0 2450776 0 2458184 4.69 % 14/02/2019
Macquarie Bank Limited Sydney New South Wales Australia 0 0 0 0 2458284 4.69 % 14/02/2019
Macquarie Investment Management Holdings Inc Delaware 2450776 0 2450776 0 2458184 4.69 % 14/02/2019
Macquarie Group Limited Sydney New South Wales Australia 0 0 0 0 2458284 4.69 % 14/02/2019
Macquarie Funds Management Hong Kong Limited Hong Kong 100 0 100 0 100 0.01 % 14/02/2019
Consonance Capital Opportunity Fund Management LP Delaware USA 0 182946 0 182946 182946 0.35 % 14/02/2019
Mitchell Blutt USA 0 4658759 0 4658759 4658759 8.88 % 14/02/2019
Consonance Capman GP LLC Delaware USA 0 4658759 0 4658759 4658759 8.88 % 14/02/2019
Consonance Capital Management LP Delaware USA 0 4475813 0 4475813 4475813 8.53 % 14/02/2019
The Vanguard Group Pennsylvania 106337 4600 4058275 106237 4164512 7.93 % 11/02/2019
BlackRock, Inc. Delaware 8529246 0 8774342 0 8774342 16.7 % 31/01/2019
BlackRock, Inc. Delaware 8682938 0 8845222 0 8845222 16.9 % 10/10/2018
Anthony Joonkyoo Yun, MD USA 0 0 0 0 9 9.25 % 14/02/2018
Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 0 0 0 9 5.66 % 14/02/2018
Patrick Lee, MD USA 0 0 0 0 9 9.25 % 14/02/2018
Palo Alto Investors, LLC California 0 0 0 0 9 9.25 % 14/02/2018
Great Point Partners, LLC USA 0 797531 0 797531 797531 1.78 % 14/02/2018
Dr. Jeffrey R. Jay, M.D. USA 0 797531 0 797531 797531 1.78 % 14/02/2018
Mr. David Kroin USA 0 797531 0 797531 797531 1.78 % 14/02/2018
Dr. Jeffrey R. Jay, M.D. USA 0 797531 0 797531 797531 1.78 % 14/02/2018
Mr. David Kroin USA 0 797531 0 797531 797531 1.78 % 14/02/2018
Great Point Partners, LLC USA 0 797531 0 797531 797531 1.78 % 14/02/2018
Point72 Asset Management, L.P. Delaware 0 125000 0 125000 125000 0.3 % 14/02/2018
Point72 Asset Management, L.P. Delaware 0 125000 0 125000 125000 0.3 % 14/02/2018
Point72 Capital Advisors, Inc. Delaware 0 125000 0 125000 125000 0.3 % 14/02/2018
Cubist Systematic Strategies, LLC Delaware 0 2357 0 2357 2357 0.1 % 14/02/2018
Point72 Asia Hong Kong 0 120 0 120 120 0.1 % 14/02/2018
Steven A. Cohen United States 0 127477 0 127477 127477 0.3 % 14/02/2018
Cubist Systematic Strategies, LLC Delaware 0 2357 0 2357 2357 0.1 % 14/02/2018
Steven A. Cohen United States 0 127477 0 127477 127477 0.3 % 14/02/2018
Point72 Asia Limited Hong Kong 0 120 0 120 120 0.1 % 14/02/2018
Point72 Capital Advisors, Inc. Delaware 0 125000 0 125000 125000 0.3 % 14/02/2018
Macquarie Investment Management Business Trust Delaware 2254411 0 2254411 0 2256291 5.02 % 14/02/2018
Macquarie Group Limited Sydney New South Wales Australia 0 0 0 0 2256291 5.02 % 14/02/2018
Macquarie Investment Management Holdings Inc Delaware 2254411 0 2254411 0 2256291 5.02 % 14/02/2018
Macquarie Bank Limited Sydney New South Wales Australia 0 0 0 0 2256291 5.02 % 14/02/2018
Armistice Capital Master Fund Ltd. Cayman Islands 0 2678000 0 2678000 2678000 5.96 % 14/02/2018
Armistice Capital, LLC Delaware 0 2678000 0 2678000 2678000 5.96 % 14/02/2018
Steven Boyd United States of America 0 2678000 0 2678000 2678000 5.96 % 14/02/2018
S Deerfield Mgmt, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
S Deerfield Management Company, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
S Deerfield Partners, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
S Deerfield Special Situations Fund, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
S James E. Flynn United States 0 0 0 0 0 0 % 14/02/2018
S Deerfield Partners, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
S Deerfield Special Situations Fund, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
S Deerfield Mgmt, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
S Deerfield International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 14/02/2018
S James E. Flynn United States 0 0 0 0 0 0 % 14/02/2018
S Deerfield International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 14/02/2018
S Deerfield Management Company, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
The Vanguard Group Pennsylvania 87966 2100 2745261 85366 2830627 6.3 % 09/02/2018
BlackRock, Inc. Delaware 4476861 0 4568159 0 4568159 10.2 % 19/01/2018
BlackRock, Inc. Delaware 4372213 0 4467718 0 4467718 10 % 10/07/2017
Armistice Capital Master Fund Ltd. Cayman Islands 0 2292000 0 2292000 2292000 5.1 % 19/06/2017
Armistice Capital, LLC Delaware 0 2292000 0 2292000 2292000 5.1 % 19/06/2017
Armistice Capital, LLC Delaware 0 2292000 0 2292000 2292000 5.1 % 19/06/2017
Armistice Capital Master Fund Ltd. Cayman Islands 0 2292000 0 2292000 2292000 5.1 % 19/06/2017
Steven Boyd United States of America 0 2292000 0 2292000 2292000 5.1 % 19/06/2017
Steven Boyd United States of America 0 2292000 0 2292000 2292000 5.1 % 19/06/2017
Great Point Partners, LLC USA 0 2216216 0 2216216 2216216 5.04 % 17/02/2017
Dr. Jeffrey R. Jay, M.D. USA 0 2216216 0 2216216 2216216 5.04 % 17/02/2017
Mr. David Kroin USA 0 2216216 0 2216216 2216216 5.04 % 17/02/2017
Mr. David Kroin USA 0 2216216 0 2216216 2216216 5.04 % 17/02/2017
Great Point Partners, LLC USA 0 2216216 0 2216216 2216216 5.04 % 17/02/2017
Dr. Jeffrey R. Jay, M.D. USA 0 2216216 0 2216216 2216216 5.04 % 17/02/2017
Point72 Capital Advisors, Inc. Delaware 0 2186600 0 2186600 2186600 5 % 16/02/2017
Cubist Systematic Strategies, LLC Delaware 0 12667 0 12667 12667 0.1 % 16/02/2017
Steven A. Cohen United States 0 2199267 0 2199267 2199267 5 % 16/02/2017
Point72 Asset Management, L.P. Delaware 0 2186600 0 2186600 2186600 5 % 16/02/2017
Point72 Capital Advisors, Inc. Delaware 0 2186600 0 2186600 2186600 5 % 16/02/2017
Cubist Systematic Strategies, LLC Delaware 0 12667 0 12667 12667 0.1 % 16/02/2017
Steven A. Cohen United States 0 2199267 0 2199267 2199267 5 % 16/02/2017
Point72 Asset Management, L.P. Delaware 0 2186600 0 2186600 2186600 5 % 16/02/2017
Paulson & Co. Inc. State of Delaware 0 0 0 0 0 0 % 14/02/2017
Mr. David Kroin USA 0 2010000 0 2010000 2010000 4.57 % 14/02/2017
Dr. Jeffrey R. Jay, M.D. USA 0 2010000 0 2010000 2010000 4.57 % 14/02/2017
Dr. Jeffrey R. Jay, M.D. USA 0 2010000 0 2010000 2010000 4.57 % 14/02/2017
Great Point Partners, LLC USA 0 2010000 0 2010000 2010000 4.57 % 14/02/2017
Mr. David Kroin USA 0 2010000 0 2010000 2010000 4.57 % 14/02/2017
Great Point Partners, LLC USA 0 2010000 0 2010000 2010000 4.57 % 14/02/2017
S James E. Flynn United States 0 3424676 0 3424676 3424676 7.79 % 14/02/2017
S Deerfield Partners, L.P. Delaware 0 1279631 0 1279631 1279631 2.91 % 14/02/2017
S Deerfield Management Company, L.P. Delaware 0 3424676 0 3424676 3424676 7.79 % 14/02/2017
S Deerfield International Master Fund, L.P. British Virgin Islands 0 1628624 0 1628624 1628624 3.71 % 14/02/2017
S Deerfield Partners, L.P. Delaware 0 1279631 0 1279631 1279631 2.91 % 14/02/2017
S Deerfield Special Situations Fund, L.P. Delaware 0 516421 0 516421 516421 1.18 % 14/02/2017
S James E. Flynn United States 0 3424676 0 3424676 3424676 7.79 % 14/02/2017
S Deerfield Mgmt, L.P. Delaware 0 3424676 0 3424676 3424676 7.79 % 14/02/2017
S Deerfield Mgmt, L.P. Delaware 0 3424676 0 3424676 3424676 7.79 % 14/02/2017
S Deerfield Management Company, L.P. Delaware 0 3424676 0 3424676 3424676 7.79 % 14/02/2017
S Deerfield International Master Fund, L.P. British Virgin Islands 0 1628624 0 1628624 1628624 3.71 % 14/02/2017
S Deerfield Special Situations Fund, L.P. Delaware 0 516421 0 516421 516421 1.18 % 14/02/2017
BlackRock, Inc. Delaware 3684676 0 3780456 0 3780456 8.6 % 26/01/2017
Palo Alto Investors, LLC California 0 4203270 0 4203270 4203270 9.56 % 12/01/2017
Anthony Joonkyoo Yun, MD U.S.A. 0 4203270 0 4203270 4203270 9.56 % 12/01/2017
Patrick Lee, MD U.S.A. 0 4203270 0 4203270 4203270 9.56 % 12/01/2017
Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 2543821 0 2543821 2543821 5.79 % 12/01/2017
Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 2543821 0 2543821 2543821 5.79 % 12/01/2017
Patrick Lee, MD U.S.A. 0 4203270 0 4203270 4203270 9.56 % 12/01/2017
Palo Alto Investors, LLC California 0 4203270 0 4203270 4203270 9.56 % 12/01/2017
Anthony Joonkyoo Yun, MD U.S.A. 0 4203270 0 4203270 4203270 9.56 % 12/01/2017
Integrated Core Strategies (US) LLC 642557 1.5 % 12/01/2017
Integrated Assets II LLC 209127 0.5 % 12/01/2017
Integrated Assets, Ltd. 54672 0.1 % 12/01/2017
Millennium International Management LP 54672 0.1 % 12/01/2017
Millennium International Management GP LLC 54672 0.1 % 12/01/2017
Millennium Management LLC 906356 2.1 % 12/01/2017
Israel A. Englander 906356 2.1 % 12/01/2017
Deerfield International Master Fund, L.P. British Virgin Islands 0 1633990 0 1633990 1633990 3.78 % 29/09/2016
Deerfield Mgmt, L.P. Delaware 0 3435576 0 3435576 3435576 7.94 % 29/09/2016
Deerfield Management Company, L.P. Delaware 0 3435576 0 3435576 3435576 7.94 % 29/09/2016
Deerfield Partners, L.P. Delaware 0 1283849 0 1283849 1283849 2.97 % 29/09/2016
Deerfield Special Situations Fund, L.P. Delaware 0 517737 0 517737 517737 1.2 % 29/09/2016
James E. Flynn United States 0 3435576 0 3435576 3435576 7.94 % 29/09/2016
Deerfield Special Situations Fund, L.P. Delaware 0 517737 0 517737 517737 1.2 % 29/09/2016
Deerfield Management Company, L.P. Delaware 0 3435576 0 3435576 3435576 7.94 % 29/09/2016
Deerfield Mgmt, L.P. Delaware 0 3435576 0 3435576 3435576 7.94 % 29/09/2016
Deerfield Partners, L.P. Delaware 0 1283849 0 1283849 1283849 2.97 % 29/09/2016
James E. Flynn United States 0 3435576 0 3435576 3435576 7.94 % 29/09/2016
Deerfield International Master Fund, L.P. British Virgin Islands 0 1633990 0 1633990 1633990 3.78 % 29/09/2016
Paulson & Co. Inc. State of Delaware 3946500 0 3946500 0 3946500 9.22 % 16/02/2016
Kingdon Capital Management, L.L.C. Delaware 0 934568 0 934568 934568 2.18 % 16/02/2016
Mark Kingdon United States of America 0 934568 0 934568 934568 2.18 % 16/02/2016
Anthony Joonkyoo Yun, MD U.S.A. 0 4030908 0 4030908 4030908 9.41 % 16/02/2016
Patrick Lee, MD U.S.A. 0 4030908 0 4030908 4030908 9.41 % 16/02/2016
Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 2206959 0 2206959 2206959 5.15 % 16/02/2016
Palo Alto Investors, LLC California 0 4030908 0 4030908 4030908 9.41 % 16/02/2016
Armistice Capital Master Fund, Ltd. Cayman Islands 0 1630000 0 1630000 1630000 3.8 % 16/02/2016
Steven Boyd United States of America 0 1630000 0 1630000 1630000 3.8 % 16/02/2016
Armistice Capital, LLC Delaware 0 1630000 0 1630000 1630000 3.8 % 16/02/2016
Deerfield International Master Fund, L.P. British Virgin Islands 0 2740122 0 2740122 2740122 6.4 % 16/02/2016
S Deerfield Mgmt, L.P. Delaware 0 5996691 0 5996691 5996691 14.01 % 16/02/2016
S Deerfield Management Company, L.P. Delaware 0 5996691 0 5996691 5996691 14.01 % 16/02/2016
S Deerfield Partners, L.P. Delaware 0 2152952 0 2152952 2152952 5.03 % 16/02/2016
S Deerfield Special Situations Fund, L.P. Delaware 0 1103617 0 1103617 1103617 2.58 % 16/02/2016
S Deerfield International Master Fund, L.P. British Virgin Islands 0 2740122 0 2740122 2740122 6.4 % 16/02/2016
S Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 16/02/2016
S James E. Flynn United States 0 5996691 0 5996691 5996691 14.01 % 16/02/2016
James E. Flynn United States 0 5996691 0 5996691 5996691 14.01 % 16/02/2016
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 16/02/2016
Deerfield Special Situations Fund, L.P. Delaware 0 1103617 0 1103617 1103617 2.58 % 16/02/2016
Deerfield Partners, L.P. Delaware 0 2152952 0 2152952 2152952 5.03 % 16/02/2016
Deerfield Management Company, L.P. Delaware 0 5996691 0 5996691 5996691 14.01 % 16/02/2016
Deerfield Mgmt, L.P. Delaware 0 5996691 0 5996691 5996691 14.01 % 16/02/2016
Millennium Management LLC 2243464 5.2 % 27/01/2016
Integrated Assets, Ltd. 384380 0.9 % 27/01/2016
Millennium International Management LP 384380 0.9 % 27/01/2016
Israel A. Englander 2243464 5.2 % 27/01/2016
Integrated Assets, Ltd. 384380 0.9 % 27/01/2016
Millennium International Management LP 384380 0.9 % 27/01/2016
Integrated Core Strategies (US) LLC 1859084 4.3 % 27/01/2016
Millennium International Management GP LLC 384380 0.9 % 27/01/2016
Integrated Core Strategies (US) LLC 1859084 4.3 % 27/01/2016
Israel A. Englander 2243464 5.2 % 27/01/2016
Millennium Management LLC 2243464 5.2 % 27/01/2016
Millennium International Management GP LLC 384380 0.9 % 27/01/2016
BlackRock, Inc. Delaware 2790706 0 2880573 0 2880573 6.7 % 27/01/2016
Stonepine Capital Management, LLC California 2017900 0 2017900 0 2017900 4.7 % 26/01/2016
Stonepine Capital Management, LLC California 2017900 0 2017900 0 2017900 4.7 % 26/01/2016
Stonepine Capital, L.P. Delaware 2017900 0 2017900 0 2017900 4.7 % 26/01/2016
Stonepine Capital, L.P. Delaware 2017900 0 2017900 0 2017900 4.7 % 26/01/2016
Great Point Partners, LLC USA 0 2334119 0 2334119 2334119 5.45 % 15/01/2016
Dr. Jeffrey R. Jay, M.D. USA 0 2334119 0 2334119 2334119 5.45 % 15/01/2016
Mr. David Kroin USA 0 2334119 0 2334119 2334119 5.45 % 15/01/2016
Dr. Jeffrey R. Jay, M.D. USA 0 2334119 0 2334119 2334119 5.45 % 15/01/2016
Great Point Partners, LLC USA 0 2334119 0 2334119 2334119 5.45 % 15/01/2016
Mr. David Kroin USA 0 2334119 0 2334119 2334119 5.45 % 15/01/2016
Stonepine Capital Management, LLC California 2321556 0 2321556 0 2321556 5.5 % 02/07/2015
Stonepine Capital, L.P. Delaware 2321556 0 2321556 0 2321556 5.5 % 02/07/2015
Stonepine Capital, L.P. Delaware 2321556 0 2321556 0 2321556 5.5 % 02/07/2015
Stonepine Capital Management, LLC California 2321556 0 2321556 0 2321556 5.5 % 02/07/2015
Abigail P. Johnson United States of America 0 0 0 0 0 0 % 10/06/2015
Abigail P. Johnson United States of America 0 0 0 0 0 0 % 10/06/2015
Edward C. Johnson 3d United States of America 0 0 0 0 0 0 % 10/06/2015
FMR LLC Delaware 0 0 0 0 0 0 % 10/06/2015
Edward C. Johnson 3d United States of America 0 0 0 0 0 0 % 10/06/2015
FMR LLC Delaware 0 0 0 0 0 0 % 10/06/2015
Felix J. Baker United States 1750230 0 1750230 0 1750230 4.2 % 10/04/2015
Baker Bros. Advisors LP Delaware 1750230 0 1750230 0 1750230 4.2 % 10/04/2015
Julian C. Baker United States 1750230 0 1750230 0 1750230 4.2 % 10/04/2015
Felix J. Baker United States 1750230 0 1750230 0 1750230 4.2 % 10/04/2015
Baker Bros. Advisors Delaware 1750230 0 1750230 0 1750230 4.2 % 10/04/2015
Baker Bros. Advisors LP Delaware 1750230 0 1750230 0 1750230 4.2 % 10/04/2015
Baker Bros. Advisors Delaware 1750230 0 1750230 0 1750230 4.2 % 10/04/2015
Julian C. Baker United States 1750230 0 1750230 0 1750230 4.2 % 10/04/2015
T. ROWE PRICE ASSOCIATES, INC. MARYLAND 0 0 0 0 365628 0.8 % 10/04/2015
T. ROWE PRICE HEALTH SCIENCES FUND, INC. Maryland 0 0 0 0 182670 0.4 % 10/04/2015
T. ROWE PRICE HEALTH SCIENCES FUND, INC. Maryland 0 0 0 0 182670 0.4 % 10/04/2015
T. ROWE PRICE ASSOCIATES, INC. MARYLAND 0 0 0 0 365628 0.8 % 10/04/2015
Select Health Care Portfolio Massachusetts 1900000 0 0 0 1900000 5.013 % 10/04/2015
Select Health Care Portfolio Massachusetts 1900000 0 0 0 1900000 5.013 % 10/04/2015
Abigail P. Johnson United States of America 0 0 2955429 0 2955429 7.797 % 10/04/2015
FMR LLC Delaware 128 0 2955429 0 2955429 7.797 % 10/04/2015
Edward C. Johnson 3d United States of America 0 0 2955429 0 2955429 7.797 % 10/04/2015
Edward C. Johnson 3d United States of America 0 0 2955429 0 2955429 7.797 % 10/04/2015
Abigail P. Johnson United States of America 0 0 2955429 0 2955429 7.797 % 10/04/2015
FMR LLC Delaware 128 0 2955429 0 2955429 7.797 % 10/04/2015
Steven Boyd United States of America 0 2280000 0 2280000 2280000 5.5 % 27/03/2015
Armistice Capital Master Fund, Ltd. Cayman Islands 0 2280000 0 2280000 2280000 5.5 % 27/03/2015
Armistice Capital, LLC Delaware 0 2280000 0 2280000 2280000 5.5 % 27/03/2015
Armistice Capital, LLC Delaware 0 2280000 0 2280000 2280000 5.5 % 27/03/2015
Steven Boyd United States of America 0 2280000 0 2280000 2280000 5.5 % 27/03/2015
Armistice Capital Master Fund, Ltd. Cayman Islands 0 2280000 0 2280000 2280000 5.5 % 27/03/2015
Patrick Lee, MD U.S.A. 0 3786908 0 3786908 3786908 9.55 % 17/02/2015
Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 2173159 0 2173159 2173159 5.48 % 17/02/2015
Palo Alto Investors, LLC California 0 3786908 0 3786908 3786908 9.55 % 17/02/2015
Anthony Joonkyoo Yun, MD U.S.A. 0 3786908 0 3786908 3786908 9.55 % 17/02/2015
Paulson & Co. Inc. State of Delaware 3625000 0 3625000 0 3625000 9.14 % 17/02/2015
Felix J. Baker United States 4472153 0 4472153 0 4472153 10.8 % 17/02/2015
Julian C. Baker United States 4472153 0 4472153 0 4472153 10.8 % 17/02/2015
Baker Bros. Advisors Delaware 4472153 0 4472153 0 4472153 10.8 % 17/02/2015
Baker Bros. Advisors LP Delaware 4472153 0 4472153 0 4472153 10.8 % 17/02/2015
Mark Kingdon United States of America 0 2461305 0 2461305 2461305 5.94 % 17/02/2015
Kingdon Capital Management, L.L.C. Delaware 0 2461305 0 2461305 2461305 5.94 % 17/02/2015
Mark Kingdon United States of America 0 2461305 0 2461305 2461305 5.94 % 17/02/2015
Kingdon Capital Management, L.L.C. Delaware 0 2461305 0 2461305 2461305 5.94 % 17/02/2015
T. ROWE PRICE HEALTH SCIENCES FUND, INC. Maryland 0 0 0 0 2381313 6.1 % 10/02/2015
T. ROWE PRICE ASSOCIATES, INC. MARYLAND 0 0 0 0 4575221 11.7 % 10/02/2015
BlackRock, Inc. Delaware 2742504 0 2826578 0 2826578 7.1 % 26/01/2015
Deerfield Management Company, L.P. Delaware 0 4139787 0 4139787 4139787 10.44 % 24/12/2014
Deerfield International Master Fund, L.P. British Virgin Islands 0 1674781 0 1674781 1674781 4.22 % 24/12/2014
Deerfield Special Situations Fund, L.P. Delaware 0 610588 0 610588 610588 1.54 % 24/12/2014
James E. Flynn United States 0 4139787 0 4139787 4139787 10.44 % 24/12/2014
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 507703 0 507703 507703 1.28 % 24/12/2014
Deerfield International Master Fund, L.P. British Virgin Islands 0 1674781 0 1674781 1674781 4.22 % 24/12/2014
Deerfield Special Situations Fund, L.P. Delaware 0 610588 0 610588 610588 1.54 % 24/12/2014
Deerfield Partners, L.P. Delaware 0 1346715 0 1346715 1346715 3.4 % 24/12/2014
James E. Flynn United States 0 4139787 0 4139787 4139787 10.44 % 24/12/2014
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 507703 0 507703 507703 1.28 % 24/12/2014
Deerfield Management Company, L.P. Delaware 0 4139787 0 4139787 4139787 10.44 % 24/12/2014
Deerfield Partners, L.P. Delaware 0 1346715 0 1346715 1346715 3.4 % 24/12/2014
Deerfield Mgmt, L.P. Delaware 0 4139787 0 4139787 4139787 10.44 % 24/12/2014
Deerfield Mgmt, L.P. Delaware 0 4139787 0 4139787 4139787 10.44 % 24/12/2014
Deerfield International Master Fund, L.P. British Virgin Islands 0 699533 0 699533 699533 2.07 % 01/08/2014
Deerfield Mgmt, L.P. Delaware 0 2061594 0 2061594 2061594 6.09 % 01/08/2014
James E. Flynn United States 0 2061594 0 2061594 2061594 6.09 % 01/08/2014
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 355329 0 355329 355329 1.05 % 01/08/2014
Deerfield Special Situations Fund, L.P. Delaware 0 440247 0 440247 440247 1.3 % 01/08/2014
Deerfield Partners, L.P. Delaware 0 566485 0 566485 566485 1.67 % 01/08/2014
James E. Flynn United States 0 2061594 0 2061594 2061594 6.09 % 01/08/2014
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 355329 0 355329 355329 1.05 % 01/08/2014
Deerfield International Master Fund, L.P. British Virgin Islands 0 699533 0 699533 699533 2.07 % 01/08/2014
Deerfield Special Situations Fund, L.P. Delaware 0 440247 0 440247 440247 1.3 % 01/08/2014
Deerfield Partners, L.P. Delaware 0 566485 0 566485 566485 1.67 % 01/08/2014
Deerfield Management Company, L.P. Delaware 0 2061594 0 2061594 2061594 6.09 % 01/08/2014
Deerfield Management Company, L.P. Delaware 0 2061594 0 2061594 2061594 6.09 % 01/08/2014
Deerfield Mgmt, L.P. Delaware 0 2061594 0 2061594 2061594 6.09 % 01/08/2014
T. ROWE PRICE ASSOCIATES, INC. MARYLAND 0 0 0 0 3426791 10.1 % 10/07/2014
T. ROWE PRICE HEALTH SCIENCES FUND, INC. Maryland 0 0 0 0 2150813 6.3 % 10/07/2014
T. ROWE PRICE HEALTH SCIENCES FUND, INC. Maryland 0 0 0 0 2150813 6.3 % 10/07/2014
T. ROWE PRICE ASSOCIATES, INC. MARYLAND 0 0 0 0 3426791 10.1 % 10/07/2014
Anthony Joonkyoo Yun, MD USA 0 0 0 0 9 9.8 % 14/02/2014
Palo Alto Investors, LLC California 0 0 0 0 9 9.8 % 14/02/2014
Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 0 0 0 9 5.6 % 14/02/2014
Patrick Lee, MD USA 0 0 0 0 9 9.8 % 14/02/2014
Kingdon Capital Management, L.L.C. Delaware 0 2239350 0 2239350 2239350 6.75 % 14/02/2014
Mark Kingdon United States of America 0 2239350 0 2239350 2239350 6.75 % 14/02/2014
Mr. David Kroin USA 0 0 0 0 0 0 % 14/02/2014
Mr. David Kroin USA 0 0 0 0 0 0 % 14/02/2014
Great Point Partners, LLC USA 0 0 0 0 0 0 % 14/02/2014
Dr. Jeffrey R. Jay, M.D. USA 0 0 0 0 0 0 % 14/02/2014
Great Point Partners, LLC USA 0 0 0 0 0 0 % 14/02/2014
Dr. Jeffrey R. Jay, M.D. USA 0 0 0 0 0 0 % 14/02/2014
Ft Eagle Investment Management, LLC Delaware 0 0 0 0 0 0 % 14/02/2014
Integrated Core Strategies (US) LLC 625559 1.9 % 06/02/2014
ICS Opportunities, Ltd. 302741 0.9 % 06/02/2014
Integrated Assets, Ltd. 0 0 % 06/02/2014
Millennium International Management LP 302741 0.9 % 06/02/2014
Millennium International Management GP LLC 302741 0.9 % 06/02/2014
Millennium Management LLC 928300 2.8 % 06/02/2014
Israel A. Englander 928300 2.8 % 06/02/2014
BlackRock, Inc. Delaware 2416442 0 2478191 0 2478191 7.5 % 30/01/2014
TANG CAPITAL PARTNERS, LP DELAWARE 0 0 0 0 0 0 % 16/01/2014
TANG CAPITAL PARTNERS, LP DELAWARE 0 0 0 0 0 0 % 16/01/2014
KEVIN C. TANG UNITED STATES 0 0 0 0 0 0 % 16/01/2014
TANG CAPITAL MANAGEMENT, LLC DELAWARE 0 0 0 0 0 0 % 16/01/2014
KEVIN C. TANG UNITED STATES 0 0 0 0 0 0 % 16/01/2014
TANG CAPITAL MANAGEMENT, LLC DELAWARE 0 0 0 0 0 0 % 16/01/2014
FMR LLC Delaware 128 0 3501328 0 3367128 10.145 % 10/12/2013
Edward C. Johnson 3d United States of America 0 0 3501328 0 3367128 10.145 % 10/12/2013
Edward C. Johnson 3d United States of America 0 0 3501328 0 3367128 10.145 % 10/12/2013
FMR LLC Delaware 128 0 3501328 0 3367128 10.145 % 10/12/2013
Millennium International Management LP 775955 2.3 % 11/10/2013
ICS Opportunities, Ltd. 655685 2 % 11/10/2013
Millennium Management LLC 1678094 5.1 % 11/10/2013
Integrated Core Strategies (US) LLC 902139 2.7 % 11/10/2013
Israel A. Englander 1678094 5.1 % 11/10/2013
Millennium International Management GP LLC 775955 2.3 % 11/10/2013
Integrated Assets, Ltd. 120270 0.4 % 11/10/2013
Baker Bros. Advisors LP Delaware 3966179 0 3966179 0 3966179 13.9 % 12/08/2013
Baker Bros. Advisors LP Delaware 3966179 0 3966179 0 3966179 13.9 % 12/08/2013
Julian C. Baker United States 3966179 0 3966179 0 3966179 13.9 % 12/08/2013
Felix J. Baker United States 3966179 0 3966179 0 3966179 13.9 % 12/08/2013
Baker Bros. Advisors Delaware 3966179 0 3966179 0 3966179 13.9 % 12/08/2013
Julian C. Baker United States 3966179 0 3966179 0 3966179 13.9 % 12/08/2013
Felix J. Baker United States 3966179 0 3966179 0 3966179 13.9 % 12/08/2013
Baker Bros. Advisors Delaware 3966179 0 3966179 0 3966179 13.9 % 12/08/2013
Palo Alto Investors, LLC California 0 3141014 0 3141014 3141014 11.1 % 30/07/2013
Anthony Joonkyoo Yun, MD U.S.A. 0 3141014 0 3141014 3141014 11.1 % 30/07/2013
Patrick Lee, MD U.S.A. 0 3141014 0 3141014 3141014 11.1 % 30/07/2013
Palo Alto Healthcare Master Fund II, L.P. Cayman Islands 0 1633784 0 1633784 1633784 5.8 % 30/07/2013
Julian C. Baker United States 3966179 0 3966179 0 3966179 14 % 10/06/2013
Baker Bros. Advisors, LLC Delaware 3966179 0 3966179 0 3966179 14 % 10/06/2013
Baker Bros. Advisors, LLC Delaware 3966179 0 3966179 0 3966179 14 % 10/06/2013
Felix J. Baker United States 3966179 0 3966179 0 3966179 14 % 10/06/2013
Julian C. Baker United States 3966179 0 3966179 0 3966179 14 % 10/06/2013
Felix J. Baker United States 3966179 0 3966179 0 3966179 14 % 10/06/2013
Patrick Lee, MD U.S.A. 0 1429462 0 1429462 1429462 5.1 % 14/02/2013
Palo Alto Investors, LLC California 0 1429462 0 1429462 1429462 5.1 % 14/02/2013
Anthony Joonkyoo Yun, MD U.S.A. 0 1429462 0 1429462 1429462 5.1 % 14/02/2013
Dr. Jeffrey R. Jay, M.D. USA 0 2300021 0 2300021 2300021 8.15 % 14/02/2013
Great Point Partners, LLC USA 0 2300021 0 2300021 2300021 8.15 % 14/02/2013
Mr. David Kroin USA 0 2300021 0 2300021 2300021 8.15 % 14/02/2013
KEVIN C. TANG UNITED STATES 0 1808525 0 1808525 1808525 6.4 % 14/02/2013
TANG CAPITAL PARTNERS, LP DELAWARE 0 1808525 0 1808525 1808525 6.4 % 14/02/2013
TANG CAPITAL MANAGEMENT, LLC DELAWARE 0 1808525 0 1808525 1808525 6.4 % 14/02/2013
Ft Eagle Investment Management, LLC Delaware 1911452 0 1911452 0 1911452 6.77 % 11/02/2013
BlackRock, Inc. Delaware 2058710 0 2058710 0 2058710 7.29 % 07/02/2013
Dr. Jeffrey R. Jay, M.D. USA 0 1930000 0 1930000 1930000 6.84 % 10/12/2012
Mr. David Kroin USA 0 1930000 0 1930000 1930000 6.84 % 10/12/2012
Great Point Partners, LLC USA 0 1930000 0 1930000 1930000 6.84 % 10/12/2012
TANG CAPITAL PARTNERS, LP DELAWARE 0 1951252 0 1951252 1951252 6.9 % 20/04/2012
TANG CAPITAL PARTNERS, LP DELAWARE 0 1951252 0 1951252 1951252 6.9 % 20/04/2012
TANG CAPITAL MANAGEMENT, LLC DELAWARE 0 1951252 0 1951252 1951252 6.9 % 20/04/2012
KEVIN C. TANG UNITED STATES 0 1951252 0 1951252 1951252 6.9 % 20/04/2012
TANG CAPITAL MANAGEMENT, LLC DELAWARE 0 1951252 0 1951252 1951252 6.9 % 20/04/2012
KEVIN C. TANG UNITED STATES 0 1951252 0 1951252 1951252 6.9 % 20/04/2012
RA Capital Healthcare Fund, L.P. Delaware 749142 0 749142 0 749142 2.67 % 12/08/2011
Peter Kolchinsky United States 1427320 0 1427320 0 1427320 5.08 % 12/08/2011
RA Capital Healthcare Fund, L.P. Delaware 749142 0 749142 0 749142 2.67 % 12/08/2011
RA Capital Management, LLC Massachusetts 1427320 0 1427320 0 1427320 5.08 % 12/08/2011
RA Capital Management, LLC Massachusetts 1427320 0 1427320 0 1427320 5.08 % 12/08/2011
Peter Kolchinsky United States 1427320 0 1427320 0 1427320 5.08 % 12/08/2011
College Retirement Equities Stock Account New York 0 1610533 0 1610533 1610533 5.74 % 11/02/2011
Teachers Advisors, Inc. Delaware 981341 0 981341 0 981341 3.5 % 11/02/2011
Investment Management, LLC Delaware 1984148 0 1984148 0 1984148 7.08 % 11/02/2011
Teachers Advisors, Inc. Delaware 981341 0 981341 0 981341 3.5 % 11/02/2011
College Retirement Equities Stock Account New York 0 1610533 0 1610533 1610533 5.74 % 11/02/2011
Investment Management, LLC Delaware 1984148 0 1984148 0 1984148 7.08 % 11/02/2011
Teachers Advisors, Inc. Delaware 981341 0 981341 0 981341 3.5 % 11/02/2011
Investment Management, LLC Delaware 1984148 0 1984148 0 1984148 7.08 % 11/02/2011
College Retirement Equities Stock Account New York 0 1610533 0 1610533 1610533 5.74 % 11/02/2011
BlackRock, Inc. Delaware 1735597 0 1735597 0 1735597 6.19 % 09/02/2011
TANG CAPITAL MANAGEMENT, LLC DELAWARE 0 100 0 100 100 0 % 05/05/2010
KEVIN C. TANG UNITED STATES 0 100 0 100 100 0 % 05/05/2010
TANG CAPITAL MANAGEMENT, LLC DELAWARE 0 100 0 100 100 0 % 05/05/2010
TANG CAPITAL PARTNERS, LP DELAWARE 0 100 0 100 100 0 % 05/05/2010
TANG CAPITAL PARTNERS, LP DELAWARE 0 100 0 100 100 0 % 05/05/2010
KEVIN C. TANG UNITED STATES 0 100 0 100 100 0 % 05/05/2010
Teachers Advisors, Inc. Delaware 997766 0 997766 0 997766 3.58 % 09/04/2010
Investment Management, LLC Delaware 1876533 0 1876533 0 1876533 6.74 % 09/04/2010
College Retirement Equities Stock Account New York 0 1546515 0 1546515 1546515 5.55 % 09/04/2010
Teachers Advisors, Inc. Delaware 997766 0 997766 0 997766 3.58 % 09/04/2010
Investment Management, LLC Delaware 1876533 0 1876533 0 1876533 6.74 % 09/04/2010
College Retirement Equities Stock Account New York 0 1546515 0 1546515 1546515 5.55 % 09/04/2010
TANG CAPITAL MANAGEMENT, LLC DELAWARE 0 1620552 0 1620552 1620552 6 % 08/03/2010
TANG CAPITAL PARTNERS, LP DELAWARE 0 1620552 0 1620552 1620552 6 % 08/03/2010
TANG CAPITAL MANAGEMENT, LLC DELAWARE 0 1620552 0 1620552 1620552 6 % 08/03/2010
KEVIN C. TANG UNITED STATES 0 1702852 0 1702852 1702852 6.3 % 08/03/2010
TANG CAPITAL PARTNERS, LP DELAWARE 0 1620552 0 1620552 1620552 6 % 08/03/2010
KEVIN C. TANG UNITED STATES 0 1702852 0 1702852 1702852 6.3 % 08/03/2010
KEVIN C. TANG UNITED STATES 0 3065852 0 3065852 3065852 11.3 % 16/02/2010
TANG CAPITAL MANAGEMENT, LLC DELAWARE 0 3065852 0 3065852 3065852 11.3 % 16/02/2010
TANG CAPITAL PARTNERS, LP DELAWARE 0 3065852 0 3065852 3065852 11.3 % 16/02/2010
RA Capital Management, LLC Massachusetts 0 0 0 0 0 0 % 16/02/2010
Peter Kolchinsky United States 0 0 0 0 0 0 % 16/02/2010
RA Capital Healthcare Fund, L.P. Delaware 0 0 0 0 0 0 % 16/02/2010
RA Capital Healthcare Fund II, L.P. Delaware 0 0 0 0 0 0 % 16/02/2010
RA Capital Management, LLC Massachusetts 0 0 0 0 0 0 % 16/02/2010
Peter Kolchinsky United States 0 0 0 0 0 0 % 16/02/2010
RA Capital Healthcare Fund, L.P. Delaware 0 0 0 0 0 0 % 16/02/2010
RA Capital Healthcare Fund II, L.P. Delaware 0 0 0 0 0 0 % 16/02/2010
S.A.C. Capital Advisors, Inc. Delaware 0 0 0 0 0 0 % 16/02/2010
S.A.C. Capital Advisors, Inc. Delaware 0 0 0 0 0 0 % 16/02/2010
Steven A. Cohen United States 0 0 0 0 0 0 % 16/02/2010
Sigma Capital Associates, LLC Anguilla British West Indies 0 0 0 0 0 0 % 16/02/2010
S.A.C. Capital Advisors, L.P. Delaware 0 0 0 0 0 0 % 16/02/2010
CR Intrinsic Investors, LLC Delaware 0 0 0 0 0 0 % 16/02/2010
Sigma Capital Management, LLC Delaware 0 0 0 0 0 0 % 16/02/2010
CR Intrinsic Investors, LLC Delaware 0 0 0 0 0 0 % 16/02/2010
Sigma Capital Management, LLC Delaware 0 0 0 0 0 0 % 16/02/2010
Sigma Capital Associates, LLC Anguilla British West Indies 0 0 0 0 0 0 % 16/02/2010
Steven A. Cohen United States 0 0 0 0 0 0 % 16/02/2010
S.A.C. Capital Advisors, L.P. Delaware 0 0 0 0 0 0 % 16/02/2010
Integrated Core Strategies Delaware 0 384000 0 384000 384000 1.4 % 22/01/2010
Millennium Management LLC Delaware 0 796033 0 796033 796033 2.9 % 22/01/2010
Israel A. Englander United States 0 796033 0 796033 796033 2.9 % 22/01/2010
Millenco LLC Delaware 0 412033 0 412033 412033 1.5 % 22/01/2010
Domain Partners VI, L.P. Delaware 0 0 0 0 0 0 % 21/01/2010
DP VI Associates, L.P. Delaware 0 0 0 0 0 0 % 21/01/2010
BAM Opportunity Fund, L.P. Delaware USA 0 28715 0 28715 28715 0.11 % 19/01/2010
Ross Berman United States America 0 28715 0 28715 28715 0.11 % 19/01/2010
Hal Mintz United States America 0 28715 0 28715 28715 0.11 % 19/01/2010
BAM Capital, LLC Delaware USA 0 28715 0 28715 28715 0.11 % 19/01/2010
BAM Opportunity Fund, L.P. Delaware USA 0 28715 0 28715 28715 0.11 % 19/01/2010
BAM Management, LLC Delaware USA 0 28715 0 28715 28715 0.11 % 19/01/2010
BAM Total Return Master Fund, Ltd. Cayman Islands 0 0 0 0 0 0 % 19/01/2010
BAM Total Return Master Fund, Ltd. Cayman Islands 0 0 0 0 0 0 % 19/01/2010
BAM Management, LLC Delaware USA 0 28715 0 28715 28715 0.11 % 19/01/2010
BAM Capital, LLC Delaware USA 0 28715 0 28715 28715 0.11 % 19/01/2010
BAM Offshore Management, LLC Delaware USA 0 0 0 0 0 0 % 19/01/2010
Hal Mintz United States America 0 28715 0 28715 28715 0.11 % 19/01/2010
Ross Berman United States America 0 28715 0 28715 28715 0.11 % 19/01/2010
BAM Offshore Management, LLC Delaware USA 0 0 0 0 0 0 % 19/01/2010
BlackRock, Inc. Delaware 4018880 0 4018880 0 4018880 14.77 % 08/01/2010
Jennison Associates LLC S.S. or I.R.S. Identification No. of Above Person: IRS Identification (formerly Delaware 2567800 0 0 2567800 2567800 9.64 % 14/02/2008

Senat trading

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Senat Divulgation

Représentant Date de la transaction Date de divulgation Type Montant District