| 2. |
Delaware |
0 |
79 |
0 |
0 |
10 |
0 % |
13/11/2023 |
| 2. |
Delaware |
0 |
1181088 |
0 |
0 |
10 |
8.5 % |
13/11/2023 |
| 2. |
Delaware |
0 |
79 |
0 |
0 |
10 |
0 % |
13/11/2023 |
| 2. |
Delaware |
0 |
79 |
0 |
0 |
10 |
0 % |
13/11/2023 |
| 2. |
Delaware |
0 |
1181088 |
0 |
0 |
10 |
8.5 % |
13/11/2023 |
| 2. |
Delaware |
0 |
1181088 |
0 |
0 |
10 |
8.5 % |
13/11/2023 |
| 2. |
Delaware |
0 |
1181167 |
0 |
0 |
10 |
8.5 % |
13/11/2023 |
| Finny Kuruvilla, M.D. Ph. D. |
United States |
0 |
1394336 |
0 |
0 |
1394336 |
9.99 % |
13/11/2023 |
| Robin C. John |
United States |
0 |
1394336 |
0 |
0 |
1394336 |
9.99 % |
13/11/2023 |
| Eventide Asset Management, LLC |
Delaware |
1394336 |
0 |
1394336 |
0 |
1394336 |
9.99 % |
13/11/2023 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1394336 |
0 |
1394336 |
1394336 |
9.99 % |
13/11/2023 |
| Bihua Chen |
Cayman Islands |
0 |
1394336 |
0 |
1394336 |
1394336 |
9.99 % |
13/11/2023 |
| Cormorant Asset Management, LP |
Cayman Islands |
0 |
1394336 |
0 |
1394336 |
1394336 |
9.99 % |
13/11/2023 |
| Cormorant Global Healthcare GP, LLC |
Cayman Islands |
0 |
1394336 |
0 |
1394336 |
1394336 |
9.99 % |
13/11/2023 |
| Len Blavatnik |
|
0 |
3201980 |
0 |
3201980 |
3201980 |
19.99 % |
13/11/2023 |
| Access Industries Holdings LLC |
|
0 |
3201980 |
0 |
3201980 |
3201980 |
19.99 % |
13/11/2023 |
| AI Biotechnology LLC |
|
0 |
3201980 |
0 |
3201980 |
3201980 |
19.99 % |
13/11/2023 |
| Access Industries Management, LLC |
|
0 |
3201980 |
0 |
3201980 |
3201980 |
19.99 % |
13/11/2023 |
| Soleus Capital, LLC |
OR PLACE OF ORGANIZATION |
0 |
890868 |
0 |
890868 |
890868 |
6.4 % |
02/11/2023 |
| Soleus
Capital Group, LLC |
OR PLACE OF ORGANIZATION |
0 |
890868 |
0 |
890868 |
890868 |
6.4 % |
02/11/2023 |
| Guy
Levy |
OR PLACE OF ORGANIZATION |
0 |
890868 |
0 |
890868 |
890868 |
6.4 % |
02/11/2023 |
| Soleus
Capital Master Fund, L.P. |
OR PLACE OF ORGANIZATION |
0 |
890868 |
0 |
890868 |
890868 |
6.4 % |
02/11/2023 |
| Joseph Edelman |
Delaware |
0 |
2425604 |
0 |
2425604 |
2425604 |
4.5 % |
14/02/2022 |
| Perceptive Advisors LLC |
Delaware |
0 |
2425604 |
0 |
2425604 |
2425604 |
4.5 % |
14/02/2022 |
| Perceptive Life Sciences Master Fund, Ltd. |
Delaware |
0 |
2425604 |
0 |
2425604 |
2425604 |
4.5 % |
14/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
1037677 |
0 |
1037677 |
0 |
1037677 |
2 % |
09/07/2021 |
| Great Point Partners, LLC |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Mr. Ortav Yehudai |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| First Manhattan Co. |
New York |
0 |
21319 |
0 |
0 |
21319 |
0.01 % |
16/02/2021 |
| EIN #00-0000000 |
Jersey Channel Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2021 |
| (1)Names of reporting persons. BlackRock, Inc. |
Delaware |
11848617 |
0 |
11988767 |
0 |
11988767 |
7.1 % |
02/02/2021 |
| Vivo
Capital VIII, LLC |
Delaware |
3643824 |
0 |
3643824 |
0 |
3643824 |
2.2 % |
11/06/2020 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
1404265 |
0 |
1404265 |
1404265 |
4 % |
21/01/2020 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
1404265 |
0 |
1404265 |
1404265 |
4 % |
21/01/2020 |
| Steven A. Cohen |
Delaware |
0 |
1404990 |
0 |
1404990 |
1404990 |
4 % |
21/01/2020 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
600 |
0 |
600 |
600 |
4 % |
21/01/2020 |
| Point72 Hong Kong Limited |
Delaware |
0 |
125 |
0 |
125 |
125 |
4 % |
21/01/2020 |
| Merck Foundation, a New Jersey Nonprofit Corporation |
New Jersey |
1243168 |
0 |
1243168 |
0 |
1243168 |
5.41 % |
14/02/2019 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
1556758 |
0 |
1556758 |
1556758 |
6.77 % |
13/08/2018 |
| Mr. David Kroin |
USA |
0 |
1556758 |
0 |
1556758 |
1556758 |
6.77 % |
13/08/2018 |
| Great Point Partners, LLC |
USA |
0 |
1556758 |
0 |
1556758 |
1556758 |
6.77 % |
13/08/2018 |
| First Trust Portfolios L.P., First Trust Advisors L.P., The Charger Corporation |
Jersey, Channel Islands |
0 |
2319698 |
0 |
2319698 |
2662136 |
5.03 % |
10/05/2018 |
| Merck & Co., Inc. |
New Jersey |
1243168 |
0 |
1243168 |
0 |
1243168 |
5.41 % |
14/02/2018 |
| Merck Sharp & Dohme Corp. |
New Jersey |
1243168 |
0 |
1243168 |
0 |
1243168 |
5.41 % |
14/02/2018 |
| Novo Holdings A/S |
Denmark |
1161182 |
0 |
1161182 |
0 |
1161182 |
5.05 % |
08/02/2018 |
| Vivo Capital VIII, LLC |
Delaware |
4011236 |
0 |
4011236 |
0 |
4011236 |
17.5 % |
02/02/2018 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
1118054 |
0 |
1118054 |
5.098 % |
31/01/2018 |
| FMR LLC |
Delaware |
1094207 |
0 |
1118054 |
0 |
1118054 |
5.098 % |
31/01/2018 |