| Venrock Opportunities Fund, L.P. |
Delaware |
0 |
1882615 |
0 |
1882615 |
1882615 |
2.9 % |
14/11/2024 |
| Venrock Opportunities Management, LLC |
Delaware |
0 |
1882615 |
0 |
1882615 |
1882615 |
2.9 % |
14/11/2024 |
| Koh, Bong |
United States |
0 |
3575309 |
0 |
3575309 |
3575309 |
5.5 % |
14/11/2024 |
| VHCP Management EG, LLC |
Delaware |
0 |
3575309 |
0 |
3575309 |
3575309 |
5.5 % |
14/11/2024 |
| Shah, Nimish |
United States |
0 |
3575309 |
0 |
3575309 |
3575309 |
5.5 % |
14/11/2024 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
3575309 |
0 |
3575309 |
3575309 |
5.5 % |
14/11/2024 |
| VHCP Holdings III, LLC |
Delaware |
0 |
3575309 |
0 |
3575309 |
3575309 |
5.5 % |
14/11/2024 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
3575309 |
0 |
3575309 |
3575309 |
5.5 % |
14/11/2024 |
| VHCP Management III, LLC |
Delaware |
0 |
3575309 |
0 |
3575309 |
3575309 |
5.5 % |
14/11/2024 |
| Senai Asefaw, M.D. |
United States of America |
3509253 |
0 |
3509253 |
0 |
3509253 |
4.6 % |
14/11/2024 |
| Paradigm BioCapital Advisors LP |
Delaware |
3509253 |
0 |
3509253 |
0 |
3509253 |
4.6 % |
14/11/2024 |
| Paradigm BioCapital Advisors GP LLC |
Delaware |
3509253 |
0 |
3509253 |
0 |
3509253 |
4.6 % |
14/11/2024 |
| Paradigm BioCapital International Fund Ltd. |
Cayman Islands |
3011327 |
0 |
3011327 |
0 |
3011327 |
3.9 % |
14/11/2024 |
| STATE STREET CORPORATION |
MA |
0 |
2205678 |
0 |
2379774 |
2379774 |
3.2 % |
18/10/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
66794 |
2896512 |
104436 |
3000948 |
5.71 % |
13/02/2024 |
| Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
4022066 |
0 |
4022066 |
4022066 |
6.7 % |
29/01/2024 |
| Perceptive Advisors LLC |
Delaware |
0 |
4022066 |
0 |
4022066 |
4022066 |
6.7 % |
29/01/2024 |
| Joseph Edelman |
United States of America |
0 |
4022066 |
0 |
4022066 |
4022066 |
6.7 % |
29/01/2024 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
2621629 |
0 |
2708383 |
2708383 |
5.15 % |
24/01/2024 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
7625542 |
0 |
7625542 |
14.501 % |
10/01/2024 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
7625542 |
0 |
7625542 |
14.501 % |
10/01/2024 |
| FMR LLC |
Delaware |
7624631 |
0 |
7625542 |
0 |
7625542 |
14.501 % |
10/01/2024 |
| FMR LLC |
Delaware |
7624631 |
0 |
7625542 |
0 |
7625542 |
14.501 % |
10/01/2024 |
| Venrock Opportunities Fund, L.P. |
Delaware |
0 |
2823921 |
0 |
2823921 |
2823921 |
5.2 % |
08/12/2023 |
| Venrock Opportunities Management, LLC |
Delaware |
0 |
2823921 |
0 |
2823921 |
2823921 |
5.2 % |
08/12/2023 |
| Paradigm BioCapital Advisors LP |
Delaware |
2310698 |
0 |
2310698 |
0 |
2310698 |
5.4 % |
11/05/2023 |
| Paradigm BioCapital Advisors LP |
Delaware |
2310698 |
0 |
2310698 |
0 |
2310698 |
5.4 % |
11/05/2023 |
| Paradigm BioCapital Advisors GP LLC |
Delaware |
2310698 |
0 |
2310698 |
0 |
2310698 |
5.4 % |
11/05/2023 |
| Dr. Senai Asefaw |
United States America |
2310698 |
0 |
2310698 |
0 |
2310698 |
5.4 % |
11/05/2023 |
| Paradigm BioCapital International Fund Ltd. |
Cayman Islands |
1824487 |
0 |
1824487 |
0 |
1824487 |
4.2 % |
11/05/2023 |
| Dr. Senai Asefaw |
United States America |
2310698 |
0 |
2310698 |
0 |
2310698 |
5.4 % |
11/05/2023 |
| Paradigm BioCapital Advisors GP LLC |
Delaware |
2310698 |
0 |
2310698 |
0 |
2310698 |
5.4 % |
11/05/2023 |
| Paradigm BioCapital International Fund Ltd. |
Cayman Islands |
1824487 |
0 |
1824487 |
0 |
1824487 |
4.2 % |
11/05/2023 |
| Vivo Opportunity, LLC |
Delaware |
1678207 |
0 |
1678207 |
0 |
1678207 |
4.2 % |
13/02/2023 |
| BlackRock, Inc. |
Delaware |
2714796 |
0 |
2761556 |
0 |
2761556 |
6.9 % |
03/02/2023 |
| Israel A. Englander |
|
|
|
|
|
785854 |
2 % |
26/01/2023 |
| Millennium Group Management LLC |
|
|
|
|
|
785854 |
2 % |
26/01/2023 |
| Millennium Management LLC |
|
|
|
|
|
785854 |
2 % |
26/01/2023 |
| Israel A. Englander |
|
|
|
|
|
785854 |
2 % |
26/01/2023 |
| Millennium Management LLC |
|
|
|
|
|
785854 |
2 % |
26/01/2023 |
| Millennium Group Management LLC |
|
|
|
|
|
785854 |
2 % |
26/01/2023 |
| Frazier Life Sciences Public Fund, L.P. |
Delaware |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| Albert Cha |
United States Citizen |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| Patrick J. Heron |
United States Citizen |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| James N. Topper |
United States Citizen |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| FHMLSP, L.L.C. |
Delaware |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| Frazier Life Sciences Public Fund, L.P. |
Delaware |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| James Brush |
United States Citizen |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| FHMLSP, L.P. |
Delaware |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| James Brush |
United States Citizen |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| Albert Cha |
United States Citizen |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| Patrick J. Heron |
United States Citizen |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| James N. Topper |
United States Citizen |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| FHMLSP, L.L.C. |
Delaware |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| FHMLSP, L.P. |
Delaware |
0 |
300000 |
0 |
300000 |
300000 |
1.1 % |
12/08/2022 |
| Millennium Group Management LLC |
|
|
|
|
|
1422477 |
5.1 % |
31/05/2022 |
| Israel A. Englander |
|
|
|
|
|
1422477 |
5.1 % |
31/05/2022 |
| Israel A. Englander |
|
|
|
|
|
1422477 |
5.1 % |
31/05/2022 |
| Millennium Group Management LLC |
|
|
|
|
|
1422477 |
5.1 % |
31/05/2022 |
| Millennium Management LLC |
|
|
|
|
|
1422477 |
5.1 % |
31/05/2022 |
| Millennium Management LLC |
|
|
|
|
|
1422477 |
5.1 % |
31/05/2022 |
| Commodore Capital Master LP |
Cayman Islands |
0 |
1371339 |
0 |
1371339 |
1371339 |
5 % |
19/05/2022 |
| Commodore Capital Master LP |
Cayman Islands |
0 |
1371339 |
0 |
1371339 |
1371339 |
5 % |
19/05/2022 |
| Commodore Capital LP |
Delaware, USA |
0 |
1371339 |
0 |
1371339 |
1371339 |
5 % |
19/05/2022 |
| Commodore Capital LP |
Delaware, USA |
0 |
1371339 |
0 |
1371339 |
1371339 |
5 % |
19/05/2022 |
| Rajeev Shah |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Peter Kolchinsky |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| D. E. Shaw & Co., L.L.C. |
Delaware |
0 |
764613 |
0 |
764613 |
764613 |
3.5 % |
14/02/2022 |
| David E. Shaw |
United States |
0 |
764613 |
0 |
764613 |
764613 |
3.5 % |
14/02/2022 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
764613 |
0 |
764613 |
764613 |
3.5 % |
14/02/2022 |
| David E. Shaw |
United States |
0 |
764613 |
0 |
764613 |
764613 |
3.5 % |
14/02/2022 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
764613 |
0 |
764613 |
764613 |
3.5 % |
14/02/2022 |
| D. E. Shaw Valence Portfolios, L.L.C. |
Delaware |
0 |
583670 |
0 |
583670 |
583670 |
2.7 % |
14/02/2022 |
| D. E. Shaw Valence Portfolios, L.L.C. |
Delaware |
0 |
583670 |
0 |
583670 |
583670 |
2.7 % |
14/02/2022 |
| D. E. Shaw & Co., L.L.C. |
Delaware |
0 |
764613 |
0 |
764613 |
764613 |
3.5 % |
14/02/2022 |
| Logos GP LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Arsani William |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Logos Global Master Fund LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Logos Global Management GP LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Logos Global Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Paradigm BioCapital Advisors GP LLC |
|
1209051 |
0 |
1209051 |
0 |
1209051 |
5.57 % |
14/02/2022 |
| Paradigm BioCapital Advisors LP |
|
1209051 |
0 |
1209051 |
0 |
1209051 |
5.57 % |
14/02/2022 |
| Paradigm BioCapital Advisors GP LLC |
|
1209051 |
0 |
1209051 |
0 |
1209051 |
5.57 % |
14/02/2022 |
| Dr. Senai Asefaw |
|
1209051 |
0 |
1209051 |
0 |
1209051 |
5.57 % |
14/02/2022 |
| Paradigm BioCapital International Fund Ltd. |
|
706000 |
0 |
706000 |
0 |
706000 |
3.25 % |
14/02/2022 |
| Paradigm BioCapital International Fund Ltd. |
|
706000 |
0 |
706000 |
0 |
706000 |
3.25 % |
14/02/2022 |
| Dr. Senai Asefaw |
|
1209051 |
0 |
1209051 |
0 |
1209051 |
5.57 % |
14/02/2022 |
| Paradigm BioCapital Advisors LP |
|
1209051 |
0 |
1209051 |
0 |
1209051 |
5.57 % |
14/02/2022 |
| Ally Bridge MedAlpha Management GP, LLC |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| ABG Management Ltd. |
Cayman Islands |
0 |
604774 |
0 |
604774 |
604774 |
2.8 % |
11/02/2022 |
| Fan Yu |
Hong Kong |
0 |
604774 |
0 |
604774 |
604774 |
2.8 % |
11/02/2022 |
| Ally Bridge MedAlpha Management L.P. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Ally Bridge Group |
Delaware |
0 |
604774 |
0 |
604774 |
604774 |
2.8 % |
11/02/2022 |
| Ally Bridge MedAlpha Master Fund L.P. |
Cayman Islands |
0 |
604774 |
0 |
604774 |
604774 |
2.8 % |
11/02/2022 |
| Frazier Life Sciences Public Fund, L.P. |
Delaware |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| James Brush |
United States Citizen |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| Albert Cha |
United States Citizen |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| Patrick J. Heron |
United States Citizen |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| James N. Topper |
United States Citizen |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| FHMLSP, L.L.C. |
Delaware |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| FHMLSP, L.P. |
Delaware |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| FHMLSP, L.L.C. |
Delaware |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| Frazier Life Sciences Public Fund, L.P. |
Delaware |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| FHMLSP, L.P. |
Delaware |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| James N. Topper |
United States Citizen |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| Patrick J. Heron |
United States Citizen |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| Albert Cha |
United States Citizen |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| James Brush |
United States Citizen |
0 |
1505200 |
0 |
1505200 |
1505200 |
6.9 % |
28/01/2022 |
| Avidity Capital Partners Fund |
Delaware |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| David Witzke |
United States of America |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| Avidity Master Fund LP |
Cayman Islands |
0 |
876577 |
0 |
876577 |
876577 |
5.2 % |
27/10/2021 |
| Michael Gregory |
United States of America |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| Avidity Partners Management LP |
Delaware |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| Avidity Partners Management |
Delaware |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| David Witzke |
United States of America |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| Michael Gregory |
United States of America |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| Avidity Partners Management |
Delaware |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| Avidity Partners Management LP |
Delaware |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| Avidity Capital Partners |
Delaware |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| Avidity Capital Partners Fund |
Delaware |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| Avidity Capital Partners |
Delaware |
0 |
1120925 |
0 |
1120925 |
1120925 |
6.6 % |
27/10/2021 |
| Avidity Master Fund LP |
Cayman Islands |
0 |
876577 |
0 |
876577 |
876577 |
5.2 % |
27/10/2021 |
| Koh, Bong 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| Shah, Nimish 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| VHCP Management III, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| Koh, Bong 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| Venrock Healthcare Capital Partners EG, L.P. 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| VHCP Management EG, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| VHCP Management III, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| Venrock Healthcare Capital Partners EG, L.P. 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| VHCP Holdings III, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| VHCP Holdings III, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| Shah, Nimish 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| VHCP Management EG, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
19430552 |
0 |
19430552 |
19430552 |
9.99 % |
14/10/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
08/10/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
08/10/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
08/10/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
08/10/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
08/10/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
08/10/2021 |
| Vivo Opportunity, LLC |
Delaware |
1300000 |
0 |
1300000 |
0 |
1300000 |
7.7 % |
30/09/2021 |
| Logos Global Master Fund LP |
Cayman Islands |
0 |
1495000 |
0 |
1495000 |
1495000 |
8.8 % |
29/09/2021 |
| Arsani William |
United States |
0 |
1495000 |
0 |
1495000 |
1495000 |
8.8 % |
29/09/2021 |
| Logos Global Management GP LLC |
Delaware |
0 |
1495000 |
0 |
1495000 |
1495000 |
8.8 % |
29/09/2021 |
| Logos Global Management LP |
Delaware |
0 |
1495000 |
0 |
1495000 |
1495000 |
8.8 % |
29/09/2021 |
| Logos GP LLC |
Delaware |
0 |
1495000 |
0 |
1495000 |
1495000 |
8.8 % |
29/09/2021 |
| Logos Global Management LP |
Delaware |
0 |
1495000 |
0 |
1495000 |
1495000 |
8.8 % |
29/09/2021 |
| Logos Global Management GP LLC |
Delaware |
0 |
1495000 |
0 |
1495000 |
1495000 |
8.8 % |
29/09/2021 |
| Arsani William |
United States |
0 |
1495000 |
0 |
1495000 |
1495000 |
8.8 % |
29/09/2021 |
| Logos Global Master Fund LP |
Cayman Islands |
0 |
1495000 |
0 |
1495000 |
1495000 |
8.8 % |
29/09/2021 |
| Logos GP LLC |
Delaware |
0 |
1495000 |
0 |
1495000 |
1495000 |
8.8 % |
29/09/2021 |
| TCG Crossover Management, LLC |
Delaware, United States |
1314000 |
0 |
1314000 |
0 |
1314000 |
8.2 % |
29/09/2021 |
| TCG Crossover Management, LLC |
Delaware, United States |
1314000 |
0 |
1314000 |
0 |
1314000 |
8.2 % |
29/09/2021 |
| Deep Track Capital, LP |
Delaware |
0 |
1819689 |
0 |
1819689 |
0 |
9.9 % |
24/09/2021 |
| Deep Track Capital, LP |
Delaware |
0 |
1819689 |
0 |
1819689 |
0 |
9.9 % |
24/09/2021 |
| Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
1819689 |
0 |
1819689 |
0 |
9.9 % |
24/09/2021 |
| David Kroin |
United States |
0 |
1819689 |
0 |
1819689 |
0 |
9.9 % |
24/09/2021 |
| David Kroin |
United States |
0 |
1819689 |
0 |
1819689 |
0 |
9.9 % |
24/09/2021 |
| Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
1819689 |
0 |
1819689 |
0 |
9.9 % |
24/09/2021 |
| TCG Crossover Management, LLC |
Delaware, United States |
1314000 |
0 |
1314000 |
0 |
1314000 |
13.7 % |
24/09/2021 |
| TCG Crossover Management, LLC |
Delaware, United States |
1314000 |
0 |
1314000 |
0 |
1314000 |
13.7 % |
24/09/2021 |
| TCG Crossover Management, LLC |
Delaware, United States |
914000 |
0 |
914000 |
0 |
914000 |
9.5 % |
10/09/2021 |
| TCG Crossover Management, LLC |
Delaware, United States |
914000 |
0 |
914000 |
0 |
914000 |
9.5 % |
10/09/2021 |
| Albert Cha |
United States Citizen |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| FHMLSP, L.P. |
Delaware |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| FHMLSP, L.L.C. |
Delaware |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| James N. Topper |
United States Citizen |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| Patrick J. Heron |
United States Citizen |
0 |
1305200 |
0 |
1305200 |
1305200 |
9.5 % |
26/08/2021 |
| Albert Cha |
United States Citizen |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| James Brush |
United States Citizen |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| Frazier Life Sciences Public Fund L.P. |
Delaware |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| Frazier Life Sciences Public Fund L.P. |
Delaware |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| FHMLSP, L.P. |
Delaware |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| FHMLSP, L.L.C. |
Delaware |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| James N. Topper |
United States Citizen |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| Patrick J. Heron |
United States Citizen |
0 |
1305200 |
0 |
1305200 |
1305200 |
9.5 % |
26/08/2021 |
| James Brush |
United States Citizen |
0 |
1305200 |
0 |
1305200 |
1305200 |
13.6 % |
26/08/2021 |
| D. E. Shaw Valence Portfolios, L.L.C. |
Delaware |
0 |
540300 |
0 |
540300 |
540300 |
6.4 % |
01/06/2021 |
| D. E. Shaw & Co., L.L.C. |
Delaware |
0 |
720373 |
0 |
720373 |
720373 |
8.5 % |
01/06/2021 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
720373 |
0 |
720373 |
720373 |
8.5 % |
01/06/2021 |
| David E. Shaw |
United States |
0 |
720373 |
0 |
720373 |
720373 |
8.5 % |
01/06/2021 |
| David E. Shaw |
United States |
0 |
720373 |
0 |
720373 |
720373 |
8.5 % |
01/06/2021 |
| D. E. Shaw Valence Portfolios, L.L.C. |
Delaware |
0 |
540300 |
0 |
540300 |
540300 |
6.4 % |
01/06/2021 |
| D. E. Shaw & Co., L.L.C. |
Delaware |
0 |
720373 |
0 |
720373 |
720373 |
8.5 % |
01/06/2021 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
720373 |
0 |
720373 |
720373 |
8.5 % |
01/06/2021 |
| David E. Shaw |
United States |
0 |
471694 |
0 |
471694 |
471694 |
6.5 % |
10/05/2021 |
| D. E. Shaw & Co., L.L.C. |
Delaware |
0 |
471694 |
0 |
471694 |
471694 |
6.5 % |
10/05/2021 |
| D. E. Shaw & Co., L.L.C. |
Delaware |
0 |
471694 |
0 |
471694 |
471694 |
6.5 % |
10/05/2021 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
471694 |
0 |
471694 |
471694 |
6.5 % |
10/05/2021 |
| David E. Shaw |
United States |
0 |
471694 |
0 |
471694 |
471694 |
6.5 % |
10/05/2021 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
471694 |
0 |
471694 |
471694 |
6.5 % |
10/05/2021 |
| Rajeev Shah |
United States of America |
0 |
388385 |
0 |
388385 |
388385 |
6.3 % |
15/03/2021 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
352938 |
0 |
352938 |
352938 |
5.7 % |
15/03/2021 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
352938 |
0 |
352938 |
352938 |
5.7 % |
15/03/2021 |
| Peter Kolchinsky |
United States of America |
0 |
388385 |
0 |
388385 |
388385 |
6.3 % |
15/03/2021 |
| Rajeev Shah |
United States of America |
0 |
388385 |
0 |
388385 |
388385 |
6.3 % |
15/03/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
388385 |
0 |
388385 |
388385 |
6.3 % |
15/03/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
388385 |
0 |
388385 |
388385 |
6.3 % |
15/03/2021 |
| Peter Kolchinsky |
United States of America |
0 |
388385 |
0 |
388385 |
388385 |
6.3 % |
15/03/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
578560 |
0 |
578560 |
578560 |
11.1 % |
10/03/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
578560 |
0 |
578560 |
578560 |
11.1 % |
10/03/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
578560 |
0 |
578560 |
578560 |
11.1 % |
10/03/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
578560 |
0 |
578560 |
578560 |
11.1 % |
10/03/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
578560 |
0 |
578560 |
578560 |
11.1 % |
10/03/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
578560 |
0 |
578560 |
578560 |
11.1 % |
10/03/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
578560 |
0 |
578560 |
578560 |
11.1 % |
10/03/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
578560 |
0 |
578560 |
578560 |
11.1 % |
10/03/2021 |
| Hawkes Bay Master Investors |
Cayman Islands |
0 |
363284 |
0 |
363284 |
363284 |
6.97 % |
19/02/2021 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
426162 |
0 |
426162 |
426162 |
10.9 % |
16/02/2021 |
| Steven A. Cohen |
United States |
0 |
426162 |
0 |
426162 |
426162 |
10.9 % |
16/02/2021 |
| Steven A. Cohen |
United States |
0 |
426162 |
0 |
426162 |
426162 |
10.9 % |
16/02/2021 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
426162 |
0 |
426162 |
426162 |
10.9 % |
16/02/2021 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
426162 |
0 |
426162 |
426162 |
10.9 % |
16/02/2021 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
426162 |
0 |
426162 |
426162 |
10.9 % |
16/02/2021 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
459144 |
0 |
459144 |
459144 |
9.99 % |
19/01/2021 |
| Bihua Chen |
United States |
0 |
459144 |
0 |
459144 |
459144 |
9.99 % |
19/01/2021 |
| Cormorant Asset Management, LP |
Delaware |
0 |
459144 |
0 |
459144 |
459144 |
9.99 % |
19/01/2021 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
459144 |
0 |
459144 |
459144 |
9.99 % |
19/01/2021 |
| Citadel Securities GP LLC |
Delaware |
0 |
6086 |
0 |
6086 |
6086 |
0.1 % |
11/01/2021 |
| Kenneth Griffin |
U.S. Citizen |
0 |
426562 |
0 |
426562 |
426562 |
9.9 % |
11/01/2021 |
| Citadel Advisors LLC |
Delaware |
0 |
420476 |
0 |
420476 |
420476 |
9.8 % |
11/01/2021 |
| Citadel Advisors Holdings LP |
Delaware |
0 |
420476 |
0 |
420476 |
420476 |
9.8 % |
11/01/2021 |
| Citadel GP LLC |
Delaware |
0 |
420476 |
0 |
420476 |
420476 |
9.8 % |
11/01/2021 |
| Citadel Securities LLC |
Delaware |
0 |
5977 |
0 |
5977 |
5977 |
0.1 % |
11/01/2021 |
| CALC IV LP |
Delaware |
0 |
6086 |
0 |
6086 |
6086 |
0.1 % |
11/01/2021 |
| Xencor, Inc. |
|
322407 |
0 |
322407 |
0 |
322407 |
7.6 % |
11/01/2021 |
| Ally Bridge MedAlpha Master Fund L.P. |
Cayman Islands |
0 |
929979 |
0 |
929979 |
929979 |
9.99 % |
07/01/2021 |
| Ally Bridge MedAlpha Management L.P. |
Cayman Islands |
0 |
929979 |
0 |
929979 |
929979 |
9.99 % |
07/01/2021 |
| Fan Yu |
Hong Kong |
0 |
929979 |
0 |
929979 |
929979 |
9.99 % |
07/01/2021 |
| ABG Management Ltd. |
Cayman Islands |
0 |
929979 |
0 |
929979 |
929979 |
9.99 % |
07/01/2021 |
| Ally Bridge Group (NY) LLC |
Delaware |
0 |
929979 |
0 |
929979 |
929979 |
9.99 % |
07/01/2021 |
| Ally Bridge MedAlpha Management GP, LLC |
Cayman Islands |
0 |
929979 |
0 |
929979 |
929979 |
9.99 % |
07/01/2021 |
| Rajeev Shah |
United States of America |
0 |
451932 |
0 |
451932 |
451932 |
11.6 % |
17/12/2020 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
410686 |
0 |
410686 |
410686 |
10.5 % |
17/12/2020 |
| Peter Kolchinsky |
United States of America |
0 |
451932 |
0 |
451932 |
451932 |
11.6 % |
17/12/2020 |
| RA Capital Management, L.P. |
Delaware |
0 |
451932 |
0 |
451932 |
451932 |
11.6 % |
17/12/2020 |
| Logos Global Master Fund LP |
Cayman Islands |
0 |
550000 |
0 |
550000 |
550000 |
14.1 % |
16/11/2020 |
| Logos Global Management GP LLC |
Delaware |
0 |
550000 |
0 |
550000 |
550000 |
14.1 % |
16/11/2020 |
| Logos GP LLC |
Delaware |
0 |
550000 |
0 |
550000 |
550000 |
14.1 % |
16/11/2020 |
| Logos Global Management LP |
Delaware |
0 |
550000 |
0 |
550000 |
550000 |
14.1 % |
16/11/2020 |
| Arsani William |
United States |
0 |
550000 |
0 |
550000 |
550000 |
14.1 % |
16/11/2020 |
| FMR LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/11/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
10/11/2020 |
| Mark N. Lampert |
United States |
0 |
7584219 |
0 |
7584219 |
7584219 |
9.99 % |
09/11/2020 |
| BVF Inc. |
Delaware |
0 |
7584219 |
0 |
7584219 |
7584219 |
9.99 % |
09/11/2020 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
10129 |
0 |
10129 |
10129 |
0 % |
09/11/2020 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
10129 |
0 |
10129 |
10129 |
0 % |
09/11/2020 |
| BVF II GP LLC |
Delaware |
0 |
58234 |
0 |
58234 |
58234 |
0 % |
09/11/2020 |
| BVF I GP LLC |
Delaware |
0 |
7515856 |
0 |
7515856 |
7515856 |
9.9 % |
09/11/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
7574090 |
0 |
7574090 |
7574090 |
9.98 % |
09/11/2020 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
58234 |
0 |
58234 |
58234 |
0 % |
09/11/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
7515856 |
0 |
7515856 |
7515856 |
9.9 % |
09/11/2020 |
| BVF Partners L.P. |
Delaware |
0 |
7584219 |
0 |
7584219 |
7584219 |
9.99 % |
09/11/2020 |
| Arsani William |
United States |
0 |
6000000 |
0 |
6000000 |
6000000 |
8.8 % |
09/11/2020 |
| Logos GP LLC |
Delaware |
0 |
6000000 |
0 |
6000000 |
6000000 |
8.8 % |
09/11/2020 |
| Logos Global Master Fund LP |
Cayman Islands |
0 |
6000000 |
0 |
6000000 |
6000000 |
8.8 % |
09/11/2020 |
| Logos Global Management GP LLC |
Delaware |
0 |
6000000 |
0 |
6000000 |
6000000 |
8.8 % |
09/11/2020 |
| Logos Global Management LP |
Delaware |
0 |
6000000 |
0 |
6000000 |
6000000 |
8.8 % |
09/11/2020 |
| Steven A. Cohen |
United States |
0 |
6500000 |
0 |
6500000 |
6500000 |
9.5 % |
29/10/2020 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
6500000 |
0 |
6500000 |
6500000 |
9.5 % |
29/10/2020 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
6500000 |
0 |
6500000 |
6500000 |
9.5 % |
29/10/2020 |
| 683 CAPITAL MANAGEMENT, LLC |
DELAWARE |
0 |
1697038 |
0 |
1697038 |
1697038 |
5.5 % |
03/01/2019 |
| 683 CAPITAL PARTNERS, LP |
DELAWARE |
0 |
1697038 |
0 |
1697038 |
1697038 |
5.5 % |
03/01/2019 |
| ARI ZWEIMAN |
UNITED STATES |
0 |
1697038 |
0 |
1697038 |
1697038 |
5.5 % |
03/01/2019 |
| FMR LLC |
Delaware |
0 |
0 |
2888656 |
0 |
2888656 |
9.44 % |
13/11/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2888656 |
0 |
2888656 |
9.44 % |
13/11/2018 |
| Select Biotechnology Portfolio |
Massachusetts |
2888656 |
0 |
0 |
0 |
2888656 |
9.44 % |
13/11/2018 |
| JAFCO SV4 Investment Limited Partnership (“JAFCO SV4”) |
Japan |
667280 |
|
667280 |
|
667280 |
3 % |
30/01/2018 |
| JAFCO Co., Ltd. |
Japan |
4 |
|
4 |
|
667280 |
3 % |
30/01/2018 |
| JAFCO Co., Ltd. |
Japan |
1160406 |
|
1160406 |
|
1160406 |
5.4 % |
03/04/2017 |
| JAFCO SV4 Investment Limited Partnership (“JAFCO SV4”) |
Japan |
1160406 |
|
1160406 |
|
1160406 |
5.4 % |
03/04/2017 |
| Select Biotechnology Portfolio |
Massachusetts |
2466347 |
0 |
0 |
0 |
2466347 |
11.579 % |
10/03/2017 |
| FMR LLC |
Delaware |
0 |
0 |
3124888 |
0 |
3124888 |
14.67 % |
10/03/2017 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3124888 |
0 |
3124888 |
14.67 % |
10/03/2017 |
| Brian Eliot Peierls |
United States |
0 |
0 |
0 |
0 |
10 |
0 % |
24/02/2017 |
| E. Jeffrey Peierls |
United States |
0 |
0 |
0 |
0 |
10 |
0 % |
24/02/2017 |
| Remeditex Ventures LLC |
Texas |
0 |
2706563 |
0 |
2706563 |
2706563 |
12.7 % |
17/02/2017 |
| Lyda Hill |
United States |
0 |
2706563 |
0 |
2706563 |
2706563 |
12.7 % |
17/02/2017 |
| Malachite Trust |
Texas |
0 |
2706563 |
0 |
2706563 |
2706563 |
12.7 % |
17/02/2017 |
| Martin D. Hoe |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
19/01/2016 |
| Ryan M. Lane |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
19/01/2016 |
| Empery Asset Management, LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
19/01/2016 |
| PEIERLS, E. JEFFREY |
NA |
85500 |
595600 |
85500 |
595600 |
681100 |
9.08 % |
20/03/2015 |
| PEIERLS, BRIAN E. |
NA |
50000 |
595600 |
50000 |
595600 |
645600 |
8.6 % |
20/03/2015 |
| HEARTLAND ADVISORS, INC. |
WISCONSIN, U.S.A. |
0 |
200000 |
0 |
200000 |
200000 |
2.8 % |
06/03/2015 |
| William J. Nasgovitz |
U.S.A. |
0 |
200000 |
0 |
200000 |
200000 |
2.8 % |
06/03/2015 |
| Ryan M. Lane |
United States |
0 |
470000 |
0 |
470000 |
470000 |
6.69 % |
20/02/2015 |
| Martin D. Hoe |
United States |
0 |
470000 |
0 |
470000 |
470000 |
6.69 % |
20/02/2015 |
| Empery Asset Management, LP |
Delaware |
0 |
470000 |
0 |
470000 |
470000 |
6.69 % |
20/02/2015 |
