| Wilmot B. Harkey |
USA |
0 |
2797588 |
0 |
0 |
2797588 |
9.9 % |
14/02/2024 |
| Nantahala Capital Management, LLC |
MA |
0 |
2797588 |
0 |
0 |
2797588 |
9.9 % |
14/02/2024 |
| Daniel Mack |
USA |
0 |
2797588 |
0 |
0 |
2797588 |
9.9 % |
14/02/2024 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
0 |
1823703 |
10809 |
1834512 |
6.79 % |
13/02/2024 |
| TCG Crossover Fund I, L.P. |
Delaware |
0 |
669145 |
0 |
669145 |
669145 |
2.5 % |
16/10/2023 |
| TCG Crossover GP I, LLC |
Delaware |
0 |
669145 |
0 |
669145 |
669145 |
2.5 % |
16/10/2023 |
| TCG Crossover GP II, LLC |
Delaware |
0 |
2033012 |
0 |
2033012 |
2033012 |
7.5 % |
16/10/2023 |
| Chen Yu |
Delaware |
0 |
2702157 |
0 |
2702157 |
2702157 |
9.9 % |
16/10/2023 |
| TCG Crossover Fund II, L.P. |
Delaware |
0 |
2033012 |
0 |
2033012 |
2033012 |
7.5 % |
16/10/2023 |
| BVF Partners L.P. |
Cayman Islands |
0 |
143400 |
0 |
143400 |
2777245 |
9.99 % |
16/10/2023 |
| 2. |
Delaware |
0 |
28107 |
0 |
0 |
10 |
0.1 % |
16/10/2023 |
| 2. |
Delaware |
0 |
1565829 |
0 |
0 |
10 |
5.6 % |
16/10/2023 |
| 2. |
Delaware |
0 |
28107 |
0 |
0 |
10 |
0.1 % |
16/10/2023 |
| 2. |
Delaware |
0 |
1593936 |
0 |
0 |
10 |
5.7 % |
16/10/2023 |
| 2. |
Delaware |
0 |
1565829 |
0 |
0 |
10 |
5.6 % |
16/10/2023 |
| 2. |
Delaware |
0 |
1565829 |
0 |
0 |
10 |
5.6 % |
16/10/2023 |
| 2. |
Delaware |
0 |
28107 |
0 |
0 |
10 |
0.1 % |
16/10/2023 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2792927 |
0 |
0 |
2792927 |
9.99 % |
12/10/2023 |
| Great Point Partners, LLC |
Delaware |
0 |
2792927 |
0 |
0 |
2792927 |
9.99 % |
12/10/2023 |
| Mr. Ortav Yehudai |
USA |
0 |
2792927 |
0 |
0 |
2792927 |
9.99 % |
12/10/2023 |
| Capital LP |
USA |
0 |
2367884 |
0 |
2367884 |
2367884 |
9.9 % |
06/10/2023 |
| Capital Master LP |
Islands |
0 |
2367884 |
0 |
2367884 |
2367884 |
9.9 % |
06/10/2023 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
1565829 |
0 |
0 |
1565829 |
5.6 % |
05/10/2023 |
| Steven A. Cohen |
United States |
0 |
1565829 |
0 |
0 |
1565829 |
5.6 % |
05/10/2023 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
1565829 |
0 |
0 |
1565829 |
5.6 % |
05/10/2023 |
| Capital LP |
USA |
0 |
1575000 |
0 |
1575000 |
1575000 |
19.7 % |
09/08/2023 |
| Capital Master LP |
Islands |
0 |
1575000 |
0 |
1575000 |
1575000 |
19.7 % |
09/08/2023 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
206972862 |
0 |
206972862 |
20697286 |
10 % |
08/07/2022 |
| Commodore Capital LP |
Delaware, USA |
0 |
10455910 |
0 |
0 |
10455910 |
5.1 % |
14/04/2022 |
| Commodore Capital Master LP |
Delaware, USA |
0 |
10455910 |
0 |
0 |
10455910 |
5.1 % |
14/04/2022 |
| Acuta Capital Fund, LP |
Delaware |
0 |
9758064 |
0 |
9758064 |
9758064 |
4.7 % |
15/02/2022 |
| Acuta Capital Partners, LLC |
Delaware |
0 |
11736283 |
0 |
11736283 |
11736283 |
5.9 % |
15/02/2022 |
| Anupam Dalal |
United States |
0 |
11736283 |
0 |
11736283 |
11736283 |
5.9 % |
15/02/2022 |
| Koh, Bong |
United States |
0 |
16047286 |
0 |
0 |
16047286 |
8 % |
14/02/2022 |
| VHCP Management II, LLC |
Delaware |
0 |
16047286 |
0 |
0 |
16047286 |
8 % |
14/02/2022 |
| VHCP Management EG, LLC |
Delaware |
0 |
16047286 |
0 |
0 |
16047286 |
8 % |
14/02/2022 |
| Shah, Nimish |
United States |
0 |
16047286 |
0 |
0 |
16047286 |
8 % |
14/02/2022 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
16047286 |
0 |
0 |
16047286 |
8 % |
14/02/2022 |
| VHCP Co-Investment Holdings II, LLC |
Delaware |
0 |
16047286 |
0 |
0 |
16047286 |
8 % |
14/02/2022 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
16047286 |
0 |
0 |
16047286 |
8 % |
14/02/2022 |
| OrbiMed Advisors LLC |
Delaware |
0 |
2390043 |
0 |
0 |
2390043 |
1.2 % |
11/02/2022 |
| OrbiMed Capital LLC |
Delaware |
10519240 |
0 |
10519240 |
0 |
10519240 |
5.3 % |
11/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
11820625 |
0 |
11894193 |
0 |
11894193 |
6 % |
04/02/2022 |
| Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
10117999 |
5.1 % |
04/02/2022 |
| Acuta
Capital Partners, LLC |
Delaware |
0 |
12464974 |
0 |
12464974 |
12464974 |
8.4 % |
22/03/2021 |
| Acuta
Capital Fund, LP |
Delaware |
0 |
9656029 |
0 |
9656029 |
9656029 |
6.5 % |
22/03/2021 |
| Anupam
Dalal |
United
States |
0 |
12464974 |
0 |
12464974 |
12464974 |
8.4 % |
22/03/2021 |
| VHCP Management EG, LLC |
Delaware |
0 |
14240237 |
0 |
0 |
14240237 |
9.99 % |
16/02/2021 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
14240237 |
0 |
0 |
14240237 |
9.99 % |
16/02/2021 |
| Management II, LLC |
Delaware |
0 |
14240237 |
0 |
0 |
14240237 |
9.99 % |
16/02/2021 |
| VHCP Co-Investment Holdings II, LLC |
Delaware |
0 |
14240237 |
0 |
0 |
14240237 |
9.99 % |
16/02/2021 |
| Koh, Bong |
United States |
0 |
14240237 |
0 |
0 |
14240237 |
9.99 % |
16/02/2021 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
14240237 |
0 |
0 |
14240237 |
9.99 % |
16/02/2021 |
| Shah, Nimish |
United States |
0 |
14240237 |
0 |
0 |
14240237 |
9.99 % |
16/02/2021 |
| Acuta
Capital Partners, LLC |
United States |
0 |
7500000 |
0 |
7500000 |
7500000 |
5.4 % |
16/02/2021 |
| Anupam Dalal |
United States |
0 |
7500000 |
0 |
7500000 |
7500000 |
5.4 % |
16/02/2021 |
| OrbiMed Capital LLC |
Delaware |
0 |
9778800 |
0 |
0 |
9778800 |
6.9 % |
12/02/2021 |
| OrbiMed Advisors LLC |
Delaware |
0 |
3258243 |
0 |
0 |
3258243 |
2.34 % |
12/02/2021 |
| S |
ONTARIO, CANADA |
0 |
1357000 |
0 |
0 |
1357000 |
4.8 % |
22/01/2021 |
| S |
CAYMAN ISLANDS |
0 |
1357000 |
0 |
0 |
1357000 |
4.8 % |
22/01/2021 |
| S |
ONTARIO, CANADA |
0 |
1357000 |
0 |
0 |
1357000 |
4.8 % |
22/01/2021 |
| New Enterprise Associates 17, L.P. |
Limited Partnership |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| NEA Partners 17, L.P. |
Limited Partnership |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| 17 GP, LLC |
Delaware Limited Liability Company |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Ali Behbahani |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Carmen Chang |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Landsman |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| H. Makhzoumi |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Edward T. Mathers |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Scott D. Sandell |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| W. Sonsini |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Growth Equity Opportunities 17, LLC |
Delaware Limited Liability Company |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Anthony A. Florence, Jr. |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Joshua Makower |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Forest Baskett |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Walker |
States |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| Rick Yang |
States citizen |
0 |
9360000 |
0 |
9360000 |
9360000 |
6.8 % |
04/01/2021 |
| S |
ONTARIO, CANADA |
0 |
4000000 |
0 |
0 |
4000000 |
5.4 % |
18/09/2020 |
| S |
ONTARIO, CANADA |
0 |
4000000 |
0 |
0 |
4000000 |
5.4 % |
18/09/2020 |
| S |
ONTARIO, CANADA |
0 |
4000000 |
0 |
0 |
4000000 |
5.4 % |
18/09/2020 |
| Sphera Global Healthcare Management LP |
Israel |
0 |
1314949 |
0 |
0 |
1314949 |
2.67 % |
11/02/2020 |
| Sphera Funds Management Ltd. |
Israel |
0 |
1314949 |
0 |
0 |
1314949 |
2.67 % |
11/02/2020 |
| Moshe Arkin |
Israel |
0 |
1314949 |
0 |
0 |
1314949 |
2.67 % |
11/02/2020 |
| Sphera Global Healthcare GP Ltd. |
Israel |
0 |
1314949 |
0 |
0 |
1314949 |
2.67 % |
11/02/2020 |
| Lincoln Park Capital, LLC |
Illinois |
0 |
4614602 |
0 |
0 |
4614602 |
9.62 % |
29/01/2020 |
| Jonathan I. Cope |
Illinois |
0 |
4614602 |
0 |
0 |
4614602 |
9.62 % |
29/01/2020 |
| Lincoln Park Capital Fund, LLC |
Illinois |
0 |
4614602 |
0 |
0 |
4614602 |
9.62 % |
29/01/2020 |
| Rockledge Capital Corporation |
Illinois |
0 |
4614602 |
0 |
0 |
4614602 |
9.62 % |
29/01/2020 |
| Joshua B. Scheinfeld |
Illinois |
0 |
4614602 |
0 |
0 |
4614602 |
9.62 % |
29/01/2020 |
| Alex Noah Investors, Inc. |
Illinois |
0 |
4614602 |
0 |
0 |
4614602 |
9.62 % |
29/01/2020 |
| Moshe Arkin |
Israel |
0 |
2788867 |
0 |
2788867 |
788867 |
8.98 % |
13/02/2019 |
| Mitchell P. Kopin |
United States America |
0 |
1442667 |
0 |
1442067 |
1442067 |
4.4 % |
08/02/2019 |
| Sphera Global Healthcare Management LP |
Israel |
0 |
2182712 |
0 |
0 |
2182712 |
9.99 % |
13/02/2018 |
| Moshe Arkin |
Israel |
0 |
2182712 |
0 |
0 |
2182712 |
9.99 % |
13/02/2018 |
| Sphera Funds Management Ltd. |
Israel |
0 |
2182712 |
0 |
0 |
2182712 |
9.99 % |
13/02/2018 |
| Sphera Global Healthcare GP Ltd. |
Israel |
0 |
2182712 |
0 |
0 |
2182712 |
9.99 % |
13/02/2018 |
| Mitchell P. Kopin |
United States of America |
0 |
2245667 |
0 |
2245667 |
2245667 |
9.5 % |
13/02/2018 |
| Intracoastal Capital LLC |
United States of America |
0 |
2245667 |
0 |
2245667 |
2245667 |
9.5 % |
13/02/2018 |
| Daniel B. Asher |
United States of America |
0 |
2245667 |
0 |
2245667 |
2245667 |
9.5 % |
13/02/2018 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
1104397 |
0 |
1104397 |
1104397 |
4.9 % |
09/02/2018 |
| Heights Capital Management, Inc. |
Delaware |
0 |
1104397 |
0 |
1104397 |
1104397 |
4.9 % |
09/02/2018 |
| Martin D. Hoe |
Delaware |
0 |
3944125 |
0 |
0 |
3944125 |
4.99 % |
12/01/2018 |
| Empery Asset Management, LP |
Delaware |
0 |
3944125 |
0 |
0 |
3944125 |
4.99 % |
12/01/2018 |
| Ryan M. Lane |
Delaware |
0 |
3944125 |
0 |
0 |
3944125 |
4.99 % |
12/01/2018 |
| Mitchell P. Kopin |
Citizenship or Place of Organization United States of America |
0 |
2339839 |
0 |
2239839 |
2339839 |
9.99 % |
20/12/2017 |
| Daniel B. Asher |
Citizenship or Place of Organization United States of America |
0 |
2339839 |
0 |
2239839 |
2339839 |
9.99 % |
20/12/2017 |
| Intracoastal Capital LLC |
Citizenship or Place of Organization United States of America |
0 |
2339839 |
0 |
2239839 |
2339839 |
9.99 % |
20/12/2017 |
| Heights Capital Management, Inc. |
Delaware |
0 |
1333333 |
0 |
1333333 |
1333333 |
6.1 % |
20/12/2017 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
1333333 |
0 |
1333333 |
1333333 |
6.1 % |
20/12/2017 |
| Sabby Volatility Warrant Master Fund, Ltd. |
USA |
0 |
2000000 |
0 |
2000000 |
2000000 |
9.15 % |
14/12/2017 |
| Empery Asset Management, LP |
Delaware |
0 |
761267 |
0 |
0 |
761267 |
8.56 % |
27/01/2017 |
| Ryan M. Lane |
United States |
0 |
761267 |
0 |
0 |
761267 |
8.56 % |
27/01/2017 |
| Martin D. Hoe |
United States |
0 |
761267 |
0 |
0 |
761267 |
8.56 % |
27/01/2017 |
| Moshe Arkin |
Israel |
0 |
838200 |
0 |
838200 |
838 |
10.52 % |
24/01/2017 |
| Sphera Global Healthcare GP Ltd. |
Israel |
0 |
588200 |
0 |
0 |
588200 |
7.63 % |
22/06/2016 |
| Sphera Global Healthcare Management LP |
Israel |
0 |
588200 |
0 |
0 |
588200 |
7.63 % |
22/06/2016 |
| Sphera Funds Management Ltd. |
Israel |
0 |
588200 |
0 |
0 |
588200 |
7.63 % |
22/06/2016 |
| Moshe Arkin |
Israel |
0 |
588200 |
0 |
0 |
588200 |
7.63 % |
22/06/2016 |
| Nexthera Capital LP |
Belgium |
0 |
138132 |
0 |
138132 |
138132 |
1.8 % |
24/05/2016 |
| Empery Asset Management, LP |
United States |
0 |
761267 |
0 |
0 |
761267 |
9.87 % |
19/05/2016 |
| Martin D. Hoe |
United States |
0 |
761267 |
0 |
0 |
761267 |
9.87 % |
19/05/2016 |
| Ryan M. Lane |
United States |
0 |
761267 |
0 |
0 |
761267 |
9.87 % |
19/05/2016 |
| Ori Hershkovitz |
Delaware |
0 |
131250 |
0 |
131250 |
131250 |
5.3 % |
29/02/2016 |
| Nexthera Capital GP LLC |
Delaware |
0 |
131250 |
0 |
131250 |
131250 |
5.3 % |
29/02/2016 |
| Nexthera Capital LP |
Delaware |
0 |
131250 |
0 |
131250 |
131250 |
5.3 % |
29/02/2016 |
| Daniel Malek |
Delaware |
0 |
131250 |
0 |
131250 |
131250 |
5.3 % |
29/02/2016 |
| Platinum Long Term Growth VII, LLC |
Delaware |
0 |
77000 |
0 |
77000 |
77000 |
9.99 % |
18/02/2015 |
| Platinum Long Term Growth VII, LLC |
Delaware |
0 |
77000 |
0 |
77000 |
77000 |
9.99 % |
17/02/2015 |
| Mark Nordlicht |
Delaware |
0 |
77000 |
0 |
77000 |
77000 |
9.99 % |
17/02/2015 |
| Platinum Management (NY) LLC |
Delaware |
0 |
77000 |
0 |
77000 |
77000 |
9.99 % |
17/02/2015 |
